Paul Mullan

Research output

Research output per year 2000 2020

• 59 Article
• 6 Meeting abstract
• 2 Other contribution
• 1 Letter
• 1 More
  • 1 Review article

Research output per year

Research output per year

Search results

• 2020

  Glucocorticoid Receptor Expression Predicts Good Outcome in response to Taxane-Free, Anthracycline-Based Therapy in Triple Negative Breast Cancer

  Elkashif, A., Bingham, V., Haddock, P., Humphries, M., McQuaid, S., Mullan, P., McCarthy, H. & Buckley, N. E., 20 May 2020, In: Journal of Oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • taxane
  • Triple Negative Breast Neoplasms
  • Anthracyclines
  • Glucocorticoid Receptors
  • Drug Therapy
  35 Downloads (Pure)

• Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer

  Haughey, C. M., Mukherjee, D., Steele, R. E., Popple, A., Dura-Perez, L., Pickard, A., Patel, M., Jain, S., Mullan, P. B., Williams, R., Oliveira, P., Buckley, N. E., Honeychurch, J., S McDade, S., Illidge, T., Mills, I. G. & Eddie, S. L., 29 Sep 2020, In: Cancers. 12, 10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Radiotherapy
  • Myeloid-Derived Suppressor Cells
  • Neoplasms
  • Up-Regulation
  • Keratin-8
  36 Downloads (Pure)

• Pin1 plays a key role in the response to treatment and clinical outcome in Triple Negative Breast Cancer

  Knowlson, C., Coulter, P., Bingham, V., McQuaid, S., Mullan, P. & Buckley, N. E., 09 Mar 2020, In: Therapeutic Advances in Medical Oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms
  • Standard of Care
  • Drug Therapy
  • Peptidylprolyl Isomerase
  • Taxoids
  2 Citations (Scopus)
• 2019

  Defining the molecular evolution of extrauterine high grade serous carcinoma

  Beirne, J. P., McArt, D. G., Roddy, A., McDermott, C., Ferris, J., Buckley, N. E., Coulter, P., McCabe, N., Eddie, S. L., Dunne, P. D., O'Reilly, P., Gilmore, A., Feeney, L., Ewing, D. L., Drapkin, R. I., Salto-Tellez, M., Kennedy, R. D., Harley, I. J. G., McCluggage, W. G. & Mullan, P. B., 04 Sep 2019, In: Gynecologic Oncology. 155, 2, p. 305-317 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Evolution
  • Carcinoma
  • Carcinoma in Situ
  • Epithelium
  • Northern Ireland
  2 Citations (Scopus)

• Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt

  Dutton, L. R., Hoare, O. P., McCorry, A. M. B., Redmond, K. L., Adam, N. E., Canamara, S., Bingham, V., Mullan, P. B., Lawler, M., Dunne, P. D. & Brazil, D. P., 23 Jul 2019, In: Oncotarget. 10, 45, p. 4630-4639 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Colorectal Neoplasms
  • Tumor Microenvironment
  • Fibroblasts
  • Epithelial Cells
  • Bone Morphogenetic Proteins
  4 Citations (Scopus)

  163 Downloads (Pure)

• Identification and SAR exploration of a novel series of Legumain inhibitors

  Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.

  Research output: Contribution to journal › Article › peer-review

  • asparaginylendopeptidase
  • Dipeptides
  • Molecules
  • In Vitro Techniques
  • Experiments
  1 Citation (Scopus)

• NUP98 – a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

  Mullan, P. B., Bingham, V., Haddock, P., Irwin, G. W., Kay, E., McQuaid, S. & Buckley, N. E., 02 Apr 2019, In: BMC Cancer. 19, 13 p., 236.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • nuclear pore complex protein 98
  • Triple Negative Breast Neoplasms
  • Anthracyclines
  • Drug Therapy
  • Standard of Care
  6 Citations (Scopus)

  166 Downloads (Pure)

• TBX2 interacts with heterochromatin protein 1 to recruit a novel repression complex to EGR1-targeted promoters to drive the proliferation of breast cancer cells

  Crawford, N. T., McIntyre, A. J., McCormick, A. J., D'Costa, Z. C., Buckley, N. E. & Mullan, P. B., 28 Jun 2019, In: Oncogene. 38, p. 5971

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • heterochromatin-specific nonhistone chromosomal protein HP-1
  • Breast Neoplasms
  • Growth
  • Histone Methyltransferases
  • Protein Binding
  7 Citations (Scopus)

  126 Downloads (Pure)
• 2018

  Activation of MAPK signalling results in resistance to saracatinib (AZD0530) in ovarian cancer

  McGivern, N., El-Helali, A., Mullan, P., McNeish, I. A., Paul Harkin, D., Kennedy, R. D. & McCabe, N., 12 Jan 2018, In: Oncotarget. 9, 4, p. 4722-4736 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • saracatinib
  • Ovarian Neoplasms
  • Mitogen-Activated Protein Kinase Kinases
  • Insulin Receptor
  • Platinum
  12 Citations (Scopus)

  207 Downloads (Pure)

• Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

  Humphries, M., Hynes, S., Bingham, V., Cougot, D., James, J., Patel-Socha, F., Parkes, E., Blayney, J., O'Rorke, M., Irwin, G., McArt, D., Kennedy, R., Mullan, P., McQuaid, S., Salto-Tellez, M. & Buckley, N. E., 17 Dec 2018, In: Journal of Oncology. 2018, 14 p., 2937012.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biomarkers
  • Breast Neoplasms
  • Pathology
  • Triple Negative Breast Neoplasms
  • Drug Therapy
  13 Citations (Scopus)

  296 Downloads (Pure)
• 2017

  Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

  Parkes, E. E., Walker, S. M., Taggart, L. E., McCabe, N., Knight, L. A., Wilkinson, R., McCloskey, K., Buckley, N. E., Savage, K. I., Salto-Tellez, M., McQuaid, S., Harte, M. T., Mullan, P. B., Harkin, D. P. & Kennedy, R. D., 01 Jan 2017, In: Journal of the National Cancer Institute. 109, 1, djw199.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage
  • Breast Neoplasms
  • Chemokine CXCL10
  • Immunohistochemistry
  • Virus Activation
  126 Citations (Scopus)

  680 Downloads (Pure)
• 2016

  A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer

  Buckley, N. E., Haddock, P., De Matos Simoes, R., Parkes, E., Irwin, G., Emmert-Streib, F., McQuaid, S., Kennedy, R. & Mullan, P., 02 Mar 2016, In: Oncotarget. 7, 15, p. 19884 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Triple Negative Breast Neoplasms
  • Neoplasms
  • Breast Neoplasms
  • Loss of Function Mutation
  • Tumor Microenvironment
  19 Citations (Scopus)

  1991 Downloads (Pure)

• Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors

  Ness, K. A., Eddie, S. L., Burton, S., Harrison, T., Mullan, P. & Williams, R., 15 Jan 2016, In: Bioorganic and Medicinal Chemistry Letters. 26, 2, p. 413-6 4 p.

  Research output: Contribution to journal › Article › peer-review

  • asparaginylendopeptidase
  • Molecules
  1 Citation (Scopus)

• Quantification of HER2 heterogeneity in breast cancer-implications for identification of sub-dominant clones for personalised treatment

  Buckley, N. E., Forde, C., McArt, D. G., Boyle, D. P., Mullan, P. B., James, J. A., Maxwell, P., McQuaid, S. & Salto-Tellez, M., 21 Mar 2016, In: Scientific Reports. 6, 8 p., 23383.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Breast Neoplasms
  • Biomarkers
  • Pathologists
  • Neoplasms
  • Phenotype
  23 Citations (Scopus)

  294 Downloads (Pure)

• The identification of a novel role for BRCA1 in regulating RNA Polymerase I transcription

  Johnston, R., D'Costa, Z., Ray, S., Gorski, J., Harkin, D. P., Mullan, P. & Panov, K. I., 31 Aug 2016, In: Oncotarget. 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage
  • Ribosomal DNA
  • Ribosomes
  • transcription factor UBF
  • Holoenzymes
  4 Citations (Scopus)

  331 Downloads (Pure)

• Thromboxane A2 receptor (TBXA2R) is a potent survival factor for triple negative breast cancers (TNBCs)

  Orr, K., Buckley, N. E., Haddock, P., James, C., Parent, J-L., McQuaid, S. & Mullan, P., 30 Jul 2016, In: Oncotarget. 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Prostaglandin H2 Receptors Thromboxane A2
  • Triple Negative Breast Neoplasms
  • Breast Neoplasms
  • Epirubicin
  • rho-Associated Kinases
  7 Citations (Scopus)

  278 Downloads (Pure)
• 2015

  Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression

  Stewart, J., James, J., McCluggage, G. W., McQuaid, S., Arthur, K., Boyle, D., Mullan, P., McArt, D., Yan, B., Irwin, G., Harkin, D. P., Zhengdeng, L., Ong, C. W., Yu, J., Virshup, D. M. & Salto-Tellez, M., 01 Mar 2015, In: Modern Pathology . 28, 3, p. 428-436 9 p.

  Research output: Contribution to journal › Article › peer-review

  • human ERBB2 protein
  • Ovarian Neoplasms
  • Stomach Neoplasms
  • Breast Neoplasms
  • Trastuzumab
  19 Citations (Scopus)

• Development of a potent and selective cell penetrant Legumain inhibitor

  Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In: Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645

  Research output: Contribution to journal › Article › peer-review

  • asparaginylendopeptidase
  • Assays
  • Molecules
  • Cells
  • Cell Survival
  6 Citations (Scopus)

• Molecular classification of non-invasive breast lesions for personalised therapy and chemoprevention

  Buckley, N., Boyle, D., McArt, D., Irwin, G., Harkin, D. P., Lioe, T., McQuaid, S., James, J. A., Maxwell, P., Hamilton, P., Mullan, P. B. & Salto-Tellez, M., 09 Dec 2015, In: Oncotarget. 6, 41, p. 43244-54 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chemoprevention
  • Carcinoma, Intraductal, Noninfiltrating
  • Breast
  • Breast Neoplasms
  • Biomarkers
  9 Citations (Scopus)

  270 Downloads (Pure)

• PICan: An integromics framework for dynamic cancer biomarker discovery

  McArt, D. G., Blayney, J. K., Boyle, D. P., Irwin, G. W., Moran, M., Hutchinson, R. A., Bankhead, P., Kieran, D., Wang, Y., Dunne, P. D., Kennedy, R. D., Mullan, P. B., Harkin, D. P., Catherwood, M. A., James, J. A., Salto-Tellez, M. & Hamilton, P. W., 01 Jun 2015, In: Molecular oncology. 9, 6, p. 1234-1240 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Biomarkers
  • Biomarkers
  • Datasets
  • RNA
  • Technology
  13 Citations (Scopus)
• 2014

  Identification and Validation of an Anthracycline/Cyclophosphamide–Based Chemotherapy Response Assay in Breast Cancer

  Mulligan, J. M., Hill, L. A., Deharo, S., Irwin, G., Boyle, D., Keating, K. E., Raji, O. Y., McDyer, F. A., O'Brien, E., Bylesjo, M., Quinn, J. E., Lindor, N. M., Mullan, P. B., James, C. R., Walker, S. M., Kerr, P., James, J., Davison, T. S., Proutski, V., Salto-Tellez, M. & 4 others, Johnston, P. G., Couch, F. J., Harkin, P. & Kennedy, R. D., 01 Jan 2014, In: Journal of the National Cancer Institute. 106, 1, 10 p., djt335.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Anthracyclines
  • Breast Neoplasms
  • Drug Therapy
  • DNA Damage
  • Fanconi Anemia
  60 Citations (Scopus)

  299 Downloads (Pure)

• NF-κB is a critical mediator of BRCA1-induced chemoresistance

  Harte, M. T., Gorski, J. J., Savage, K. I., Purcell, J. W., Barros, E. M., Burn, P. M., McFarlane, C., Mullan, P. B., Kennedy, R. D., Perkins, N. D. & Harkin, D. P., 06 Feb 2014, In: Oncogene. 33, 6, p. 713-723 11 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Damage
  • Camptothecin
  • Etoposide
  • DNA
  • Neoplasms
  28 Citations (Scopus)

• P3 SAR exploration of biphenyl carbamate based Legumain inhibitors

  Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In: Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524

  Research output: Contribution to journal › Article › peer-review

  • asparaginylendopeptidase
  • Carbamates
  • diphenyl
  • Enzymes
  4 Citations (Scopus)

• S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability

  Buckley, N. E., D'Costa, Z., Kaminska, M. & Mullan, P. B., 20 Feb 2014, In: Cell, Death & Disease. 5, 10 p., e1070.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tumor Suppressor Genes
  • Proteins
  • tanespimycin
  • Growth
  • BRCA1 Protein
  15 Citations (Scopus)

  237 Downloads (Pure)

• TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

  D'Costa, Z. C., Higgins, C., Ong, C. W., Irwin, G. W., Boyle, D., McArt, D. G., McCloskey, K., Buckley, N. E., Crawford, N. T., Thiagarajan, L., Murray, J. T., Kennedy, R. D., Mulligan, K. A., Harkin, D. P., Waugh, D. J. J., Scott, C. J., Salto-Tellez, M., Williams, R. & Mullan, P. B., 08 Feb 2014, In: Oncotarget. 5, 6, p. 1609-1620 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cystatin M
  • asparaginylendopeptidase
  • Breast Neoplasms
  • Cathepsins
  • Neoplasms
  25 Citations (Scopus)

  277 Downloads (Pure)

• The prognostic significance of the aberrant extremes of p53 immunophenotypes in breast cancer

  Boyle, D. P., McArt, D. G., Irwin, G., Wilhelm-Benartzi, C. S., Lioe, T. F., Sebastian, E., McQuaid, S., Hamilton, P. W., James, J. A., Mullan, P. B., Catherwood, M. A., Harkin, D. P. & Salto-Tellez, M., Sep 2014, In: Histopathology. 65, 3, p. 340-352 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Survival
  • Immunohistochemistry
  • Mutation
  • Exons
  46 Citations (Scopus)
• 2013

  A strong correlation between expression of Wntless and of human epidermal growth factor receptor 2 in gastric, ovarian, and breast cancers suggests a novel-signalling pathway involving NFκB and STAT3

  Stewart, J., James, J., McCluggage, G., McQuaid, S., Boyle, D., Arthur, K., Mullan, P., Kidson, C., McCabe, N., Kennedy, R., McArt, D., Carson, A., Yan, B., Zhengdeng, L., Tan, P., Virshup, D. & Salto-Tellez, M., 27 Feb 2013, In: The Lancet. 381, p. S106

  Research output: Contribution to journal › Article

  • human ERBB2 protein
  • Ovarian Neoplasms
  • Stomach Neoplasms
  • Breast Neoplasms
  • Wnt Proteins

• BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers

  Buckley, N. E., Nic An tSaoir, C. B., Blayney, J. K., Oram, L. C., Crawford, N. T., D'Costa, Z. C., Quinn, J. E., Kennedy, R. D., Harkin, D. P. & Mullan, P. B., Oct 2013, In: Nucleic Acids Research. 41, 18, p. 8601-8614 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Jagged-1 Protein
  • Breast
  • Breast Neoplasms
  • Estrogen Receptors
  • aldehyde dehydrogenase 1
  22 Citations (Scopus)

  458 Downloads (Pure)

• Molecular mapping the presence of druggable targets in preinvasive and precursor breast lesions: A comprehensive review of biomarkers related to therapeutic interventions

  Boyle, D. P., Mullan, P. & Salto-Tellez, M., Apr 2013, In: Biochimica et biophysica acta. 1835, 2, p. 230-242

  Research output: Contribution to journal › Article › peer-review

  • Breast
  • Biomarkers
  • Breast Neoplasms
  • Medical Overuse
  • Pathologists
  5 Citations (Scopus)
• 2011

  BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers

  Tkocz, D., Crawford, N., Buckley, N. E., Berry, F. B., Kennedy, R., Miskelly, J., Harkin, P. & Mullan, P., 09 Dec 2011, In: Oncogene. 531, 32, p. 3667-3678 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • GATA3 Transcription Factor
  • BRCA1 Protein
  • Mutant Proteins
  • Epithelial-Mesenchymal Transition
  48 Citations (Scopus)

• Identification of a novel breast cancer molecular subgroup associated with a deficiency in DNA-damage response

  Mulligan, J. M., Hill, L. A., Deharo, S., McDyer, F. A., Davison, T. S., Bylesjo, M., Lindor, N. M., Galligan, L., Delaney, T., Halfpenny, I. A., Farztdinov, V., Goffard, N., Proutski, V., Keating, K. E., Mullan, P. B., Quinn, J. E., Johnston, P. G., Couch, F. J., Harkin, D. P. & Kennedy, R. D., 20 May 2011, In: Journal of Clinical Oncology. 29, 15_suppl, p. 10511

  Research output: Contribution to journal › Article › peer-review

  • DNA Damage
  • Breast Neoplasms
  • DNA
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Fanconi Anemia

• The Delta Np63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer

  Buckley, N., Conlon, S., Jirstrom, K., Kay, E. W., Crawford, N., O'Grady, A., Sheehan, K., McDade, S., Wang, C-W., McCance, D., Johnston, P., Kennedy, R., Harkin, P. & Mullan, P., 01 Mar 2011, In: Cancer Research. 71, 5, p. 1933-1944 12 p.

  Research output: Contribution to journal › Article › peer-review

  • delta protein
  • Breast Neoplasms
  • Protein Isoforms
  • Stem Cells
  • Transcription Factor AP-2
  32 Citations (Scopus)
• 2010

  BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer

  Gorski, J. J., James, C., Quinn, J. E., Stewart, G. E., Staunton, K. C., Buckley, N., McDyer, F. A., Kennedy, R., Wilson, R., Mullan, P. & Harkin, P., Aug 2010, In: Breast Cancer Research and Treatment. 122, 3, p. 721-731 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromatin Immunoprecipitation
  • Breast Neoplasms
  • Phenotype
  • Keratin-17
  • Keratin-5
  52 Citations (Scopus)

• BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription

  Harte, M. T., O'Brien, G. J., Ryan, N. M., Gorski, J. J., Savage, K. I., Crawford, N. T., Mullan, P. B. & Harkin, D. P., 15 Mar 2010, In: Cancer Research. 70, 6, p. 2538-2547 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Fulvestrant
  • Estrogen Receptor Modulators
  • Chromatin Assembly and Disassembly
  • RNA Polymerase II
  80 Citations (Scopus)

• T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells

  Redmond, K. L., Crawford, N., Farmer, H., D'Costa, Z. C., O'Brien, G. J., Buckley, N., Kennedy, R., Johnston, P., Harkin, P. & Mullan, P., 03 Jun 2010, In: Oncogene. 29, 22, p. 3252-3262 11 p.

  Research output: Contribution to journal › Article › peer-review

  • myc Genes
  • Breast Neoplasms
  • Growth
  • Gene Drive Technology
  • Breast
  46 Citations (Scopus)
• 2007

  BRCA1, a potential biomarker in the treatment of breast cancer

  James, C., O'Brien, J., Mullan, P., Johnston, P. & Harkin, P., Feb 2007, In: The Oncologist. 12, 2, p. 142-150 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Biomarkers
  • Breast Neoplasms
  • Drug Therapy
  • ErbB-2 Receptor
  • Decision Support Techniques
  127 Citations (Scopus)

• BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy.

  Quinn, J., James, C., Stewart, G., O'Donnell, J., Russell, H., Chang, G., White, P., Mullan, P., Johnston, P., Wilson, R. & Harkin, P., 15 Dec 2007, In: Clinical Cancer Research. 13 (24), 24, p. 7413-7420 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ovarian Neoplasms
  • Drug Therapy
  • Messenger RNA
  • Survival
  • Ovarian Epithelial Carcinoma
  182 Citations (Scopus)

• BRCA1 mRNA Expression Levels predict for overall Survival in Ovarian Cancer following Chemotherapy

  O'Brien, J., James, C., Stewart, G., Mulligan, J., White, P., Chang, G. K. F., Mullan, P., Wilson, P. G. & Harkin, P., 2007, In: Clinical Cancer Research. -

  Research output: Contribution to journal › Article › peer-review

• BRCA1 Regulates IFN-γ Signaling through a Mechanism Involving the Type I IFNs

  Buckley, N., Hosey, A. M., Gorski, J. J., Purcell, J. W., Mulligan, J. M., Harkin, D. P. & Mullan, P. B., Mar 2007, In: Molecular Cancer Research. 5, 3, p. 261-270 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Up-Regulation
  • STAT1 Transcription Factor
  • Apoptosis
  • Ubiquitination
  • Genetic Predisposition to Disease
  33 Citations (Scopus)

• Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer

  Hosey, A. M., Gorski, J. J., Murray, M. M., Quinn, J. E., Chung, W. Y., Stewart, G. E., James, C. R., Farragher, S. M., Mulligan, J. M., Scott, A. N., Dervan, P. A., Johnston, P. G., Couch, F. J., Daly, P. A., Kay, E., McCann, A., Mullan, P. B. & Harkin, D. P., 21 Nov 2007, In: Journal of the National Cancer Institute. 99, 22, p. 1683-1694 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Estrogen Receptor alpha
  • Breast Neoplasms
  • Fulvestrant
  • MCF-7 Cells
  • Estrogen Receptor Modulators
  162 Citations (Scopus)

• Molecular subtyping of breast cancer: Opportunities for new therapeutic approaches

  Mullan, P. & Millikan, R. C., Dec 2007, In: Cellular and molecular life sciences : CMLS. 64, 24, p. 3219-3232 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Chemotherapy
  • ErbB-2 Receptor
  • Keratin-5
  • Breast Neoplasms
  • Toxicity
  21 Citations (Scopus)

• Role played by BRCA1 in transcriptional regulation in response to therapy

  Murray, M. M., Mullan, P. B. & Harkin, D. P., Nov 2007, In: Biochemical society transactions. 35, 5, p. 1342-1346 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Cycle Checkpoints
  • Cells
  • Chemotherapy
  • Holoenzymes
  • DNA
  21 Citations (Scopus)
• 2006

  BRCA1 - A good predictive marker of drug sensitivity in breast cancer treatment?

  Mullan, P., Gorski, J. J. & Harkin, P., Dec 2006, In: Biochimica et biophysica acta. 1766, 2, p. 205-216 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Drug Therapy
  • Ovarian Neoplasms
  • Pharmaceutical Preparations
  • Estrogen Receptor alpha
  30 Citations (Scopus)

• The role of BRCA1 in transcriptional regulation and cell cycle control

  Mullan, P., O'Brien, J. & Harkin, D., 25 Sep 2006, In: Oncogene. 25, 43, p. 5854-5863 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Cycle Checkpoints
  • Ubiquitination
  • DNA Repair
  • Epigenomics
  • Chromatin
  195 Citations (Scopus)
• 2005

  BRCA1 and c-Myc Associate to Transcriptionally Repress Psoriasin, a DNA Damage-Inducible Gene

  Kennedy, R. D., Gorski, J. J., Quinn, J. E., Stewart, G. E., James, C. R., Moore, S., Mulligan, K., Emberley, E. D., Lioe, T. F., Morrison, P. J., Mullan, P. B., Reid, G., Johnston, P. G., Watson, P. H. & Harkin, D. P., 15 Nov 2005, In: Cancer Research. 65, 22, p. 10265-10272 8 p.

  Research output: Contribution to journal › Article › peer-review

  • S100 Calcium Binding Protein A7
  • DNA Damage
  • Genes
  • Etoposide
  • Calcium-Binding Proteins
  68 Citations (Scopus)

• The 2,5 Oligoadenylate Synthetase/RNaseL pathway is a novel effector of BRCA1 - and interferon-gamma-mediated apoptosis

  Mullan, P., Kennedy, R., Buckley, N., O'Brien, J., Hosey, A., Johnston, P. & Harkin, P., 18 Aug 2005, In: Oncogene. 24(35), 35, p. 5492-5501 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 2',5'-oligoadenylate
  • Ligases
  • Interferon-gamma
  • Apoptosis
  • Small Interfering RNA
  41 Citations (Scopus)
• 2004

  BRCA1 Interacts with and Is Required for Paclitaxel-Induced Activation of Mitogen-Activated Protein Kinase Kinase Kinase 3

  Gilmore, P. M., McCabe, N., Liu, E. T., O'Brien, J., Kennedy, R., Mullan, P., Miskelly, J., Andrews, H. N., McWilliams, S., Carty, M., Duprex, P., Johnston, P. & Harkin, P., 15 Jun 2004, In: Cancer Research. 64(12), 12, p. 4148-4154 7 p.

  Research output: Contribution to journal › Article › peer-review
  42 Citations (Scopus)

• The Role of BRCA1 in the Cellular Response to Chemotherapy

  Kennedy, R., O'Brien, J., Mullan, P., Johnston, P. & Harkin, D., 17 Nov 2004, In: Journal of the National Cancer Institute. 96(22), 22, p. 1659-1668 10 p.

  Research output: Contribution to journal › Article › peer-review
  336 Citations (Scopus)
• 2003

  BRCA1 Functions as a Differential Modulator of Chemotherapy-induced Apoptosis

  O'Brien, J., Kennedy, R., Mullan, P., Gilmore, P. M., Carty, M., Johnston, P. & Harkin, P., 01 Oct 2003, In: Cancer Research. 63(19), 19, p. 6221-6228 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis
  • Drug Therapy
  • DNA
  • Vinorelbine
  • Poly(ADP-ribose) Polymerases
  376 Citations (Scopus)

• BRCA1 is a differential mediator of apoptosis.

  Kennedy, R., Quinn, J. F., Mullan, P., Johnston, P. & Harkin, P., 2003, In: Clinical Cancer Research. 9, p. 6154S-6154S

  Research output: Contribution to journal › Article › peer-review