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    United Kingdom

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PhD projects

Molecular subtyping in colorectal cancer Stromal and immune interactions in colorectal cancer Tumour invasion and dissemination

20092019

Research output per year

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Personal profile

Research Focus

My research programme is focused on investigating mechanisms underlying disease progression in colorectal cancer, with a particular interest in signalling associated with early dissemination of tumours cells and their interaction with the tumour microenvironment. The research programme also includes development of molecular subtypes, using signalling associated with intrinsic (epithelial) and extrinsic (stromal and immune) components of the tumour.

 

My group employs a wide range of laboratory techniques, both “wet-lab” and “dry-lab”, by combining in vivo and in vitro molecular biology, in situ molecular pathology and in silico translational bioinformatics.

Research Statement

My laboratory research programme is truly interdisciplinary, performing digital pathology and standard histology characterisation of human tumour tissue samples, followed by molecular profiling and subsequent translational bioinformatics analyses, leading to biomarker assessment and validation in situ with additional scope for further assessment using flow cytometery.

My research programme then utilises this combined molecular pathology approach to develop (and inform the development of) pre-clinical models of disease, based on specific molecular and pathological subtyping information, for testing of potential therapeutic strategies to target the phenotypes of interest. Finally, given my position on a number of national colorectal clinical trial panels and international clinical/translational consortia, my research has the ability to directly link these findings into prospective clinical trials across Europe.

Although the flow of projects described above begins with tissue and proceeds via molecular analysis and model development/testing, the dynamic nature of my interdisciplinary research team enables my programme to pursue its research aims from multiple starting points in any direction.

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Projects

Research Output

A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

Gilmore, A., Alderdice, M., Savage, K., O’Reilly, P. G., Roddy, A., Dunne, P., Lawler, M., McDade, S., Waugh, D. & McArt, D., 13 Feb 2019, In : Cancer Research.

Research output: Contribution to journalArticle

Open Access
File
  • 1 Citation (Scopus)
    16 Downloads (Pure)

    Defining the molecular evolution of extrauterine high grade serous carcinoma

    Beirne, J. P., McArt, D. G., Roddy, A., McDermott, C., Ferris, J., Buckley, N. E., Coulter, P., McCabe, N., Eddie, S. L., Dunne, P. D., O'Reilly, P., Gilmore, A., Feeney, L., Ewing, D. L., Drapkin, R. I., Salto-Tellez, M., Kennedy, R. D., Harley, I. J. G., McCluggage, W. G. & Mullan, P. B., 04 Sep 2019, In : Gynecologic Oncology. 155, 2, p. 305-317 13 p.

    Research output: Contribution to journalArticle

  • Open Access
    File
  • 1 Citation (Scopus)
    95 Downloads (Pure)
  • The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

    Amirkhah, R., Naderi-Meshkin, H., Shah, J. S., Dunne, P. D. & Schmitz, U., 19 Aug 2019, In : Cells. 8, 8

    Research output: Contribution to journalReview article

    Open Access
    File
  • 79 Downloads (Pure)

    Prizes

    European Alliance for Personalised Medicine Congress Proffered Paper Prize

    Philip Dunne (Recipient), Dec 2017

    Prize: Prize (including medals and awards)

  • IACR Proffered Paper Prize

    Philip Dunne (Recipient), Mar 2015

    Prize: Prize (including medals and awards)

    Invest Northern Ireland – Innovation award

    Philip Dunne (Recipient), 2010

    Prize: Prize (including medals and awards)

    QUB CCRCB Cancer Researcher of the Year award

    Philip Dunne (Recipient), Dec 2013

    Prize: Prize (including medals and awards)

    The Dr. J.D. Williamson prize for Excellence in Medical Research

    Philip Dunne (Recipient), 2016

    Prize: Prize (including medals and awards)

    Activities

    • 1 Participation in workshop, seminar, course

    Early Career Researchers Forum Inaugural

    Aidan Cole (Organiser), Cristina Branco (Chair), Seyed Mehdi Jafarnejad (Organiser), Emma Allott (Organiser), Stephen McMahon (Participant), Karl Butterworth (Participant), Emma Kerr (Participant), Philip Dunne (Participant), Adone Tielenius Kruythoff-Mohd Sarip (Participant), Melissa LaBonte Wilson (Participant)
    25 Nov 2019

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course