Projects per year
Personal profile
Teaching
MSc Bioinformatics and Computational Genomics
Programme Deputy Coordinator
SCM7046 Introductory Cell Biology and Computational Analysis.
Lecturer and Module Coordinator.
- Cancer Cell Signalling
- Hallmarks of Cancer.
- Molecular Pathology.
SCM7047 Scientific Programming & Statistical Computing.
Lecturer and Module Coordinator.
- Fundamental elements of the statistical framework R.
- Translational Bioinformatics.
SCM8053 MSc Dissertation.
Project Supervisor.
MSc Data Analytics Placement-based Projects.
Project Supervisor.
SCM8066 MRes in Translational Cancer Medicine.
Lecturer.
- Data Analysis.
- Translational Case Studies
BMS3104 Molecular markers of Disease BSc.
Lecturer and Student-led Seminars.
- Epithelium
- Stroma
- Cancer
- Connective Tissue
Undergraduate BSc Years 1-3
Peer Mentor and Tutor (Multiple Groups).
BMS3012 Honours Project in Biomedical Science
Project Supervisor.
Research Focus
My research programme is focused on investigating mechanisms underlying disease progression in colorectal cancer, with a particular interest in signalling associated with early dissemination of tumours cells and their interaction with the tumour microenvironment. The research programme also includes development of molecular subtypes, using signalling associated with intrinsic (epithelial) and extrinsic (stromal and immune) components of the tumour.
My group employs a wide range of laboratory techniques, both “wet-lab” and “dry-lab”, by combining in vivo and in vitro molecular biology, in situ molecular pathology and in silico translational bioinformatics.
Research Statement
My laboratory research programme is truly interdisciplinary, performing digital pathology and standard histology characterisation of human tumour tissue samples, followed by molecular profiling and subsequent translational bioinformatics analyses, leading to biomarker assessment and validation in situ with additional scope for further assessment using flow cytometery.
My research programme then utilises this combined molecular pathology approach to develop (and inform the development of) pre-clinical models of disease, based on specific molecular and pathological subtyping information, for testing of potential therapeutic strategies to target the phenotypes of interest. Finally, given my position on a number of national colorectal clinical trial panels and international clinical/translational consortia, my research has the ability to directly link these findings into prospective clinical trials across Europe.
Although the flow of projects described above begins with tissue and proceeds via molecular analysis and model development/testing, the dynamic nature of my interdisciplinary research team enables my programme to pursue its research aims from multiple starting points in any direction.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D. (PI), Dunne, P. (CoI), Harrison, T. (CoI), Kerr, E. (CoI) & McDade, S. (CoI)
29/03/2019 → …
Project: Research
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R2551CNR: ACRCelerate: Colorectal Cancer Stratified Medicine Network
Dunne, P. (PI) & Lawler, M. (CoI)
03/01/2019 → …
Project: Research
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R4805CNR: Systems Modeling of Tumor Heterogeneity & Therapy response in Colorectal Cancer
Longley, D. (PI), Dunne, P. (CoI), Lawler, M. (CoI), McArt, D. (CoI) & Salto-Tellez, M. (CoI)
28/06/2017 → …
Project: Research
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R1917CNR: Health Data Research UK (HDR UK)
Lawler, M. (PI), Blayney, J. (CoI), Coleman, H. (CoI), Dunne, P. (CoI), Heaney, L. (CoI), Kee, F. (CoI), McArt, D. (CoI), Nikolopoulos, D. (CoI), O'Reilly, D. (CoI), Overton, I. (CoI), Salto-Tellez, M. (CoI) & Woods, R. (CoI)
29/10/2018 → 31/03/2023
Project: Research
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Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer
Malla, S. B., Byrne, R. M., Lafarge, M. W., Corry, S. M., Fisher, N. C., Tsantoulis, P. K., Mills, M. L., Ridgway, R. A., Lannagan, T. R. M., Najumudeen, A. K., Gilroy, K. L., Amirkhah, R., Maguire, S. L., Mulholland, E. J., Belnoue-Davis, H. L., Grassi, E., Viviani, M., Rogan, E., Redmond, K. L. & Sakhnevych, S. & 23 others, , 01 Jun 2024, In: Nature Genetics. 56, 6, 1 p., 1321.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)12 Downloads (Pure) -
Correction to: Molecular pathological classification of colorectal cancer-an update
Dunne, P. D. & Arends, M. J., 28 Feb 2024, In: Virchows Archiv. 484, p. 287 1 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Downloads (Pure) -
Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data
Bull, C., Byrne, R. M., Fisher, N. C., Corry, S. M., Amirkhah, R., Edwards, J., Hillson, L. V. S., Lawler, M., Ryan, A. E., Lamrock, F., Dunne, P. D. & Malla, S. B., 04 Dec 2024, In: Scientific Reports. 14, 13 p., 30202 .Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictors
The S:CORT Consortium, Aug 2024, In: EBioMedicine. 106, 105228.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)33 Downloads (Pure) -
Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy
Lafarge, M. W., Domingo, E., Sirinukunwattana, K., Wood, R., Samuel, L., Murray, G., Richman, S. D., Blake, A., Sebag-Montefiore, D., Gollins, S., Klieser, E., Neureiter, D., Huemer, F., Greil, R., Dunne, P., Quirke, P., Weiss, L., Rittscher, J., Maughan, T. & Koelzer, V. H., 09 Apr 2024, In: npj Precision Oncology. 8, 89.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)23 Downloads (Pure)
Datasets
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Data Portal for human and mouse molecular data analyses
Dunne, P. (Creator), Queen's University Belfast, 2022
DOI: 10.1242/dmm.049257
Dataset
Prizes
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European Alliance for Personalised Medicine Congress Proffered Paper Prize
Dunne, P. (Recipient), Dec 2017
Prize: Prize (including medals and awards)
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Invest Northern Ireland – Innovation award
Dunne, P. (Recipient), 2010
Prize: Prize (including medals and awards)
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QUB CCRCB Cancer Researcher of the Year award
Dunne, P. (Recipient), Dec 2013
Prize: Prize (including medals and awards)
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The Dr. J.D. Williamson prize for Excellence in Medical Research
Dunne, P. (Recipient), 2016
Prize: Prize (including medals and awards)
Activities
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NCRI Colorectal Strategy Session 4: Living with and beyond cancer (LWBC)
Dunne, P. (Chair)
13 Jan 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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NCRI Colorectal Group Strategy Session 3 - Screening, Prevention and Early Detection (SPED)
Dunne, P. (Chair)
12 Dec 2022Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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NCRI Colorectal Group Strategy Session 2 - Treatment options and selection
Dunne, P. (Chair)
05 Dec 2022Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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NCRI Colorectal Group Strategy Session 1 - Translational Medicine and Basic Biology
Dunne, P. (Chair)
22 Nov 2022Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Pathway-derived subtypes in cancer
Dunne, P. (Invited speaker)
15 Nov 2022 → 17 Nov 2022Activity: Talk or presentation types › Invited talk
Press/Media
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Preventing misinterpretation of cancer gene expression signatures
05/08/2022
1 item of Media coverage
Press/Media: Research
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PGJCCR Cancer Digest: Digital Pathology
Branco, C., Loughrey, M., Fisher, N., Craig, S., McGill, K., Dunne, P., Allott, E., Huang, L., Walls, G., Small, D., Morelli, R., Salto-Tellez, M., James, J., Maxwell, P. & Makhlouf, Y.
20/07/2022
1 Media contribution
Press/Media: Public Engagement Activities
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Scientists awaken viral response to target bowel cancer
28/04/2022
1 item of Media coverage
Press/Media: Research