• Room 03.005 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Molecular subtyping in colorectal cancer Stromal and immune interactions in colorectal cancer Tumour invasion and dissemination

20092020

Research output per year

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Personal profile

Research Focus

My research programme is focused on investigating mechanisms underlying disease progression in colorectal cancer, with a particular interest in signalling associated with early dissemination of tumours cells and their interaction with the tumour microenvironment. The research programme also includes development of molecular subtypes, using signalling associated with intrinsic (epithelial) and extrinsic (stromal and immune) components of the tumour.

 

My group employs a wide range of laboratory techniques, both “wet-lab” and “dry-lab”, by combining in vivo and in vitro molecular biology, in situ molecular pathology and in silico translational bioinformatics.

Research Statement

My laboratory research programme is truly interdisciplinary, performing digital pathology and standard histology characterisation of human tumour tissue samples, followed by molecular profiling and subsequent translational bioinformatics analyses, leading to biomarker assessment and validation in situ with additional scope for further assessment using flow cytometery.

My research programme then utilises this combined molecular pathology approach to develop (and inform the development of) pre-clinical models of disease, based on specific molecular and pathological subtyping information, for testing of potential therapeutic strategies to target the phenotypes of interest. Finally, given my position on a number of national colorectal clinical trial panels and international clinical/translational consortia, my research has the ability to directly link these findings into prospective clinical trials across Europe.

Although the flow of projects described above begins with tissue and proceeds via molecular analysis and model development/testing, the dynamic nature of my interdisciplinary research team enables my programme to pursue its research aims from multiple starting points in any direction.

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Projects

Research Output

AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer

Dunne, P. D., McArt, D. G., Blayney, J. K., Kalimutho, M., Greer, S., Wang, T., Srivastava, S., Ong, C. W., Arthur, K., Loughrey, M., Redmond, K., Longley, D. B., Salto-Tellez, M., Johnston, P. G. & Van Schaeybroeck, S., 01 Jan 2014, In : Clinical Cancer Research. 20, 1, p. 164-175 12 p.

Research output: Contribution to journalArticle

  • 65 Citations (Scopus)

    Challenging the cancer molecular stratification dogma: Intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in colorectal cancer

    Dunne, P. D., McArt, D. G., Bradley, C. A., O'Reilly, P. G., Barrett, H. L., Cummins, R., O'Grady, A., Arthur, K., Loughrey, M. B., Moore, W. L., McDade, S. S., Waugh, D. J., Hamilton, P. W., Longley, D. B., Kay, E. W., Johnston, P. G., Lawler, M., Salto-Tellez, M. & Van Schaeybroeck, S., 15 Aug 2016, In : Clinical Cancer Research.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 62 Citations (Scopus)
    251 Downloads (Pure)

    Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

    Dunne, P. D., Alderdice, M., O'Reilly, P. G., Roddy, A. C., McCorry, A. M. B., Richman, S., Maughan, T., McDade, S. S., Johnston, P. G., Longley, D. B., Kay, E., McArt, D. G. & Lawler, M., 31 May 2017, In : Nature Communications. 8, p. 15657 15657.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 24 Citations (Scopus)
    335 Downloads (Pure)
    Open Access
    File
  • 24 Citations (Scopus)
    245 Downloads (Pure)
    Open Access
    File
  • 6 Citations (Scopus)
    161 Downloads (Pure)

    Prizes

    European Alliance for Personalised Medicine Congress Proffered Paper Prize

    Dunne, Philip (Recipient), Dec 2017

    Prize: Prize (including medals and awards)

  • IACR Proffered Paper Prize

    Dunne, Philip (Recipient), Mar 2015

    Prize: Prize (including medals and awards)

    Invest Northern Ireland – Innovation award

    Dunne, Philip (Recipient), 2010

    Prize: Prize (including medals and awards)

    QUB CCRCB Cancer Researcher of the Year award

    Dunne, Philip (Recipient), Dec 2013

    Prize: Prize (including medals and awards)

    The Dr. J.D. Williamson prize for Excellence in Medical Research

    Dunne, Philip (Recipient), 2016

    Prize: Prize (including medals and awards)

    Activities

    • 4 Invited talk
    • 2 Invited or keynote talk at national or international conference
    • 1 Participation in workshop, seminar, course

    Stratified medicine in colorectal cancer

    Philip Dunne (Invited speaker)

    Jan 2020

    Activity: Talk or presentation typesInvited talk

    Molecular Subtyping In Colorectal Cancer To Enable Improved Clinical Stratification

    Philip Dunne (Invited speaker)

    18 Feb 2020

    Activity: Talk or presentation typesInvited or keynote talk at national or international conference

    Transcriptional classification in colorectal cancer

    Philip Dunne (Invited speaker)

    13 Nov 2019

    Activity: Talk or presentation typesInvited talk

    Drivers of prognosis in stromal-rich colorectal cancer

    Philip Dunne (Invited speaker)

    30 Apr 2019

    Activity: Talk or presentation typesInvited talk

    Stratified medicine in colorectal cancer; from discovery to treatment

    Philip Dunne (Invited speaker)

    10 May 2019

    Activity: Talk or presentation typesInvited talk

    Thesis

    Interpreting transcriptional signatures and their relevance to disease biology, prognosis and treatment resistance in colorectal cancer

    Author: Hoare, O., Jul 2020

    Supervisor: Lawler, M. (Supervisor), Dunne, P. (Supervisor) & Van Schaeybroeck, S. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

    File