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    United Kingdom

Accepting PhD Students

PhD projects

Molecular subtyping in colorectal cancer Stromal and immune interactions in colorectal cancer Tumour invasion and dissemination

20092019
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Personal profile

Research Focus

My research programme is focused on investigating mechanisms underlying disease progression in colorectal cancer, with a particular interest in signalling associated with early dissemination of tumours cells and their interaction with the tumour microenvironment. The research programme also includes development of molecular subtypes, using signalling associated with intrinsic (epithelial) and extrinsic (stromal and immune) components of the tumour.

 

My group employs a wide range of laboratory techniques, both “wet-lab” and “dry-lab”, by combining in vivo and in vitro molecular biology, in situ molecular pathology and in silico translational bioinformatics.

Research Statement

My laboratory research programme is truly interdisciplinary, performing digital pathology and standard histology characterisation of human tumour tissue samples, followed by molecular profiling and subsequent translational bioinformatics analyses, leading to biomarker assessment and validation in situ with additional scope for further assessment using flow cytometery.

My research programme then utilises this combined molecular pathology approach to develop (and inform the development of) pre-clinical models of disease, based on specific molecular and pathological subtyping information, for testing of potential therapeutic strategies to target the phenotypes of interest. Finally, given my position on a number of national colorectal clinical trial panels and international clinical/translational consortia, my research has the ability to directly link these findings into prospective clinical trials across Europe.

Although the flow of projects described above begins with tissue and proceeds via molecular analysis and model development/testing, the dynamic nature of my interdisciplinary research team enables my programme to pursue its research aims from multiple starting points in any direction.

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Colorectal Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
Colonic Neoplasms Medicine & Life Sciences
Biomarkers Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Tumor Microenvironment Medicine & Life Sciences
Gene Expression Medicine & Life Sciences
Adjuvant Chemotherapy Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2017 2019

Research Output 2009 2019

1 Citation (Scopus)

A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

Gilmore, A., Alderdice, M., Savage, K., O’Reilly, P. G., Roddy, A., Dunne, P., Lawler, M., McDade, S., Waugh, D. & McArt, D., 13 Feb 2019, In : Cancer Research.

Research output: Contribution to journalArticle

Atlases
Genome
Neoplasms
Breast Neoplasms
RNA Sequence Analysis

Defining the molecular evolution of extrauterine high grade serous carcinoma

Beirne, J. P., McArt, D. G., Roddy, A., McDermott, C., Ferris, J., Buckley, N. E., Coulter, P., McCabe, N., Eddie, S. L., Dunne, P. D., O'Reilly, P., Gilmore, A., Feeney, L., Ewing, D. L., Drapkin, R. I., Salto-Tellez, M., Kennedy, R. D., Harley, I. J. G., McCluggage, W. G. & Mullan, P. B., 04 Sep 2019, In : Gynecologic Oncology. 155, 2, p. 305-317 13 p.

Research output: Contribution to journalArticle

Molecular Evolution
Carcinoma
Fallopian Tubes
Carcinoma in Situ
Epithelium
1 Citation (Scopus)
66 Downloads (Pure)
Open Access
File
Tumor Microenvironment
Colorectal Neoplasms
Fibroblasts
Epithelial Cells
Bone Morphogenetic Proteins
Colorectal Neoplasms
Cohort Studies
Population
Confidence Intervals
Recurrence
47 Downloads (Pure)

The Intricate Interplay between Epigenetic Events, Alternative Splicing and Noncoding RNA Deregulation in Colorectal Cancer

Amirkhah, R., Naderi-Meshkin, H., Shah, J. S., Dunne, P. D. & Schmitz, U., 19 Aug 2019, In : Cells. 8, 8

Research output: Contribution to journalReview article

Open Access
File
Untranslated RNA
Alternative Splicing
Epigenomics
Colorectal Neoplasms
Histone Code

Prizes

European Alliance for Personalised Medicine Congress Proffered Paper Prize

Philip Dunne (Recipient), Dec 2017

Prize: Prize (including medals and awards)

medicine
congress

IACR Proffered Paper Prize

Philip Dunne (Recipient), Mar 2015

Prize: Prize (including medals and awards)

Invest Northern Ireland – Innovation award

Philip Dunne (Recipient), 2010

Prize: Prize (including medals and awards)

QUB CCRCB Cancer Researcher of the Year award

Philip Dunne (Recipient), Dec 2013

Prize: Prize (including medals and awards)

The Dr. J.D. Williamson prize for Excellence in Medical Research

Philip Dunne (Recipient), 2016

Prize: Prize (including medals and awards)