Our research strategically focuses on deciphering the molecular mechanisms linking nutritional signalling (e.g. high-fat/high-carbohydrate diet and functional foods) with the onset of chronic metabolic disease, including diabetes, non-alcoholic fatty liver disease, cardiovascular disease and inflammatory bowel disease.

We employ a wide range of laboratory approaches from in vivo physiology to molecular biology and cell culture, such as genetically engineered animal models, Crispr/cas9 gene editing, single cell RNA-sequencing and microRNA profiling, to investigate the underlying molecular mechanisms that link lipid/carbohydrate metabolism and gut microbiomes with the pathogenesis of metabolic syndrome. We further investigate the therapeutic potentials of functional food (i.e. Fenugreek) and identify pharmaceutical targets that may lend supports for the prevention and treatment of diabetes, non-alcoholic fatty liver disease and cardiovascular disease.