• Room 02.063 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Medina offers research projects investigating vascular stem cell biology with focus on vascular ageing, cellular therapies, and diabetic vasculopathy.

20032020

Research output per year

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Research Output

2020

Editorial: Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation

Medina, R. & Smadja, D. M., 08 Jan 2020, In : Frontiers in Medicine. 6, 2 p., 290.

Research output: Contribution to journalEditorial

Open Access
File
38 Downloads (Pure)

Tibetan PHD2, an allele with loss-of-function properties

Song, D., Navalsky, B. E., Guan, W., Ingersoll, C., Wang, T., Loro, E., Eeles, L., Matchett, K. B., Percy, M. J., Walsby-Tickle, J., McCullagh, J. S. O., Medina, R. J., Khurana, T. S., Bigham, A. W., Lappin, T. R. & Lee, F. S., 15 May 2020, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journalArticle

2019

No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells

Dutton, L. R., O'Neill, C. L., Medina, R. J. & Brazil, D. P., 29 Nov 2019, In : The Journal of biological chemistry. 294, 48, p. 18041-18045 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
43 Downloads (Pure)

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation

O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, McDonald, D. M., Watson, C. J., Stitt, A. W., Margariti, A., Medina, R. J. & Grieve, D. J., 01 Apr 2019, In : Cardiovascular Research.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies

McLoughlin, K. J., Pedrini, E., MacMahon, M., Guduric-Fuchs, J. & Medina, R. J., 11 Mar 2019, In : Frontiers in Medicine. 6, 9 p., 33.

Research output: Contribution to journalArticle

Open Access
File
130 Downloads (Pure)

Therapies for Type 1 Diabetes: Current Scenario and Future Perspectives

Pathak, V., Pathak, N. M., O’Neill, C. L., Guduric-Fuchs, J. & Medina, R. J., 03 May 2019, In : Clinical Medicine Insights: Endocrinology and Diabetes. 12, 13 p.

Research output: Contribution to journalReview article

Open Access
File
2 Citations (Scopus)
75 Downloads (Pure)
Open Access
2 Citations (Scopus)
2018

Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors

Dittmer, M., Young, A., O'Hagan, T., Eleftheriadis, G., Bankhead, P., Dombrowski, Y., Medina, R. J. & Fitzgerald, D. C., 02 May 2018, In : Molecular Brain. 11, 1, p. 1-25

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
249 Downloads (Pure)

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, Margariti, A., 17 Nov 2018, In : Stem Cells.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
245 Downloads (Pure)

NADPH oxidase 4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischemic revascularisation

O'Neill, K., Campbell, D., Edgar, K., Moez, A., McLoughlin, K., O'Neill, C., Dellett, M., Hargey, C., Abudalo, R., Gill, E., Doyle, P., Toh, T., Khoo, J., McCrudden, C., Brunssen, C., Morawietz, H., Yoder, M. C., Stitt, A., Margariti, A., Medina, R. & 1 others, Grieve, D., 03 Feb 2018.

Research output: Contribution to conferenceAbstract

Open Access
File
10 Citations (Scopus)
156 Downloads (Pure)

REDUCED PRO-ANGIOGENIC FUNCTION OF CORD BLOOD ENDOTHELIAL COLONY-FORMING CELLS IN HYPERGLYCAEMIA IS MEDIATED BY NOX4

Toh, T., O'Neill, K., Campbell, D., Yoder, M. C., Medina, R. & Grieve, D., 10 Sep 2018.

Research output: Contribution to conferenceAbstract

The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β

Chambers, S. E. J., O'Neill, C. L., Guduric-Fuchs, J., McLoughlin, K. J., Liew, A., Egan, A. M., O'Brien, T., Stitt, A. W. & Medina, R. J., 09 Apr 2018, In : Stem Cells. p. 1-11

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
36 Downloads (Pure)

The Vasoreparative Potential of Endothelial Colony Forming Cells: A Journey Through Pre-clinical Studies

O'Neill, C., McLoughlin, K., Chambers, S., Guduric-Fuchs, J., Stitt, A. & Medina, R., 16 Oct 2018, In : Frontiers in Medicine. 5, 273, p. 1-9

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
159 Downloads (Pure)
2017

Endothelial Progenitors: A Consensus Statement on Nomenclature

Medina, R. J., Barber, C. L., Sabatier, F., Dignat-George, F., Melero-Martin, J. M., Khosrotehrani, K., Ohneda, O., Randi, A. M., Chan, J. K. Y., Yamaguchi, T., Van Hinsbergh, V. W. M., Yoder, M. C. & Stitt, A. W., 10 Mar 2017, In : Stem cells translational medicine.

Research output: Contribution to journalArticle

Open Access
File
119 Citations (Scopus)
209 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
221 Downloads (Pure)

Regulatory T cells enhance oligodendrocyte differentiation

Dittmer, M., O'Hagan, T., Eleftheriadis, G., Fleville, S., Falconer, J., Bankhead, P., Medina, R., Dombrowski, Y. & Fitzgerald, D., 2017.

Research output: Contribution to conferencePoster

Regulatory T cells enhance oligodendrocyte differentiation in vitro

Dittmer, M., O'Hagan, T., Eleftheriadis, G., Fleville, S., Bankhead, P., Dombrowski, Y., Medina, R. & Fitzgerald, D., 2017.

Research output: Contribution to conferencePoster

2016
Open Access
File
14 Citations (Scopus)
228 Downloads (Pure)

Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor

Hookham, M. B., Ali, I. H. A., O'Neill, C. L., Hackett, E., Lambe, M. H., Schmidt, T., Medina, R. J., Chamney, S., Rao, B., McLoone, E., Sweet, D., Stitt, A. W. & Brazil, D. P., 29 Nov 2016, In : Stem Cell Research & Therapy. 7, 173, 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
179 Downloads (Pure)

Myeloid Angiogenic Cells reparative function is impaired by Pentraxin 3

Medina, R., O'Neill, C., Guduric-Fuchs, J. & Stitt, A., 30 Oct 2016.

Research output: Contribution to conferencePoster

Regulatory T cells enhance oligodendrocyte differentiation through Treg-derived CCN3 in vitro

Dittmer, M., O'Hagan, T., Eleftheriadis, G., Fleville, S., Falconer, J., Bankhead, P., Medina, R. & Fitzgerald, D., 2016.

Research output: Contribution to conferencePoster

The progress in understanding and treatment of diabetic retinopathy

Stitt, A. W., Curtis, T. M., Chen, M., Medina, R. J., McKay, G. J., Jenkins, A., Gardiner, T. A., Lyons, T. J., Hammes, H-P., Simó, R. & Lois, N., Mar 2016, In : Progress in Retinal and Eye Research. 51, p. 156-186

Research output: Contribution to journalArticle

214 Citations (Scopus)

Use of endothelial colony forming cell vesicles to modulate retinal angiogenesis

Dellett, M., Brown, E., Guduric-Fuchs, J., Medina, R. & Simpson, D. A., Sep 2016, In : Investigative Opthalmology and Visual Science. 57, 12, 1 p., 3658.

Research output: Contribution to journalMeeting abstract

Open Access
2015

CD362+ stromal stem cells (SSCs) promote revascularisation of the retina in a paracrine manner

Wong, V. H. Y., Allen, L-D., Guduric-Fuchs, J., Medina, R. J., Acuna Medina, C., Elliman, S., Loftus, P., O'Flynn, L. & Stitt, A. W., Jun 2015, In : Investigative Opthalmology and Visual Science. 56, 7, p. 1828-9 2 p.

Research output: Contribution to journalMeeting abstract

CD362+ stromal stem cells (SSCs) promote revascularisation of the retina in a paracrine manner

Wong, V., Medina, R., Allen, L-D., Medina Acuna, C., Elliman, S., Loftus, P., O'Flynn, L. & Stitt, A., May 2015.

Research output: Contribution to conferenceAbstract

CD362+ stromal stem cells (SSCs) promote revascularisation of the retina in a paracrine manner.

Wong, V., Allen, L-D., Medina, R., Elliman, S. & Stitt, A., Apr 2015.

Research output: Contribution to conferenceAbstract

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

Rajasekar, P., O'Neill, C. L., Eeles, L., Stitt, A. W. & Medina, R. J., 2015, In : Journal of Diabetes Research. 2015, p. 1-17 17 p., 436879.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
250 Downloads (Pure)

IL8 is a key component of the senescence-associated secretome in human endothelial colony-forming cells

Medina, R., O'Neill, C., Chambers, S., Guduric-Fuchs, J. & Stitt, A., Jul 2015, p. 2343-2344. 2 p.

Research output: Contribution to conferenceAbstract

Intravitreal AAV2.COMP-Ang1 prevents neurovascular degeneration in a murine model of diabetic retinopathy

Cahoon, J. M., Rai, R. R., Carroll, L. S., Uehara, H., Zhang, X., O'Neil, C. L., Medina, R. J., Das, S. K., Muddana, S. K., Olson, P. R., Nielson, S., Walker, K., Flood, M. M., Messenger, W. B., Archer, B. J., Barabas, P., Krizaj, D., Gibson, C. C., Li, D. Y., Koh, G. Y. & 3 others, Gao, G., Stitt, A. W. & Ambati, B. K., 01 Dec 2015, In : Diabetes. 64, 12, p. 4247-4259 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Mir-130 increases the vasculogenic properties of human endothelial colony-forming cells under hypoxic conditions

Medina, R., Guduric-Fuchs, J., O'Neill, C., Chambers, S. & Stitt, A., 24 Jun 2015, p. F-1152, 444-5.

Research output: Contribution to conferenceAbstract

NADPH Oxidase Influences the Angiogenic Function of Endothelial Colony-Forming Cells

Campbell, DC., Medina, RJ., Stitt, AW. & Grieve, DJ., 08 Sep 2015, p. A10. 1 p.

Research output: Contribution to conferenceAbstract

Regulatory T cells enhance oligodendrocyte differentiation in vitro

Dittmer, M., O'Hagan, T., Eleftheriadis, G., Fleville, S., Bankhead, P., Dombrowski, Y., Medina, R. & Fitzgerald, D., 2015.

Research output: Contribution to conferencePoster

Regulatory T cells enhance oligodendrocyte differentiation in vitro

Dittmer, M., O'Hagan, T., Eleftheriadis, G., Medina, R., Bankhead, P., Dombrowski, Y. & Fitzgerald, D., 2015.

Research output: Contribution to conferencePoster

Regulatory T cells enhance oligodendrocyte differentiation in vitro

Dittmer, M., O'Hagan, T., Eleftheriadis, G., Fleville, S., Falconer, J., Bankhead, P., Dombrowski, Y., Medina, R. & Fitzgerald, D., 2015.

Research output: Contribution to conferencePoster

The cellular density of Circulating Angiogenic Cells (CACs) dictates their angiogenic function

O'Neill, C., O'Doherty, M., Chambers, S., Guduric-Fuchs, J., Bottazzi, B., Medina, R. & Stitt, A., Apr 2015, p. 45.

Research output: Contribution to conferenceAbstract

The cellular density of Myeloid Angiogenic Cells (MACs) dictates their angiogenic function

O'Neill, C., O'Doherty, M., Chambers, S., Guduric-Fuchs, J., Bottazzi, B., Stitt, A. & Medina, R., Jun 2015.

Research output: Contribution to conferenceAbstract

Vasculogenic properties of endothelial colony forming cells (ECFCS) in hypoxia are regulated by MIR-130

Guduric-Fuchs, J., O'Neill, C., Bojdo, J., Chambers, S., Medina, R. & Stitt, A., Jun 2015, p. 30.

Research output: Contribution to conferenceAbstract

Vasgulogenic Properties of Endothelial Colony Forming Cells (ECFCS) in Hypoxia are Regulated by MIR-130

Guduric-fuchs, J., O'Neill, C., James, B., Chambers, S., Medina, R. & Stitt, A., Jun 2015, In : Journal of Vascular Research. 52, Supplement 1, p. 87-88

Research output: Contribution to journalMeeting abstract

Vasoreparative potential of a unique population of stromal stem cells (SSCs) in ischaemic retina.

Wong, V., Allen, L-D., Medina, R., Elliman, S., Loftus, P. & Stitt, A., Jun 2015.

Research output: Contribution to conferenceAbstract

Vasoreparative potential of endothelial progenitor cells is enhanced by a novel erythropoietin (EPO) mimetic peptide.

O'Leary, O., Brazil, D., Brines, M., Cerami, A., Medina, R. & Stitt, A., Apr 2015.

Research output: Contribution to conferenceAbstract

2014

Characterization of Microvascular Changes and Retinal Pathology in a Mouse Model of Laser-induced Retinal Vein Occlusion

Reid, E., Bojdo, J., Lois, N., Medina, R. & Stitt, A., May 2014, p. 2092-2.

Research output: Contribution to conferenceAbstract

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells

Prasain, N., Lee, M. R., Vemula, S., Meador, J. L., Yoshimoto, M., Ferkowicz, M. J., Fett, A., Gupta, M., Rapp, B. M., Saadatzadeh, M. R., Ginsberg, M., Elemento, O., Lee, Y., Voytik-Harbin, S. L., Chung, H. M., Hong, K. S., Reid, E., O'Neill, C. L., Medina, R. J., Stitt, A. W. & 4 others, Murphy, M. P., Rafii, S., Broxmeyer, H. E. & Yoder, M. C., Nov 2014, In : Nature Biotechnology. 32, 11, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Endothelial progenitor cells in diabetic retinopathy

Lois, N., McCarter, R. V., O'Neill, C., Medina, R. J. & Stitt, A. W., Apr 2014, In : Frontiers in endocrinology. 5, 44, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
216 Downloads (Pure)
2013

Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors

Jarajapu, Y. P. R., Bhatwadekar, A. D., Caballero, S., Hazra, S., Shenoy, V., Medina, R., Kent, D., Stitt, A. W., Thut, C., Finney, E. M., Raizada, M. K. & Grant, M. B., Apr 2013, In : Diabetes. 62, 4, p. 1258-69

Research output: Contribution to journalArticle

48 Citations (Scopus)

Advances in our understanding of diabetic retinopathy

Stitt, A. W., Lois, N., Medina, R. J., Adamson, P. & Curtis, T. M., 01 Jul 2013, In : Clinical science (London, England : 1979). 125, 1, p. 1-17

Research output: Contribution to journalArticle

99 Citations (Scopus)
2 Citations (Scopus)