• Room 02.063 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Medina offers research projects investigating vascular stem cell biology with focus on vascular ageing, cellular therapies, and diabetic vasculopathy.

20032020

Research output per year

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Research Output

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Article
2020

Tibetan PHD2, an allele with loss-of-function properties

Song, D., Navalsky, B. E., Guan, W., Ingersoll, C., Wang, T., Loro, E., Eeles, L., Matchett, K. B., Percy, M. J., Walsby-Tickle, J., McCullagh, J. S. O., Medina, R. J., Khurana, T. S., Bigham, A. W., Lappin, T. R. & Lee, F. S., 15 May 2020, In : Proceedings of the National Academy of Sciences of the United States of America.

Research output: Contribution to journalArticle

2019

No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cells

Dutton, L. R., O'Neill, C. L., Medina, R. J. & Brazil, D. P., 29 Nov 2019, In : The Journal of biological chemistry. 294, 48, p. 18041-18045 5 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
44 Downloads (Pure)

NOX4 is a major regulator of cord blood-derived endothelial colony-forming cells which promotes postischaemic revascularisation

O'Neill, K. M., Campbell, D. C., Edgar, K. S., Gill, E. K., Moez, A., McLoughlin, K. J., O'Neill, C. L., Dellett, M., Hargey, C. J., Abudalo, R. A., O'Hare, M., Doyle, P., Toh, T., Khoo, J., Wong, J., McCrudden, C. M., Meloni, M., Brunssen, C., Morawietz, H., Yoder, M. C. & 6 others, McDonald, D. M., Watson, C. J., Stitt, A. W., Margariti, A., Medina, R. J. & Grieve, D. J., 01 Apr 2019, In : Cardiovascular Research.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)

Selection of a Real-Time PCR Housekeeping Gene Panel in Human Endothelial Colony Forming Cells for Cellular Senescence Studies

McLoughlin, K. J., Pedrini, E., MacMahon, M., Guduric-Fuchs, J. & Medina, R. J., 11 Mar 2019, In : Frontiers in Medicine. 6, 9 p., 33.

Research output: Contribution to journalArticle

Open Access
File
131 Downloads (Pure)
Open Access
2 Citations (Scopus)
2018

Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors

Dittmer, M., Young, A., O'Hagan, T., Eleftheriadis, G., Bankhead, P., Dombrowski, Y., Medina, R. J. & Fitzgerald, D. C., 02 May 2018, In : Molecular Brain. 11, 1, p. 1-25

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
252 Downloads (Pure)

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Vilà-González, M., Kelaini, S., Magee, C., Caines, R., Campbell, D., Eleftheriadou, M., Cochrane, A., Drehmer, D., Tsifaki, M., O'Neill, K., Pedrini, E., Yang, C., Medina, R., McDonald, D., Simpson, D., Zampetaki, A., Zeng, L., Grieve, D., Lois, N., Stitt, A. W. & 1 others, Margariti, A., 17 Nov 2018, In : Stem Cells.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
249 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
158 Downloads (Pure)

The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β

Chambers, S. E. J., O'Neill, C. L., Guduric-Fuchs, J., McLoughlin, K. J., Liew, A., Egan, A. M., O'Brien, T., Stitt, A. W. & Medina, R. J., 09 Apr 2018, In : Stem Cells. p. 1-11

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
37 Downloads (Pure)

The Vasoreparative Potential of Endothelial Colony Forming Cells: A Journey Through Pre-clinical Studies

O'Neill, C., McLoughlin, K., Chambers, S., Guduric-Fuchs, J., Stitt, A. & Medina, R., 16 Oct 2018, In : Frontiers in Medicine. 5, 273, p. 1-9

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
162 Downloads (Pure)
2017

Endothelial Progenitors: A Consensus Statement on Nomenclature

Medina, R. J., Barber, C. L., Sabatier, F., Dignat-George, F., Melero-Martin, J. M., Khosrotehrani, K., Ohneda, O., Randi, A. M., Chan, J. K. Y., Yamaguchi, T., Van Hinsbergh, V. W. M., Yoder, M. C. & Stitt, A. W., 10 Mar 2017, In : Stem cells translational medicine.

Research output: Contribution to journalArticle

Open Access
File
121 Citations (Scopus)
210 Downloads (Pure)
Open Access
File
12 Citations (Scopus)
221 Downloads (Pure)
2016
Open Access
File
14 Citations (Scopus)
230 Downloads (Pure)

Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor

Hookham, M. B., Ali, I. H. A., O'Neill, C. L., Hackett, E., Lambe, M. H., Schmidt, T., Medina, R. J., Chamney, S., Rao, B., McLoone, E., Sweet, D., Stitt, A. W. & Brazil, D. P., 29 Nov 2016, In : Stem Cell Research & Therapy. 7, 173, 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
184 Downloads (Pure)

The progress in understanding and treatment of diabetic retinopathy

Stitt, A. W., Curtis, T. M., Chen, M., Medina, R. J., McKay, G. J., Jenkins, A., Gardiner, T. A., Lyons, T. J., Hammes, H-P., Simó, R. & Lois, N., Mar 2016, In : Progress in Retinal and Eye Research. 51, p. 156-186

Research output: Contribution to journalArticle

219 Citations (Scopus)
2015

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

Rajasekar, P., O'Neill, C. L., Eeles, L., Stitt, A. W. & Medina, R. J., 2015, In : Journal of Diabetes Research. 2015, p. 1-17 17 p., 436879.

Research output: Contribution to journalArticle

Open Access
File
33 Citations (Scopus)
252 Downloads (Pure)

Intravitreal AAV2.COMP-Ang1 prevents neurovascular degeneration in a murine model of diabetic retinopathy

Cahoon, J. M., Rai, R. R., Carroll, L. S., Uehara, H., Zhang, X., O'Neil, C. L., Medina, R. J., Das, S. K., Muddana, S. K., Olson, P. R., Nielson, S., Walker, K., Flood, M. M., Messenger, W. B., Archer, B. J., Barabas, P., Krizaj, D., Gibson, C. C., Li, D. Y., Koh, G. Y. & 3 others, Gao, G., Stitt, A. W. & Ambati, B. K., 01 Dec 2015, In : Diabetes. 64, 12, p. 4247-4259 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2014

Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells

Prasain, N., Lee, M. R., Vemula, S., Meador, J. L., Yoshimoto, M., Ferkowicz, M. J., Fett, A., Gupta, M., Rapp, B. M., Saadatzadeh, M. R., Ginsberg, M., Elemento, O., Lee, Y., Voytik-Harbin, S. L., Chung, H. M., Hong, K. S., Reid, E., O'Neill, C. L., Medina, R. J., Stitt, A. W. & 4 others, Murphy, M. P., Rafii, S., Broxmeyer, H. E. & Yoder, M. C., Nov 2014, In : Nature Biotechnology. 32, 11, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Endothelial progenitor cells in diabetic retinopathy

Lois, N., McCarter, R. V., O'Neill, C., Medina, R. J. & Stitt, A. W., Apr 2014, In : Frontiers in endocrinology. 5, 44, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
217 Downloads (Pure)
2013

Activation of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis Enhances the Reparative Function of Dysfunctional Diabetic Endothelial Progenitors

Jarajapu, Y. P. R., Bhatwadekar, A. D., Caballero, S., Hazra, S., Shenoy, V., Medina, R., Kent, D., Stitt, A. W., Thut, C., Finney, E. M., Raizada, M. K. & Grant, M. B., Apr 2013, In : Diabetes. 62, 4, p. 1258-69

Research output: Contribution to journalArticle

49 Citations (Scopus)

Advances in our understanding of diabetic retinopathy

Stitt, A. W., Lois, N., Medina, R. J., Adamson, P. & Curtis, T. M., 01 Jul 2013, In : Clinical science (London, England : 1979). 125, 1, p. 1-17

Research output: Contribution to journalArticle

101 Citations (Scopus)
2 Citations (Scopus)

Characterisation and therapeutic potential of endothelial progenitor cells

McAllister, S. E., Medina, R., O'Neill, C. & Stitt, A. W., 27 Feb 2013, In : Lancet. 381, p. 73-74 2 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

The role of immune-related myeloid cells in angiogenesis

Chambers, S. E. J., O'Neill, C. L., O'Doherty, T. M., Medina, R. J. & Stitt, A. W., Nov 2013, In : Immunobiology. 218, 11, p. 1370-1375 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2012

Endothelial Progenitors as Tools to Study Vascular Disease

Medina, R. J., O'Neill, C. L., O'Doherty, T. M., Wilson, S. E. J. & Stitt, A. W., 2012, In : Stem Cells International. 2012, p. 1-5 346735.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
196 Downloads (Pure)

Therapeutic revascularisation of ischaemic tissue. The opportunities and challenges for therapy using vascular stem/ progenitor cells

O'Neill, C. L., O'Doherty, M. T., Wilson, S. EJ., Rana, A. A., Hirst, C. E., Stitt, A. W. & Medina, R. J., 16 Aug 2012, In : Stem Cell Research & Therapy. 3, 4, p. 1-7 7 p., 31.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Vasculogenic and osteogenesis-enhancing potential of human umbilical cord blood endothelial colony-forming cells

Liu, Y., Teoh, S-H., Chong, M. S. K., Lee, E. S. M., Mattar, C. N. Z., Randhawa, N. K., Zhang, Z-Y., Medina, R. J., Kamm, R. D., Fisk, N. M., Choolani, M. & Chan, J. K. Y., Sep 2012, In : Stem Cells. 30, 9, p. 1911-24 14 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)
2011
8 Citations (Scopus)

Myeloid Angiogenic Cells Act as Alternative M2 Macrophages and Modulate Angiogenesis through Interleukin-8

Medina, R. J., O'Neill, C. L., O'Doherty, T. M., Knott, H., Guduric-Fuchs, J., Gardiner, T. A. & Stitt, A. W., Sep 2011, In : Molecular medicine. 17, 9-10, p. 1045-55 11 p.

Research output: Contribution to journalArticle

Open Access
File
100 Citations (Scopus)
292 Downloads (Pure)

Vascular stem cells and ischaemic retinopathies

Stitt, A. W., O'Neill, C. L., O'Doherty, M. T., Archer, D. B., Gardiner, T. A. & Medina, R. J., May 2011, In : Progress in Retinal and Eye Research. 30, 3, p. 149-166 18 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2010

Differential modulation of angiogenesis by erythropoiesis-stimulating agents in a mouse model of ischaemic retinopathy

McVicar, C. M., Colhoun, L. M., Kitson, C. L., Abrahams, J. L., Hamilton, R., Medina, R. J., Durga, D., Gardiner, T. A., Rudd, P. M. & Stitt, A. W., 01 Jan 2010, In : PLoS ONE. 5, 7, 16 p., e11870.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Evidence supporting a role for N-epsilon-(3-formyl-3,4-dehydropiperidino)lysine accumulation in Muller glia dysfunction and death in diabetic retinopathy

Yong, P. H., Zong, H., Medina, R. J., Limb, G. A., Uchida, K., Stitt, A. W. & Curtis, T. M., 02 Dec 2010, In : Molecular Vision. 16, 270, p. 2524-2538 15 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Outgrowth Endothelial Cells: Characterization and Their Potential for Reversing Ischemic Retinopathy

Medina, R., O'Neill, C., Humphreys, M., Gardiner, T. & Stitt, A., Nov 2010, In : Investigative Ophthalmology and Visual Science. 51, 11, p. 5906-5913 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Transcriptional regulation of a brown adipocyte-specific gene, UCP1, by KLF11 and KLF15

Yamamoto, K., Sakaguchi, M., Medina, R. J., Niida, A., Sakaguchi, Y., Miyazaki, M., Kataoka, K. & Huh, N., Sep 2010, In : Biochemical and Biophysical Research Communications. 400, 1, p. 175-80 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2009

A novel three-dimensional culture system for isolation and clonal propagation of neural stem cells using a thermo-reversible gelation polymer

Yang, X-Z., Kataoka, K., Medina, R., Yamamoto, K-I., Than, S. S., Miyazaki, M. & Huh, N-H., Dec 2009, In : Tissue engineering. Part C, Methods. 15, 4, p. 615-23 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2008

The Pleiotropic Effects of Simvastatin on Retinal Microvascular Endothelium Has Important Implications for Ischaemic Retinopathies

Medina, R. J., O'Neill, C. L., Devine, A. B., Gardiner, T. A. & Stitt, A. W., Jul 2008, In : PLoS ONE. 3, 7, 12 p., e2584.

Research output: Contribution to journalArticle

Open Access
File
46 Citations (Scopus)
170 Downloads (Pure)
2007

Isolation of a bone marrow-derived stem cell line with high proliferation potential and its application for preventing acute fatal liver failure

Miyazaki, M., Hardjo, M., Masaka, T., Tomiyama, K., Mahmut, N., Medina, R. J., Niida, A., Sonegawa, H., Du, G., Yong, R., Takaishi, M., Sakaguchi, M. & Huh, N., Nov 2007, In : Stem Cells. 25, 11, p. 2855-63 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2006

Efficient differentiation into skin cells of bone marrow cells recovered in a pellet after density gradient fractionation

Medina, R. J., Kataoka, K., Miyazaki, M. & Huh, N-H., May 2006, In : International Journal of Molecular Medicine. 17, 5, p. 721-7 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Isolation of epithelial stem cells from dermis by a three-dimensional culture system

Medina, R. J., Kataoka, K., Takaishi, M., Miyazaki, M. & Huh, N., 01 May 2006, In : Journal of Cellular Biochemistry. 98, 1, p. 174-84 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2003

Participation of adult mouse bone marrow cells in reconstitution of skin

Kataoka, K., Medina, R. J., Kageyama, T., Miyazaki, M., Yoshino, T., Makino, T. & Huh, N-H., Oct 2003, In : American Journal of Pathology. 163, 4, p. 1227-31 5 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)