Richard Turkington

2025

Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer

Ganguli, P., Basanta, C. C., Acha-Sagredo, A., Misetic, H., Armero, M., Mendez, A., Zahra, A., Devonshire, G., Kelly, G., Freeman, A., Green, M., Nye, E., Bichisecchi, A., Bonfanti, P., Bartlett, F., Petty, R. D., Coleman, H., McManus, D., Turkington, R. & Grabowska, A. & 31 others, Moorthy, K., Peters, C. J., Hanna, G. B., Lishman, S., Sothi, S., Scott, M., Haidry, R., Lovat, L., Saunders, J., Kaye, P., Soomro, I., Parsons, S. L., Sreedharan, L., Kumar, B., Cheong, E., Chan, D., Berrisford, R., Sanders, G., Ciccarelli, F. D., Goh, V., Mahadeva, U., Chang, F., Davies, A., Gossage, J., Lagergren, J., Grace, B. L., Walker, R. C., Underwood, T. J., Contino, G., Puig, S. & Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium, 03 Jan 2025, In: Nature Cancer. p. 158–174 27 p.

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2024

An investigation of the clinical impact and therapeutic relevance of a DNA damage immune response (DDIR) signature in patients with advanced gastroesophageal adenocarcinoma

Baxter, M. A., Spender, L. C., Cairns, D., Walsh, S., Oparka, R., Porter, R. J., Bray, S., Skinner, G., King, S., Turbitt, J., Collinson, D., Miedzybrodzka, Z. H., Jellema, G., Logan, G., Kennedy, R. D., Turkington, R. C., McLean, M. H., Swinson, D., Grabsch, H. I. & Lord, S. & 3 others, Seymour, M. J., Hall, P. S. & Petty, R. D., 13 May 2024, In: ESMO Open. 9, 5, 12 p., 103450.

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Disentangling oncogenic amplicons in esophageal adenocarcinoma

Ng, A. W. T., McClurg, D. P., Wesley, B., Zamani, S. A., Black, E., Miremadi, A., Giger, O., Hoopen, R. T., Devonshire, G., Redmond, A. M., Grehan, N., Jammula, S., Blasko, A., Li, X., Aparicio, S., Tavaré, S., Edwards, P. A. W., Grehan, N., Nutzinger, B. & Loreno, C. & 31 others, Abbas, S., Freeman, A., Smyth, E. C., O’Donovan, M., Miremadi, A., Malhotra, S., Tripathi, M., Cheah, C., Coles, H., Millington, C., Eldridge, M., Secrier, M., Jammula, S., Davies, J., Crichton, C., Carroll, N., Hardwick, R. H., Safranek, P., Hindmarsh, A., Sujendran, V., Hayes, S. J., Ang, Y., Sharrocks, A., Preston, S. R., Bagwan, I., Save, V., Scott, M., Turkington, R., McManus, D., Coleman, H. & Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium, 14 May 2024, In: Nature Communications. 15, 4074.

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5 Citations (Scopus)

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Immune microenvironment modulation following neoadjuvant therapy for oesophageal adenocarcinoma: a translational analysis of the DEBIOC clinical trial

Scanlon, E., Lavery, A., Albraikat, M., Stevenson, L., Kennedy, C., Byrne, R., Walker, A., Mullan-Young, B., McManus, D. T., Virdee, P. S., Elhussein, L., Turbitt, J., Collinson, D., Miedzybrodzka, Z., Van Schaeybroeck, S., McQuaid, S., James, J. A., Craig, S. G., Blayney, J. K. & Petty, R. D. & 6 others, Harkin, D. P., Kennedy, R. D., Eatock, M. M., Middleton, M. R., Thomas, A. & Turkington, R. C., Nov 2024, In: ESMO Open. 9, 11, 14 p., 103930.

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Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

Stevenson, L., Cairns, L., Li, X., Jammula, S., Taylor, H., Douglas, R., McCabe, N., Gavory, G., Jacq, X., Fitzgerald, R. C., Kennedy, R. D., Harrison, T. & Turkington, R. C., 30 Dec 2024, In: Scientific Reports. 14, 14 p., 32121 .

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Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma

O’Shea, R., Withey, S. J., Owczarczyk, K., Rookyard, C., Gossage, J., Godfrey, E., Jobling, C., Parsons, S. L., Skipworth, R. J. E., Goh, V., Crosby, T. D. L., Bartlett, F., Petty, R. D., Coleman, H., McManus, D., Turkington, R., Grabowska, A., Moorthy, K., Peters, C. J. & Hanna, G. B. & 31 others, Sothi, S., Scott, M., Haidry, R., Lovat, L., Saunders, J., Kaye, P., Soomro, I., Sreedharan, L., Kumar, B., Cheong, E., Chan, D., Sanders, G., Ciccarelli, F. D., Mahadeva, U., Chang, F., Davies, A., Lagergren, J., Grace, B. L., Underwood, T. J., Contino, G., Puig, S., Taniere, P., Beggs, A., Tucker, O., O’Neill, J. R., Save, V., Bagwan, I., Preston, S. R., Sharrocks, A., Ang, Y. & on behalf of the OCCAMS Consortium, Oct 2024, In: European Radiology. 34, 10, p. 6919-6928 10 p.

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Multi-omic analysis of esophageal adenocarcinoma uncovers candidate therapeutic targets and cancer-selective posttranscriptional regulation

Robert O'Neill, J., Mayordomo, M. Y., Mitulović, G., Al Shboul, S., Bedran, G., Faktor, J., Hernychova, L., Uhrik, L., Gómez-Herranz, M., Kocikowski, M., Save, V., Vojtěšek, B., Arends, M. J., Hupp, T., Alfaro, J. A., Fitzgerald, R. C., Edwards, P. A. W., Grehan, N., Nutzinger, B. & Loreno, C. & 31 others, Redmond, A. M., Abbas, S., Freeman, A., Smyth, E. C., O'Donovan, M., Miremadi, A., Malhotra, S., Tripathi, M., Cheah, C., Coles, H., Millington, C., Devonshire, G., Eldridge, M., Secrier, M., Jammula, S., Davies, J., Crichton, C., Carroll, N., Hardwick, R. H., Safranek, P., Hindmarsh, A., Sujendran, V., Hayes, S. J., Ang, Y., Sharrocks, A., Preston, S. R., Scott, M., Turkington, R., McManus, D., Coleman, H. & OCCAMS Consortium, 19 Jun 2024, In: Molecular and Cellular Proteomics. 23, 6, 100764.

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4 Citations (Scopus)

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REsolution of symptoms afTer Oesophago-gastric cancer REsection delphi (RESTOREd) - standardizing the definition, investigation and management of gastrointestinal symptoms and conditions after surgery

Byrne, B. E., Siaw-Acheampong, K., Evans, O., Taylor, J., Huddy, F., Nilsson, M., Griffiths, E. A., Low, D., Gossage, J., Dunn, J., Zeki, S., Markar, S., Avery, K., Blazeby, J. M., Cockbain, A., Moss, C., Van Hemelrijck, M., Andreyev, J., Davies, A. R. & Allum, W. & 31 others, Chaudry, A., Kumar, S., Muls, A., Shaw, C., Baker, C., Coombes, A., Kelly, M., Wong, T., Beales, I., Berrisford, R., Wright, A., Boger, P., Bunting, D., Carter, N., Mercer, S., Pucher, P. H., Robinson, B., Cheong, E., Kumar, B., Hill, M., Griffin, N., Phillips, A., Mainie, I., Moore, A., Pritchard, D. M., Ryan, S., Sloan, T., Smyth, E., Turkington, R., White, C. & RESTORE Delphi study group, 09 Dec 2024, In: British Journal of Surgery. 111, 12, znae286.

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SMAD4 and KCNQ3 alterations are associated with lymph node metastases in oesophageal adenocarcinoma

Foley, K., Shorthouse, D., Rahrmann, E., Zhuang, L., Devonshire, G., Gilbertson, R. J., Fitzgerald, R. C., Hall, B. A., Fitzgerald, R. C., Edwards, P. A. W., Grehan, N., Nutzinger, B., Fidziukiewicz, E., Redmond, A. M., Abbas, S., Freeman, A., Smyth, E. C., O’Donovan, M., Miremadi, A. & Malhotra, S. & 31 others, Tripathi, M., Cheah, C., Coles, H., Flint, C., Eldridge, M., Secrier, M., Devonshire, G., Jammula, S., Davies, J., Crichton, C., Carroll, N., Hardwick, R. H., Safranek, P., Hindmarsh, A., Sujendran, V., Hayes, S. J., Ang, Y., Sharrocks, A., Preston, S. R., Bagwan, I., Save, V., Skipworth, R. J. E., Hupp, T. R., O’Neill, J. R., Tucker, O., Beggs, A., Scott, M., Turkington, R., McManus, D., Coleman, H. & Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium, Jan 2024, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1870, 1, 166867.

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The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis

Holloway, J., Seeley, A., Cobbe, N., Turkington, R. C., Longley, D. B. & Evergren, E., 12 Jan 2024, In: Cell, Death & Disease. 15, 1, 13 p., 40.

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10 Citations (Scopus)

51 Downloads (Pure)

2023

Exploring the immune microenvironment in small bowel adenocarcinoma using digital image analysis

Sidi, F. A., Bingham, V., McQuaid, S., Craig, S. G., Turkington, R. C., James, J. A., Humphries, M. P. & Salto-Tellez, M., 01 Aug 2023, In: PLOS ONE. 18, 8, 14 p., e0289355.

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Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series

Brown, M., O'Connor, D., Turkington, R., Eatock, M., Vince, R., Hulme, C., Bowdery, R., Robinson, R., Wadsley, J., Maraveyas, A. & Prue, G., 21 Sept 2023, In: BMC Sports Science, Medicine and Rehabilitation. 15, 13 p., 116.

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Mismatch repair and microsatellite instability testing for Immune Checkpoint Inhibitor Therapy: ASCO endorsement of College of American Pathologists Guideline

Vikas, P., Messersmith, H., Compton, C., Sholl, L., Broaddus, R. R., Davis, A., Estevez-Diz, M., Garje, R., Konstantinopoulos, P. A., Leiser, A., Mills, A. M., Norquist, B., Overman, M. J., Sohal, D., Turkington, R. C. & Johnson, T., 01 Apr 2023, In: Journal of Clinical Oncology. 41, 10, p. 1943-1948 6 p.

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56 Citations (Scopus)

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Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma

Abbas, S., Pich, O., Devonshire, G., Zamani, S. A., Katz-Summercorn, A., Killcoyne, S., Cheah, C., Nutzinger, B., Grehan, N., Lopez-Bigas, N., Edwards, P. A. W., Fidziukiewicz, E., Redmond, A. M., Freeman, A., Smyth, E. C., O’Donovan, M., Miremadi, A., Malhotra, S., Tripathi, M. & Coles, H. & 31 others, Flint, C., Eldridge, M., Jammula, S., Davies, J., Crichton, C., Carroll, N., Hardwick, R. H., Safranek, P., Hindmarsh, A., Sujendran, V., Hayes, S. J., Ang, Y., Sharrocks, A., Preston, S. R., Bagwan, I., Save, V., Skipworth, R. J. E., Hupp, T. R., O’Neill, J. R., Tucker, O., Beggs, A., Taniere, P., Puig, S., Contino, G., Underwood, T. J., Walker, R. C., Scott, M., Turkington, R., McManus, D., Coleman, H. & OCCAMS Consortium, 15 Jul 2023, In: Nature Communications. 14, 1, 16 p., 4239.

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10 Citations (Scopus)

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Pathological lymph node regression after neoadjuvant chemotherapy predicts recurrence and survival in esophageal adenocarcinoma: a multicenter study in the United Kingdom

Moore, J. L., Green, M., Santaolalla, A., Deere, H., Evans, R. P. T., Elshafie, M., Lavery, A., McManus, D. T., McGuigan, A., Douglas, R., Horne, J., Walker, R., Mir, H., Terlizzo, M., Kamarajah, S. K., Van Hemelrijck, M., Maisey, N., Sita-Lumsden, A., Ngan, S. & Kelly, M. & 33 others, Baker, C. R., Kumar, S., Lagergren, J., Allum, W. H., Gossage, J. A., Griffiths, E. A., Grabsch, H. I., Turkington, R. C., Underwood, T. J., Smyth, E. C., Fitzgerald, R. C., Cunningham, D., Davies, A. R., Puig, S., Chaudry, A., Jacques, A., Griffin, N., Goh, V., Owczarczyk, K., Qureshi, A., Subesinghe, M., Chang, F., Mahadeva, U., Gill-Barman, B., George, S., Ong, M., Waters, J., Cominos, M., Sevitt, T., Hill, M., OCCAMS Consortium, The Guy's and St Thomas' Oesophago-gastric Research Group & The PROGRESS study group, 01 Oct 2023, In: Journal of Clinical Oncology. 41, 28, p. 4522-4534 13 p.

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21 Citations (Scopus)

Real world outcomes in cancer patients with COVID-19 infection: Northern Ireland experience

Feeney, L., Hamilton, A., Lavery, A., O'Neill, C., Walls, G., Taylor, K. & Turkington, R. C., Jan 2023, In: The Ulster medical journal. 92, 1, p. 29-37 9 p.

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The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes

Kazachenka, A., Loong, J. H., Attig, J., Young, G. R., Ganguli, P., Devonshire, G., Grehan, N., Ciccarelli, F. D., Fitzgerald, R. C., Kassiotis, G., Fitzgerald, R. C., Edwards, P. A. W., Grehan, N., Nutzinger, B., Fidziukiewicz, E., Redmond, A. M., Abbas, S., Freeman, A., Smyth, E. C. & O'Donovan, M. & 31 others, Miremadi, A., Malhotra, S., Tripathi, M., Cheah, C., Coles, H., Flint, C., Eldridge, M., Secrier, M., Devonshire, G., Jammula, S., Davies, J., Crichton, C., Carroll, N., Hardwick, R. H., Safranek, P., Hindmarsh, A., Sujendran, V., Hayes, S. J., Ang, Y., Sharrocks, A., Preston, S. R., Bagwan, I., Save, V., Skipworth, R. J. E., Hupp, T. R., O'Neill, J. R., Scott, M., Turkington, R., McManus, D., Coleman, H. & the OCCAMS consortium, 01 Sept 2023, In: NAR Cancer. 5, 3, 20 p., zcad040.

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Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial

Reynolds, J. V., Preston, S. R., O'Neill, B., Lowery, M. A., Baeksgaard, L., Crosby, T., Cunningham, M., Cuffe, S., Griffiths, G. O., Parker, I., Risumlund, S. L., Roy, R., Falk, S., Hanna, G. B., Bartlett, F. R., Alvarez-Iglesias, A., Achiam, M. P., Nilsson, M., Piessen, G. & Ravi, N. & 31 others, O'Toole, D., Johnston, C., McDermott, R. S., Turkington, R. C., Wahed, S., Sothi, S., Ford, H., Wadley, M. S., Power, D., Mukherjee, S., Morgan, C., Parsons, S. L., Bhuva, N., Campbell, S., Grogan, L., Leonard, G., Bateman, A. R., Mitchell, C., O'Reilly, S., Mulroe, E., McLoughlin, O., Shevlin, A., Shannon, A. M., Marron, J., Nolan, M., Burch, G., Costello, M., Griffiths, D., Cozens, K., Moore, J. & Neo-AEGIS Investigators and Trial Group, Nov 2023, In: The Lancet Gastroenterology and Hepatology. 8, 11, p. 1015-1027 13 p.

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92 Citations (Scopus)

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2022

Apoptosis and autophagy markers predict survival in neoadjuvant treated oesophageal adenocarcinoma patients

El Mashed, S., O'Donovan, T. R., Kay, E., O'Grady, A., McManus, D., Turkington, R. C. & McKenna, S. L., 20 Aug 2022, In: BMC Cancer. 22, 908.

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4 Citations (Scopus)

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Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Campiani, G., Khan, T., Ulivieri, C., Staiano, L., Papulino, C., Magnano, S., Nathwani, S., Ramunno, A., Lucena-Agell, D., Relitti, N., Federico, S., Pozzetti, L., Carullo, G., Casagni, A., Brogi, S., Vanni, F., Galatello, P., Ghanim, M., McCabe, N. & Lamponi, S. & 13 others, Valoti, M., Ibrahim, O., O'Sullivan, J., Turkington, R., Kelly, V. P., VanWemmel, R., Díaz, J. F., Gemma, S., Zisterer, D., Altucci, L., De Matteis, A., Butini, S. & Benedetti, R., 20 Mar 2022, (Early online date) In: European Journal of Medicinal Chemistry. 114274.

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8 Citations (Scopus)

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Identification of Src as a therapeutic target in oesophageal adenocarcinoma through functional genomic and high-throughput drug screening approaches

McCabe, N. H., Stevenson, L., Scanlon, E., Douglas, R., Kennedy, S., Keminer, O., Windshügel, B., Zisterer, D., Kennedy, R. D., Blayney, J. K. & Turkington, R. C., 30 Jul 2022, In: Cancers. 14, 15, 18 p., 3726.

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3 Citations (Scopus)

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Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas

Ng, A. W. T., Contino, G., Killcoyne, S., Devonshire, G., Hsu, R., Abbas, S., Su, J., Redmond, A. M., Weaver, J. M. J., Eldridge, M. D., Tavaré, S., Grehan, N., Nutzinger, B., Fidziukiewicz, E., Freeman, A., Smyth, E. C., O’Donovan, M., Miremadi, A., Malhotra, S. & Tripathi, M. & 31 others, Cheah, C., Coles, H., Flint, C., Eldridge, M., Secrier, M., Jammula, S., Davies, J., Crichton, C., Carroll, N., Hardwick, R. H., Safranek, P., Hindmarsh, A., Sujendran, V., Hayes, S. J., Ang, Y., Sharrocks, A., Preston, S. R., Bagwan, I., Save, V., Skipworth, R. J. E., Hupp, T. R., O’Neill, J. R., Tucker, O., Beggs, A., Taniere, P., Puig, S., Scott, M., Turkington, R., McManus, D., Coleman, H. & Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium, 08 Apr 2022, In: Communications Biology. 5, 335.

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9 Citations (Scopus)

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The role of circulating protein and metabolite biomarkers in the development of pancreatic ductal adenocarcinoma (PDAC): a systematic review and meta-analysis

Kumar, S., Santos, R. J., McGuigan, A. J., Singh, U., Johnson, P., Kunzmann, A. T. & Turkington, R. C., 01 May 2022, In: American Journal of Cancer. 31, 5, p. 1090-1102

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2021

A DNA-damage immune response assay combined with PET biomarkers predicts response to neo-adjuvant chemotherapy and survival in oesophageal adenocarcinoma

Foley, K. G., Lavery, A., Napier, E., Campbell, D., Eatock, M. M., Kennedy, R. D., Bradley, K. M. & Turkington, R. C., 22 Jun 2021, In: Scientific Reports. 11, 1, 13061.

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Exercise efficacy and prescription during treatment for pancreatic ductal adenocarcinoma: a systematic review

O’Connor, D., Brown, M., Eatock, M., Turkington, R. C. & Prue, G., 09 Jan 2021, In: BMC Cancer. 21, 1, 17 p., 43.

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14 Citations (Scopus)

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Immune cell infiltrates as prognostic biomarkers in pancreatic ductal adenocarcinoma: a systematic review and meta‐analysis

McGuigan, A. J., Coleman, H. G., McCain, R. S., Kelly, P. J., Johnston, D. I., Taylor, M. A. & Turkington, R. C., Mar 2021, In: Journal of Pathology: Clinical Research. 7, 2, p. 99-112

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17 Citations (Scopus)

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Inequalities in the decline and recovery of pathological cancer diagnoses during the first six months of the COVID-19 pandemic a population-based study

Hamilton, A. C., Donnelly, D. W., Loughrey, M. B., Turkington, R. C., Fox, C., Fitzpatrick, D., O'Neill, C. E., Gavin, A. T. & Coleman, H. G., 14 Sept 2021, In: British Journal of Cancer. 125, 6, p. 798–805

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38 Citations (Scopus)

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Serial ctDNA detection using a personalized, tumor-informed assay in esophageal adenocarcinoma patients following resection

OCCAMS Consortium, 17 Jul 2021, (Early online date) In: Gastroenterology. 161, 5, 6 p.

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11 Citations (Scopus)

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The impact of the COVID-19 pandemic on Barrett’s esophagus and esophago-gastric cancer

Turkington, R. C., Lavery, A., Donnelly, D., Cairnduff, V., McManus, D. T. & Coleman, H. G., 01 May 2021, In: Gastroenterology. 160, 6, p. 2169-2171.e1 4 p.

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19 Citations (Scopus)

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2020

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

McCain, R. S., McManus, D. T., McQuaid, S., James, J. A., Salto-Tellez, M., Reid, N. B., Craig, S., Chisambo, C., Bingham, V., McCarron, E., Parkes, E., Turkington, R. C. & Coleman, H. G., Jan 2020, In: Cancer Causes and Control. 31, 1, p. 1-11 11 p.

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19 Citations (Scopus)

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Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Rheinbay, E., Nielsen, M. M., Abascal, F., Wala, J. A., Shapira, O., Tiao, G., Hornshøj, H., Hess, J. M., Juul, R. I., Lin, Z., Feuerbach, L., Sabarinathan, R., Madsen, T., Kim, J., Mularoni, L., Shuai, S., Lanzós, A., Herrmann, C., Maruvka, Y. E. & Zhang, C. Z. & 33 others, Zhang, J., Lawrence, M. S., Zhang, Y., Jones, D. T. W., Adams, D. J., Anderson, M. J., Bustamante, C. D., Byrne, N. J., Cooper, C. S., Haider, S., Jones, D. T. W., Li, C., Liu, J., McDermott, U., Nicholson, J., Ogden, C., Quinn, M. C., Richardson, A. L., Scott, D., Simpson, P. T., Thompson, A. M., Thompson, J. F. F., Turkington, R., Wang, J., Wang, Q., Wilson, J. M., Wilson, R. K., Wright, A. J., Yang, Y., Zhang, F., PCAWG Consortium, PCAWG Drivers and Functional Interpretation Working Group & PCAWG Structural Variation Working Group, 06 Feb 2020, In: Nature. 578, 7793, p. 102-111 10 p.

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401 Citations (Scopus)

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Author’s Response: The unified definition of relapse-free survival should be used for evaluating survival benefit in oesophageal adenocarcinoma

Lavery, A., Blayney, J. & Turkington, R., 30 Jun 2020, (Early online date) In: Gut. 1 p.

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Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Carlevaro-Fita, J., Lanzós, A., Feuerbach, L., Hong, C., Mas-Ponte, D., Pedersen, J. S., Johnson, R., Abascal, F., Amin, S. B., Bader, G. D., Barenboim, J., Beroukhim, R., Bertl, J., Boroevich, K. A., Brunak, S., Campbell, P. J., Chakravarty, D., Chan, C. W. Y., Chen, K. & Lawrence, M. S. & 32 others, Zhang, J., Zhang, Y., Adams, D. J., Anderson, M. J., Bustamante, C. D., Byrne, N. J., Cooper, C. S., Haider, S., Jones, D. R., Jones, D. R., Li, C., Liu, J., McDermott, U., Nicholson, J., Ogden, C., Quinn, M. C., Richardson, A. L., Scott, D., Simpson, P. T., Thompson, A. M., Thompson, J. F. F., Turkington, R., Wang, J., Wang, Q., Wilson, J. M., Wilson, R. K., Wright, A. J., Yang, Y., Zhang, C. Z., Zhang, F., PCAWG Drivers and Functional Interpretation Group & PCAWG Consortium, 01 Dec 2020, In: Communications Biology. 3, 56.

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153 Citations (Scopus)

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Does risk of progression from Barrett’s esophagus to esophageal adenocarcinoma change based on the number of non-dysplastic endoscopies?

Kunzmann, A. T., Coleman, H. G., Johnston, B. T., Turkington, R. C., McManus, D., Anderson, L. A. & Thrift, A. P., 20 Jul 2020, (Early online date) In: Digestive Diseases and Sciences. 66, p. 1965–1973 10 p.

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Dual Erb B Inhibition in Oesophago-gastric Cancer (DEBIOC): A phase I dose escalating safety study and randomised dose expansion of AZD8931 in combination with oxaliplatin and capecitabine chemotherapy in patients with oesophagogastric adenocarcinoma

Thomas, A., Virdee, P. S., Eatock, M., Lord, S. R., Falk, S., Anthoney, D. A., Turkington, R. C., Goff, M., Elhussein, L., Collins, L., Love, S., Moschandreas, J. & Middleton, M. R., Jan 2020, In: European Journal of Cancer. 124, p. 131-141 11 p.

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Endoscopic tumour morphology impacts survival in adenocarcinoma of the oesophagus

Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium, 28 Jul 2020, (Early online date) In: European Journal of Surgical Oncology.

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Genomic basis for RNA alterations in cancer

Calabrese, C., Davidson, N. R., Demircioğlu, D., Fonseca, N. A., He, Y., Kahles, A., Lehmann, K. V., Liu, F., Shiraishi, Y., Soulette, C. M., Urban, L., Greger, L., Li, S., Liu, D., Perry, M. D., Xiang, Q., Zhang, F., Zhang, J., Bailey, P. & Erkek, S. & 33 others, Li, C., Wang, J., Adams, D. J., Anderson, M. J., Bustamante, C. D., Byrne, N. J., Cooper, C. S., Haider, S., Jones, D. T. W., Jones, D. T. W., Lawrence, M. S., Liu, J., McDermott, U., Nicholson, J., Ogden, C., Quinn, M. C., Richardson, A. L., Scott, D., Simpson, P. T., Thompson, A. M., Thompson, J. F. F., Turkington, R., Wang, Q., Wilson, J. M., Wilson, R. K., Wright, A. J., Yang, Y., Zhang, C. Z., Zhang, J., Zhang, Y., PCAWG Transcriptome Core Group, PCAWG Transcriptome Working Group & PCAWG Consortium, 06 Feb 2020, In: Nature. 578, 7793, p. 129-136 8 p.

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Identification of Subtypes of Barrett's Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data

Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium, May 2020, In: Gastroenterology. 158, 6, p. 1682-1697.e1

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69 Citations (Scopus)

Machine learning to predict early recurrence after oesophageal cancer surgery

Rahman, S. A., Walker, R. C., Lloyd, M. A., Grace, B. L., van Boxel, G. I., Kingma, B. F., Ruurda, J. P., van Hillegersberg, R., Harris, S., Parsons, S., Mercer, S., Griffiths, E. A., O'Neill, J. R., Turkington, R., Fitzgerald, R. C., Underwood, T. J. & on behalf of the OCCAMS Consortium, 15 Jun 2020, In: British Journal of Surgery. 107, 8, p. 1042-1052 11 p.

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Pan-cancer analysis of whole genomes

Campbell, P. J., Getz, G., Korbel, J. O., Stuart, J. M., Jennings, J. L., Stein, L. D., Perry, M. D., Nahal-Bose, H. K., Ouellette, B. F. F., Li, C. H., Rheinbay, E., Nielsen, G. P., Sgroi, D. C., Wu, C. L., Faquin, W. C., Deshpande, V., Boutros, P. C., Lazar, A. J., Hoadley, K. A. & Louis, D. N. & 31 others, Dursi, L. J., Yung, C. K., Bustamante, C. D., Jones, D. T. W., Zhang, F., Wang, J., Scott, D., Byrne, N. J., Liu, J., Nicholson, J., Zhang, J., Zhang, Y., Wang, Q., Jones, D. T. W., Zhang, C. Z., Haider, S., Adams, D. J., Yang, Y., Cooper, C. S., Quinn, M. C., Anderson, M. J., Thompson, J. F., Wilson, J. M., Richardson, A. L., Simpson, P. T., Thompson, A. M., Turkington, R., McDermott, U., Ogden, C., Wilson, R. K. & The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, 06 Feb 2020, In: Nature. 578, 7793, p. 82-93 12 p.

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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Rodriguez-Martin, B., Alvarez, E. G., Baez-Ortega, A., Zamora, J., Supek, F., Demeulemeester, J., Santamarina, M., Ju, Y. S., Temes, J., Garcia-Souto, D., Detering, H., Li, Y., Rodriguez-Castro, J., Dueso-Barroso, A., Bruzos, A. L., Dentro, S. C., Blanco, M. G., Contino, G., Ardeljan, D. & Jones, D. T. W. & 32 others, Zhang, C. Z., Adams, D. J., Anderson, M. J., Bustamante, C. D., Byrne, N. J., Cooper, C. S., Haider, S., Jones, D. T. W., Lawrence, M. S., Li, C., Liu, J., McDermott, U., Nicholson, J., Ogden, C., Quinn, M. C., Richardson, A. L., Scott, D., Simpson, P. T., Thompson, A. M., Thompson, J. F. F., Turkington, R., Wang, J., Wang, Q., Wilson, J. M., Wilson, R. K., Wright, A. J., Yang, Y., Zhang, F., Zhang, J., Zhang, Y., PCAWG Structural Variation Working Group & PCAWG Consortium, 02 Mar 2020, In: Nature Genetics. 52, 3, p. 306-319 14 p.

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PancREatic Cancer and Individualised Supervised Exercise (PRECISE): a feasibility trial protocol for patients with resectable pancreatic ductal adenocarcinoma

O'Connor, D., Brown, M., Eatock, M., Turkington, R. C., Vince, R., Wadsley, J. & Prue, G., 17 Aug 2020, In: AMRC Open Research. 2, 11 p., 22.

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Pathway and network analysis of more than 2500 whole cancer genomes

Reyna, M. A., Haan, D., Paczkowska, M., Verbeke, L. P. C., Vazquez, M., Kahraman, A., Pulido-Tamayo, S., Barenboim, J., Wadi, L., Dhingra, P., Shrestha, R., Getz, G., Lawrence, M. S., Pedersen, J. S., Rubin, M. A., Wheeler, D. A., Brunak, S., Zhang, J., Zhang, Y. & Adams, D. J. & 32 others, Anderson, M. J., Bustamante, C. D., Byrne, N. J., Cooper, C. S., Haider, S., Jones, D. T. W., Jones, D. T. W., Lawrence, M. S., Li, C., Liu, J., McDermott, U., Nicholson, J., Ogden, C., Quinn, M. C., Richardson, A. L., Scott, D., Simpson, P. T., Thompson, A. M., Thompson, J. F. F., Turkington, R., Wang, J., Wang, Q., Wilson, J. M., Wilson, R. K., Wright, A. J., Yang, Y., Zhang, C. Z., Zhang, F., Zhang, J., Zhang, Y., PCAWG Drivers and Functional Interpretation Working Group & PCAWG Consortium, 05 Feb 2020, In: Nature Communications. 11, 729.

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Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation

Saraswati, A. P., Relitti, N., Brindisi, M., Osko, J. D., Chemi, G., Federico, S., Grillo, A., Brogi, S., McCabe, N. H., Turkington, R. C., Ibrahim, O., O'Sullivan, J., Lamponi, S., Ghanim, M., Kelly, V. P., Zisterer, D., Amet, R., Hannon Barroeta, P., Vanni, F. & Ulivieri, C. & 11 others, Herp, D., Sarno, F., Di Costanzo, A., Saccoccia, F., Ruberti, G., Jung, M., Altucci, L., Gemma, S., Butini, S., Christianson, D. W. & Campiani, G., 12 Nov 2020, In: ACS Medicinal Chemistry Letters. 11, 11, p. 2268-2276 9 p.

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The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation

Humphries, M., Craig, S., Kacprzyk, R., Fisher, N., Bingham, V., McQuaid, S., Murray, G. I., McManus, D., Turkington, R., James, J. & Salto-Tellez, M., 01 Jun 2020, In: BMC Cancer. 20, 1, 11 p., 500.

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2019

External validation of a model to determine risk of progression of Barrett’s oesophagus to neoplasia

Kunzmann, A. T., Thrift, A. P., Johnston, B. T., McManus, D. T., Gavin, A. T., Turkington, R. C. & Coleman, H. G., 01 May 2019, In: Alimentary Pharmacology and Therapeutics. 49, 10, p. 1274-1281 8 p.

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High PTGS2 expression in post neoadjuvant chemotherapy treated oesophageal adenocarcinoma is associated with improved survival: a population-based cohort study

Spence, A. D., Trainor, J., McMenamin, Ú., Turkington, R. C., McQuaid, S., Bingham, V., James, J., Salto-Tellez, M., McManus, D. T., Johnston, B. T., Cardwell, C. R. & Coleman, H. G., Mar 2019, In: Histopathology. 74, 4, p. 587-596 10 p.

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Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma

Turkington, R., Knight, L., Blayney, J., Secrier, M., Douglas, R., Parkes, E., Sutton, E., Stevenson, L., McManus, D., Halliday, S., McCavigan, A., Logan, G., Walker, S., Steele, C., Perner, J., Bornscein, J., MacRae, S., Miremadi, A., McCarron, E. & McQuaid, S. & 10 others, Arthur, K., James, J., Eatock, M., O'Neill, R., Noble, F., Underwood, T., Harkin, D., Salto-Tellez, M., Fitzgerald, R. C. & Kennedy, R., 09 Mar 2019, (Early online date) In: Gut. 68, 11, p. 1918-1927 10 p.

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