Robert Ladner

2024

Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective

Sulieman, H., Emerson, A., Wilson, P. M., Mulligan, K. A., Ladner, R. D. & LaBonte, M. J., 22 Sept 2024, (Early online date) In: The FEBS Journal. 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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13 Downloads (Pure)

2023

Health diplomacy in action: the cancer legacy of the Good Friday Agreement

Lawler, M., Sullivan, R., Abou-Alfa, G. K., McCloskey, K., Keatley, D., Feighan, J., Dahut, W., Mulroe, E., Ladner, R., Genead, M., Lowery, M., Gulley, J. L., Scott, C. J., Longley, D. B., Culhane, A., Gallagher, W. M., Orr, N., Chanock, S. J. & Gopal, S., Dec 2023, In: Journal of Cancer Policy. 38, 3 p., 100448.

Research output: Contribution to journal › Article › peer-review

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2021

Targeting nucleotide metabolism enhances the efficacy of anthracyclines and anti-metabolites in triple-negative breast cancer

Davison, C., Ladner, R., Morelli, R., Knowlson, C., McKechnie, M., Carson, R., McLaughlin, K., Prise, V., Stachtea, X., Savage, K., Wilson, R., Mulligan, K., Wilson, P. & LaBonte Wilson, M., 06 Apr 2021, In: npj Breast Cancer. 7, p. 3 13 p., 38.

Research output: Contribution to journal › Article › peer-review

Open Access

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10 Citations (Scopus)

133 Downloads (Pure)

2018

Imbalanced nucleotide metabolism sensitizes breast cancer cells to standard of care chemotherapy.

Davison, C., Ladner, R., Chevallier, O., Carson, R., Oliver Esteve, J. A., Elliott, C., Mullan, P., Wilson, R., Savage, K. & LaBonte Wilson, M., Apr 2018.

Research output: Contribution to conference › Poster › peer-review

Inhibition of dUTPase induces a state of nucleotide pool and DNA repair imbalance that sensitizes triple negative breast cancer cells to standard of care chemotherapies.

Davison, C., Knowlson, C., McKechnie, M., Savage, K., Wilson, R., Ladner, R. & LaBonte Wilson, M., 13 Nov 2018.

Research output: Contribution to conference › Poster › peer-review

Inhibition of dUTPase represents a novel therapeutic strategy in triple negative breast cancer.

Ladner, R., Davison, C., Knowlson, C., Savage, K., Mulligan, K., Wilson, P. & Johnston, P., 2018.

Research output: Contribution to conference › Poster › peer-review

2017

Imbalanced nucleotide metabolism sensitises breast cancer cells to anthracyclines

Davison, C., Chevallier, O., McKechnie, M., Carson, R., Oliver Esteve, J. A., Stachtea, X., Wilson, R., Ladner, R. & LaBonte Wilson, M., Nov 2017.

Research output: Contribution to conference › Poster › peer-review

Imbalanced nucleotide metabolism sensitizes breast cancer cells to anthracyclines.

Davison, C., Wilson, R., Ladner, R. & LaBonte Wilson, M., 28 Nov 2017.

Research output: Contribution to conference › Abstract › peer-review

Targeting the base-excision repair pathway results in enhanced synthetic lethality following inhibition of thymidylate metabolism in colorectal cancer cells.

Carson, R., Davison, C., McKechnie, M., Oliver Esteve, J. A., Stachtea, X., LaBonte Wilson, M. & Ladner, R., 2017.

Research output: Contribution to conference › Poster › peer-review

2016

Delivering a Research-Enabled Multistakeholder Partnership for Enhanced Patient Care at a Population Level: The Northern Ireland Comprehensive Cancer Program

Lawler, M., Gavin, A., Salto-Tellez, M., Kennedy, R. D., Van Schaeybroeck, S., Wilson, R. H., Harkin, D. P., Grayson, M., Boyd, R. E., Hamilton, P. W., McArt, D. G., James, J., Robson, T., Ladner, R. D., Prise, K. M., O'Sullivan, J. M., Harrison, T., Murray, L., Johnston, P. G. & Waugh, D. J., 01 Mar 2016, In: Cancer. 122, 5, p. 664-673 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

379 Downloads (Pure)

2015

Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer

Benhaim, L., Zhang, W., Wakatsuki, T., Yang, D., Gerger, A., Bohanes, P., Paez, D., Loupakis, F., LaBonte, M. J., Ning, Y., El-Khoueiry, R., Ladner, R., Wilson, P., Zhang, H., Giamas, G., Stebbing, J. & Lenz, H. J., Jun 2015, In: The pharmacogenomics journal. 15, 3, p. 235-40 6 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

2014

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

Wilson, P. M., Danenberg, P. V., Johnston, P. G., Lenz, H.-J. & Ladner, R. D., May 2014, In: Nature reviews. Clinical oncology. 11, 5, p. 282-98 17 p.

Research output: Contribution to journal › Review article › peer-review

309 Citations (Scopus)

2013

Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration

Choi, I., Lee, Y. S., Chung, H. K., Choi, D., Ecoiffier, T., Lee, H. N., Kim, K. E., Lee, S., Park, E. K., Maeng, Y. S., Kim, N. Y., Ladner, R. D., Petasis, N. A., Koh, C. J., Chen, L., Lenz, H.-J. & Hong, Y.-K., Jan 2013, In: Angiogenesis. 16, 1, p. 29-44 16 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib)

Wilson, P. M., Yang, D., Azuma, M., Shi, M. M., Danenberg, K. D., Lebwohl, D., Sherrod, A., Ladner, R. D., Zhang, W., Danenberg, P. V., Trarbach, T., Folprecht, G., Meinhardt, G. & Lenz, H.-J., Oct 2013, In: The pharmacogenomics journal. 13, 5, p. 410-6 7 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer

Wilson, P. M., Labonte, M. J., Martin, S. C., Kuwahara, S. T., El-Khoueiry, A., Lenz, H.-J., Ladner, R. D. & LaBonte Wilson, M., Aug 2013, In: INVESTIGATIONAL NEW DRUGS. 31, 4, p. 845-57 13 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

2012

Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer

Wilson, P. M., LaBonte, M. J., Lenz, H.-J., Mack, P. C., Ladner, R. D. & LaBonte Wilson, M., Mar 2012, In: Molecular Cancer Therapeutics. 11, 3, p. 616-28 13 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

Lee, Y. S., Choi, I., Ning, Y., Kim, N. Y., Khatchadourian, V., Yang, D., Chung, H. K., Choi, D., LaBonte, M. J., Ladner, R. D., Nagulapalli Venkata, K. C., Rosenberg, D. O., Petasis, N. A., Lenz, H.-J., Hong, Y.-K. & LaBonte Wilson, M., 22 May 2012, In: British Journal of Cancer. 106, 11, p. 1833-41 9 p.

Research output: Contribution to journal › Article › peer-review

248 Citations (Scopus)

The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models

Ning, Y., Labonte, M. J., Zhang, W., Bohanes, P. O., Gerger, A., Yang, D., Benhaim, L., Paez, D., Rosenberg, D. O., Nagulapalli Venkata, K. C., Louie, S. G., Petasis, N. A., Ladner, R. D., Lenz, H.-J. & LaBonte Wilson, M., Jun 2012, In: Molecular Cancer Therapeutics. 11, 6, p. 1353-64 12 p.

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer

Labonte, M. J., Wilson, P. M., Yang, D., Zhang, W., Ladner, R. D., Ning, Y., Gerger, A., Bohanes, P. O., Benhaim, L., El-Khoueiry, R., El-Khoueiry, A., Lenz, H.-J. & LaBonte Wilson, M., Jun 2012, In: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 23, 6, p. 1455-64 10 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

2011

A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression

Ou, C.-Y., LaBonte, M. J., Manegold, P. C., So, A.Y.-L., Ianculescu, I., Gerke, D. S., Yamamoto, K. R., Ladner, R. D., Kahn, M., Kim, J. H., Stallcup, M. R. & LaBonte Wilson, M., May 2011, In: Molecular cancer research : MCR. 9, 5, p. 660-70 11 p.

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates

Wilson, P. M., Labonte, M. J., Russell, J., Louie, S., Ghobrial, A. A., Ladner, R. D. & LaBonte Wilson, M., 01 Sept 2011, In: Nucleic Acids Research. 39, 17, p. e112

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Gender-specific genomic profiling in metastatic colorectal cancer patients treated with 5-fluorouracil and oxaliplatin

Gordon, M. A., Zhang, W., Yang, D., Iqbal, S., El-Khouiery, A., Nagashima, F., Lurje, G., Labonte, M., Wilson, P., Sherrod, A., Ladner, R. D., Lenz, H.-J. & LaBonte Wilson, M., Jan 2011, In: Pharmacogenomics. 12, 1, p. 27-39 13 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models

Ning, Y., Manegold, P. C., Hong, Y. K., Zhang, W., Pohl, A., Lurje, G., Winder, T., Yang, D., LaBonte, M. J., Wilson, P. M., Ladner, R. D., Lenz, H.-J. & LaBonte Wilson, M., 01 May 2011, In: International journal of cancer. Journal international du cancer. 128, 9, p. 2038-49 12 p.

Research output: Contribution to journal › Article › peer-review

384 Citations (Scopus)

The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models

LaBonte, M. J., Wilson, P. M., Fazzone, W., Russell, J., Louie, S. G., El-Khoueiry, A., Lenz, H.-J., Ladner, R. D. & LaBonte Wilson, M., 15 May 2011, In: Cancer Research. 71, 10, p. 3635-48 14 p.

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

2010

A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy

Wilson, P. M., El-Khoueiry, A., Iqbal, S., Fazzone, W., LaBonte, M. J., Groshen, S., Yang, D., Danenberg, K. D., Cole, S., Kornacki, M., Ladner, R. D., Lenz, H.-J. & LaBonte Wilson, M., Apr 2010, In: Cancer Chemotherapy and Pharmacology. 65, 5, p. 979-88 10 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

2009

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines

LaBonte, M. J., Wilson, P. M., Fazzone, W., Groshen, S., Lenz, H.-J., Ladner, R. D. & LaBonte Wilson, M., 2009, In: BMC Medical Genomics. 2, p. 67

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells

Fazzone, W., Wilson, P. M., Labonte, M. J., Lenz, H.-J., Ladner, R. D. & LaBonte Wilson, M., 15 Jul 2009, In: International journal of cancer. Journal international du cancer. 125, 2, p. 463-73 11 p.

Research output: Contribution to journal › Article › peer-review

67 Citations (Scopus)

Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression

Kumar, S. R., Scehnet, J. S., Ley, E. J., Singh, J., Krasnoperov, V., Liu, R., Manchanda, P. K., Ladner, R. D., Hawes, D., Weaver, F. A., Beart, R. W., Singh, G., Nguyen, C., Kahn, M. & Gill, P. S., 01 May 2009, In: Cancer Research. 69, 9, p. 3736-45 10 p.

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

Wilson, P. M., Fazzone, W., LaBonte, M. J., Lenz, H.-J., Ladner, R. D. & LaBonte Wilson, M., Jan 2009, In: Nucleic Acids Research. 37, 1, p. 78-95 18 p.

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38

LaBonte, M. J., Manegold, P. C., Wilson, P. M., Fazzone, W., Louie, S. G., Lenz, H.-J., Ladner, R. D. & LaBonte Wilson, M., 15 Dec 2009, In: International journal of cancer. Journal international du cancer. 125, 12, p. 2957-69 13 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

2008

Novel opportunities for thymidylate metabolism as a therapeutic target

Wilson, P. M., Fazzone, W., LaBonte, M. J., Deng, J., Neamati, N., Ladner, R. D. & LaBonte Wilson, M., Sept 2008, In: Molecular Cancer Therapeutics. 7, 9, p. 3029-37 9 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab

Lurje, G., Nagashima, F., Zhang, W., Yang, D., Chang, H. M., Gordon, M. A., El-Khoueiry, A., Husain, H., Wilson, P. M., Ladner, R. D., Mauro, D. J., Langer, C., Rowinsky, E. K. & Lenz, H.-J., 01 Dec 2008, In: Clinical Cancer Research. 14, 23, p. 7884-95 12 p.

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

Lurje, G., Zhang, W., Yang, D., Groshen, S., Hendifar, A. E., Husain, H., Nagashima, F., Chang, H. M., Fazzone, W., Ladner, R. D., Pohl, A., Ning, Y., Iqbal, S., El-Khoueiry, A. & Lenz, H.-J., Feb 2008, In: Pharmacogenetics and Genomics. 18, 2, p. 161-8 8 p.

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

2007

ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan

Rhodes, K. E., Zhang, W., Yang, D., Press, O. A., Gordon, M., Vallböhmer, D., Schultheis, A. M., Lurje, G., Ladner, R. D., Fazzone, W., Iqbal, S. & Lenz, H.-J., Jan 2007, In: Drug metabolism letters. 1, 1, p. 23-30 8 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Exploring alternative individualized treatment strategies in colorectal cancer

Wilson, P. M., Ladner, R. D. & Lenz, H.-J., Dec 2007, In: Clinical colorectal cancer. 7 Suppl 1, p. S28-36

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Predictive and prognostic markers in colorectal cancer

Wilson, P. M., Ladner, R. D. & Lenz, H.-J., Nov 2007, In: Gastrointestinal cancer research : GCR. 1, 6, p. 237-46 10 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

2006

Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1

Pullmann, R., Abdelmohsen, K., Lal, A., Martindale, J. L., Ladner, R. D. & Gorospe, M., 18 Aug 2006, In: The Journal of Biological Chemistry. 281, 33, p. 23456-63 8 p.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer

Yang, D., Schneider, S., Azuma, M., Iqbal, S., El-Khoueiry, A., Groshen, S., Agafitei, D., Danenberg, K. D., Danenberg, P. V., Ladner, R. D. & Lenz, H.-J., Nov 2006, In: Clinical colorectal cancer. 6, 4, p. 305-11 7 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2004

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

Mandola, M. V., Stoehlmacher, J., Zhang, W., Groshen, S., Yu, M. C., Iqbal, S., Lenz, H.-J. & Ladner, R. D., May 2004, In: Pharmacogenetics. 14, 5, p. 319-27 9 p.

Research output: Contribution to journal › Article › peer-review

291 Citations (Scopus)

Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition

Koehler, S. E. & Ladner, R. D., Sept 2004, In: Molecular Pharmacology. 66, 3, p. 620-6 7 p.

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

2003

A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity

Mandola, M. V., Stoehlmacher, J., Muller-Weeks, S., Cesarone, G., Yu, M. C., Lenz, H.-J. & Ladner, R. D., 01 Jun 2003, In: Cancer Research. 63, 11, p. 2898-904 7 p.

Research output: Contribution to journal › Article › peer-review

358 Citations (Scopus)

hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae

Elateri, I., Tinkelenberg, B. A., Hansbury, M., Caradonna, S., Muller-Weeks, S. & Ladner, R. D., 01 Mar 2003, In: DNA Repair. 2, 3, p. 315-23 9 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Identification of sequence determinants of human nuclear dUTPase isoform localization

Tinkelenberg, B. A., Fazzone, W., Lynch, F. J. & Ladner, R. D., 01 Jul 2003, In: Experimental Cell Research. 287, 1, p. 39-46 8 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

2002

dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae

Tinkelenberg, B. A., Hansbury, M. J. & Ladner, R. D., 01 Sept 2002, In: Cancer Research. 62, 17, p. 4909-15 7 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

2001

The role of dUTPase and uracil-DNA repair in cancer chemotherapy

Ladner, R. D., Dec 2001, In: Current Protein and Peptide Science. 2, 4, p. 361-70 10 p.

Research output: Contribution to journal › Review article › peer-review

102 Citations (Scopus)

2000

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

Webley, S. D., Hardcastle, A., Ladner, R. D., Jackman, A. L. & Aherne, G. W., Sept 2000, In: British Journal of Cancer. 83, 6, p. 792-9 8 p.

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer

Ladner, R. D., Lynch, F. J., Groshen, S., Xiong, Y. P., Sherrod, A., Caradonna, S. J., Stoehlmacher, J. & Lenz, H. J., 01 Jul 2000, In: Cancer Research. 60, 13, p. 3493-503 11 p.

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

1999

Phase II/pharmacodynamic trial of dose-intensive, weekly parenteral hydroxyurea and fluorouracil administered with interferon alfa-2a in patients with refractory malignancies of the gastrointestinal tract

Wadler, S., Damle, S., Haynes, H., Kaleya, R., Schechner, R., Berkenblit, R., Ladner, R. D. & Murgo, A., Jun 1999, In: Journal of Clinical Oncology. 17, 6, p. 1771-8 8 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

1997

Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay

Horowitz, R. W., Zhang, H., Schwartz, E. L., Ladner, R. D. & Wadler, S., 01 Sept 1997, In: Biochemical Pharmacology. 54, 5, p. 635-8 4 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

The human dUTPase gene encodes both nuclear and mitochondrial isoforms. Differential expression of the isoforms and characterization of a cDNA encoding the mitochondrial species

Ladner, R. D. & Caradonna, S. J., 25 Jul 1997, In: The Journal of Biological Chemistry. 272, 30, p. 19072-80 9 p.

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Robert Ladner

Research output

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