• Room 02.024 - H.S.B

    United Kingdom

19962017

Research output per year

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Research Output

2017

Imbalanced nucleotide metabolism sensitises breast cancer cells to anthracyclines

Davison, C., Chevallier, O., McKechnie, M., Carson, R., Oliver Esteve, J. A., Stachtea, X., Wilson, R., Ladner, R. & LaBonte Wilson, M., Nov 2017.

Research output: Contribution to conferencePoster

2016

Delivering a Research-Enabled Multistakeholder Partnership for Enhanced Patient Care at a Population Level: The Northern Ireland Comprehensive Cancer Program

Lawler, M., Gavin, A., Salto-Tellez, M., Kennedy, R. D., Van Schaeybroeck, S., Wilson, R. H., Harkin, D. P., Grayson, M., Boyd, R. E., Hamilton, P. W., McArt, D. G., James, J., Robson, T., Ladner, R. D., Prise, K. M., O'Sullivan, J. M., Harrison, T., Murray, L., Johnston, P. G. & Waugh, D. J., 01 Mar 2016, In : Cancer. 122, 5, p. 664-673 10 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
298 Downloads (Pure)
2015

Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer

Benhaim, L., Zhang, W., Wakatsuki, T., Yang, D., Gerger, A., Bohanes, P., Paez, D., Loupakis, F., LaBonte, M. J., Ning, Y., El-Khoueiry, R., Ladner, R., Wilson, P., Zhang, H., Giamas, G., Stebbing, J. & Lenz, H. J., Jun 2015, In : The pharmacogenomics journal. 15, 3, p. 235-40 6 p.

Research output: Contribution to journalArticle

2014

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

Wilson, P. M., Danenberg, P. V., Johnston, P. G., Lenz, H-J. & Ladner, R. D., May 2014, In : Nature reviews. Clinical oncology. 11, 5, p. 282-98 17 p.

Research output: Contribution to journalReview article

169 Citations (Scopus)
2013

Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration

Choi, I., Lee, Y. S., Chung, H. K., Choi, D., Ecoiffier, T., Lee, H. N., Kim, K. E., Lee, S., Park, E. K., Maeng, Y. S., Kim, N. Y., Ladner, R. D., Petasis, N. A., Koh, C. J., Chen, L., Lenz, H-J. & Hong, Y-K., Jan 2013, In : Angiogenesis. 16, 1, p. 29-44 16 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib)

Wilson, P. M., Yang, D., Azuma, M., Shi, M. M., Danenberg, K. D., Lebwohl, D., Sherrod, A., Ladner, R. D., Zhang, W., Danenberg, P. V., Trarbach, T., Folprecht, G., Meinhardt, G. & Lenz, H-J., Oct 2013, In : The pharmacogenomics journal. 13, 5, p. 410-6 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Sustained inhibition of deacetylases is required for the antitumor activity of the histone deactylase inhibitors panobinostat and vorinostat in models of colorectal cancer

Wilson, P. M., Labonte, M. J., Martin, S. C., Kuwahara, S. T., El-Khoueiry, A., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., Aug 2013, In : INVESTIGATIONAL NEW DRUGS. 31, 4, p. 845-57 13 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2012

Inhibition of dUTPase induces synthetic lethality with thymidylate synthase-targeted therapies in non-small cell lung cancer

Wilson, P. M., LaBonte, M. J., Lenz, H-J., Mack, P. C., Ladner, R. D. & LaBonte Wilson, M., Mar 2012, In : Molecular Cancer Therapeutics. 11, 3, p. 616-28 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

Lee, Y. S., Choi, I., Ning, Y., Kim, N. Y., Khatchadourian, V., Yang, D., Chung, H. K., Choi, D., LaBonte, M. J., Ladner, R. D., Nagulapalli Venkata, K. C., Rosenberg, D. O., Petasis, N. A., Lenz, H-J., Hong, Y-K. & LaBonte Wilson, M., 22 May 2012, In : British Journal of Cancer. 106, 11, p. 1833-41 9 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models

Ning, Y., Labonte, M. J., Zhang, W., Bohanes, P. O., Gerger, A., Yang, D., Benhaim, L., Paez, D., Rosenberg, D. O., Nagulapalli Venkata, K. C., Louie, S. G., Petasis, N. A., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., Jun 2012, In : Molecular Cancer Therapeutics. 11, 6, p. 1353-64 12 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer

Labonte, M. J., Wilson, P. M., Yang, D., Zhang, W., Ladner, R. D., Ning, Y., Gerger, A., Bohanes, P. O., Benhaim, L., El-Khoueiry, R., El-Khoueiry, A., Lenz, H-J. & LaBonte Wilson, M., Jun 2012, In : Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 23, 6, p. 1455-64 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2011

A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression

Ou, C-Y., LaBonte, M. J., Manegold, P. C., So, A. Y-L., Ianculescu, I., Gerke, D. S., Yamamoto, K. R., Ladner, R. D., Kahn, M., Kim, J. H., Stallcup, M. R. & LaBonte Wilson, M., May 2011, In : Molecular cancer research : MCR. 9, 5, p. 660-70 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates

Wilson, P. M., Labonte, M. J., Russell, J., Louie, S., Ghobrial, A. A., Ladner, R. D. & LaBonte Wilson, M., 01 Sep 2011, In : Nucleic Acids Research. 39, 17, p. e112

Research output: Contribution to journalArticle

41 Citations (Scopus)

Gender-specific genomic profiling in metastatic colorectal cancer patients treated with 5-fluorouracil and oxaliplatin

Gordon, M. A., Zhang, W., Yang, D., Iqbal, S., El-Khouiery, A., Nagashima, F., Lurje, G., Labonte, M., Wilson, P., Sherrod, A., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., Jan 2011, In : Pharmacogenomics. 12, 1, p. 27-39 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Interleukin-8 is associated with proliferation, migration, angiogenesis and chemosensitivity in vitro and in vivo in colon cancer cell line models

Ning, Y., Manegold, P. C., Hong, Y. K., Zhang, W., Pohl, A., Lurje, G., Winder, T., Yang, D., LaBonte, M. J., Wilson, P. M., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., 01 May 2011, In : International journal of cancer. Journal international du cancer. 128, 9, p. 2038-49 12 p.

Research output: Contribution to journalArticle

250 Citations (Scopus)

The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models

LaBonte, M. J., Wilson, P. M., Fazzone, W., Russell, J., Louie, S. G., El-Khoueiry, A., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., 15 May 2011, In : Cancer Research. 71, 10, p. 3635-48 14 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)
2010

A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy

Wilson, P. M., El-Khoueiry, A., Iqbal, S., Fazzone, W., LaBonte, M. J., Groshen, S., Yang, D., Danenberg, K. D., Cole, S., Kornacki, M., Ladner, R. D., Lenz, H-J. & LaBonte Wilson, M., Apr 2010, In : Cancer Chemotherapy and Pharmacology. 65, 5, p. 979-88 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2009

DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines

LaBonte, M. J., Wilson, P. M., Fazzone, W., Groshen, S., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., 2009, In : BMC Medical Genomics. 2, p. 67

Research output: Contribution to journalArticle

66 Citations (Scopus)
57 Citations (Scopus)

Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression

Kumar, S. R., Scehnet, J. S., Ley, E. J., Singh, J., Krasnoperov, V., Liu, R., Manchanda, P. K., Ladner, R. D., Hawes, D., Weaver, F. A., Beart, R. W., Singh, G., Nguyen, C., Kahn, M. & Gill, P. S., 01 May 2009, In : Cancer Research. 69, 9, p. 3736-45 10 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage

Wilson, P. M., Fazzone, W., LaBonte, M. J., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., Jan 2009, In : Nucleic Acids Research. 37, 1, p. 78-95 18 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38

LaBonte, M. J., Manegold, P. C., Wilson, P. M., Fazzone, W., Louie, S. G., Lenz, H-J., Ladner, R. D. & LaBonte Wilson, M., 15 Dec 2009, In : International journal of cancer. Journal international du cancer. 125, 12, p. 2957-69 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2008

Novel opportunities for thymidylate metabolism as a therapeutic target

Wilson, P. M., Fazzone, W., LaBonte, M. J., Deng, J., Neamati, N., Ladner, R. D. & LaBonte Wilson, M., Sep 2008, In : Molecular Cancer Therapeutics. 7, 9, p. 3029-37 9 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab

Lurje, G., Nagashima, F., Zhang, W., Yang, D., Chang, H. M., Gordon, M. A., El-Khoueiry, A., Husain, H., Wilson, P. M., Ladner, R. D., Mauro, D. J., Langer, C., Rowinsky, E. K. & Lenz, H-J., 01 Dec 2008, In : Clinical Cancer Research. 14, 23, p. 7884-95 12 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

Lurje, G., Zhang, W., Yang, D., Groshen, S., Hendifar, A. E., Husain, H., Nagashima, F., Chang, H. M., Fazzone, W., Ladner, R. D., Pohl, A., Ning, Y., Iqbal, S., El-Khoueiry, A. & Lenz, H-J., Feb 2008, In : Pharmacogenetics and Genomics. 18, 2, p. 161-8 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2007

ABCB1, SLCO1B1 and UGT1A1 gene polymorphisms are associated with toxicity in metastatic colorectal cancer patients treated with first-line irinotecan

Rhodes, K. E., Zhang, W., Yang, D., Press, O. A., Gordon, M., Vallböhmer, D., Schultheis, A. M., Lurje, G., Ladner, R. D., Fazzone, W., Iqbal, S. & Lenz, H-J., Jan 2007, In : Drug metabolism letters. 1, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Exploring alternative individualized treatment strategies in colorectal cancer

Wilson, P. M., Ladner, R. D. & Lenz, H-J., Dec 2007, In : Clinical colorectal cancer. 7 Suppl 1, p. S28-36

Research output: Contribution to journalReview article

5 Citations (Scopus)

Predictive and prognostic markers in colorectal cancer

Wilson, P. M., Ladner, R. D. & Lenz, H-J., Nov 2007, In : Gastrointestinal cancer research : GCR. 1, 6, p. 237-46 10 p.

Research output: Contribution to journalArticle

2006

Differential stability of thymidylate synthase 3'-untranslated region polymorphic variants regulated by AUF1

Pullmann, R., Abdelmohsen, K., Lal, A., Martindale, J. L., Ladner, R. D. & Gorospe, M., 18 Aug 2006, In : The Journal of biological chemistry. 281, 33, p. 23456-63 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer

Yang, D., Schneider, S., Azuma, M., Iqbal, S., El-Khoueiry, A., Groshen, S., Agafitei, D., Danenberg, K. D., Danenberg, P. V., Ladner, R. D. & Lenz, H-J., Nov 2006, In : Clinical colorectal cancer. 6, 4, p. 305-11 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2004

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

Mandola, M. V., Stoehlmacher, J., Zhang, W., Groshen, S., Yu, M. C., Iqbal, S., Lenz, H-J. & Ladner, R. D., May 2004, In : Pharmacogenetics. 14, 5, p. 319-27 9 p.

Research output: Contribution to journalArticle

270 Citations (Scopus)

Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition

Koehler, S. E. & Ladner, R. D., Sep 2004, In : Molecular Pharmacology. 66, 3, p. 620-6 7 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
2003

A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity

Mandola, M. V., Stoehlmacher, J., Muller-Weeks, S., Cesarone, G., Yu, M. C., Lenz, H-J. & Ladner, R. D., 01 Jun 2003, In : Cancer Research. 63, 11, p. 2898-904 7 p.

Research output: Contribution to journalArticle

337 Citations (Scopus)

hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae

Elateri, I., Tinkelenberg, B. A., Hansbury, M., Caradonna, S., Muller-Weeks, S. & Ladner, R. D., 01 Mar 2003, In : DNA Repair. 2, 3, p. 315-23 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identification of sequence determinants of human nuclear dUTPase isoform localization

Tinkelenberg, B. A., Fazzone, W., Lynch, F. J. & Ladner, R. D., 01 Jul 2003, In : Experimental Cell Research. 287, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2002

dUTPase and uracil-DNA glycosylase are central modulators of antifolate toxicity in Saccharomyces cerevisiae

Tinkelenberg, B. A., Hansbury, M. J. & Ladner, R. D., 01 Sep 2002, In : Cancer Research. 62, 17, p. 4909-15 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2001

The role of dUTPase and uracil-DNA repair in cancer chemotherapy

Ladner, R. D., Dec 2001, In : Current Protein and Peptide Science. 2, 4, p. 361-70 10 p.

Research output: Contribution to journalReview article

84 Citations (Scopus)
2000

Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331

Webley, S. D., Hardcastle, A., Ladner, R. D., Jackman, A. L. & Aherne, G. W., Sep 2000, In : British Journal of Cancer. 83, 6, p. 792-9 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

dUTP nucleotidohydrolase isoform expression in normal and neoplastic tissues: association with survival and response to 5-fluorouracil in colorectal cancer

Ladner, R. D., Lynch, F. J., Groshen, S., Xiong, Y. P., Sherrod, A., Caradonna, S. J., Stoehlmacher, J. & Lenz, H. J., 01 Jul 2000, In : Cancer Research. 60, 13, p. 3493-503 11 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
1999

Phase II/pharmacodynamic trial of dose-intensive, weekly parenteral hydroxyurea and fluorouracil administered with interferon alfa-2a in patients with refractory malignancies of the gastrointestinal tract

Wadler, S., Damle, S., Haynes, H., Kaleya, R., Schechner, R., Berkenblit, R., Ladner, R. D. & Murgo, A., Jun 1999, In : Journal of Clinical Oncology. 17, 6, p. 1771-8 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
1997

Measurement of deoxyuridine triphosphate and thymidine triphosphate in the extracts of thymidylate synthase-inhibited cells using a modified DNA polymerase assay

Horowitz, R. W., Zhang, H., Schwartz, E. L., Ladner, R. D. & Wadler, S., 01 Sep 1997, In : Biochemical Pharmacology. 54, 5, p. 635-8 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
81 Citations (Scopus)
1996

A CUC triplet confers leucine-dependent regulation of the Bacillus subtilis ilv-leu operon

Marta, P. T., Ladner, R. D. & Grandoni, J. A., Apr 1996, In : Journal of Bacteriology. 178, 7, p. 2150-3 4 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases

Caradonna, S., Ladner, R., Hansbury, M., Kosciuk, M., Lynch, F. & Muller, S., 01 Feb 1996, In : Experimental Cell Research. 222, 2, p. 345-59 15 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase

Ladner, R. D., McNulty, D. E., Roberts, G. D. & Caradonna, S. J., 29 Mar 1996, In : The Journal of biological chemistry. 271, 13, p. 7745-51 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Identification of a consensus cyclin-dependent kinase phosphorylation site unique to the nuclear form of human deoxyuridine triphosphate nucleotidohydrolase

Ladner, R. D., Carr, S. A., Huddleston, M. J., McNulty, D. E. & Caradonna, S. J., 29 Mar 1996, In : The Journal of biological chemistry. 271, 13, p. 7752-7 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)