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Personal profile
Research Statement
Dr Burden began her scientific career by achieving a BSc (Hons) 2.1 degree in Biochemistry at Queen’s University Belfast in 2002. Following this she undertook a Masters degree in Medical Sciences within the Department of Haematology at the university, where her research was focused on delineating a molecular signature in Chronic Myeloid Leukaemia. In 2003, Dr Burden transferred to the School of Pharmacy when she was awarded a DEL CAST award to commence her PhD studies in the area of protease biochemistry. This work was focused on the development of novel inhibition strategies for targeting the cysteine cathepsin family of proteases. During this time, Dr Burden developed and characterized several biologic-based inhibitors (recombinant protein and antibodies) that resulted in a number of patent applications and publications.
Upon completion of her PhD, Dr Burden embarked upon her postdoctoral career in 2007 when she was appointed as a Knowledge Transfer Partnership associate in a collaboration between the Centre for Cancer Research and Cell Biology and Fusion Antibodies Ltd. This project was focused on the further development of the therapeutics that had been developed during her PhD studies in a number of tumour models and the identification of novel therapeutic targets in lung carcinomas that could also be amenable to antibody based targeting. Within Fusion Antibodies, Dr Burden was promoted to Team Leader within the R&D department and was responsible for liaising with the company directors and investors, giving regular updates on the scientific research that was being undertaken within the company.
After her time in industry, Dr Burden returned to academic research to undertake postdoctoral positions in the Drug Discovery research group within the Centre for Cancer Research and Cell Biology and the Molecular Therapeutics Research cluster within the School of Pharmacy. Her research in the Drug Discovery group was focused on characterizing novel targets for breast cancer treatment, whilst in the School of Pharmacy she undertook a MRC-funded postdoctoral position focused on the molecular and pharmacological evaluation of Cathepsin S as a target for disease treatment.
In June 2012, Dr Burden was appointed as a Lecturer in Pharmacology in the Molecular Therapeutics research cluster within the School of Pharmacy. Her research interest is primarily centered around the cellular microenvironment (in both health and disease) and regulatory mechanisms mediated by proteases and chemokines. Currently, Dr Burden’s work is focused on ageing and inflammatory maladies such as cancer, cardiovascular disease and fibrosis.
Research Interests
- Microenvironment
- Inflammation
- Ageing
- Tumourigenesis
- Fibrosis
- Proteases
- Therapeutics
- Angiogenesis
- Chemokines
- Senescence
Teaching
- PMY1014: Introduction to Pharmacy Practice Skills
- PMY2002: Medicinal Substances: Structure and Function
- PMY2104: The Pharmacological basis of Therapeutics
- PMY2105: Clinical Therapeutics 1
- PMY3082: Applied Pharmaceutical Analysis and Drug Design
- PMY3174: Clinical Therapeutics 2
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 1 Active
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R1300CNR: Future Medicines Institute
Scott, C. (PI), Bruce, I. (CoI), Burden, R. (CoI), Burrows, J. (CoI), Collins, B. (CoI), Harrison, T. (CoI), James, J. (CoI), Kennedy, R. (CoI), Lawler, M. (CoI), Longley, D. (CoI), Maguire, S. (CoI), Malinova, D. (CoI), Maule, A. (CoI), McCloskey, K. (CoI), McDade, S. (CoI), Salto-Tellez, M. (CoI), Savage, K. (CoI), Stitt, A. (CoI) & Williams, R. (CoI)
15/10/2024 → …
Project: Research
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Editorial: Peptidases as a therapeutic target in anti-cancer management
Mitrović, A., Burden, R. E., Softič, A. & Kavčič, N., 11 Apr 2024, In: Frontiers in Pharmacology. 15, 3 p., 1394018.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile23 Downloads (Pure) -
Optimising intracellular delivery of antibiotic loaded PLGA nanoparticles to macrophages
Alsa'd, A. A., Greene, M. K., Tayyem, M., Elmore, B., Abed, A., Burden, R. E., Gilmore, B. F., Scott, C. J. & Burrows, J. F., 25 Oct 2024, In: International Journal of Pharmaceutics. 664, 15 p., 124567.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)22 Downloads (Pure) -
Cathepsin V regulates cell cycle progression and histone stability in the nucleus of breast cancer cells
Sereesongsaeng, N., Burrows, J. F., Scott, C. J., Brix, K. & Burden, R. E., 06 Nov 2023, In: Frontiers in Pharmacology. 14, 13 p., 1271435.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)53 Downloads (Pure) -
Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy
Smyth, P., Ferguson, L., Burrows, J. F., Burden, R. E., Tracey, S. R., Herron, Ú. M., Kovaleva, M., Williams, R., Porter, A. J., Longley, D. B., Barelle, C. J. & Scott, C. J., 05 Dec 2023, In: Frontiers in Pharmacology. 14, 13 p., 1296567.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)49 Downloads (Pure) -
Personalised pharmacy: embedding pharmacogenomics in the curriculum
Murray, C., Burden, R., Buckley, N. E. & Hanna, L.-A., 07 Nov 2023.Research output: Contribution to conference › Poster › peer-review
File58 Downloads (Pure)
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Cathepsin V in the pathogenesis of luminal breast cancer: a bimodal approach.
Murray, A. (Presenter) & Burden, R. (Advisor)
27 Jun 2023 → 29 Jun 2023Activity: Talk or presentation types › Oral presentation
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Dissecting the role of Cathepsin V in breast cancer
Burden, R. (Invited speaker)
Sept 2022Activity: Talk or presentation types › Invited talk
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Dissecting the role of cathepsin S in dna damage repair deficient tumours.
Gallaher, S. (Speaker), Burden, R. (Advisor), Williams, R. (Advisor) & Scott, C. (Advisor)
Feb 2021Activity: Talk or presentation types › Oral presentation
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Investigation into the Modulation of Intracellular Protease Activities by Accumulation of Non-Biodegradable Silica Particulates
Ishaq, F. (Presenter), Scott, C. (Advisor) & Burden, R. (Advisor)
Apr 2018Activity: Talk or presentation types › Oral presentation
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Silica Nanoparticles Modulates Intracellular Protease Activities and Toxicity in Macrophages.
Ishaq, F. (Presenter), Hughes, C. (Contributor), Cogo, F. (Contributor), Burden, R. (Advisor) & Scott, C. (Advisor)
Mar 2017Activity: Talk or presentation types › Oral presentation