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Accepting PhD Students

PhD projects

Open to PhD applications in the fields of protease biology and inhibitor development (small molecule and biological inhibitors).

20032019
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Research Output 2003 2019

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Article
2019
61 Downloads (Pure)

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Triple Negative Breast Neoplasms
Biomarkers
Neoplasms
DNA Repair

Identification and SAR exploration of a novel series of Legumain inhibitors

Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.

Research output: Contribution to journalArticle

asparaginylendopeptidase
Dipeptides
Molecules
Research
Experiments
2018
1 Citation (Scopus)
25 Downloads (Pure)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, In : Nanoscale - Royal Society of Chemistry.

Research output: Contribution to journalArticle

Open Access
File
Caspase 3
Labels
Labeling
Tumors
Pharmacodynamics
3 Citations (Scopus)
134 Downloads (Pure)
Open Access
File
Cytotoxicity
skin (animal)
cytotoxicity
Skin
Fusion reactions
105 Downloads (Pure)

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journalArticle

Open Access
File
Clathrin
Protein-Tyrosine Kinases
Exons
Chemical activation
Apoptosis
2016
12 Citations (Scopus)
242 Downloads (Pure)

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

Wilkinson, R. D. A., Young, A., Burden, R. E., Williams, R. & Scott, C. J., 21 Apr 2016, In : Molecular Cancer. 15, 29, 11 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Nitriles
Neoplasms
MCF-7 Cells
Apoptosis
16 Citations (Scopus)
230 Downloads (Pure)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Caspase 1
Macrophages
Biomarkers
Interleukin-1
7 Citations (Scopus)

Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside

Hughes, C. S., Burden, R. E., Gilmore, B. F. & Scott, C. J., Mar 2016, In : Biochimie. 122, p. 48-61 14 p.

Research output: Contribution to journalArticle

Cathepsins
Cysteine
Peptide Hydrolases
Sulfhydryl Compounds
Labeling
2 Citations (Scopus)
cathepsin S
Cathepsins
Cysteine
Biotin
Click Chemistry
2015
63 Citations (Scopus)

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Wilkinson, R. D. A., Williams, R., Scott, C. J. & Burden, R. E., Aug 2015, In : Biological Chemistry. 396, 8, p. 867-82 16 p.

Research output: Contribution to journalArticle

cathepsin S
Cathepsins
Cysteine
Peptide Hydrolases
Therapeutics
16 Citations (Scopus)
185 Downloads (Pure)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Wilkinson, R., Magorrian, S., Williams, R., Young, A., Small, D., Scott, C. & Burden, R., 22 Aug 2015, In : Oncotarget. p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
protease S
Neoplasms
Tumor Microenvironment
2013
48 Citations (Scopus)
273 Downloads (Pure)

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Growth
Neoplasms
2012
28 Citations (Scopus)

Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.

Burden, R. E., Gormley, J. A., Kuehn, D., Ward, C., Kwok, H. F., Gazdoiu, M., McClurg, A., Jaquin, T. J., Johnston, J. A., Scott, C. J. & Olwill, S. A., Feb 2012, In : Biochimie. 94, 2, p. 487-493 7 p.

Research output: Contribution to journalArticle

cathepsin S
irinotecan
Chemotherapy
Colorectal Neoplasms
Tumors
2011
11 Citations (Scopus)

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A. & 3 others, Scott, C. J., Johnston, J. A. & Olwill, S. A., 14 Dec 2011, In : Molecular Cancer. 10, 147.

Research output: Contribution to journalArticle

cathepsin S
Antibodies
Neoplasms
Colorectal Neoplasms
Cellular Microenvironment
20 Citations (Scopus)
cathepsin S
Cysteine Proteases
Histocompatibility Antigens Class II
Antigen Presentation
Psoriasis
2010
40 Citations (Scopus)

Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

Ward, C., Kuehn, D., Burden, R. E., Gormley, J. A., Jaquin, T. J., Gazdoiu, M., Small, D., Bicknell, R., Johnston, J. A., Scott, C. J. & Olwill, S. A., 2010, In : PLoS ONE. 5, 9, 8 p., e12543.

Research output: Contribution to journalArticle

cathepsin S
vascular endothelial growth factors
angiogenesis
Vascular Endothelial Growth Factor A
antibodies
2009
53 Citations (Scopus)

USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J. & Johnston, J. A., 03 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9587-9595 9 p.

Research output: Contribution to journalArticle

Cell proliferation
Chemical activation
Cell Proliferation
Enzymes
Membranes
2008
94 Citations (Scopus)

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

McCarron, P. A., Marouf, W. M., Quinn, D. J., Fay, F., Burden, R. E., Olwill, S. A. & Scott, C. J., Aug 2008, In : Bioconjugate Chemistry. 19, 8, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

Camptothecin
Antibodies
Nanoparticles
Tumors
Cells
18 Citations (Scopus)

Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment

Burden, R., Snoddy, P., Buick, R. J., Johnston, J., Walker, B. & Scott, C., Mar 2008, In : Molecular Cancer Therapeutics. 7, 3, p. 538-547 10 p.

Research output: Contribution to journalArticle

cathepsin S
Cathepsin L
Tumor Microenvironment
Peptide Hydrolases
Neoplasms
2007
19 Citations (Scopus)

Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.

Flannery, T., McConnell, R. S., McQuaid, S., McGregor, G., Mirakhur, M., Martin, L., Scott, C., Burden, R., Walker, B., McGoohan, C. & Johnston, P., Apr 2007, In : British Journal of Neurosurgery. 21, 2, p. 204-209 6 p.

Research output: Contribution to journalArticle

cathepsin S
Cysteine Proteases
Brain Neoplasms
Microdialysis
Brain
10 Citations (Scopus)

Inhibition of cathepsin L-like proteases by cathepsin V propeptide

Burden, R., Snoddy, P., Jefferies, C. A., Walker, B. & Scott, C., 01 May 2007, In : Biological Chemistry. 388(5), 5, p. 541-545 5 p.

Research output: Contribution to journalArticle

Cathepsin L
Cathepsins
Peptide Hydrolases
Cysteine Proteases
Purification
2004

Bcr-Abl down-regulates CCN3 expression

Gilmour, L. M. R., Price, S., Burden, R., Pierce, A., Whetton, A. D., Perbal, B. & Irvine, A., Apr 2004, In : British Journal of Haematology. 125, p. 15-15 1 p.

Research output: Contribution to journalArticle

2003

CCN3 is down-regulated in chronic myeloid leukemia.

Gilmour, L. M. R., Burden, R., Price, S., Perbal, B., Pierce, A., Whetton, A. & Irvine, A., Dec 2003, In : Blood. 102, p. 651A-651A

Research output: Contribution to journalArticle