• Room 03.034 - Whitla Medical Building

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the fields of protease biology and inhibitor development (small molecule and biological inhibitors).

20032019

Research output per year

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Research Output

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Article
2019

A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In : Journal of Oncology.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
94 Downloads (Pure)

Identification and SAR exploration of a novel series of Legumain inhibitors

Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.

Research output: Contribution to journalArticle

2018

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

Cogo, F., Smyth, P., Burden, R., Longley, D. B., Williams, R., Johnston, M., Poreba, M., Rut, W., Groborz, K., Salvesen, G., Drag, M. & Scott, C. J., 13 Dec 2018, In : Nanoscale - Royal Society of Chemistry.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
168 Downloads (Pure)

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In : Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
140 Downloads (Pure)
2016

A bioavailable cathepsin S nitrile inhibitor abrogates tumor development

Wilkinson, R. D. A., Young, A., Burden, R. E., Williams, R. & Scott, C. J., 21 Apr 2016, In : Molecular Cancer. 15, 29, 11 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
276 Downloads (Pure)

Extracellular cathepsin S and intracellular caspase 1 activation are surrogate biomarkers of particulate-induced lysosomal disruption in macrophages

Hughes, C. S., Colhoun, L. M., Bains, B. K., Kilgour, J. D., Burden, R. E., Burrows, J. F., Lavelle, E. C., Gilmore, B. F. & Scott, C. J., 23 Apr 2016, In : Particle and fibre toxicology. 13, 19, 13 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
263 Downloads (Pure)

Strategies for detection and quantification of cysteine cathepsins-evolution from bench to bedside

Hughes, C. S., Burden, R. E., Gilmore, B. F. & Scott, C. J., Mar 2016, In : Biochimie. 122, p. 48-61 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2 Citations (Scopus)
2015

Cathepsin S: therapeutic, diagnostic, and prognostic potential

Wilkinson, R. D. A., Williams, R., Scott, C. J. & Burden, R. E., Aug 2015, In : Biological Chemistry. 396, 8, p. 867-82 16 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Wilkinson, R., Magorrian, S., Williams, R., Young, A., Small, D., Scott, C. & Burden, R., 22 Aug 2015, In : Oncotarget. p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
209 Downloads (Pure)

Development of a potent and selective cell penetrant Legumain inhibitor

Ness, K. A., Eddie, S. L., Higgins, C. A., Templeman, A., D'Costa, Z., Gaddale, K. K. D., Bouzzaoui, S., Jordan, L., Janssen, D., Harrison, T., Burkamp, F., Young, A., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 01 Dec 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 23, p. 5642-5645

Research output: Contribution to journalArticle

6 Citations (Scopus)
2013

Cathepsin S from both tumour and tumour-associated cells promote cancer growth and neovascularisation

Small, D. M., Burden, R. E., Jaworski, J., Hegarty, S. M., Spence, S., Burrows, J. F., McFarlane, C., Kissenpfennig, A., McCarthy, H. O., Johnston, J. A., Walker, B. & Scott, C. J., Nov 2013, In : International Journal of Cancer. 133, 9, p. 2102-2112 11 p.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
312 Downloads (Pure)
2012

Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas.

Burden, R. E., Gormley, J. A., Kuehn, D., Ward, C., Kwok, H. F., Gazdoiu, M., McClurg, A., Jaquin, T. J., Johnston, J. A., Scott, C. J. & Olwill, S. A., Feb 2012, In : Biochimie. 94, 2, p. 487-493 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2011

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A. & 3 others, Scott, C. J., Johnston, J. A. & Olwill, S. A., 14 Dec 2011, In : Molecular Cancer. 10, 147.

Research output: Contribution to journalArticle

13 Citations (Scopus)
21 Citations (Scopus)
2010

Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

Ward, C., Kuehn, D., Burden, R. E., Gormley, J. A., Jaquin, T. J., Gazdoiu, M., Small, D., Bicknell, R., Johnston, J. A., Scott, C. J. & Olwill, S. A., 2010, In : PLoS ONE. 5, 9, 8 p., e12543.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2009

USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

Burrows, J. F., Kelvin, A. A., McFarlane, C., Burden, R. E., McGrattan, M. J., De la Vega, M., Govender, U., Quinn, D. J., Dib, K., Gadina, M., Scott, C. J. & Johnston, J. A., 03 Apr 2009, In : Journal of Biological Chemistry. 284, 14, p. 9587-9595 9 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2008

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

McCarron, P. A., Marouf, W. M., Quinn, D. J., Fay, F., Burden, R. E., Olwill, S. A. & Scott, C. J., Aug 2008, In : Bioconjugate Chemistry. 19, 8, p. 1561-1569 9 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment

Burden, R., Snoddy, P., Buick, R. J., Johnston, J., Walker, B. & Scott, C., Mar 2008, In : Molecular Cancer Therapeutics. 7, 3, p. 538-547 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2007

Detection of cathepsin S cysteine protease in human brain tumour microdialysates in vivo.

Flannery, T., McConnell, R. S., McQuaid, S., McGregor, G., Mirakhur, M., Martin, L., Scott, C., Burden, R., Walker, B., McGoohan, C. & Johnston, P., Apr 2007, In : British Journal of Neurosurgery. 21, 2, p. 204-209 6 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Inhibition of cathepsin L-like proteases by cathepsin V propeptide

Burden, R., Snoddy, P., Jefferies, C. A., Walker, B. & Scott, C., 01 May 2007, In : Biological Chemistry. 388(5), 5, p. 541-545 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2004

Bcr-Abl down-regulates CCN3 expression

Gilmour, L. M. R., Price, S., Burden, R., Pierce, A., Whetton, A. D., Perbal, B. & Irvine, A., Apr 2004, In : British Journal of Haematology. 125, p. 15-15 1 p.

Research output: Contribution to journalArticle

2003

CCN3 is down-regulated in chronic myeloid leukemia.

Gilmour, L. M. R., Burden, R., Price, S., Perbal, B., Pierce, A., Whetton, A. & Irvine, A., Dec 2003, In : Blood. 102, p. 651A-651A

Research output: Contribution to journalArticle