Sandra Van Schaeybroeck

2024

Immune microenvironment modulation following neoadjuvant therapy for oesophageal adenocarcinoma: a translational analysis of the DEBIOC clinical trial

Scanlon, E., Lavery, A., Albraikat, M., Stevenson, L., Kennedy, C., Byrne, R., Walker, A., Mullan-Young, B., McManus, D. T., Virdee, P. S., Elhussein, L., Turbitt, J., Collinson, D., Miedzybrodzka, Z., Van Schaeybroeck, S., McQuaid, S., James, J. A., Craig, S. G., Blayney, J. K. & Petty, R. D. & 6 others, Harkin, D. P., Kennedy, R. D., Eatock, M. M., Middleton, M. R., Thomas, A. & Turkington, R. C., Nov 2024, In: ESMO Open. 9, 11, 14 p., 103930.

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Downloads (Pure)

Ruthenium drug BOLD-100 regulates BRAFMT colorectal cancer cell apoptosis through AhR/ROS/ATR signaling axis modulation

Griffin, D., Carson, R., Moss, D., Sessler, T., Lavin, D., Tiwari, V., Karelia, S., Kennedy, R., Savage, K. I., McDade, S., Carie, A., Pankovich, J., Bazett, M. & Van Schaeybroeck, S., 04 Sept 2024, (Early online date) In: Molecular Cancer Research. 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

12 Downloads (Pure)

2023

Bcl-xL is a key mediator of apoptosis following KRAS^G12C inhibition in KRAS^G12C-mutant colorectal cancer

Khawaja, H., Briggs, R., Latimer, C. H., Rassel, M., Griffin, D., Hanson, L., Bardelli, A., Di Nicolantonio, F., McDade, S. S., Scott, C. J., Lambe, S., Maurya, M., Lindner, A. U., Prehn, J. H. M., Sousa, J., Winnington, C., LaBonte, M. J., Ross, S. & Van Schaeybroeck, S., 01 Jan 2023, In: Molecular Cancer Therapeutics. 22, 1, p. 135–149 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

80 Downloads (Pure)

2022

USP17 is required for peripheral trafficking of lysosomes

Lin, J., McCann, A., Sereesongsaeng, N., Burden, J., Alsa'd, A. A. M., Burden, R., Micu, I., Williams, R., Van Schaeybroeck, S., Evergren, E., Mullan, P., Scott, C. & Burrows, J., 26 Jan 2022, In: EMBO Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

267 Downloads (Pure)

2021

An atlas of inter- and intra-tumor heterogeneity of apoptosis competency in colorectal cancer tissue at single-cell resolution

Lindner, A. U., Salvucci, M., McDonough, E., Cho, S., Stachtea, X., O'Connell, E. P., Corwin, A. D., Santamaria-Pang, A., Carberry, S., Fichtner, M., Van Schaeybroeck, S., Laurent-Puig, P., Burke, J. P., McNamara, D. A., Lawler, M., Sood, A., Graf, J. F., Rehm, M., Dunne, P. D. & Longley, D. B. & 2 others, Ginty, F. & Prehn, J. H. M., 09 Nov 2021, (Early online date) In: Cell death and differentiation.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

97 Downloads (Pure)

A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress

Ruiz-Torres, V., Forsythe, N., Pérez-Sánchez, A., Van Schaeybroeck, S., Barrajón-Catalán, E. & Micol, V., 08 Apr 2021, In: Frontiers in Pharmacology. 12, 18 p., 625946.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

81 Downloads (Pure)

Development of a protein signature to enable clinical positioning of IAP inhibitors in colorectal cancer

McCann, C., Matveeva, A., McAllister, K., Van Schaeybroeck, S., Sessler, T., Fichtner, M., Carberry, S., Rehm, M., Prehn, J. H. M. & Longley, D. B., Sept 2021, In: The FEBS Journal. 288, 18, p. 5374-5388

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

31 Downloads (Pure)

FLINO-A new method for immunofluorescence bioimage normalization

Graf, J., Cho, S., McDonough, E., Corwin, A., Sood, A., Lindner, A., Salvucci, M., Stachtea, X., Van Schaeybroeck, S., Dunne, P. D., Laurent-Puig, P., Longley, D., Prehn, J. H. M. & Ginty, F., 02 Oct 2021, (Early online date) In: Bioinformatics (Oxford, England).

Research output: Contribution to journal › Article › peer-review

Open Access

File

13 Citations (Scopus)

63 Downloads (Pure)

Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

Amoroso, F., Glass, K., Singh, R., Liberal, F., Steele, R. E., Maguire, S., Tarapore, R., Allen, J. E., Van Schaeybroeck, S., Butterworth, K. T., Prise, K., O'Sullivan, J. M., Jain, S., Waugh, D. J. & Mills, I. G., 19 Feb 2021, In: Scientific Reports. 11, 1, p. 4252

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

177 Downloads (Pure)

Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications

Craig, S. G., Mende, S., Humphries, M., Bingham, V., Viratham Pulsawatdi, A., Loughrey, M. B., Coleman, H. G., McQuaid, S., Wilson, R., Van Schaeybroeck, S., James, J. A. & Salto-Tellez, M., 01 Nov 2021, (Early online date) In: Molecular oncology.

Research output: Contribution to journal › Article › peer-review

Open Access

File

5 Citations (Scopus)

98 Downloads (Pure)

Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations

Stachtea, X., Loughrey, M. B., Salvucci, M., Lindner, A. U., Cho, S., McDonough, E., Sood, A., Graf, J., Santamaria-Pang, A., Corwin, A., Laurent-Puig, P., Dasgupta, S., Shia, J., Owens, J. R., Abate, S., Van Schaeybroeck, S., Lawler, M., Prehn, J. H. M., Ginty, F. & Longley, D. B., 03 Nov 2021, (Early online date) In: Modern Pathology .

Research output: Contribution to journal › Article › peer-review

Open Access

File

17 Citations (Scopus)

116 Downloads (Pure)

TRAIL signaling promotes entosis in colorectal cancer

Bozkurt, E., Düssmann, H., Salvucci, M., Cavanagh, B. L., Van Schaeybroeck, S., Longley, D. B., Martin, S. J. & Prehn, J. H. M., 21 Sept 2021, In: The Journal of cell biology. 220, 11, e202010030.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

305 Downloads (Pure)

2020

Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer

Greene, M. K., Chen, T., Robinson, E., Straubinger, N. L., Minx, C., Chan, D. K. W., Wang, J., Burrows, J. F., Van Schaeybroeck, S., Baker, J. R., Caddick, S., Longley, D. B., Mager, D. E., Straubinger, R. M., Chudasama, V. & Scott, C. J., 11 Sept 2020, In: British Journal of Cancer.

Research output: Contribution to journal › Article › peer-review

Open Access

File

17 Citations (Scopus)

173 Downloads (Pure)

Fundamental control of grade-specific colorectal cancer morphology by Src regulation of ezrin-centrosome engagement

Rainey, L., Deevi, R. K., McClements, J., Khawaja, H., Watson, C. J., Roudier, M., Van Schaeybroeck, S. & Campbell, F. C., 04 Jun 2020, (Early online date) In: Journal of Pathology. 251, 3, p. 310-322 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

81 Downloads (Pure)

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

Khawaja, H., Campbell, A., Roberts, J. Z., Javadi, A., O’Reilly, P., McArt, D., Allen, W. L., Majkut, J., Rehm, M., Bardelli, A., Di Nicolantonio, F., Scott, C. J., Kennedy, R., Vitale, N., Harrison, T., Sansom, O. J., Longley, D. B., Evergren, E. & Van Schaeybroeck, S., 29 Oct 2020, (Early online date) In: Cell death and disease. 11, 10, 18 p., 930.

Research output: Contribution to journal › Article › peer-review

Open Access

File

10 Citations (Scopus)

109 Downloads (Pure)

2019

A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic

Salvucci, M., Rahman, A., Resler, A. J., Udupi, G. M., McNamara, D. A., Kay, E. W., Laurent-Puig, P., Longley, D. B., Johnston, P. G., Lawler, M., Wilson, R., Salto-Tellez, M., Van Schaeybroeck, S., Rafferty, M., Gallagher, W. M., Rehm, M. & Prehn, J. H. M., 17 Apr 2019, In: JCO Clinical Cancer Informatics. 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

167 Downloads (Pure)

Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours

McDaid, W. J., Greene, M. K., Johnston, M. C., Pollheimer, E., Smyth, P., McLaughlin, K., Van Schaeybroeck, S., Straubinger, R. M., Longley, D. B. & Scott, C. J., 18 Oct 2019, (Early online date) In: Nanoscale. 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

45 Citations (Scopus)

406 Downloads (Pure)

THE ROLE OF USP17 IN LYSOSOME TRAFFICKING

Lin, J., McCann, A., Evergren, E., Burden, R., Van Schaeybroeck, S., Scott, C. & Burrows, J., Jun 2019.

Research output: Contribution to conference › Poster

2018

A phase I dose escalation multi-centre study of crizotinib (MET inhibitor) combined with binimetinib (MEK inhibitor) in patients with advanced solid tumours

Wilson, R., Dass, P. H., Van Schaeybroeck, S., Elez, E., Quinton, A., Jones, R., Houlden, J., Collins, L., Roberts, C., Love, S., Lawler, M., Di Nicolantonio, F., Grayson, M., Bardelli, A., Laurent=puig, P., Maughan, T., Tabernero, J., Peeters, M., Middleton, M. & Rolfo, C., Nov 2018, In: European Journal of Cancer. 103, Suppl 1, p. e140-e141

Research output: Contribution to journal › Meeting abstract › peer-review

Corrigendum: Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges

Bradley, C. A., Salto-Tellez, M., Laurent-Puig, P., Bardelli, A., Rolfo, C., Tabernero, J., Khawaja, H. A., Lawler, M., Johnston, P. G., Van Schaeybroeck, S. & MErCuRIC consortium, 23 Jan 2018, (Early online date) In: Nature reviews. Clinical oncology. 15, 3, p. 150 1 p.

Research output: Contribution to journal › Article › peer-review

Targeting the dopamine receptor 2 in BRAF mutant colorectal cancer

Javadi, A., Forsythe, N., Refaat, A., Weir, J.-A., Khawaja, H., Waugh, D., Tarapore, R., Allen, J. E., Johnston, P. & Van Schaeybroeck, S., Jul 2018, In: Cancer Research. 78, Issue 13 Supplement, 1 p., Abstract 3448.

Research output: Contribution to journal › Meeting abstract › peer-review

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

Forsythe, N., Refaat, A., Javadi, A., Khawaja, H., Weir, J.-A., Emam, H., Allen, W. L., Burkamp, F., Popovici, V., Jithesh, P. V., Isella, C., Labonte , M. J., Mills, I. G., Johnston, P. G. & Van Schaeybroeck, S., 26 Feb 2018, (Early online date) In: Molecular Cancer Therapeutics.

Research output: Contribution to journal › Article › peer-review

Open Access

File

20 Citations (Scopus)

472 Downloads (Pure)

Transcriptional subtyping and CD8 immunohistochemistry identifies patients with stage II and III colorectal cancer with poor prognosis who benefit from adjuvant chemotherapy

Allen, W. L., Dunne, P. D., McDade, S., Scanlon, E., Loughrey, M., Coleman, H. G., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N. A., Jithesh, P. V., Arthur, K., Wilson, R., Coyle, V. M., McArt, D., Johnston, P., Murray, G. I., Samuel, L. M., Nuciforo, P. & Jimenez, J. & 12 others, Argiles,, G., Dienstmann, R., Picariello, L., Nobili, S., Mini, E., Sheahan, K., Ryan, E., Tabernero, J., Messerini, L., Van Schaeybroeck, S., Lawler, M. & Longley, D., 01 Nov 2018, In: JCO Precision Oncology. 2, 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

58 Citations (Scopus)

377 Downloads (Pure)

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

McCann, A. P., Smyth, P., Cogo, F., McDaid, W. J., Jiang, L., Lin, J., Evergren, E., Burden, R. E., Van Schaeybroeck, S., Scott, C. J. & Burrows, J. F., 08 Nov 2018, In: Cell communication and signaling : CCS. 16, 1, p. 77

Research output: Contribution to journal › Article › peer-review

Open Access

File

14 Citations (Scopus)

228 Downloads (Pure)

2017

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

Salvucci, M., Würstle, M. L., Morgan, C., Curry, S., Cremona, M., Lindner, A. U., Bacon, O., Resler, A. J., Murphy, Á. C., O'Byrne, R., Flanagan, L., Dasgupta, S., Rice, N., Pilati, C., Zink, E., Schöller, L. M., Toomey, S., Lawler, M., Johnston, P. G. & Wilson, R. & 10 others, Camilleri-Broët, S., Salto-Tellez, M., McNamara, D. A., Kay, E. W., Laurent-Puig, P., Van Schaeybroeck, S., Hennessy, B. T., Longley, D. B., Rehm, M. & Prehn, J. H. M., 01 Mar 2017, In: Clinical Cancer Research. 23, 5, p. 1200-1212 13 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

BCL-2 system analysis identifies high-risk colorectal cancer patients

Lindner, A. U., Salvucci, M., Morgan, C., Monsefi, N., Resler, A., Cremona, M., Curry, S., Toomey, S., O'Byrne, R., Bacon, O., Stuhler, M., Flanagan, L., Wilson, R., Johnston, P. G., Salto-Tellez, M., Camilleri-Broët, S., McNamara, D. A., Kay, E., Hennessy, B. T. & Laurent-Puig, P. & 2 others, Van Schaeybroeck, S. & Prehn, J. H. M., 13 Nov 2017, In: Gut. 66, 12, p. 2141-2148

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

RalB GTPase: A potential novel target for RAS mutant colorectal cancer.

Khawaja, H., O'Reilly, P., McArt, D., Harrison, T., Johnston, P. & Van Schaeybroeck, S., 18 Sept 2017, In: Annals of Oncology. 28, supply_5, p. v573

Research output: Contribution to journal › Meeting abstract › peer-review

Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges

MErCuRIC consortium, 04 Apr 2017, In: Nature reviews. Clinical oncology. 14, 9

Research output: Contribution to journal › Review article › peer-review

143 Citations (Scopus)

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

Van Schaeybroeck, S., Forsythe, N., Refaat, A., Javadi, A., Khawaja, H., Weir, J.-A., Emam, H., Moore, W., Burkamp, F., Popovici, V., Jithesh, P., Isella, C., LaBonte Wilson, M., Mills, I. & Johnston, P., 2017, The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer. National Cancer Research Insitute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2016

ADAM17: a potential regulator of resistance to EGFR targeted therapies in RAS wild type colorectal cancer.

Weir, J.-A., Gilliland, P., Fuchs, M.-A., Williams, R., Murray, L., Johnston, P. & Van Schaeybroeck, S., Nov 2016, ADAM17: a potential regulator of resistance to EGFR targeted therapies in RAS wild type colorectal cancer.. National Cancer Research Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

A systems model of BCL-2 dependent apoptosis to predict stage II CRC patients benefiting from adjuvant chemotherapy and as a prognostic tool for stage III CRC patients with increased risk of recurrence.

Prehn, J. H. M., Lindner, A. U., Salvucci, M., Cremona, M., Monsefi, N., Curry, S., Morgan, C., Resler, A., Byrne, R., Bacon, O., Flanagan, L., Wilson, R., Johnston, P. G., Salto-Tellez, M., Camilleri-Broët, S., McNamara, D. A., Hennessy, B. T., Kay, E., Laurent-puig, P. & Van Schaeybroeck, S., 2016, In: Journal of Clinical Oncology. 34, (suppl; abstr 3584)

Research output: Contribution to journal › Meeting abstract › peer-review

Caspase modelling to predict personalised risk in stage III colorectal cancer (CRC) patients.

Salvucci, M., Wuerstle, M., Cremona, M., Curry, S., Morgan, C., Lindner, A. U., Bacon, O., Resler, A., Murphy, A., Longley, D., Wilson, R., Camilleri-Broët, S., Salto-Tellez, M., McNamara, D. A., Kay, E., Hennessy, B. T., Laurent-puig, P., Van Schaeybroeck, S., Rehm, M. & Prehn, J. H. M., 30 Jun 2016, In: Journal of Clinical Oncology. 34, (suppl, abstr 11592)

Research output: Contribution to journal › Meeting abstract › peer-review

Challenging the cancer molecular stratification dogma: Intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in colorectal cancer

Dunne, P. D., McArt, D. G., Bradley, C. A., O'Reilly, P. G., Barrett, H. L., Cummins, R., O'Grady, A., Arthur, K., Loughrey, M. B., Moore, W. L., McDade, S. S., Waugh, D. J., Hamilton, P. W., Longley, D. B., Kay, E. W., Johnston, P. G., Lawler, M., Salto-Tellez, M. & Van Schaeybroeck, S., 15 Aug 2016, In: Clinical Cancer Research. 22, 16, p. 4095

Research output: Contribution to journal › Article › peer-review

Open Access

File

124 Citations (Scopus)

419 Downloads (Pure)

Delivering a Research-Enabled Multistakeholder Partnership for Enhanced Patient Care at a Population Level: The Northern Ireland Comprehensive Cancer Program

Lawler, M., Gavin, A., Salto-Tellez, M., Kennedy, R. D., Van Schaeybroeck, S., Wilson, R. H., Harkin, D. P., Grayson, M., Boyd, R. E., Hamilton, P. W., McArt, D. G., James, J., Robson, T., Ladner, R. D., Prise, K. M., O'Sullivan, J. M., Harrison, T., Murray, L., Johnston, P. G. & Waugh, D. J., 01 Mar 2016, In: Cancer. 122, 5, p. 664-673 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

6 Citations (Scopus)

376 Downloads (Pure)

Deubiquitylating enzymes in receptor endocytosis and trafficking

McCann, A. P., Scott, C. J., Van Schaeybroeck, S. & Burrows, J. F., 09 Dec 2016, In: Biochemical Journal. 473, 24, p. 4507-4525 19 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

Dunne, P. D., Dasgupta, S., Blayney, J. K., McArt, D. G., Redmond, K. L., Weir, J.-A., Bradley, C. A., Sasazuki, T., Shirasawa, S., Wang, T., Srivastava, S., Ong, C. W., Arthur, K., Salto-Tellez, M., Wilson, R. H., Johnston, P. G. & Van Schaeybroeck, S., 01 Jan 2016, In: Clinical Cancer Research. 22, 1, p. 230-242 13 p.

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Immune-derived PD-L1 gene expression defines a subgroup of stage II/III colorectal cancer patients with favorable prognosis that may be harmed by adjuvant chemotherapy

Dunne, P. D., McArt, D. G., O'Reilly, P. G., Coleman, H. G., Allen, W. L., Loughrey, M., Van Schaeybroeck, S., McDade, S., Salto-Tellez, M., Longley, D. B., Lawler, M. & Johnston, P. G., 13 May 2016, (Early online date) In: Cancer Immunology Research. 4, 7, p. 582

Research output: Contribution to journal › Article › peer-review

Open Access

File

36 Citations (Scopus)

403 Downloads (Pure)

MErCuRIC1: A phase 1a study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in patients with advanced solid tumours

Wilson, R., Middleton, M., Houlden, J., Van Schaeybroeck, S., Rolfo, C., Elez, E., Taieb, J., Andre, T., Bardelli, A., Laurent=puig, P., Tabernero, J., Peeters, M., Maughan, T., Roberts, C., Love, S., Lawler, M., Salto-Tellez, M., Grayson, M., Popovici, V. & Di Nicolantonio, F., 08 Oct 2016, In: Annals of Oncology.

Research output: Contribution to journal › Meeting abstract › peer-review

MErCuRIC1: A Phase Ia study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in patients with advanced solid tumours

Woodcock, V., Middleton, M., Rolfo, C., Elez, E., Van Schaeybroeck, S., Taieb, J., Houlden, J., Collins, L., Love, S., Roberts, C., Andre, T., Jones, R., Lawler, M., Di Nicolantonio, F., Grayson, M., Bardelli, A., Laurent=puig, P., McGregor, G., Maughan, T. & Tabernero, J. & 2 others, Peeters, M. & Wilson, R., 11 Oct 2016, MErCuRIC1: A Phase Ia study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in patients with advanced solid tumours. National Cancer Research Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

Bradley, C. A., Dunne, P. D., Bingham, V., McQuaid, S., Khawaja, H., Craig, S., James, J., Moore, W. L., McArt, D. G., Lawler, M., Dasgupta, S., Johnston, P. G. & Van Schaeybroeck, S., 26 Oct 2016, In: Oncotarget. 7, 48, p. 78932-78945 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

33 Citations (Scopus)

322 Downloads (Pure)

Upregulation of the MET transcript is consistently associated with invasion and tumor budding in colorectal cancer

Bradley, C., Dunne, P., McQuaid, S., Bingham, V., Lawler, M., Salto-Tellez, M., Johnston, P. & Van Schaeybroeck, S., 2016, Upregulation of the MET transcript is consistently associated with invasion and tumor budding in colorectal cancer. abstract 924 ed. Proceedings: AACR Annual Meeting 2016; April 16-20 New Orleans

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Validation of a MEK/MET-specific NGS panel for early phase trial interrogation

Maxwell, P., del favero, J., Fuchs, M.-A., Tabernero, J., Maughan, T., Middleton, M., Adams, R., Rolfo, C., Hennessy, B. T., Laurent=puig, P., Bardelli, A., Andre, T., Popovici, V., Johnston, P., Wilson, R., Lawler, M., Van Schaeybroeck, S. & Salto-Tellez, M., 01 May 2016, Validation of a MEK/MET-specific NGS panel for early phase trial interrogation . Proceedings: AACR Annual Meeting 2016; April 16-20 New Orleans, Vol. abstract 1396.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2015

Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies

Wen, Q., O'Reilly, P., Dunne, P. D., Lawler, M., Van Schaeybroeck, S., Salto-Tellez, M., Hamilton, P. & Zhang, S.-D., 01 Sept 2015, In: BMC Systems Biology. 9 , Suppl 5, 11 p., S4.

Research output: Contribution to journal › Article › peer-review

Open Access

File

16 Citations (Scopus)

337 Downloads (Pure)

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

Carson, R., Celtikci, B., Fenning, C., Javadi, A., Crawford, N., Perez Carbonell, L., Lawler, M., Longley, D. B., Johnston, P. G. & Van Schaeybroeck, S., 15 Jul 2015, In: Clinical Cancer Research. 21, 14, p. 3230-3240 11 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

MErCuRIC1: A Phase I study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor crizotinib in RASMT and RASWT (with aberrant c-MET) metastatic colorectal cancer (mCRC) patients.

Van Schaeybroeck, S., Rolfo, C., Elez, E., Kelly, S., Houlden, J., Collins, L., Love, S., Andre, T., lawler, M., Di Nicolantonio, F., Grayson, M., Popovici, V., Bardelli, A., Laurent=puig, P., Salto-Tellez, M., Maughan, T., Tabernero, J., Peeters, M., Wilson, R. & Middleton, M., 2015, In: Journal of Clinical Oncology. 33, (suppl; abstr TPS3632)

Research output: Contribution to journal › Meeting abstract › peer-review

Molecular Classification of the invasive front in colorectal cancer

McArt, D., Dunne, P., Kay, E., O'Grady, A., Barrett, H., Arthur, K., Longley, D., Hamilton, P. W., Waugh, D. J., Lawler, M., Johnston, P. G., Salto-Tellez, M. & Van Schaeybroeck, S., 20 May 2015, In: Journal of Clinical Oncology. 33, Suppl 15, 3573.

Research output: Contribution to journal › Meeting abstract › peer-review

Overcoming Resistance to Targeted Therapies in Cancer

Redmond, K. L., Papafili, A., Lawler, M. & Van Schaeybroeck, S., Dec 2015, In: Seminars in Oncology. 42, 6, p. 896-908 13 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Probing a 3,4'-bis-guanidinium diaryl derivative as an allosteric inhibitor of the Ras pathway

Diez-Cecilia , E., Carson, R., Kelly, B., Van Schaeybroeck, S., Murray, J. T. & Rozas, I., 01 Oct 2015, In: Bioorganic and Medicinal Chemistry Letters. 25, 19, p. 4287-4292 6 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

Ong, C. W., Chong, P. Y., McArt, D. G., Chan, J. Y., Tan, H. T., Kumar, A. P., Chung, M. C. M., Clément, M.-V., Soong, R., Van Schaeybroeck, S., Waugh, D. J. J., Johnston, P. G., Dunne, P. D. & Salto-Tellez, M., 20 May 2015, In: Oncotarget. 6, 14, p. 12763-73 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

18 Citations (Scopus)

265 Downloads (Pure)

The role of c-MET/HGF signaling as a critical mediator of an invasive and resistant phenotype in colorectal cancer

Bradley, C., Dunne, P., McArt, D., Arthur, K., McQuaid, S., Salto-Tellez, M., Johnston, P. & Van Schaeybroeck, S., 2015, The role of c-MET/HGF signaling as a critical mediator of an invasive and resistant phenotype in colorectal cancer. Proceedings: AACR Annual Meeting 2015; April 18-22, Philadelphia, Vol. Abstract 4018.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sandra Van Schaeybroeck

Research output

Search results