Seyed Mehdi Jafarnejad

Research Output

Research Output per year

2007 2021

• 36 Article
• 1 Other contribution

Research Output per year

Research Output per year

Search results

• 2021

  microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP

  Zhang, X., Chapat, C., Wang, P., Choi, J-H., Li, Q., Luo, J., Wiebe, S., Kim, S-H., Robichaud, N., Karam, I. F., Dai, D., Hackett, A. P., Lin, R., Alain, T., Yang, L., Jafarnejad, S. M. & Sonenberg, N., 12 Feb 2021, In: Molecular Cell.

  Research output: Contribution to journal › Article › peer-review

  • RNA Cap-Binding Proteins
  • Interferons
  • MicroRNAs
  • Antiviral Agents
  • Immunity
• 2020

  Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation

  Kim, S-H., Choi, J-H., Wang, P., Go, C. D., Hesketh, G. G., Gingras, A-C., Jafarnejad, S. M. & Sonenberg, N., 18 Dec 2020, In: Molecular Cell. 81

  Research output: Contribution to journal › Article › peer-review

  • Threonine-tRNA Ligase
  • Mechanistic Target of Rapamycin Complex 1
  • Threonine
  • Guanosine Triphosphate
  • GTP Phosphohydrolases

• Monitoring translation in synaptic fractions using a ribosome profiling strategy

  Simbriger, K., Amorim, I. S., Chalkiadaki, K., Lach, G., Jafarnejad, S. M., Khoutorsky, A. & Gkogkas, C. G., 01 Jan 2020, In: Journal of Neuroscience Methods. 329, p. 108456 7 p., 108456.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ribosomes
  • Percoll
  • Learning Disorders
  • Workflow
  • Memory Disorders
  73 Downloads (Pure)

• The translational landscape of ground state pluripotency

  Atlasi, Y., Jafarnejad, S. M., Gkogkas, C. G., Vermeulen, M., Sonenberg, N. & Stunnenberg, H. G., 01 Apr 2020, In: Nature Communications. 11, 1617.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ground state
  • stem cells
  • Stem cells
  • Embryonic Stem Cells
  • proteins
  1 Citation (Scopus)

  29 Downloads (Pure)

• Uncovering memory-related gene expression in contextual fear conditioning using ribosome profiling

  Simbriger, K., Amorim, I. S., Lach, G., Chalkiadaki, K., Kouloulia, S., Jafarnejad, S. M., Khoutorsky, A. & Gkogkas, C. G., 26 Aug 2020, In: Progress in neurobiology. p. 101903

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ribosomes
  • Conditioning (Psychology)
  • Fear
  • Memory
  • Gene Expression

• β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells

  Mousavizadeh, R., Hojabrpour, P., Eltit, F., McDonald, P. C., Dedhar, S., McCormack, R. G., Duronio, V., Jafarnejad, S. M. & Scott, A., 28 Jul 2020, In: Scientific Reports. 10, 1, p. 12644

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • integrin-linked kinase
  • Integrins
  • Tendons
  • Collagen
  • Extracellular Matrix
  38 Downloads (Pure)
• 2019

  Characterizing Cellular Responses During Oncolytic Maraba Virus Infection

  Hassanzadeh, G., Naing, T., Graber, T., Jafarnejad, S. M., Stojdl, D. F., Alain, T. & Holcik, M., 29 Jan 2019, In: International Journal of Molecular Science. 20, 3, 16 p., 580.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oncolytic Viruses
  • infectious diseases
  • viruses
  • Viruses
  • eukaryotic initiation factor-5B
  5 Citations (Scopus)

  152 Downloads (Pure)

• Induction of an Alternative mRNA 5' Leader Enhances Translation of the Ciliopathy Gene Inpp5e and Resistance to Oncolytic Virus Infection

  Hoang, H-D., Graber, T. E., Jia, J-J., Vaidya, N., Gilchrist, V. H., Xiang, X., Li, W., Cowan, K. N., Gkogkas, C. G., Jaramillo, M., Jafarnejad, S. M. & Alain, T., 17 Dec 2019, In: Cell Reports. 29, 12, p. 4010-4023.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ciliopathies
  • Oncolytic Viruses
  • Viruses
  • Genes
  • Virus Diseases
  11 Downloads (Pure)

• Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

  Kouloulia, S., Hallin, E. I., Simbriger, K., Amorim, I. S., Lach, G., Amvrosiadis, T., Chalkiadaki, K., Kampaite, A., Truong, V. T., Hooshmandi, M., Jafarnejad, S. M., Skehel, P., Kursula, P., Khoutorsky, A. & Gkogkas, C. G., 10 Dec 2019, In: Cell Reports. 29, 11, p. 3620-3635.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Raptors
  • Peptide Initiation Factors
  • Mechanistic Target of Rapamycin Complex 1
  • Glutamate Receptors
  • Protein Biosynthesis
  1 Citation (Scopus)

  47 Downloads (Pure)
• 2018

  Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis

  Zakaria, C., Sean, P., Hoang, H-D., Leroux, L-P., Watson, M., Workenhe, S. T., Hearnden, J., Pearl, D., Truong, V. T., Robichaud, N., Yanagiya, A., Tahmasebi, S., Jafarnejad, S. M., Jia, J-J., Pelin, A., Diallo, J-S., Le Boeuf, F., Bell, J. C., Mossman, K. L., Graber, T. E. & 3 others, Jaramillo, M., Sonenberg, N. & Alain, T., 23 Aug 2018, In: PLoS Pathogens. 14, 8, 23 p., e1007264.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eukaryotic Initiation Factor-4E
  • Human Herpesvirus 1
  • Catalytic Domain
  • Infection
  • Neoplasms
  5 Citations (Scopus)

  125 Downloads (Pure)

• Alternative Splicing of the Delta-Opioid Receptor Gene Suggests Existence of New Functional Isoforms

  Piltonen, M., Parisien, M., Grégoire, S., Chabot-Doré, A-J., Jafarnejad, S. M., Bérubé, P., Djambazian, H., Sladek, R., Geneau, G., Willett, P., Stone, L. S., Shabalina, S. A. & Diatchenko, L., 31 Jul 2018, In: Molecular Neurobiology. 15 p.

  Research output: Contribution to journal › Article › peer-review

  • delta Opioid Receptor
  • Alternative Splicing
  • Exons
  • Protein Isoforms
  • Genes
  10 Citations (Scopus)

• Aminoacylation of Proteins: New Targets for the Old ARSenal

  Jafarnejad, S. M., Kim, S-H. & Sonenberg, N., 09 Jan 2018, In: Cell metabolism. 27, 1, p. 1-3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transfer RNA Aminoacylation
  • Amino Acids
  • Lysine
  • Proteins
  5 Citations (Scopus)

• Loss of eIF4E phosphorylation engenders depression-like behaviors via selective mRNA translation

  Amorim, I. S., Kedia, S., Kouloulia, S., Simbriger, K., Gantois, I., Jafarnejad, S. M., Li, Y., Kampaite, A., Pooters, T., Romanò, N. & Gkogkas, C. G., 21 Feb 2018, In: The Journal of Neuroscience. 38, 8, p. 2118-2133

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eukaryotic Initiation Factor-4E
  • Protein Biosynthesis
  • Phosphorylation
  • Depression
  • Serotonin
  25 Citations (Scopus)

  156 Downloads (Pure)

• Translational control of ERK signaling through miRNA/4EHP-directed silencing

  Jafarnejad, S. M., Chapat, C., Matta-Camacho, E., Gelbart, I. A., Hesketh, G. G., Arguello, M., Garzia, A., Kim, S-H., Attig, J., Shapiro, M., Morita, M., Khoutorsky, A., Alain, T., Christos, G. G., Stern-Ginossar, N., Tuschl, T., Gingras, A-C., Duchaine, T. F. & Sonenberg, N., 20 Feb 2018, In: eLife. 7, 18 p., e35034.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • MicroRNAs
  • Messenger RNA
  • Gene Silencing
  • Genes
  • RNA Cap-Binding Proteins
  17 Citations (Scopus)

  154 Downloads (Pure)

• Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain

  Uttam, S., Wong, C., Amorim, I. S., Jafarnejad, S. M., Tansley, S. N., Yang, J., Prager-Khoutorsky, M., Mogil, J. S., Gkogkas, C. G. & Khoutorsky, A., 18 Apr 2018, In: Neurobiology of pain. 4, p. 35-44 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein Biosynthesis
  • Spinal Ganglia
  • Neuralgia
  • Chronic Pain
  • Spinal Cord
  22 Citations (Scopus)

  7 Downloads (Pure)
• 2017

  Cap-binding protein 4EHP effects translation silencing by microRNAs.

  Chapat, C., Jafarnejad, SM., Matta-Camacho, E., Hesketh, GG., Gelbart, IA., Attig, J., Gkogkas, CG., Alain, T., Stern-Ginossar, N., Fabian, MR., Gingras, AC., Duchaine, TF. & Sonenberg, N., 09 May 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 21, p. 5425

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Metformin ameliorates core deficits in a mouse model of fragile X syndrome.

  Gantois, I., Khoutorsky, A., Popic, J., Aguilar-Valles, A., Freemantle, E., Cao, R., Sharma, V., Pooters, T., Nagpal, A., Skalecka, A., Truong, VT., Wiebe, S., Groves, IA., Jafarnejad Shourkaei, S. M., Chapat, C., McCullagh, E. A., Gamache, K., Nader, K., Lacaille, J-C., Gkogkas, C. G. & 1 others, Sonenberg, N., 06 Jun 2017, In: Nature Medicine. p. 1-7

  Research output: Contribution to journal › Article › peer-review

  • Fragile X Syndrome
  • Metformin
  • Phosphorylation
  • Trinucleotide Repeat Expansion
  • Trinucleotide Repeats
  76 Citations (Scopus)

• The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

  Garzia, A., Jafarnejad, SM., Meyer, C., Chapat, C., Gogakos, T., Morozov, P., Amiri, M., Shapiro, M., Molina, H., Tuschl, T. & Sonenberg, N., 07 Jul 2017, In: Nature Communications. 8, 16056.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ribosomes
  • RNA-Binding Proteins
  • Ubiquitin-Protein Ligases
  • Zinc Fingers
  • quality control
  61 Citations (Scopus)

  173 Downloads (Pure)
• 2016

  Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.

  Tahmasebi, S., Jafarnejad, SM., Tam, IS., Gonatopoulos-Pournatzis, T., Matta-Camacho, E., Tsukumo, Y., Yanagiya, A., Li, W., Atlasi, Y., Caron, M., Braunschweig, U., Sonenberg, N., Pearl, D., Khoutorsky, A., Gkogkas, C. G., Nadon, R., Bourque, G., Yang, X-J., Tian, B., Stunnenberg, H. G. & 3 others, Yamanaka, Y., Blencowe, B. J. & Giguère, V., Nov 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 44, p. 12360

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• eIF2α phosphorylation controls thermal nociception.

  Khoutorsky, A., Sorge, RE., Prager-Khoutorsky, M., Pawlowski, SA., Longo, G., Jafarnejad, SM., Tahmasebi, S., Martin, LJ., Pitcher, MH., Gkogkas, CG., Sharif-Naeini, R., Ribeiro-da-Silva, A., Bourque, C. W., Cervero, F., Mogil, J. S. & Sonenberg, N., 18 Oct 2016, In: Proceedings of the National Academy of Sciences of the United States of America.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer.

  Chio, IIC., Jafarnejad, SM., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Wilson, J., Sangar, V., Hao, Y., Öhlund, D., Wright, K., Filippini, D., Lee, EJ., Da, S. B., Tuveson, DA., Schoepfer, C., Erby Wilkinson, J., Buscaglia, J. M., Denicola, G. M., Tiriac, H. & 6 others, Hammell, M., Crawford, H. C., Schmidt, E. E., Thompson, C. B., Pappin, D. J. & Sonenberg, N., 11 Aug 2016, In: Cell. 166, 4, p. 963

  Research output: Contribution to journal › Article › peer-review
  160 Citations (Scopus)
• 2015

  Translational control of nociception via 4E-binding protein 1

  Khoutorsky, A., Bonin, RP., Sorge, RE., Gkogkas, CG., Pawlowski, SA., Jafarnejad, SM., Pitcher, MH., Alain, T., Perez-Sanchez, J., Salter, EW., Martin, L., Ribeiro-da-Silva, A., De Koninck, Y., Cervero, F., Mogil, J. S. & Sonenberg, N., 18 Dec 2015, In: eLife. 18 p., e12002.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • neuroligin 1
  • Nociception
  • TOR Serine-Threonine Kinases
  • Carrier Proteins
  • Hypersensitivity
  18 Citations (Scopus)

  158 Downloads (Pure)
• 2014

  Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.

  Gkogkas, CG., Khoutorsky, A., Cao, R., Jafarnejad, SM., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, TJ., Konicek, BW., Graff, JR., Tzinia, A. K., Lacaille, J-C. & Sonenberg, N., 11 Dec 2014, In: Cell Reports. 9, 5, p. 1742-1755

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pharmacogenetics
  • Eukaryotic Initiation Factor-4E
  • Fragile X Syndrome
  • Protein Biosynthesis
  • Genes
  99 Citations (Scopus)

  162 Downloads (Pure)
• 2013

  Disease progression and patient survival are significantly influenced by BRAF protein expression in primary melanoma.

  Safaee, A. G., Jafarnejad, SM., Khosravi, S., Martinka, M., Ho, V. & Li, G., Aug 2013, In: British Journal of Dermatology.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Expression of the RNase III enzyme DROSHA is reduced during progression of human cutaneous melanoma

  Jafarnejad, S. M., Sjoestroem, C., Martinka, M. & Li, G., 01 Feb 2013, In: Modern pathology.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• JWA inhibits melanoma angiogenesis by suppressing ILK signaling and is an independent prognostic biomarker for melanoma

  Lu, J., Tang, Y., Farshidpour, M., Cheng, Y., Zhang, G., Jafarnejad, S. M., Yip, A., Martinka, M., Dong, Z., Zhou, J., Xu, J. & Li, G., Sep 2013, In: Carcinogenesis.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Reduced expression of nuclear Dicer correlates with melanoma progression.

  Jafarnejad, S. M., Sjoestroem, C., Ardekani, G. S., Martinka, M. & Li, G., 01 Jan 2013, In: Pigment Cell and Melanoma Research. 26, 1, p. 147-149

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Sox4-mediated Dicer expression is critical for suppression of melanoma cell invasion.

  Jafarnejad, SM., Ardekani, GS., Ghaffari, M., Martinka, M. & Li, G., Apr 2013, In: Oncogene.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)
• 2012

  Pleiotropic function of SRY-related HMG box transcription factor 4 in regulation of tumorigenesis

  Jafarnejad, S. M., Ardekani, G. S., Ghaffari, M. & Li, G., Oct 2012, In: Cellular and Molecular Life Sciences.

  Research output: Contribution to journal › Article › peer-review
  35 Citations (Scopus)
• 2011

  Integrin-linked kinase regulates melanoma angiogenesis by activating NF-κB/interleukin-6 signaling pathway.

  Wani, AA., Jafarnejad, SM., Zhou, J. & Li, G., 16 Jun 2011, In: Oncogene.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)

• Regulation of p53 by ING family members in suppression of tumor initiation and progression

  Jafarnejad, S. M. & Li, G., Nov 2011, In: Cancer and Metastasis Reviews.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Tumour suppressor ING1b maintains genomic stability upon replication stress

  Wong, R. P. C., Lin, H., Khosravi, S., Piche, B., Jafarnejad, S. M., Chen, D. W. C. & Li, G., Jan 2011, In: Nucleic Acids Research.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)
• 2010

  Prognostic significance of Sox4 expression in human cutaneous melanoma and its role in cell migration and invasion.

  Jafarnejad, SM., Wani, AA., Martinka, M. & Li, G., Dec 2010, In: The American journal of pathology.

  Research output: Contribution to journal › Article › peer-review
  54 Citations (Scopus)
• 2009

  Detection of OCT-4 in Bladder Cancer: Role of Cancer Stem Cell

  Mowla, S. J., Jafarnejad, S. M. & Atlasi, Y., 10 Oct 2009

  Research output: Other contribution

• Differential effects of Nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710.

  Nikpour, P., Mowla, S. J., Jafarnejad, SM., Fischer, U. & Schulz, WA., Dec 2009, In: Cell Proliferation.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)
• 2008

  Knocking-down the expression of nucleostemin significantly decreases rate of proliferation of rat bone marrow stromal stem cells in an apparently p53-independent manner.

  Jafarnejad, SM., Mowla, SJ. & Matin, MM., Feb 2008, In: Cell Proliferation.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)
• 2007

  Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs)

  Marandi, M., Mowla, S. J., Tavallaei, M., Yaghoobi, M. M. & Jafarnejad, S. M., Jun 2007, In: Neuroscience Letters.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)