• Room 0G.017 - Institute of Pathology Block 1 R.V.H. Site

    United Kingdom

20012016
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Personal profile

Interests

Infertility affects one in six couples and 40% of the problems are contributed to the male partner. With birth rates in Europe now only 1.4 children/couple and 1-5% of those births aided by assisted reproductive technology (ART), research to understand infertility and improve infertility treatments could not be more timely. Over the past decade the Reproductive Medicine Research Group has focused on Andrology with twin aims:

- to understand the endocrine, cellular and molecular reproductive dysfunctions in infertile men

- to establish novel prognostic tests to enhance ART success

Within this framework, the group has explored the effects of specific lifestyle (recreational drugs and diet) and disease (diabetes mellitus) factors on male fertility. We have recently developed novel male fertility tests (based on sperm nuclear DNA damage assessed by strand breaks and oxidised bases) with both diagnostic and prognostic value in assisted reproductive technology (for IUI, IVF and ICSI).

Other interests include the impact of cancer on male fertility and the social impacts of ART failure and twin successes on the wellbeing of male and female patients.

Other

I am managing director of Lewis Fertility Testing Ltd; a spin out company from Queen's University. Lewis Fertility Testing Ltd provides a diagnostic service for male fertility health. See http://www.lewisfertilitytesting.com/

Teaching

I am a strong supporter of the SSC programme introduced by the GMC in 1993 (summarised in publication 'Tomorrows Doctors').  Due to its popularity, I have been running a second year SSC in Reproductive Technology in both semesters since the inception of the SSC programme here in 1998. 

Fingerprint Dive into the research topics where Sheena Lewis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
Spermatozoa Medicine & Life Sciences
DNA Fragmentation Medicine & Life Sciences
DNA Damage Medicine & Life Sciences
Semen Medicine & Life Sciences
Fertility Medicine & Life Sciences
Comet Assay Medicine & Life Sciences
Cryopreservation Medicine & Life Sciences
Intracytoplasmic Sperm Injections Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Selected Research Output 2001 2016

96 Citations (Scopus)

Sperm DNA damage has a negative association with live birth rates after IVF.

Simon, L., Proutski, I., Stevenson, M., Jennings, D., McManus, J., Lutton, D. & Lewis, S., Jan 2013, In : Reproductive BioMedicine Online. 26, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

Open Access
File
Birth Rate
Live Birth
DNA Damage
Spermatozoa
Intracytoplasmic Sperm Injections
240 Citations (Scopus)

The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis

Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Miller, D., Lewis, S., Kirkman-Brown, J. & Coomarasamy, A., Oct 2012, In : Human reproduction. 27, 10, p. 2908-2917 10 p.

Research output: Contribution to journalArticle

Spontaneous Abortion
DNA Fragmentation
DNA Damage
Meta-Analysis
Spermatozoa
128 Citations (Scopus)

Clinical significance of sperm DNA damage in assisted reproduction outcome

Simon, L., Stevenson, M., Lutton, D., McManus, J., Lewis, S. & Brunborg, G., Jul 2010, In : Human reproduction. 25, 7, p. 1594-1608 15 p.

Research output: Contribution to journalArticle

File
DNA Fragmentation
Density Gradient Centrifugation
DNA Damage
Reproduction
Spermatozoa
34 Citations (Scopus)

Differences in the Endocannabinoid System of Sperm from Fertile and Infertile Men

Lewis, S. E. M., Rapino, C., Di Tommaso, M., Pucci, M., Battista, N., Paro, R., Simon, L., Lutton, D. & Maccarrone, M., 17 Oct 2012, In : PLoS ONE. 7, 10, p. 1-8 8 p., e47704.

Research output: Contribution to journalArticle

Open Access
File
Endocannabinoids
Spermatozoa
spermatozoa
male fertility
receptors

Prizes

Chair of the British Andrology Society

Sheena Lewis (Recipient), 2012

Prize: Election to learned society

Elected Deputy Co-ordinator

Sheena Lewis (Recipient), 2009

Prize: Election to learned society

Elected Treasurer, British Andrology Society

Sheena Lewis (Recipient), 2009

Prize: Election to learned society

Activities 2001 2012

External Examiner, MSc in Lifestyle, Aging and Reproductive Health

Sheena Lewis (Examiner)
2012 → …

Activity: Examination typesPGT external examination

Northern Ireland Medico-Legal Society

Sheena Lewis (Chair)
20102011

Activity: Visiting an external institution typesResearch and Teaching at External Organisation

Managing Director, Lewis Fertility Testing

Sheena Lewis (Member)
2010 → …

Activity: Other activity typesOther

Annual Conference of the British Andrology Society (Chair of Organising Committee)

Sheena Lewis (Member of programme committee)
2009

Activity: Participating in or organising an event typesParticipation in conference

European Society of Human Reproduction and Embryology (External organisation)

Sheena Lewis (Member)
2008 → …

Activity: Membership typesMembership of peer review panel or committee

Thesis

Endocrine, Cellular and Molecular Effects of Diabetes Mellitus on Male Fertility

Author: Agbaje, I., Nov 2008

Supervisor: McClure, N. (Supervisor), Lewis, S. (Supervisor) & Atkinson, A. B. (External person) (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

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