Projects per year
Personal profile
Particulars
Dr Sheiliza Carmali graduated with a BSc (Licenciatura) in Applied Chemistry - Organic Chemistry from Universidade Nova de Lisboa in 2008, followed by an MSc in Drug Delivery from the School of Pharmacy, University of London. She completed her PhD in Chemistry at University College London in 2015 under the supervision of Professor Steve Brocchini, in collaboration with PolyTherics Ltd. (now Abzena).
Sheiliza subsequently held a series of international research fellowships that shaped her interdisciplinary expertise in protein engineering, polymer chemistry, and biotherapeutics. She was first awarded a research fellowship with Professor Helena Florindo at Universidade de Lisboa and University College London, working on ligand‑modified nanoparticle vaccines. Sheiliza then joined Carnegie Mellon University (Pittsburgh, USA) working within the laboratories of Professor Alan Russell and Professor Krzysztof Matyjaszewski, contributing to pioneering work on polymer–protein conjugation, enzymatic materials, and controlled radical polymerisation for bioconjugation.
In 2018, Sheiliza moved to Aarhus University, Denmark as a Lundbeckfonden Postdoctoral Fellow in the group of Professor Alexander Zelikin, where she investigated artificial receptor systems and supramolecular approaches to modulate CAR‑T cell signalling.
Sheiliza was appointed as a Lecturer at the School of Pharmacy, Queen’s University Belfast in June 2020. Her research focuses on engineering biomolecular interfaces, integrating protein engineering, supramolecular assembly, nanocarrier technologies, and biotherapeutic delivery.
She is a member of the Royal Society of Chemistry and a Fellow of the Higher Education Academy.
Research Focus
Dr Carmali's research focuses on understanding, predicting, and engineering biomolecular interfaces to control the stability, activity, and therapeutic performance of proteins and other macromolecular drugs. Her work integrates molecular and supramolecular design with protein engineering and nanostructured delivery systems to enable biologics to function effectively in complex environments, supported by international collaborations across the UK, Europe, the US and Brazil.
Her research investigates protein-material interactions, including protein-polymer and protein-surfactant systems, to uncover how interfacial interactions govern protein behaviour. Through approaches such as hydrophobic ion pairing and supramolecular complexation, she develops strategies to modulate these interactions and improve protein compatibility and performace. Complementing this, she is developing predictive tools and design frameworks, including open-source software (PRELYM) to guide the rational engineering of biomolecular systems.
Building on these mechanistic and predictive insights, her group develops nanostructured and supramolecular delivery platforms, including nanostructured lipid carriers and engineered protein nanocages, to enable the controlled delivery of proteins, peptides, and immunomodulatory agents. Recent works extends toward locally acting immunomodulatory systems for women's health.
Teaching
Dr Carmali teaches across the BSc Pharmaceutical Sciences, BSc Pharmaceutical Biotechnology, MPharm, and MSc Industrial Pharmaceutics programmes, contributing to modules in pharmaceutical chemistry, medicinal chemistry, biotechnology, and research skills. She adopts an active, student‑centred approach and consistently receives strong student feedback.
She has contributed to the development and enhancement of modules within the School and supports Queen’s transnational education activities through teaching at the China Medical University–Queen’s University Belfast Joint College. She also supervises undergraduate and MSc research projects and is actively involved in student support, recruitment, and admissions.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 9 Industry, Innovation, and Infrastructure
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Collaborations and top research areas from the last five years
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R1221PMY: Development of cyclosporine-loaded nanostructured lipid carrier vaginal ring for endometriosis treatment
Carmali, S. (PI) & Malcolm, K. (CoI)
11/12/2025 → …
Project: Research
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R1875PMY: Dynamic Control of Ferritin Nanocage Self-Assembly via Polymer Integration
Carmali, S. (PI)
11/03/2025 → …
Project: Research
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R2856PMY: Tailoring Host-Guest Interactions in Protein Nanocages using Polymer Engineering
Carmali, S. (PI)
23/02/2022 → 28/02/2023
Project: Research
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Artificial lipidation of proteins and peptides: from mechanism to clinical applications
Mu, J., Vong, E. & Carmali, S., Mar 2026, In: The FEBS Journal. 293, 5, p. 1269-1284 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Link opens in a new tab Citations (Scopus)29 Downloads (Pure) -
Biologics in drug delivery
Carmali, S., Mao, L. & Simakova, A., 19 Jul 2026, Drug delivery. From fundamentals to the future. Lamprou, D. A. & Wylie, M. P. (eds.). Taylor and Francis, p. 205-225 21 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Hydrophobic ion pairing improves protein thermal stability and lipid nanocarrier integration through controlled surface modification
Mu, J., Sedough-Abbasian, D., Mao, L. & Carmali, S., 12 May 2026, (Early online date) In: ACS Nanoscience Au. 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure) -
Exploiting supercooled medium-chain lipids and surfactant combinations for solid-phase dominant nanostructured lipid carrier production
Sedough-Abbasian, D., Mu, J., Joseph, J. G., Andrews, G. P. & Carmali, S., 21 Nov 2025, In: Journal of Materials Chemistry B. 13, 43, p. 13992-14004 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)60 Downloads (Pure) -
Protection and safety of aluminum hydroxide adjuvant and chimeric antigen containing predicted epitopes from bacteria murC gene in Aeromonas hydrophila fish infection
Rodrigues, J., Roméria da Silva, M., Martins, C. A., Zuanon, L. A., Boechat Martins, K. V., Tótola, P. S., Pereira Rocha, J. G., Parma, M. G., Lima Castro, I. S., Nascimento, T. F., Pires, A. R., Azevedo, F. S., Gonçalves, R. V., Carmali, S., Sampaio Zuanon, J. A. & Antônio de Oliveira Mendes, T., Oct 2025, In: Fish and Shellfish Immunology. 165, 110543.Research output: Contribution to journal › Article › peer-review
1 Link opens in a new tab Citation (Scopus)
Prizes
Activities
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Biopark Educação
Carmali, S. (Advisor)
16 Feb 2025 → 23 Feb 2025Activity: Visiting an external institution types › Visiting an external academic institution
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MHLS Faculty Research Ethics Committee
Carmali, S. (Member)
07 Jan 2025 → …Activity: Other activity types › Other
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Chair MPhil Viva: 3D printing in the manufacturing of vascular grafts
Carmali, S. (Examiner)
13 Dec 2024Activity: Examination types › Other examination
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Chair PhD viva: Transdermal delivery of enfuvirtide using hydrogel-forming and dissolving microneedle array patches with novel feedback systems
Carmali, S. (Examiner)
01 Nov 2024Activity: Examination types › Other examination
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Chair PhD viva: Development of implantable devices for sustained delivery of schizophrenia treatment
Carmali, S. (Examiner)
25 Oct 2024Activity: Examination types › Other examination