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  • Room 01.064 - Pharmacy & MCI

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in protein engineering, nanocarrier design, supramolecular delivery systems, and smart biomaterials for therapeutic applications.

20102026

Research activity per year

Personal profile

Particulars

Dr Sheiliza Carmali graduated with a BSc (Licenciatura) in Applied Chemistry - Organic Chemistry from Universidade Nova de Lisboa in 2008, followed by an MSc in Drug Delivery from the School of Pharmacy, University of London. She completed her PhD in Chemistry at University College London in 2015 under the supervision of Professor Steve Brocchini, in collaboration with PolyTherics Ltd. (now Abzena).

Sheiliza subsequently held a series of international research fellowships that shaped her interdisciplinary expertise in protein engineering, polymer chemistry, and biotherapeutics. She was first awarded a research fellowship with Professor Helena Florindo at Universidade de Lisboa and University College London, working on ligand‑modified nanoparticle vaccines. Sheiliza then joined Carnegie Mellon University (Pittsburgh, USA) working within the laboratories of Professor Alan Russell and Professor Krzysztof Matyjaszewski, contributing to pioneering work on polymer–protein conjugation, enzymatic materials, and controlled radical polymerisation for bioconjugation.

In 2018, Sheiliza moved to Aarhus University, Denmark as a Lundbeckfonden Postdoctoral Fellow in the group of Professor Alexander Zelikin, where she investigated artificial receptor systems and supramolecular approaches to modulate CAR‑T cell signalling.

Sheiliza was appointed as a Lecturer at the School of Pharmacy, Queen’s University Belfast in June 2020. Her research focuses on engineering biomolecular interfaces, integrating protein engineering, supramolecular assembly, nanocarrier technologies, and biotherapeutic delivery.

She is a member of the Royal Society of Chemistry and a Fellow of the Higher Education Academy.

Research Focus

Dr Carmali's research focuses on understanding, predicting, and engineering biomolecular interfaces to control the stability, activity, and therapeutic performance of proteins and other macromolecular drugs. Her work integrates molecular and supramolecular design with protein engineering and nanostructured delivery systems to enable biologics to function effectively in complex environments, supported by international collaborations across the UK, Europe, the US and Brazil.

Her research investigates protein-material interactions, including protein-polymer and protein-surfactant systems, to uncover how interfacial interactions govern protein behaviour. Through approaches such as hydrophobic ion pairing and supramolecular complexation, she develops strategies to modulate these interactions and improve protein compatibility and performace. Complementing this, she is developing predictive tools and design frameworks, including open-source software (PRELYM) to guide the rational engineering of biomolecular systems.

Building on these mechanistic and predictive insights, her group develops nanostructured and supramolecular delivery platforms, including nanostructured lipid carriers and engineered protein nanocages, to enable the controlled delivery of proteins, peptides, and immunomodulatory agents. Recent works extends toward locally acting immunomodulatory systems for women's health.

Sheiliza has secured competitive funding from the Lundbeck Foundation, the Royal Society, the Royal Society of Chemistry, and the Medical Research Council, and her work has been published in leading journals including Nature Communications, Advanced Science, Bioconjugate Chemistry, and Acta Biomaterialia. Her growing profile is further demonstrated through patents, open-source software contributions and active engagement with the international scientific community.

Teaching

Dr Carmali teaches across the BSc Pharmaceutical Sciences, BSc Pharmaceutical Biotechnology, MPharm, and MSc Industrial Pharmaceutics programmes, contributing to modules in pharmaceutical chemistry, medicinal chemistry, biotechnology, and research skills. She adopts an active, student‑centred approach and consistently receives strong student feedback.

She has contributed to the development and enhancement of modules within the School and supports Queen’s transnational education activities through teaching at the China Medical University–Queen’s University Belfast Joint College. She also supervises undergraduate and MSc research projects and is actively involved in student support, recruitment, and admissions.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  2. SDG 4 - Quality Education
    SDG 4 Quality Education
  3. SDG 9 - Industry, Innovation, and Infrastructure
    SDG 9 Industry, Innovation, and Infrastructure

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