Projects per year
Personal profile
Research Interests
Dr Shu Li's research interests cover the development of novel pharmaceutical dosage forms via innovative manufacturing. Shu specialises particularly in the use of continuous manufacturing techniques, such as hot-melt extrusion, multilayer co-extrusion to enhance the bioavailability of poorly absorbed drugs in order to increase their clinical efficacy when administered orally. Formulation strategies familiar to Dr Li include the design and preparation of amorphous solid dispersions and novel multi-component pharmaceutical materials (such as pharmaceutical cocrystals). She is also interested in extending her field of research to enabling formulations with customisable platform designs, such as flexible-dose combination products, for stratefied treatment and precision medicine. This includes understanding and determination of multi-component behaviour and interactions as well as understanding and predicting the influences such inter-species network may exert on the bioavailability and efficacy of the final dosage forms. To achieve high level of comprehension, a number of analytical techniques are routinely used including thermal analysis (DSC, TGA, DMA), vibrational spectroscopy, X-ray diffraction, thermo and polarised-light microscopy, High Performance Liquid Chromatography, Gas Chromatography, vapour sorption, Nuclear Magnetic Resonance spectroscopy and theoretical modelling.
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Projects
- 1 Active
S2412PMY: KTP/Devenish Nutrition Ltd
Andrews, G., Jones, D., Li, S. & Tian, J.
01/05/2017 → …
Project: ktp
Research Output
Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method
Mohylyuk, V., Hutton, T., Dadou, S., Tian, J., Li, S., Jones, D. & Andrews, G., 06 Feb 2020, (Accepted). 2 p.Research output: Contribution to conference › Abstract
Co-extruded Fixed Dose Combination Products with Enabled Properties for the Treatment of Cardiovascular Diseases
Almajaan, A., Li, S., Gilvary, G. C., Senta Loys, Z., Tian, Y., Kelleher, J., Healy, A-M., Jones, D. & Andrews, G., 03 Apr 2019.Research output: Contribution to conference › Paper
Open Access
Fixed Dose Combination Formulations: Multi-Layered Platforms Designed for the Management of Cardiovascular Disease
Andrews, G. P., Li, S., Almajaan, A., Yu, T., Martini, L., Healy, A. M. & Jones, D. S., 06 May 2019, In : Molecular Pharmaceutics. 16, 5, p. 1827-1838 12 p.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
24
Downloads
(Pure)
Mechanochemical synthesis of a multicomponent complex containing albendazole and maleic acid for improved physiochemical properties
Culkin, A., Jones, D., Andrews, G. & Li, S., Nov 2019.Research output: Contribution to conference › Poster
Metformin Hydrochloride and Sitagliptin Phosphate Fixed Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology
Kelleher, J., Madi, A., Gilvary, G. C., Tian, J., Li, S., Almajaan, A., Senta Loys, Z., Jones, D., Andrews, G. & Healy, A. M., 12 Dec 2019, In : AAPS PharmSciTech. 21, 1, 14 p.Research output: Contribution to journal › Article
Activities
Therapeutic Delivery (Journal)
Shu Li (Editorial board member)14 Jan 2020 → …
Activity: Publication peer-review and editorial work types › Editorial activity
Lead for CQC Exchange Programme
Nicola Irwin (Organiser), Shu Li (Organiser)13 Jan 2020 → 19 Feb 2020
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
International Journal of Pharmaceutics (Journal)
Shu Li (Peer reviewer)2020 → …
Activity: Publication peer-review and editorial work types › Publication peer-review
CQC Exchange Programme
Nicola Irwin (Organiser), Shu Li (Organiser)14 Jan 2019 → 20 Feb 2019
Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Journal of Drug Delivery Science and Technology (Journal)
Shu Li (Peer reviewer)2019 → …
Activity: Publication peer-review and editorial work types › Publication peer-review