Projects per year
Dr Shu Li's research interests cover the development of novel pharmaceutical dosage forms via innovative manufacturing. Shu specialises particularly in the use of continuous manufacturing techniques, such as hot-melt extrusion, multilayer co-extrusion to enhance the bioavailability of poorly absorbed drugs in order to increase their clinical efficacy when administered orally. Formulation strategies familiar to Dr Li include the design and preparation of amorphous solid dispersions and novel multi-component pharmaceutical materials (such as pharmaceutical cocrystals). She is also interested in extending her field of research to enabling formulations with customisable platform designs, such as flexible-dose combination products, for stratefied treatment and precision medicine. This includes understanding and determination of multi-component behaviour and interactions as well as understanding and predicting the influences such inter-species network may exert on the bioavailability and efficacy of the final dosage forms. To achieve high level of comprehension, a number of analytical techniques are routinely used including thermal analysis (DSC, TGA, DMA), vibrational spectroscopy, X-ray diffraction, thermo and polarised-light microscopy, High Performance Liquid Chromatography, Gas Chromatography, vapour sorption, Nuclear Magnetic Resonance spectroscopy and theoretical modelling.
Research Output per year
Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion methodMohylyuk, V., Hutton, T., Dadou, S., Tian, J., Li, S., Jones, D. & Andrews, G., 06 Feb 2020, (Accepted). 2 p.
Research output: Contribution to conference › Abstract
The development and validation of a quality by design based process analytical tool for the inline quantification of Ramipril during hot-melt extrusionDadou, S., Senta Loys, Z., Almajaan, A., Li, S., Jones, D., Healy, A. M., Tian, J. & Andrews, G., 30 Jun 2020, In : International Journal of Pharmaceutics. 584
Research output: Contribution to journal › Article
Co-extruded Fixed Dose Combination Products with Enabled Properties for the Treatment of Cardiovascular DiseasesAlmajaan, A., Li, S., Gilvary, G. C., Senta Loys, Z., Tian, Y., Kelleher, J., Healy, A-M., Jones, D. & Andrews, G., 03 Apr 2019.
Research output: Contribution to conference › Paper
Activities per year
Mechanochemical Synthesis of a Multicomponent Complex Containing Albendazole and Maleic Acid for Improved Physiochemical Propertie
Activity: Talk or presentation types › Oral presentation