• Room 01.065 - Pharmacy & MCI

    United Kingdom

Accepting PhD Students

PhD projects

Open to PhD applications in the field of multi-component pharmaceutical materials (including pharmaceutical cocrystals), mechanochemical synthesis, enabling formulation strategies and medical device preparation via hot-melt extrusion.

20092019
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Personal profile

Research Interests

Dr Shu Li's research interests cover the development of novel pharmaceutical dosage forms via innovative manufacturing. Shu specialises particularly in the use of continuous manufacturing techniques, such as hot-melt extrusion, multilayer co-extrusion to enhance the bioavailability of poorly absorbed drugs in order to increase their clinical efficacy when administered orally. Formulation strategies familiar to Dr Li include the design and preparation of amorphous solid dispersions and novel multi-component pharmaceutical materials (such as pharmaceutical cocrystals). She is also interested in extending her field of research to enabling formulations with customisable platform designs, such as flexible-dose combination products, for stratefied treatment and precision medicine. This includes understanding and determination of multi-component behaviour and interactions as well as understanding and predicting the influences such inter-species network may exert on the bioavailability and efficacy of the final dosage forms. To achieve high level of comprehension, a number of analytical techniques are routinely used including thermal analysis (DSC, TGA, DMA), vibrational spectroscopy, X-ray diffraction, thermo and polarised-light microscopy, High Performance Liquid Chromatography, Gas Chromatography, vapour sorption, Nuclear Magnetic Resonance spectroscopy and theoretical modelling. 

Fingerprint Dive into the research topics where Shu Li is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Pharmaceutical Preparations Medicine & Life Sciences
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Dispersions Chemical Compounds

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Projects 2017 2017

Research Output 2009 2019

Co-extruded Fixed Dose Combination Products with Enabled Properties for the Treatment of Cardiovascular Diseases

Almajaan, A., Li, S., Gilvary, G. C., Senta Loys, Z., Tian, Y., Kelleher, J., Healy, A-M., Jones, D. & Andrews, G., 03 Apr 2019.

Research output: Contribution to conferencePaper

Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Simvastatin
Cardiovascular Diseases
Dyslipidemias
Aspirin

Fixed Dose Combination Formulations: Multi-Layered Platforms Designed for the Management of Cardiovascular Disease

Andrews, G. P., Li, S., Almajaan, A., Yu, T., Martini, L., Healy, A. M. & Jones, D. S., 31 Jan 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

Simvastatin
Cardiovascular Diseases
Hyperlipidemias
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Aspirin

Metformin Hydrochloride and Sitagliptin Phosphate Fixed Dose Combination Product Prepared Using Melt Granulation Continuous Processing Technology

Kelleher, J., Madi, A., Gilvary, G. C., Tian, J., Li, S., Almajaan, A., Senta Loys, Z., Jones, D., Andrews, G. & Healy, A. M., 12 Dec 2019, In : AAPS PharmSciTech. 21, 1, 14 p.

Research output: Contribution to journalArticle

Metformin
Dosage Forms
Technology
Freezing
Tablets
Ramipril
Quality Control
Raman Spectrum Analysis
High Pressure Liquid Chromatography
Diketopiperazines

Activities 2017 2020

Lead for CQC Exchange Programme

Nicola Irwin (Organiser), Shu Li (Organiser)
13 Jan 202019 Feb 2020

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

International Journal of Pharmaceutics (Journal)

Shu Li (Peer reviewer)
2020 → …

Activity: Publication peer-review and editorial work typesPublication peer-review

Therapeutic Delivery (Journal)

Shu Li (Editorial board member)
14 Jan 2020 → …

Activity: Publication peer-review and editorial work typesEditorial activity

QUB Open Day

Shu Li (Host)
05 Sep 2019

Activity: Other activity typesHosting a school group or open day

Mechanochemical Synthesis of a Multicomponent Complex Containing Albendazole and Maleic Acid for Improved Physiochemical Propertie

Alice Culkin (Presenter), Gavin Andrews (Advisor), Shu Li (Advisor)
17 Apr 201918 Apr 2019

Activity: Talk or presentation typesOral presentation