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Simon McDade

Dr

 https://orcid.org/0000-0002-3024-4773

  • Room 01.004 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr McDade functional genomics (FGG) lab, utilises a range of genomic technologies (RNA-seq, ChIP-seq, CRISPR screen) and integrative data analysis tools to identify novel treatment strategies to improve treatment of cancer patients outcomes. The labs field of interest include: - Transcription factor dysfunction in cancer - Epigenetic lab and data analysis tool development - Colorectal, Prostate and Squamous cancer - Data analysis and Shiny app development We are open to wide ranging lab and data analysis projects from those with a background biology, genomics, data analysis and computational backgrounds. Previous research experience is desirable although not essential

20052020

Research output per year

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Personal profile

Research Statement

The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family.  Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application. 

 

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Projects

R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine

McDade, S., Jafarnejad, S. M. & Scott, C.

10/01/2020 → …

Project: Research

R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex

McDade, S. & Longley, D.

11/08/2019 → …

Project: Research

R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer

Longley, D., Dunne, P., Harrison, T., Kerr, E. & McDade, S.

29/03/2019 → …

Project: Research

R2421CNR: Impact of chemotherapy on anti-cancer immunity in molecular-stratified subgroups of colorectal cancer

Longley, D., Coleman, H., Dunne, P., Lawler, M., McArt, D. & McDade, S.

03/07/2017 → …

Project: Research

R1605CNR: MRC P2D 2015 - Development and validation of TempO-Seq assays for Immuno-Oncology application in cancer research and diagnostics

McDade, S. & McArt, D.

19/02/2016 → 30/11/2016

Project: Research

Research Output

  • 39 Article
  • 1 Chapter (peer-reviewed)
  • 1 Meeting abstract
  • 1 Other contribution

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journal › Article

Open Access
File
    • 4 Citations (Scopus)
    50 Downloads (Pure)

    Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland

    Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., Jan 2020, In : Cancer Epidemiology, Biomarkers, & Prevention. 29, 1, p. 31-38

    Research output: Contribution to journal › Article

    • 1 Citation (Scopus)

    Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation

    Haughey, C. M., Mukherjee, D., Steele, R. E., Popple, A., Dura-Perez, L., Pickard, A., Jain, S., Mullan, P. B., Williams, R., Oliveira, P., Buckley, N. E., Honeychurch, J., Williams, R., McDade, S., Illidge, T., Mills, I. G. & Eddie, S. L., 2020

    Research output: Other contribution

    Open Access

    • The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

    Lees, A., McIntyre, A. J., Crawford, N. T., Falcone, F., McCann, C., Holohan, C., Quinn, G. P., Roberts, J. Z., Sessler, T., Gallagher, P. F., Gregg, G. M. A., McAllister, K., McLaughlin, K. M., Allen, W. L., Egan, L. J., Ryan, A. E., Labonte-Wilson, M. J., Dunne, P. D., Wappett, M., Coyle, V. M. & 4 others, Johnston, P. G., Kerr, E. M., Longley, D. B. & McDade, S. S., Jul 2020, In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journal › Article

    Open Access

    • The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

    Roberts, J. Z., Holohan, C., Sessler, T., Fox, J., Crawford, N., Riley, J. S., Khawaja, H., Majkut, J., Evergren, E., Humphreys, L. M., Ferris, J., Higgins, C., Espona-Fiedler, M., Moynagh, P., McDade, S. S. & Longley, D. B., 20 Apr 2020, In : Cell Death and Differentiation.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 17 Downloads (Pure)

    Prizes

    EACR Young Scientist Prize

    McDade, Simon (Recipient), 2011

    Prize: Prize (including medals and awards)

    Activities

    Nature Communications (Journal)

    Simon McDade (Peer reviewer)

    Sep 2018

    Activity: Publication peer-review and editorial work types › Publication peer-review

    Irish Association for Cancer Research (External organisation)

    Simon McDade (Reviewer)

    Dec 2018

    Activity: Membership types › Membership of peer review panel or committee

    Nucleic Acids Research (Journal)

    Simon McDade (Peer reviewer)

    Mar 2018

    Activity: Publication peer-review and editorial work types › Publication peer-review

    Oncogene (Journal)

    Simon McDade (Peer reviewer)

    Oct 2018

    Activity: Publication peer-review and editorial work types › Publication peer-review

    MPhil External Examiner Manchester University

    Simon McDade (Examiner)

    26 Feb 2018

    Activity: Examination types › PhD external examination

    Press / Media

    Media coverage of the CCRCB (Wilson, McDade) led phase-I first in man trial of Lillys novel CDC7 inhibitor in p53 mutant cancers

    Simon McDade, Richard Wilson & Daniel Longley

    10/10/2017

    1 item of Media coverage

    Press/Media: Research