Projects per year
Personal profile
Research Statement
The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family. Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R1300CNR: Future Medicines Institute
Scott, C. (PI), Bruce, I. (CoI), Burden, R. (CoI), Burrows, J. (CoI), Collins, B. (CoI), Harrison, T. (CoI), James, J. (CoI), Kennedy, R. (CoI), Lawler, M. (CoI), Longley, D. (CoI), Maguire, S. (CoI), Malinova, D. (CoI), Maule, A. (CoI), McCloskey, K. (CoI), McDade, S. (CoI), Salto-Tellez, M. (CoI), Savage, K. (CoI), Stitt, A. (CoI) & Williams, R. (CoI)
15/10/2024 → …
Project: Research
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R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex
McDade, S. (PI) & Longley, D. (CoI)
11/08/2019 → …
Project: Research
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D. (PI), Dunne, P. (CoI), Harrison, T. (CoI), Kerr, E. (CoI) & McDade, S. (CoI)
29/03/2019 → …
Project: Research
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R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine
McDade, S. (PI), Jafarnejad, S. M. (CoI) & Scott, C. (CoI)
10/01/2020 → 30/06/2022
Project: Research
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R2421CNR: Impact of chemotherapy on anti-cancer immunity in molecular-stratified subgroups of colorectal cancer
Longley, D. (PI), Coleman, H. (CoI), Dunne, P. (CoI), Lawler, M. (CoI), McArt, D. (CoI) & McDade, S. (CoI)
03/07/2017 → 31/01/2023
Project: Research
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ClassifieR 2.0: expanding interactive gene expression-based stratification to prostate and high-grade serous ovarian cancer
McCabe, A., Quinn, G. P., Jain, S., Ó Dálaigh, M., Dean, K., Murphy, R. G. & McDade, S. S., 21 Nov 2024, In: BMC Bioinformatics. 25, 13 p., 362.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)5 Downloads (Pure) -
Dual-hit strategy for therapeutic targeting of pancreatic cancer in patient-derived xenograft tumors
Roy Chaudhuri, T., Lin, Q., Stachowiak, E. K., Rosario, S. R., Spernyak, J. A., Ma, W. W., Stachowiak, M. K., Greene, M. K., Quinn, G. P., McDade, S. S., Clynes, M., Scott, C. J. & Straubinger, R. M., 01 Apr 2024, In: Clinical Cancer Research. 30, 7, p. 1367-1381 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)98 Downloads (Pure) -
Integrated multiplex analysis of cell death regulators in stage II colorectal cancer suggests patients with ‘persister’ cell profiles fail to benefit from adjuvant chemotherapy
Cho, S., McDonough, E., Graf, J., Shia, J., Firat, C., Urganci, N., Surrette, C., Lindner, A., Salvucci, M., Matveeva, A., Kisakol, B., O’Grady, A., Azimi, M., Burke, J. P., McNamara, D. A., McDade, S., Longley, D. B., Prehn, J. H. & Ginty, F., 06 Aug 2024, In: BMJ Oncology. 3, 12 p., e000362.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)55 Downloads (Pure) -
Nanoencapsulation of MDM2 inhibitor RG7388 and class-I HDAC inhibitor entinostat enhances their therapeutic potential through synergistic antitumor effects and reduction of systemic toxicity
Abed, A., Greene, M. K., Alsa'd, A. A., Lees, A., Hindley, A., Longley, D. B., McDade, S. S. & Scott, C. J., 04 Mar 2024, In: Molecular Pharmaceutics. 21, 3, p. 1246–1255 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)29 Downloads (Pure) -
Ribosome quality control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Chatterjee, S., Naeli, P., Onar, O., Simms, N., Garzia, A., Hackett, A., Coyle, K., Harris Snell, P., McGirr, T., Sawant, T. N., Dang, K., Stoichkova, Z. V., Azam, Y., Saunders, M. P., Braun, M., Alain, T., Tuschl, T., McDade, S. S., Longley, D. B. & Gkogkas, C. G. & 3 others, , 11 Nov 2024, In: Nucleic Acids Research. 52, 20, p. 12534-12548 15 p., gkae849.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)40 Downloads (Pure)
Prizes
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Department for the Economy (DfE) Higher Education Research Capital Grant Funding
Ward, C. (Recipient), Maguire, S. (Recipient), McDade, S. (Recipient) & Simpson, D. (Recipient), 2023
Prize: Other distinction
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Activities
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PhD External Examiner
McDade, S. (Examiner)
04 Nov 2024Activity: Examination types › PhD external examination
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AICC Annual Meeting Galway 2024
McDade, S. (President)
25 May 2024Activity: Participating in or organising an event types › Participation in conference
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UK oncology diagnostics hub meeting
McDade, S. (Participant)
07 Mar 2024Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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EACR-AACR-IACR 2024:
McDade, S. (Participant)
27 Feb 2024 → 29 Feb 2024Activity: Participating in or organising an event types › Participation in conference
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QUB UCD Cancer partnership strategy workshop
McDade, S. (Participant)
08 Dec 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
Press/Media
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Prostate cancer: QUB donation to 'transform' research
25/10/2022
1 Media contribution
Press/Media: Research
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Award of Prostate Cancer UK Resaerch Innovation Award (RIA)
McDade, S. & LaBonte Wilson, M.
04/11/2021
2 Media contributions
Press/Media: Research
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Queen's University receives huge grant to boost research into prostate cancer
McDade, S., Coulter, J. & LaBonte Wilson, M.
04/11/2021
1 item of Media coverage
Press/Media: Research
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Queen’s University receives huge grants to boost prostate cancer research
McDade, S., Coulter, J. & LaBonte Wilson, M.
02/11/2021
1 item of Media coverage
Press/Media: Research
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Impacts
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Implementation of HPV-specific testing in addition to assessment of p16 expression in oropharyngeal squamous cell carcinoma
Craig, S. (Participant), Anderson, L. (Participant), Schache, A. (Participant), Moran, M. (Participant), Graham, L. (Participant), Currie, K. (Participant), Rooney, K. (Participant), Robinson, M. (Participant), Upile, N. (Participant), Brooker, R. (Participant), Mesri, M. (Participant), Bingham, V. (Participant), Cuschieri, K. (Participant), McQuaid, S. (Participant), Jones, T. (Participant), McCance, D. (Participant), Salto-Tellez, M. (Participant), McDade, S. (Participant) & James, J. (Participant)
Impact: Health Impact, Quality of Life Impact