Projects per year
Personal profile
Research Statement
The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family. Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex
11/08/2019 → …
Project: Research
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D., Dunne, P., Harrison, T., Kerr, E. & McDade, S.
29/03/2019 → …
Project: Research
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R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine
McDade, S., Jafarnejad, S. M. & Scott, C.
10/01/2020 → 30/06/2022
Project: Research
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R2421CNR: Impact of chemotherapy on anti-cancer immunity in molecular-stratified subgroups of colorectal cancer
Longley, D., Coleman, H., Dunne, P., Lawler, M., McArt, D. & McDade, S.
03/07/2017 → 31/01/2023
Project: Research
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R1605CNR: MRC P2D 2015 - Development and validation of TempO-Seq assays for Immuno-Oncology application in cancer research and diagnostics
McDade, S. & McArt, D.
19/02/2016 → 30/11/2016
Project: Research
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Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
Steiner, I., Flores-Tellez, T. D. N. J., Mevel, R., Ali, A., Wang, P., Schofield, P., Behan, C., Forsythe, N., Ashton, G., Taylor, C., Mills, I. G., Oliveira, P., McDade, S. S., Zaiss, D. M., Choudhury, A., Lacaud, G. & Baena, E., 25 Apr 2023, In: Cell Reports. 42, 4, 112377.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
Bcl-xL is a key mediator of apoptosis following KRASG12C inhibition in KRASG12C-mutant colorectal cancer
Khawaja, H., Briggs, R., Latimer, C. H., Rassel, M., Griffin, D., Hanson, L., Bardelli, A., Di Nicolantonio, F., McDade, S. S., Scott, C. J., Lambe, S., Maurya, M., Lindner, A. U., Prehn, J. H. M., Sousa, J., Winnington, C., LaBonte, M. J., Ross, S. & Van Schaeybroeck, S., 01 Jan 2023, In: Molecular Cancer Therapeutics. 22, 1, p. 135–149 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Downloads (Pure) -
Investigating the suitability of in vitro cell lines as models for the major subtypes of epithelial ovarian cancer
McCabe, A., Zaheed, O., McDade, S. S. & Dean, K., 13 Feb 2023, In: Frontiers in Cell and Developmental Biology. 11, 1104514.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure) -
Activation of innate-adaptive immune machinery by Poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer
Corry, S. M., McCorry, A. MB., Lannagan, T. R. M., Leonard, N. A., Fisher, N. C., Byrne, R. M., Tsantoulis, P., Cortes-Lavaud, X., Amirkhah, R., Redmond, K. L., McCooey, A. J., Malla, S. B., Rogan, E., Sakhnevych, S., Gillespie, M., White, M., Richman, S., Jackstadt, R., Campbell, C. A., Maguire, S., & 13 others, 07 Nov 2022, In: Gut. 71, 12, p. 2502–2517 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Downloads (Pure) -
classifieR a flexible interactive cloud-application for functional annotation of cancer transcriptomes
Quinn, G. P., Sessler, T., Ahmaderaghi, B., Lambe, S., VanSteenhouse, H., Lawler, M., Wappett, M., Seligmann, B., Longley, D. B. & McDade, S. S., 31 Mar 2022, In: BMC Bioinformatics. 23, 9 p., 114.Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Downloads (Pure)
Prizes
Activities
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Turin PhD External Examiner
Simon McDade (Examiner)
May 2023Activity: Examination types › PhD external examination
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Galway PhD External Examiner
Simon McDade (Examiner)
Apr 2023Activity: Examination types › PhD external examination
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Turing Health-AI Summit
Simon McDade (Contributor)
Feb 2023Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Review Commons (Journal)
Simon McDade (Peer reviewer)
Feb 2023Activity: Publication peer-review and editorial work types › Publication peer-review
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2nd All Ireland Chromatin Consortium annual symposium
Simon McDade (Member of the organising committee)
2023Activity: Participating in or organising an event types › Participation in conference
Press/Media
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Award of Prostate Cancer UK Resaerch Innovation Award (RIA)
Simon McDade & Melissa LaBonte Wilson
04/11/2021
2 Media contributions
Press/Media: Research
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Queen's University receives huge grant to boost research into prostate cancer
Simon McDade, Jonathan Coulter & Melissa LaBonte Wilson
04/11/2021
1 item of Media coverage
Press/Media: Research
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Queen’s University receives huge grants to boost prostate cancer research
Simon McDade, Jonathan Coulter & Melissa LaBonte Wilson
02/11/2021
1 item of Media coverage
Press/Media: Research
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Media coverage of SynLeGG cancer 'Achilles' heels' research article
Ian Overton, Mark Wappett & Simon McDade
19/05/2021
4 items of Media coverage
Press/Media: Research
Impact
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Implementation of HPV-specific testing in addition to assessment of p16 expression in oropharyngeal squamous cell carcinoma
Stephanie Craig (Participant), Lesley Anderson (Participant), Andrew Schache (Participant), Michael Moran (Participant), Laura Graham (Participant), Keith Currie (Participant), Keith Rooney (Participant), Max Robinson (Participant), Navdeep Upile (Participant), Rachel Brooker (Participant), Mina Mesri (Participant), Victoria Bingham (Participant), Kate Cuschieri (Participant), Stephen McQuaid (Participant), Terry Jones (Participant), Dennis McCance (Participant), Manuel Salto-Tellez (Participant), Simon McDade (Participant) & Jacqueline James (Participant)
Impact: Health Impact, Quality of Life Impact