Simon McDade

Senior Lecturer, School of Medicine, Dentistry and Biomedical Sciences
Centre for Cancer Research and Cell Biology

Phone+44 (0)28 9097 2183
EmailS.McDade@qub.ac.uk

Room 01.004 - CCRCB
United Kingdom

Accepting PhD Students

PhD projects

Dr McDade functional genomics (FGG) lab, utilises a range of genomic technologies (RNA-seq, ChIP-seq, CRISPR screen) and integrative data analysis tools to identify novel treatment strategies to improve treatment of cancer patients outcomes. The labs field of interest include: - Transcription factor dysfunction in cancer - Epigenetic lab and data analysis tool development - Colorectal, Prostate and Squamous cancer - Data analysis and Shiny app development We are open to wide ranging lab and data analysis projects from those with a background biology, genomics, data analysis and computational backgrounds. Previous research experience is desirable although not essential

Research output per year

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Personal profile

Research Statement

The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family. Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application.

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Projects

3 Finished
4 Active

R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine

McDade, S., Jafarnejad, S. M. & Scott, C.

10/01/2020 → …

Project: Research

R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex

McDade, S. & Longley, D.

11/08/2019 → …

Project: Research

R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer

Longley, D., Dunne, P., Harrison, T., Kerr, E. & McDade, S.

29/03/2019 → …

Project: Research

R2421CNR: Impact of chemotherapy on anti-cancer immunity in molecular-stratified subgroups of colorectal cancer

Longley, D., Coleman, H., Dunne, P., Lawler, M., McArt, D. & McDade, S.

03/07/2017 → …

Project: Research

R1605CNR: MRC P2D 2015 - Development and validation of TempO-Seq assays for Immuno-Oncology application in cancer research and diagnostics

McDade, S. & McArt, D.

19/02/2016 → 30/11/2016

Project: Research

Research Output

37 Article
1 Chapter (peer-reviewed)
1 Meeting abstract
1 Other contribution

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journal › Article

Open Access

File

27 Downloads (Pure)

Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland

Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., Jan 2020, In : Cancer Epidemiology, Biomarkers, & Prevention. 29, 1, p. 31-38

Research output: Contribution to journal › Article

Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation

Haughey, C. M., Mukherjee, D., Steele, R. E., Popple, A., Dura-Perez, L., Pickard, A., Jain, S., Mullan, P. B., Williams, R., Oliveira, P., Buckley, N. E., Honeychurch, J., Williams, R., McDade, S., Illidge, T., Mills, I. G. & Eddie, S. L., 2020

Research output: Other contribution

Open Access

A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

Gilmore, A., Alderdice, M., Savage, K., O’Reilly, P. G., Roddy, A., Dunne, P., Lawler, M., McDade, S., Waugh, D. & McArt, D., 13 Feb 2019, In : Cancer Research.

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

16 Downloads (Pure)

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

Craig, S., Anderson, L., Schache, A., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Upile, N., Brooker, R., Mesri, M., Bingham, V., McQuaid, S., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., 20 Mar 2019, In : British Journal of Cancer.

Research output: Contribution to journal › Article

Open Access

File