Projects per year
Personal profile
Research Statement
The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family. Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application.
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine
McDade, S., Jafarnejad, S. M. & Scott, C.
10/01/2020 → …
Project: Research
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R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex
11/08/2019 → …
Project: Research
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D., Dunne, P., Harrison, T., Kerr, E. & McDade, S.
29/03/2019 → …
Project: Research
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R1605CNR: MRC P2D 2015 - Development and validation of TempO-Seq assays for Immuno-Oncology application in cancer research and diagnostics
19/02/2016 → 30/11/2016
Project: Research
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3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
Peck, B., Bland, P., Mavrommati, I., Muirhead, G., Cottom, H., Wai, P. T., Maguire, S. L., Barker, H. E., Morrison, E., Kriplani, D., Yu, L., Gibson, A., Falgari, G., Brennan, K., Farnie, G., Buus, R., Marlow, R., Novo, D., Knight, E., Guppy, N. & 22 others, , Feb 2021, In: Cancer Research. 81, 4, p. 847-859 13 p.Research output: Contribution to journal › Article › peer-review
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Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer
Crawford, N., Stott, K. J., Sessler, T., McCann, C., McDaid, W., Lees, A., Latimer, C., Fox, J. P., Munck, J. M., Smyth, T., Shah, A., Martins, V., Lawler, M., Dunne, P. D., Kerr, E. M., McDade, S. S., Coyle, V. M. & Longley, D. B., 13 Aug 2021, (Early online date) In: Molecular Cancer Therapeutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Dying to Survive—The p53 Paradox
Lees, A., Sessler, T. & McDade, S., 29 Jun 2021, In: Cancers. 13, 13, 3257.Research output: Contribution to journal › Review article › peer-review
Open AccessFile56 Downloads (Pure) -
SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships: Analysis and visualization of multiomics data for discovery of cancer 'Achilles Heels' and gene function relationships
Wappett, M., Harris, A., Lubbock, A. L. R., Lobb, I., McDade, S. & Overton, IM., 02 Jul 2021, In: Nucleic Acids Research. p. W613-W618Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Downloads (Pure) -
A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis
Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, (Early online date) In: EMBO Reports. 21, e49254.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)58 Downloads (Pure)
Prizes
Activities
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Frontiers in Cell and Developmental Biology (Journal)
Simon McDade (Peer reviewer)
Mar 2021 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Nucleic Acids Research (Journal)
Simon McDade (Peer reviewer)
Nov 2020Activity: Publication peer-review and editorial work types › Publication peer-review
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Cancers (Journal)
Simon McDade (Peer reviewer)
2020 → 2021Activity: Publication peer-review and editorial work types › Editorial activity
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BMC Cancer (Journal)
Simon McDade (Peer reviewer)
Dec 2020Activity: Publication peer-review and editorial work types › Publication peer-review