Simon McDade

Senior Lecturer, School of Medicine, Dentistry and Biomedical Sciences
Centre for Cancer Research and Cell Biology

Phone+44 (0)28 9097 2183
EmailS.McDade@qub.ac.uk

Room 01.004 - CCRCB Block 5 MBC Site
United Kingdom

Accepting PhD Students

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Personal profile

Research Statement

The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family. Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application.

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Projects 2014 2019

2 Finished
4 Active

R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex

McDade, S. & Longley, D.

11/08/2019 → …

Project: Research

R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer

Longley, D., Dunne, P., Harrison, T., Kerr, E. & McDade, S.

29/03/2019 → …

Project: Research

R2421CNR: Impact of chemotherapy on anti-cancer immunity in molecular-stratified subgroups of colorectal cancer

Longley, D., Coleman, H., Dunne, P., Lawler, M., McArt, D. & McDade, S.

03/07/2017 → …

Project: Research

R2116CNR: MOVEMBER CENTRE OF EXCELLENCE

O'Sullivan, J., Jain, S., Kennedy, R., McDade, S., Prise, K., Salto-Tellez, M. & Waugh, D.

21/05/2014 → …

Project: Research

R1605CNR: MRC P2D 2015 - Development and validation of TempO-Seq assays for Immuno-Oncology application in cancer research and diagnostics

McDade, S. & McArt, D.

19/02/2016 → 30/11/2016

Project: Research

Research Output 2005 2019

36 Article
1 Chapter (peer-reviewed)
1 Meeting abstract

A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

Gilmore, A., Alderdice, M., Savage, K., O’Reilly, P. G., Roddy, A., Dunne, P., Lawler, M., McDade, S., Waugh, D. & McArt, D., 13 Feb 2019, In : Cancer Research.

Research output: Contribution to journal › Article

Atlases

Genome

Neoplasms

Breast Neoplasms

RNA Sequence Analysis

Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland

Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., 23 Oct 2019, (Accepted) In : Cancer Epidemiology, Biomarkers, & Prevention.

Research output: Contribution to journal › Article

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

Craig, S., Anderson, L., Schache, A., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Upile, N., Brooker, R., Mesri, M., Bingham, V., McQuaid, S., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., 20 Mar 2019, In : British Journal of Cancer.

Research output: Contribution to journal › Article

Open Access

File

Oropharyngeal Neoplasms

Guidelines

Squamous Cell Carcinoma

Survival

Immunohistochemistry

1 Citation (Scopus)