Projects per year
Personal profile
Research Statement
The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family. Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application.
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Projects
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R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine
McDade, S., Jafarnejad, S. M. & Scott, C.
10/01/2020 → …
Project: Research
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R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex
11/08/2019 → …
Project: Research
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D., Dunne, P., Harrison, T., Kerr, E. & McDade, S.
29/03/2019 → …
Project: Research
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R1605CNR: MRC P2D 2015 - Development and validation of TempO-Seq assays for Immuno-Oncology application in cancer research and diagnostics
19/02/2016 → 30/11/2016
Project: Research
Research Output
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A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis
Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)75 Downloads (Pure) -
Chronic loss of STAG2 leads to altered chromatin structure contributiong to de-regulated transcription in AML
Smith, J., Lappin, K., Craig, S., Liberante, F., McDade, S., Thompson, A., Mills, K. & Savage, K., 03 Sep 2020, In : JOURNAL OF TRANSLATIONAL MEDICINE. 18, p. 339-357 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland
Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., Jan 2020, In : Cancer Epidemiology, Biomarkers, & Prevention. 29, 1, p. 31-38Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)36 Downloads (Pure) -
Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation
Haughey, C. M., Mukherjee, D., Steele, R. E., Popple, A., Dura-Perez, L., Pickard, A., Jain, S., Mullan, P. B., Williams, R., Oliveira, P., Buckley, N. E., Honeychurch, J., Williams, R., McDade, S., Illidge, T., Mills, I. G. & Eddie, S. L., 2020Research output: Other contribution
Open Access -
Dissecting the DNA binding landscape and gene regulatory network of p63 and p53
Riege, K., Kretzmer, H., Sahm, A., McDade, S. S., Hoffmann, S. & Fischer, M., 14 Dec 2020, In : eLife. 9, 26 p., e63266.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Prizes
Activities
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International Mens Day Events, Faculty of Medicine, Health and Life Sciences
Sean Roe (Organiser), Paul Caplat (Member of the organising committee), Erin Davidson (Member of the organising committee), Maria Healy (Member of the organising committee), Mark Linden (Member of the organising committee), Simon McDade (Member of the organising committee), Declan McLaughlin (Member of the organising committee) & Paul Mullan (Member of the organising committee)
19 Nov 2020Activity: Participating in or organising an event types › Participation in Festival/Exhibition
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Annual Meeting of the Irish Association of Cancer Research (IACR)
Simon McDade (Speaker)
23 Feb 2018Activity: Talk or presentation types › Oral presentation
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Irish Association for Cancer Research (External organisation)
Simon McDade (Reviewer)
Dec 2018Activity: Membership types › Membership of peer review panel or committee
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Oncogene (Journal)
Simon McDade (Peer reviewer)
Oct 2018Activity: Publication peer-review and editorial work types › Publication peer-review
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Nucleic Acids Research (Journal)
Simon McDade (Peer reviewer)
Mar 2018Activity: Publication peer-review and editorial work types › Publication peer-review
Press / Media
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Media coverage of the CCRCB (Wilson, McDade) led phase-I first in man trial of Lillys novel CDC7 inhibitor in p53 mutant cancers
Simon McDade, Richard Wilson & Daniel Longley
10/10/2017
1 item of Media coverage
Press/Media: Research