Projects per year
Personal profile
Research Statement
The research interests of my lab are in utilising integrative genomic strategies to define genome wide targets, mechanism of action and consequences of deregualtion of transcription factors in cancer with a particular emphasis on the p53 family. Our ultimate goal is to identify genes or processes altered as a consequence of mutation or de-regulation which could be exploited for diagnostic or therapeutic application.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R1135CNR: Exploiting the cancer epigenome to develop a common cancer vaccine
McDade, S., Jafarnejad, S. M. & Scott, C.
10/01/2020 → …
Project: Research
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R1093CNR: Regulation of cell fate by a novel p53-inducible ligand-independent TRAIL-R2 complex
11/08/2019 → …
Project: Research
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R1049CNR: The cell death regulator FLIP: evaluation of novel inhibitors in colorectal cancer
Longley, D., Dunne, P., Harrison, T., Kerr, E. & McDade, S.
29/03/2019 → …
Project: Research
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R1605CNR: MRC P2D 2015 - Development and validation of TempO-Seq assays for Immuno-Oncology application in cancer research and diagnostics
19/02/2016 → 30/11/2016
Project: Research
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Activation of innate-adaptive immune machinery by Poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer
Corry, S., McCorry, A., Lannagan, T. R. M., Leonard, N. A., Fisher, N., Byrne, R., Tsantoulis, P., Cortes-Lavaud, X., Amirkhah, R., Redmond, K., McCooey, A. J., Malla, S., Rogan, E., Sakhnevych, S., Gillespie, M., White, M., Richman, S., Jackstadt, R., Campbell, C. A., Maguire, S. & 13 others, , 22 Apr 2022, (Early online date) In: Gut.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Downloads (Pure) -
classifieR a flexible interactive cloud-application for functional annotation of cancer transcriptomes
Quinn, G. P., Sessler, T., Ahmaderaghi, B., Lambe, S., VanSteenhouse, H., Lawler, M., Wappett, M., Seligmann, B., Longley, D. B. & McDade, S. S., 31 Mar 2022, In: BMC Bioinformatics. 23, 1, p. 114Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
Grinkevich, V., Wappett, M., Crawford, N., Price, S., Lees, A., McCann, C., McAllister, K. A., Prehn, J. H., Young, J., Bateson, J. H., Gallagher, L., Michaut, M., Iyer, V., Chatzipli, A., Barthorpe, S., Ciznadija, D., Sloma, I., Wesa, A., Tice, D. A., Wessels, L. F. A. & 4 others, , 01 Apr 2022, In: Molecular Cancer Therapeutics. 21, 4, p. 594-606Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Downloads (Pure) -
Molecular Subtyping Resource: a user-friendly tool for rapid biological discovery from transcriptional data
Ahmaderaghi, B., Amirkhah, R., Jackson, J., Lannagan, T. R. M., Gilroy, K., Malla, S. B., Redmond, K. L., Quinn, G., McDade, S., Maughan, T., Consortium, ACRC., Leedham, S., Campbell, A. S., Sansom, O. J., Lawler, M. & Dunne, P. D., 30 Mar 2022, In: Disease Models and Mechanisms. 15, 3Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure) -
VPRBP functions downstream of the androgen receptor and OGT to restrict p53 activation in prostate cancer
Poulose, N., Forsythe, N., Polonski, A., Gregg, G., Maguire, S., Fuchs, M., Minner, S., Sauter, G., McDade, S. S. & Mills, I. G., 29 Mar 2022, (Early online date) In: Molecular cancer research : MCR.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
Activities
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Balmoral Show - Public Engagement
Philip Dunne (Host), Donna Small (Recipient), Stephanie Craig (Recipient), Simon McDade (Recipient), Sudhir Malla (Recipient), Raheleh Amirkhah (Recipient), Yaser Atlasi (Recipient), Joe O'Sullivan (Recipient) & James Boncan (Recipient)
2022 → …Activity: Other activity types › Other
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Frontiers in Cell and Developmental Biology (Journal)
Simon McDade (Peer reviewer)
Mar 2021 → …Activity: Publication peer-review and editorial work types › Editorial activity
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BMC Cancer (Journal)
Simon McDade (Peer reviewer)
Dec 2020Activity: Publication peer-review and editorial work types › Publication peer-review
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CRUK Manchester Seminar Series
Simon McDade (Advisor)
24 Nov 2020Activity: Talk or presentation types › Invited talk
Press / Media
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Queen's University receives huge grant to boost research into prostate cancer
Simon McDade, Jonathan Coulter & Melissa LaBonte Wilson
04/11/2021
1 item of Media coverage
Press/Media: Research
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Queen’s University receives huge grants to boost prostate cancer research
Simon McDade, Jonathan Coulter & Melissa LaBonte Wilson
02/11/2021
1 item of Media coverage
Press/Media: Research
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Media coverage of SynLeGG cancer 'Achilles' heels' research article
Ian Overton, Mark Wappett & Simon McDade
19/05/2021
4 items of Media coverage
Press/Media: Public Engagement Activities
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Impact
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Implementation of HPV-specific testing in addition to assessment of p16 expression in oropharyngeal squamous cell carcinoma
Stephanie Craig (Participant), Lesley Anderson (Participant), Andrew Schache (Participant), Michael Moran (Participant), Laura Graham (Participant), Keith Currie (Participant), Keith Rooney (Participant), Max Robinson (Participant), Navdeep Upile (Participant), Rachel Brooker (Participant), Mina Mesri (Participant), Victoria Bingham (Participant), Kate Cuschieri (Participant), Stephen McQuaid (Participant), Terry Jones (Participant), Dennis McCance (Participant), Manuel Salto-Tellez (Participant), Simon McDade (Participant) & Jacqueline James (Participant)
Impact: Health Impact, Quality of Life Impact