• Room 01.004 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr McDade functional genomics (FGG) lab, utilises a range of genomic technologies (RNA-seq, ChIP-seq, CRISPR screen) and integrative data analysis tools to identify novel treatment strategies to improve treatment of cancer patients outcomes. The labs field of interest include: - Transcription factor dysfunction in cancer - Epigenetic lab and data analysis tool development - Colorectal, Prostate and Squamous cancer - Data analysis and Shiny app development We are open to wide ranging lab and data analysis projects from those with a background biology, genomics, data analysis and computational backgrounds. Previous research experience is desirable although not essential

20052020

Research output per year

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Research Output

  • 38 Article
  • 1 Chapter (peer-reviewed)
  • 1 Meeting abstract
  • 1 Other contribution
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Article
2020

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, In : EMBO Reports. e49254.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
40 Downloads (Pure)

Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland

Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., Jan 2020, In : Cancer Epidemiology, Biomarkers, & Prevention. 29, 1, p. 31-38

Research output: Contribution to journalArticle

1 Citation (Scopus)

The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

Roberts, J. Z., Holohan, C., Sessler, T., Fox, J., Crawford, N., Riley, J. S., Khawaja, H., Majkut, J., Evergren, E., Humphreys, L. M., Ferris, J., Higgins, C., Espona-Fiedler, M., Moynagh, P., McDade, S. S. & Longley, D. B., 20 Apr 2020, In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
File
8 Downloads (Pure)
2019

A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

Gilmore, A., Alderdice, M., Savage, K., O’Reilly, P. G., Roddy, A., Dunne, P., Lawler, M., McDade, S., Waugh, D. & McArt, D., 13 Feb 2019, In : Cancer Research.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
23 Downloads (Pure)

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

Craig, S., Anderson, L., Schache, A., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Upile, N., Brooker, R., Mesri, M., Bingham, V., McQuaid, S., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., 20 Mar 2019, In : British Journal of Cancer.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
134 Downloads (Pure)
2018

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

McCann, C., Crawford, N., Majkut, J., Holohan, C., Armstrong, C., Maxwell, P., Ong, C. W., LaBonte Wilson, M., McDade, S., Waugh, D. & Longley, D., 22 Oct 2018, In : Cell, Death & Disease. 9, 1081, 13 p., 1081.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
187 Downloads (Pure)

Transcriptional Subtyping and CD8 Immunohistochemistry Identifies Patients With Stage II and III Colorectal Cancer With Poor Prognosis Who Benefit From Adjuvant Chemotherapy

Allen, W., Dunne, P., McDade, S., Scanlon, E., Loughrey, M., Coleman, H., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N. A., Jithesh, P. V., Arthur, K., Wilson, R., Coyle, V., McArt, D., Johnston, P., Murray, G. I., Samuel, L. M., Nuciforo, P., Jimenez, J. & 12 others, Argiles, G., Dienstmann, R., Picariello, L., Nobili, S., Mini, E., Sheahan, K., Ryan, E., Tabernero, J., Messerini, L., Van Schaeybroeck, S., Lawler, M. & Longley, D., 13 Jun 2018, In : JCO Precision Oncology. 2018, p. 1-15

Research output: Contribution to journalArticle

Open Access
File
267 Downloads (Pure)

ΔNp63γ/SRC/Slug signalling axis promotes epithelial-to-mesenchymal transition in squamous cancers

Srivastava, K., Pickard, A., Craig, S., Quinn, G., Lambe, S., James, J., McCance, D. & McDade, S., 08 May 2018, In : Clinical Cancer Research. 24, 16, p. 3917-3927 11 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
198 Downloads (Pure)
2017

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Dunne, P. D., Alderdice, M., O'Reilly, P. G., Roddy, A. C., McCorry, A. M. B., Richman, S., Maughan, T., McDade, S. S., Johnston, P. G., Longley, D. B., Kay, E., McArt, D. G. & Lawler, M., 31 May 2017, In : Nature Communications. 8, p. 15657 15657.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
324 Downloads (Pure)

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology

Walker, S. M., Knight, L. A., McCavigan, A. M., Logan, G. E., Berge, V., Sherif, A., Pandha, H., Warren, A. Y., Davidson, C., Uprichard, A., Blayney, J. K., Price, B., Jellema, G. L., Steele, C. J., Svindland, A., McDade, S. S., Eden, C. G., Foster, C., Mills, I. G., Neal, D. E. & 7 others, Mason, M. D., W Kay, E., Waugh, D. J., Harkin, D. P., Watson, R. W., Clarke, N. W. & Kennedy, R. D., 10 Apr 2017, In : European Urology.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
212 Downloads (Pure)

p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling

Srivastava, K., Pickard, A., McDade, S. & McCance, D. J., 2017, In : Oncotarget. 8, 10, p. 16202-16219 18 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
410 Downloads (Pure)

Transcription factor activities enhance markers of drug sensitivity in cancer

Garcia-Alonso, L. M., Iorio, F., Matchan, A., Fonseca, N. A., Jaaks, P., Peat, G., Pignatelli, M., Falcone, F., Benes, C. H., Dunham, I., Bignell, G. R., McDade, S., Garnett, M. J. & Saez-Rodriguez, J., 11 Dec 2017, In : Cancer Research. p. 1-35

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
126 Downloads (Pure)

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy

Jain, S., Lyons, C. A., Walker, S. M., McQuaid, S., Hynes, S., Mitchell, D., Pang, B., Logan, G. E., McCavigan, A. M., O'Rourke, D., McArt, D., McDade, S., Mills, I., Prise, K. M., Knight, L. A., Steele, C. J., Medlow, P. W., Berge, V., Katz, B., Loblaw, D. A. & 5 others, Harkin, D. P., James, J., O'Sullivan, J. M., Kennedy, R. D. & Waugh, D. J., 10 Oct 2017, In : Annals of Oncology.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
163 Downloads (Pure)
2016

Challenging the cancer molecular stratification dogma: Intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in colorectal cancer

Dunne, P. D., McArt, D. G., Bradley, C. A., O'Reilly, P. G., Barrett, H. L., Cummins, R., O'Grady, A., Arthur, K., Loughrey, M. B., Moore, W. L., McDade, S. S., Waugh, D. J., Hamilton, P. W., Longley, D. B., Kay, E. W., Johnston, P. G., Lawler, M., Salto-Tellez, M. & Van Schaeybroeck, S., 15 Aug 2016, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
241 Downloads (Pure)
Open Access
File
24 Citations (Scopus)
227 Downloads (Pure)

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib

Miller, R. E., Brough, R., Bajrami, I., Williamson, C. T., McDade, S., Campbell, J., Kigozi, A., Rafiq, R., Pemberton, H., Natrajan, R., Joel, J., Astley, H., Mahoney, C., Moore, J. D., Torrance, C., Gordan, J. D., Webber, J. T., Levin, R. S., Shokat, K. M., Bandyopadhyay, S. & 2 others, Lord, C. J. & Ashworth, A., 01 Jul 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1472-1484 13 p.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
363 Downloads (Pure)
2015

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

Brien, G. L., Healy, E., Jerman, E., Conway, E., Fadda, E., O'Donovan, D., Krivtsov, A. V., Rice, A. M., Kearney, C. J., Flaus, A., McDade, S. S., Martin, S. J., McLysaght, A., O'Connell, D. J., Armstrong, S. A. & Bracken, A. P., 01 Nov 2015, In : Genes and Development. 29, 21, p. 2231-43 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures

Pickard, A., McDade, S. S., McFarland, M., McCluggage, W. G., Wheeler, C. M. & McCance, D. J., Jun 2015, In : PLoS Pathogens. 11, 6, 23 p., 1004988.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
207 Downloads (Pure)
2014

BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability

Savage, K. I., Matchett, K. B., Barros, E. M., Cooper, K. M., Irwin, G. W., Gorski, J. J., Orr, K. S., Vohhodina, J., Kavanagh, J. N., Madden, A. F., Powell, A., Manti, L., McDade, S. S., Park, B. H., Prise, K. M., McIntosh, S. A., Salto-Tellez, M., Richard, D. J., Elliott, C. T., Harkin, D. P. & 1 others, McDade, S., 15 May 2014, In : Cancer Research. 74, 10, p. 2773-2784 12 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Functional and genetic analysis of the colon cancer network

Emmert-Streib, F., de Matos Simoes, R., Glazko, G., McDade, S., Haibe-Kains, B., Holzinger, A., Dehmer, M. & Campbell, F. C., 16 May 2014, In : BMC Bioinformatics. 15 , Suppl 6, 15 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
200 Downloads (Pure)

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

McDade, S. S., Patel, D., Moran, M., Campbell, J., Fenwick, K., Kozarewa, I., Orr, N. J., Lord, C. J., Ashworth, A. A. & McCance, D. J., 02 Jun 2014, In : Nucleic Acids Research. 42, 10, p. 6270-6285 16 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
222 Downloads (Pure)

Identification of a BRCA1-mRNA Splicing Complex Required for Efficient DNA Repair and Maintenance of Genomic Stability

Savage, K. I., Gorski, J. J., Barros, E. M., Irwin, G. W., Manti, L., Powell, A. J., Pellagatti, A., Lukashchuk, N., McCance, D. J., McCluggage, W. G., Schettino, G., Salto-Tellez, M., Boultwood, J., Richard, D. J., McDade, S. S. & Harkin, D. P., 08 May 2014, In : Molecular Cell. 54, 3, p. 445-459 15 p.

Research output: Contribution to journalArticle

Open Access
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85 Citations (Scopus)
247 Downloads (Pure)
2013

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells

Cichon, A-C., Pickard, A., McDade, S. S., Sharpe, D. J., Moran, M., James, J. A. & McCance, D. J., 14 Jul 2013, In : Oncotarget. 4, 7, p. 1103-1116 14 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
161 Downloads (Pure)

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner

Ray, S., Johnston, R., Campbell, D. C., Nugent, S., McDade, S. S., Waugh, D. & Panov, K. I., 19 Apr 2013, In : Gene. 526, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2012

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

Natrajan, R., Mackay, A., Lambros, M. B., Weigelt, B., Wilkerson, P. M., Manie, E., Grigoriadis, A., A'hern, R., van der Groep, P., Kozarewa, I., Popova, T., Mariani, O., Turajlic, S., Furney, S. J., Marais, R., Rodruigues, D-N., Flora, A. C., Wai, P., Pawar, V., McDade, S. & 13 others, Carroll, J., Stoppa-Lyonnet, D., Green, A. R., Ellis, I. O., Swanton, C., van Diest, P., Delattre, O., Lord, C. J., Foulkes, W. D., Vincent-Salomon, A., Ashworth, A., Henri Stern, M. & Reis-Filho, J. S., May 2012, In : Journal of Pathology. 227, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs

McDade, S. S., Chacko, A. D., Chanduloy, S., Church, S. W., Kennedy, R., Price, J., Hall, P. A. & Russell, S. E., 01 Apr 2012, In : Cellular Oncology. 35, 2, p. 85-93 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

McDade, S., Henry, A., Pivato, G., Kozarewa, I., Mitspoulos, C., Fenwick, K., Assiotis, I., Hakas, J., Zvelebil, M., Orr, N., Lord, C., Patel, D., Ashworth, A. & McCance, D., May 2012, In : Nucleic Acids Research. 40, 15, p. 7190-7206 17 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Orr, N., Lemnrau, A., Cooke, R., Fletcher, O., Tomczyk, K., Jones, M., Johnson, N., Lord, C. J., Mitsopoulos, C., Zvelebil, M., McDade, S. S., Buck, G., Blancher, C., Trainer, A. H., James, P. A., Bojesen, S. E., Bokmand, S., Nevanlinna, H., Mattson, J., Friedman, E. & 25 others, Laitman, Y., Palli, D., Masala, G., Zanna, I., Ottini, L., Giannini, G., Hollestelle, A., Ouweland, A. M. W. V. D., Novaković, S., Krajc, M., Gago-Dominguez, M., Castelao, J. E., Olsson, H., Hedenfalk, I., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Bishop, D. T., Neuhausen, S. L., Steele, L., Houlston, R. S., Garcia-Closas, M., Ashworth, A., Swerdlow, A. J. & KConFab Consortium, 23 Sep 2012, In : Nature Genetics. 44, 11, p. 1182-4 3 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2011

Evidence for Alteration of EZH2, BMI1, and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type 16 E6/E7-Expressing Keratinocytes

Hyland, P., McDade, S., McCloskey, R., Dickson, G., Authur, K., McCance, D. & Patel, D., Nov 2011, In : Journal of Virology. 85, 21, p. 10999-11006 8 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels

McDade, S., Patel, D. & McCance, D., 01 May 2011, In : Journal of Cell Science. 124, 10, p. 1635-1643 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis

Gorski, J. J., Savage, K. I., Mulligan, J. M., McDade, S. S., Blayney, J. K., Ge, Z. & Harkin, P., 01 Dec 2011, In : Nucleic Acids Research. 39, 22, p. 9536-9548 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Role of Delta Np63 gamma in Epithelial to Mesenchymal Transition

Lindsay, J., McDade, S., Pickard, A., McCloskey, K. & McCance, D., 04 Feb 2011, In : Journal of Biological Chemistry. 286, 5, p. 3915-3924 10 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

The Delta Np63 Proteins Are Key Allies of BRCA1 in the Prevention of Basal-Like Breast Cancer

Buckley, N., Conlon, S., Jirstrom, K., Kay, E. W., Crawford, N., O'Grady, A., Sheehan, K., McDade, S., Wang, C-W., McCance, D., Johnston, P., Kennedy, R., Harkin, P. & Mullan, P., 01 Mar 2011, In : Cancer Research. 71, 5, p. 1933-1944 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2010

MicroRNA 203 Expression in Keratinocytes Is Dependent on Regulation of p53 Levels by E6.

McKenna, D., McDade, S., Patel, D. & McCance, D., Oct 2010, In : Journal of Virology. 84, 20, p. 10644-10652 9 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

The role of p63 in epidermal morphogenesis and neoplasia

McDade, S. S. & McCance, D. J., 2010, In : Biochemical society transactions. 38, Pt 1, p. 223-8 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2007

Translational control of SEPT9 isoforms is perturbed in disease

McDade, S. S., Hall, P. A. & Russell, H., 01 Apr 2007, In : Human Molecular Genetics. 16, 7, p. 742-752 11 p.

Research output: Contribution to journalArticle

Open Access
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47 Citations (Scopus)
213 Downloads (Pure)
2005

SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity

Chacko, A. D., Hyland, P. L., McDade, S. S., Hamilton, P. W., Russell, S. E. H. & Hall, P. A., Aug 2005, In : American Journal of Pathology. 206, 4, p. 458-465 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

The Septin-Binding Protein Anillin is Over-Expressed in Diverse Human Tumours

Hall, P. A., Todd, C. B., Hyland, P. L., McDade, S. S., Grabsch, H., Dattani, M., Hillan, K. J. & Russell, S. E. H., 01 Oct 2005, In : Clinical Cancer Research. 11, 19, p. 6780-6786 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)