Projects per year
After graduating with a BSc (Hons) degree in Cell Biology and Molecular Genetics from University College Dublin, I completed a PhD in the Institute of Molecular Medicine, Trinity College Dublin (2001 – 2004). During this time, I developed an interest in innate host defence mechanisms in atherosclerosis and their modulation by dietary fatty acids. Following my PhD, I joined the Respiratory Research Division in the Royal College of Surgeons in Ireland as a postdoctoral scientist. In 2007, I moved to Queen’s University Belfast and I was appointed as a Lecturer in 2013.
Since 2004, I have been actively involved in research programmes centred on host defence mechanisms and their regulation in acute and chronic lung inflammation to better understand the pathogenesis of lung diseases, such as Cystic Fibrosis (CF), Chronic Obstructive Pulmonary Disease (COPD), Alpha-1 Antitrypsin Deficiency and Acute Respiratory Distress Syndrome (ARDS). These studies investigated the status, integrity and mechanisms of action of host defence proteins (e.g. antimicrobial peptides, antiproteases, proteases), how this activity may be compromised during disease and exploited for biomarker and therapeutic potential.
Full publication list available on Google Scholar.
Building on this experience, current research in our group focusses on:
- Identifying and developing biomarkers of pulmonary infection, inflammation and damage
- Characterising immunomodulatory properties of pulmonary proteases, antiproteases and microRNAs
- Investigating therapeutic strategies to prevent and repair the damage in chronic lung disease
- Developing novel peptides as anti-inflammatory and antimicrobial therapies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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02/01/2020 → …
15/04/2019 → 30/11/2021
06/09/2018 → 31/08/2019
R1744CEM: The role of Cathepsin S in PAR-1 mediated lung inflammation - a new paradigm for neutrophilic inflammation
26/04/2017 → 31/07/2020
Bateman, G., Guo-Parke, H., Rodgers, A. M., Linden, D., Bailey, M., Weldon, S., Kidney, J. C. & Taggart, C. C., 23 Jul 2023, In: Biomedicines. 11, 7, 14 p., 2072.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile30 Downloads (Pure)
In vitro evaluation of the potential use of snake-derived peptides in the treatment of respiratory infections using inhalation therapy: A proof of concept studyCreane, S., Joyce, M., MacLoughlin, R., Weldon, S., Dalton, J. P. & Taggart, C. C., 01 Apr 2023, In: European Journal of Pharmaceutical Sciences. 183, 106398.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile20 Downloads (Pure)
Altered Differentiation and Inflammation Profiles Contribute to Enhanced Innate Responses in Severe COPD Epithelium to Rhinovirus InfectionGuo-Parke, H., Linden, D., Mousnier, A., Scott, I. C., Killick, H., Borthwick, L. A., Fisher, A. J., Weldon, S., Taggart, C. C. & Kidney, J. C., 25 Feb 2022, In: Frontiers in Medicine. 9, 741989.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile43 Downloads (Pure)
McKelvey, M. C., Abladey, A. A., Small, D. M., Doherty, D. F., Williams, R., Scott, A., Spek, C. A., Borensztajn, K. S., Holsinger, L., Booth, R., O'Kane, C. M., McAuley, D. F., Taggart, C. C. & Weldon, S., 01 Apr 2022, In: American Journal of Respiratory and Critical Care Medicine. 205, 7, p. 769-782 14 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Guo-Parke, H., Linden, D., Weldon, S., Kidney, J. C. & Taggart, C. C., 13 Jan 2022, (Early online date) In: Medicina. 58, 1, 16 p., e121.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile56 Downloads (Pure)