• Room 02.021 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Dr Weldon is open to PhD applications from motivated and enthusiastic students in the areas of; - Airway inflammation and host defence - Repair and regeneration in the lung - MiRNAs as mediators of inflammation/disease and their potential therapeutic value - Pathogenesis of lung diseases such as Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Alpha-1-Antitrypsin Deficiency, Acute Respiratory Distress Syndrome

20042020
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Personal profile

Research Statement

After graduating with a BSc (Hons) degree in Cell Biology and Molecular Genetics from University College Dublin, I completed a PhD in the Institute of Molecular Medicine, Trinity College Dublin (2001 – 2004). During this time, I developed an interest in innate host defence mechanisms in atherosclerosis and their modulation by dietary fatty acids. Following my PhD, I joined the Respiratory Research Division in the Royal College of Surgeons in Ireland as a postdoctoral scientist. In 2007, I moved to Queen’s University Belfast and I was appointed as a Lecturer in 2013.

Since 2004, I have been actively involved in research programmes centred on host defence mechanisms and their regulation in acute and chronic lung inflammation to better understand the pathogenesis of lung diseases, such as Cystic Fibrosis (CF), Chronic Obstructive Pulmonary Disease (COPD), Alpha-1 Antitrypsin Deficiency and Acute Respiratory Distress Syndrome (ARDS). These studies investigated the status, integrity and mechanisms of action of host defence proteins (e.g. antimicrobial peptides, antiproteases, proteases), how this activity may be compromised during disease and exploited for biomarker and therapeutic potential.

Full publication list available on Google Scholar.

 

Research Interests

Building on this experience, current research in our group focusses on:

  • Identifying and developing biomarkers of pulmonary infection, inflammation and damage
  • Characterising immunomodulatory properties of pulmonary proteases, antiproteases and microRNAs
  • Investigating therapeutic strategies to prevent and repair the damage in chronic lung disease
  • Developing novel peptides as anti-inflammatory and antimicrobial therapies.

 

Achievements

Fingerprint Dive into the research topics where Sinead Weldon is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 9 Similar Profiles
Secretory Leukocyte Peptidase Inhibitor Medicine & Life Sciences
Cystic Fibrosis Medicine & Life Sciences
Elafin Medicine & Life Sciences
Lung Medicine & Life Sciences
cathepsin S Medicine & Life Sciences
Protease Inhibitors Medicine & Life Sciences
Lung Diseases Medicine & Life Sciences
Peptide Hydrolases Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2016 2020

Research Output 2004 2019

Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease

Brown, R., Paulsen, M., Schmidt, S., Schaterrny, J., Frank, A., Hirtz, S., Delaney, R., Doherty, D., Hagner, M., Taggart, C., Weldon, S. & Mall, M. A., 09 Sep 2019, In : American Journal of Respiratory Cell and Molecular Biology.

Research output: Contribution to journalArticle

Obstructive Lung Diseases
Pulmonary diseases
Interleukin-1 Receptors
Eosinophilia
Eosinophils
3 Citations (Scopus)
188 Downloads (Pure)

Protein Phosphatase 2A Reduces Cigarette Smoke-Induced Cathepsin S and Loss of Lung Function

Doherty, D. F., Nath, S., Poon, J., Foronjy, R. F., Ohlmeyer, M., Dabo, A. J., Salathe, M., Birrell, M., Belvisi, M., Baumlin, N., Kim, M. D., Weldon, S., Taggart, C. & Geraghty, P., 14 Jan 2019, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journalArticle

Open Access
File
cathepsin S
Protein Phosphatase 2
Smoke
Tobacco Products
Chronic Obstructive Pulmonary Disease
1 Citation (Scopus)
48 Downloads (Pure)

Sea snake cathelicidin (Hc-cath) exerts a protective effect in mouse models of lung inflammation and infection

Carlile, S. R., Shiels, J., Kerrigan, L., Delaney, R., Megaw, J., Gilmore, B. F., Weldon, S., Dalton, J. P. & Taggart, C. C., 15 Apr 2019, In : Scientific Reports. 9, 9 p., 6071.

Research output: Contribution to journalArticle

Open Access
File
Elapidae
Pseudomonas aeruginosa
Pneumonia
Inflammation
Elapid Venoms
1 Citation (Scopus)

Targeting of Cathepsin S Reduces Cystic Fibrosis-like Lung Disease

Small, D. M., Brown, R. R., Doherty, D. F., Abladey, A., Zhou- Suckow, Z., Delaney, R. J., Kerrigan, L., Dougan, C. M., Borensztajn, K. S., Holsinger, L., Booth, R., Scott, C. J., Lopez Campos, G., Elborn, J. S., Mall, M. A., Weldon, S. & Taggart, C. C., 28 Mar 2019, In : European Respiratory Journal. 53, 3, 1801523.

Research output: Contribution to journalArticle

cathepsin S
Cystic Fibrosis
Lung Diseases
Cats
Epithelial Sodium Channels
48 Downloads (Pure)
Open Access
File
Cystic Fibrosis
Lung Diseases
Peptide Hydrolases
Lung
cathepsin S