Projects per year
Personal profile
Research Interests
We are a Medicinal Chemistry and Chemical Biology group that focus on chemcial solutions to antimicrobial resistance. This includes the synthesis and mechanistic study of non-ribosomal antimicrobial peptides, and the synthesis and application of chemically labelled polyprenyls/glycolipids in antibiotic discovery or mechanistic studies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R1540CCE: Interrogating the Nisin:Lipid II Interaction: A Chemical Biology Approach
07/07/2021 → …
Project: Research
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R2395CCE: Uncovering the Mode of Action of Lipid II Flippase: A New Antibiotic Target
09/06/2017 → …
Project: Research
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R1485CCE: EPSRC Equipment Grant 2020 - Chemistry
Cochrane, S., Johnson, C. & Taylor, S.
19/11/2020 → 31/10/2022
Project: Research
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R1451CCE: UKRI COA EP/V5205241/1 - COA Allocation for R1972CCE
30/09/2020 → 30/06/2021
Project: Research
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A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens
Buijs, N. P., Vlaming, H. C., Kotsogianni, I., Arts, M., Willemse, J., Duan, Y., Alexander, F. M., Cochrane, S. A., Schneider, T. & Martin, N. I., 11 Jul 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 29, e2315310121.Research output: Contribution to journal › Article › peer-review
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Computational design of cyclic peptide inhibitors of a bacterial membrane lipoprotein peptidase
Craven, T. W., Nolan, M. D., Bailey, J., Olatunji, S., Bann, S. J., Bowen, K., Ostrovitsa, N., Da Costa, T. M., Ballantine, R. D., Weichert, D., Levine, P. M., Stewart, L. J., Bhardwaj, G., Geoghegan, J. A., Cochrane, S. A., Scanlan, E. M., Caffrey, M. & Baker, D., 17 May 2024, In: ACS Chemical Biology. 19, 5, p. 1125-1130 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Downloads (Pure) -
Discovery and derivatization of tridecaptin antibiotics with altered host specificity and enhanced bioactivity
Machushynets, N. V., Al Ayed, K., Terlouw, B. R., Du, C., Buijs, N. P., Willemse, J., Elsayed, S. S., Schill, J., Trebosc, V., Pieren, M., Alexander, F. M., Cochrane, S. A., Liles, M. R., Medema, M. H., Martin, N. I. & van Wezel, G. P., 11 Apr 2024, (Early online date) In: ACS Chemical Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Downloads (Pure) -
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism
Jekhmane, S., Derks, M., Maity, S., Slingerland, C., Tehrani, K., Medeiros-Silva, J., Charitou, V., Ammerlaan, D., Fetz, C., Consoli, N., Cochrane, R. V. K., Matheson, E. J., van der Weijde, M., Elenbaas, B., Lavore, F., Cox, R., Lorent, J., Baldus, M., Künzler, M. & Lelli, M. & 5 others, , 23 May 2024, (Early online date) In: Nature Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)24 Downloads (Pure) -
Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target
Karak, M., Cloonan, C. R., Baker, B., Cochrane, R. V. K. & Cochrane, S. A., 06 Feb 2024, In: Beilstein Journal of Organic Chemistry. 20, p. 220–227Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Downloads (Pure)
Prizes
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Sir Henry Wellcome Postdoctoral Fellowship
Cochrane, Stephen (Recipient), 23 Nov 2015
Prize: Fellowship awarded competitively
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Thieme Chemistry Journals Award
Cochrane, Stephen (Recipient), 27 Nov 2018
Prize: Prize (including medals and awards)
Activities
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RSC Medicinal Chemistry (Journal)
Stephen Cochrane (Peer reviewer)
23 Aug 2024Activity: Publication peer-review and editorial work types › Publication peer-review
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Journal of Medicinal Chemistry (Journal)
Stephen Cochrane (Peer reviewer)
19 Aug 2024Activity: Publication peer-review and editorial work types › Publication peer-review
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July 2024 EPSRC Physical Sciences Panel Member (Event)
Stephen Cochrane (Advisor)
16 Jul 2024 → 17 Jul 2024Activity: Membership types › Membership of peer review panel or committee
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Microbiological Research (Journal)
Stephen Cochrane (Peer reviewer)
12 Jul 2024Activity: Publication peer-review and editorial work types › Publication peer-review
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Labelling the Unlabellable: Semi-Synthesis of Labelled Polyprenyls for Chemical Biology Applications
Stephen Cochrane (Speaker)
10 Jul 2024Activity: Talk or presentation types › Invited talk
Press/Media
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Peer reviewers: chill out and don’t let the power go to your head
04/07/2024
1 Media contribution
Press/Media: Expert Comment
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Chemistry Olympics: A marathon in PPE and optimized jumping blades
29/06/2024
1 Media contribution
Press/Media: Public Engagement Activities
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ITV News - Queen's University scientist breaks new world record at London Marathon
22/04/2024
1 Media contribution
Press/Media: Public Engagement Activities
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Belfast Telegraph - Appliance of science sees QUB boffin set London Marathon record
22/04/2024
1 Media contribution
Press/Media: Public Engagement Activities