• Room 02.004 - David Keir Building David Keir

    United Kingdom

Accepting PhD Students

20112019
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Personal profile

Research Interests

Our lab uses the tools of organic synthesis, genetic engineering and molecular biology to study novel enzymatic processes, antimicrobial resistance mechanisms and the mechanism of action of antimicrobial and anticancer peptides

Fingerprint Dive into the research topics where Stephen Cochrane is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Lipopeptides Medicine & Life Sciences
Gram-Negative Bacteria Medicine & Life Sciences
Peptides Medicine & Life Sciences
Bacteriocins Medicine & Life Sciences
Bacteria Chemical Compounds
Anti-Bacterial Agents Medicine & Life Sciences
Campylobacter jejuni Medicine & Life Sciences
proline dipeptidase Medicine & Life Sciences

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Research Output 2011 2019

A Chemical-Intervention Strategy to Circumvent Peptide Hydrolysis by D-Stereoselective Peptidases

Bann, S., Ballantine, R., Li, Y-X., Qian, P-Y. & Cochrane, S., 28 Oct 2019, (Accepted) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Open Access
File
proline dipeptidase
Hydrolysis
Peptides
Anti-Bacterial Agents

Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II

Chiorean, S., Antwi, I., Carney, D., Kotsogianni, I., Giltrap, A., Alexander, F. M., Cochrane, S. A., Payne, R., Martin, N., Henninot, A. & Vederas, J., 24 Sep 2019, In : ChemBioChem. 6 p.

Research output: Contribution to journalArticle

Cell Wall
Cells
Peptides
Gram-Negative Bacteria
Bacteria
2 Citations (Scopus)

Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria

Ballantine, R., McCallion, C. E., Nassour, E., Tokajian, S. & Cochrane, S., 12 Mar 2019, In : Med Chem Commun. 10, 3, p. 484-487 4 p.

Research output: Contribution to journalArticle

Open Access
File
Bacteria
Peptides
Isoleucine
Anti-Bacterial Agents
Derivatives
5 Citations (Scopus)

Rational Design of New Cyclic Analogues of the Antimicrobial Lipopeptide Tridecaptin A1

Ballantine, R., Li, Y-X., Qian, P-Y. & Cochrane, S., 04 Sep 2018, In : Chemical Communications. p. 1-4

Research output: Contribution to journalArticle

Open Access
File
Lipopeptides
proline dipeptidase
Peptides
Antibiotics
Bacteria
9 Citations (Scopus)

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design

Dong, Y. Y., Wang, H., Pike, A. C. W., Cochrane, S. A., Hamedzadeh, S., Wyszynski, F., Bushell, S., Royer, S. F., Widdick, D. A., Sajid, A., Boshoff, H. I., Park, Y., Lucas, R., Liu, W-M., Lee, S. S., Machida, T., Minall, L., Mehmood, S., Belaya, K., Liu, W-W. & 12 othersChu, A., Shrestha, L., Mukhopadhyay, S. M. M., Strain-Damerell, C., Chalk, R., Burgess-Brown, N. A., Bibb, M., Barry 3rd, C., Robinson, C., Beeson, D., Davis, B. & Carpenter, E. P., 01 Nov 2018, In : Cell. 175, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

Open Access
File
Glycosylation
Tunicamycin
Anti-Bacterial Agents
Congenital Myasthenic Syndromes
Congenital Disorders of Glycosylation

Prizes

Sir Henry Wellcome Postdoctoral Fellowship

Stephen Cochrane (Recipient), 23 Nov 2015

Prize: Fellowship awarded competitively

Thieme Chemistry Journals Award

Stephen Cochrane (Recipient), 27 Nov 2018

Prize: Prize (including medals and awards)

Catalysis
Organic Chemistry

Activities 2014 2019

Nature Scientific Reports (Journal)

Stephen Cochrane (Peer reviewer)
19 Jul 2019

Activity: Publication peer-review and editorial work typesPublication peer-review

Molecules (Journal)

Stephen Cochrane (Peer reviewer)
05 Aug 2019

Activity: Publication peer-review and editorial work typesPublication peer-review

RSC Chemical Biology Symposium

Stephen Cochrane (Participant)
20 May 2019

Activity: Participating in or organising an event typesParticipation in conference

Semi-synthesis of labelled polyprenols as tools to study glycolipid-processing enzymes

Stephen Cochrane (Speaker)
06 Sep 2019

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Science Translational Medicine (Journal)

Stephen Cochrane (Peer reviewer)
02 Aug 2019

Activity: Publication peer-review and editorial work typesPublication peer-review