Projects per year
Personal profile
Research Interests
We are a Medicinal Chemistry and Chemical Biology group that focus on chemcial solutions to antimicrobial resistance. This includes the synthesis and mechanistic study of non-ribosomal antimicrobial peptides, and the synthesis and application of chemically labelled polyprenyls/glycolipids in antibiotic discovery or mechanistic studies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R2395CCE: Uncovering the Mode of Action of Lipid II Flippase: A New Antibiotic Target
Cochrane, S. (PI)
09/06/2017 → …
Project: Research
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R1540CCE: Interrogating the Nisin:Lipid II Interaction: A Chemical Biology Approach
Cochrane, S. (PI)
07/07/2021 → 22/03/2024
Project: Research
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R1485CCE: EPSRC Equipment Grant 2020 - Chemistry
Cochrane, S. (PI), Johnson, C. (CoI) & Taylor, S. (CoI)
19/11/2020 → 31/10/2022
Project: Research
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R1451CCE: UKRI COA EP/V5205241/1 - COA Allocation for R1972CCE
Cochrane, S. (PI)
30/09/2020 → 30/06/2021
Project: Research
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R1173CCE: Synthesis of Novel Brevicidine and Laterocidine Analogues
Cochrane, S. (PI)
20/05/2020 → 31/12/2023
Project: Research
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A novel approach for the synthesis of the cyclic lipopeptide globomycin
Bann, S. J. & Cochrane, S. A., 01 Jan 2025, In: RSC Medicinal Chemistry. 16, 1, p. 373-378 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)31 Downloads (Pure) -
Chemical diversification of polyprenyl quinones for mechanistic studies on menaquinone-binding peptide antibiotics
Matheson, E. J., van Beekveld, R. A. M., Innocenti, P., Martin, N. I., Weingarth, M. & Cochrane, S. A., 30 Jul 2025, In: Chemical Science. 16, 30, p. 13629-13635 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)7 Downloads (Pure) -
Hijacking the electron train: menaquinone-binding antimicrobial peptides
Matheson, E. J. & Cochrane, S. A., 18 Sept 2025, In: ChemBioChem. 26, 18, 11 p., e202500478.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Downloads (Pure) -
Lipid II unlocked: strategies for obtaining a major antibiotic target
Tyrie, L. J., Karak, M. & Cochrane, S. A., 25 Nov 2025, In: Chemical Communications. 61, 91, p. 17787-17809 23 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Lipid-modulated, graduated inhibition of N-glycosylation pathway priming suggests wide tolerance of ER proteostasis to stress
Giltrap, A. M., Morris, N., Dong, Y. Y., Cochrane, S. A., Krulle, T., Hoekman, S., Semmelroth, M., Wollnik, C., Palmai-Pallag, T., Carpenter, E. P., Hollick, J., Parkes, A., Rudhard, Y. & Davis, B. G., 22 Jan 2025, In: ACS Central Science. 11, 1, p. 107–115Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)8 Downloads (Pure)
Prizes
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Sir Henry Wellcome Postdoctoral Fellowship
Cochrane, S. (Recipient), 23 Nov 2015
Prize: Fellowship awarded competitively
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Thieme Chemistry Journals Award
Cochrane, S. (Recipient), 27 Nov 2018
Prize: Prize (including medals and awards)
Activities
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Peer Review of NSERC Discovery Award Application
Cochrane, S. (Reviewer)
04 Dec 2025Activity: Other activity types › Other
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Cross-Faculty Grant Success Series – New Investigator Award Session
Cochrane, S. (Invited speaker)
03 Dec 2025Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Queen’s University Belfast & Utrecht University Inaugural Colloquium
Cochrane, S. (Organiser)
16 Oct 2025 → 17 Oct 2025Activity: Participating in or organising an event types › Participation in conference
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Invited Talk at Manchester University - Leveraging the Lipids: Lipopeptides and Labelled Polyprenyls for Studying and Discovering Novel Antimicrobials
Cochrane, S. (Invited speaker)
08 Oct 2025Activity: Talk or presentation types › Invited talk
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ACS Infectious Diseases (Journal)
Cochrane, S. (Peer reviewer)
29 Sept 2025Activity: Publication peer-review and editorial work types › Publication peer-review
Press/Media
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Expert Opinion given on "Antibiotic found hiding in plain sight could treat dangerous infections, early study finds" for Live Science
10/11/2025
1 Media contribution
Press/Media: Expert Comment
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Québec Science Magazine - Il ya a un record pur ça !
01/09/2024
1 Media contribution
Press/Media: Public Engagement Activities
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Peer reviewers: chill out and don’t let the power go to your head
04/07/2024
1 Media contribution
Press/Media: Expert Comment
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Chemistry Olympics: A marathon in PPE and optimized jumping blades
29/06/2024
1 Media contribution
Press/Media: Public Engagement Activities
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