Research output per year
Research output per year
- 35 results
Search results
-
2024
A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens
Buijs, N. P., Vlaming, H. C., Kotsogianni, I., Arts, M., Willemse, J., Duan, Y., Alexander, F. M., Cochrane, S. A., Schneider, T. & Martin, N. I., 11 Jul 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 29, e2315310121.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Computational design of cyclic peptide inhibitors of a bacterial membrane lipoprotein peptidase
Craven, T. W., Nolan, M. D., Bailey, J., Olatunji, S., Bann, S. J., Bowen, K., Ostrovitsa, N., Da Costa, T. M., Ballantine, R. D., Weichert, D., Levine, P. M., Stewart, L. J., Bhardwaj, G., Geoghegan, J. A., Cochrane, S. A., Scanlan, E. M., Caffrey, M. & Baker, D., 17 May 2024, In: ACS Chemical Biology. 19, 5, p. 1125-1130 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure) -
Discovery and derivatization of tridecaptin antibiotics with altered host specificity and enhanced bioactivity
Machushynets, N. V., Al Ayed, K., Terlouw, B. R., Du, C., Buijs, N. P., Willemse, J., Elsayed, S. S., Schill, J., Trebosc, V., Pieren, M., Alexander, F. M., Cochrane, S. A., Liles, M. R., Medema, M. H., Martin, N. I. & van Wezel, G. P., 11 Apr 2024, (Early online date) In: ACS Chemical Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Downloads (Pure) -
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism
Jekhmane, S., Derks, M., Maity, S., Slingerland, C., Tehrani, K., Medeiros-Silva, J., Charitou, V., Ammerlaan, D., Fetz, C., Consoli, N., Cochrane, R. V. K., Matheson, E. J., van der Weijde, M., Elenbaas, B., Lavore, F., Cox, R., Lorent, J., Baldus, M., Künzler, M. & Lelli, M. & 5 others, , 23 May 2024, (Early online date) In: Nature Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)25 Downloads (Pure) -
Microbiome-derived antimicrobial peptides show therapeutic activity against the critically important priority pathogen, Acinetobacter baumannii
Alexander, P. J., Oyama, L. B., Olleik, H., Godoy Santos, F., O’Brien, S., Cookson, A., Cochrane, S. A., Gilmore, B. F., Maresca, M. & Huws, S. A., 30 Sept 2024, In: NPJ Biofilms and Microbiomes. 10, 13 p., 92.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Downloads (Pure) -
Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target
Karak, M., Cloonan, C. R., Baker, B., Cochrane, R. V. K. & Cochrane, S. A., 06 Feb 2024, In: Beilstein Journal of Organic Chemistry. 20, p. 220–227Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure) -
2023
Linearization of the brevicidine and laterocidine lipopeptides yields analogues that retain full antibacterial activity
Ballantine, R. D., Al Ayed, K., Bann, S. J., Hoekstra, M., Martin, N. I. & Cochrane, S. A., 27 Apr 2023, In: Journal of Medicinal Chemistry. 66, 8, p. 6002–6009 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)54 Downloads (Pure) -
Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic
Buijs, N. P., Matheson, E. J., Cochrane, S. A. & Martin, N. I., 25 Jun 2023, In: Chemical Communications. 59, 50, p. 7685-7703 19 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
2022
Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine
Ballantine, R. D., Al Ayed, K., Bann, S. J., Hoekstra, M., Martin, N. I. & Cochrane, S. A., 01 Dec 2022, In: RSC Medicinal Chemistry. 13, 12, p. 1640-1643 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)57 Downloads (Pure) -
Synthetic Studies with the Brevicidine and Laterocidine Lipopeptide Antibiotics Including Analogues with Enhanced Properties and in vivo Efficacy.
Al Ayed, K., Ballantine, R., Hoekstra, M., Bann, S., Wesseling, C., Bakker, A., Zhong, Z., Li, Y.-X., Brüchle, N., van der Stelt, M., Cochrane, S. & Martin, N., 2022, (Early online date) In: Chemical Science.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2021
Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin
Kotsogianni, I., Wood, T. M., Alexander, F. M., Cochrane, S. A. & Martin, N. I., 18 Aug 2021, (Early online date) In: ACS Infectious Diseases.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)108 Downloads (Pure) -
Purification of novel phospholipase A2 enzymes with anticancer activity from Pseudechis australis snake venom
Boncan, J., Bann, S., Cochrane, S., Cobice, D., McClean, S., Jordan, A., McCloskey, K. & Mills, K., 25 Sept 2021, p. 12. 1 p.Research output: Contribution to conference › Abstract › peer-review
-
The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria
Bann, S. J., Ballantine, R. D. & Cochrane, S. A., 22 Jan 2021, In: RSC Medicinal Chemistry. 12, p. 538-551Research output: Contribution to journal › Review article › peer-review
Open AccessFile16 Citations (Scopus)67 Downloads (Pure) -
Undecaprenol kinase: function, mechanism and substrate specificity of a potential antibiotic target
Baker, B. R., Ives, C. M., Bray, A., Caffrey, M. & Cochrane, S. A., 15 Jan 2021, In: European Journal of Medicinal Chemistry. 210, 12 p., 113062.Research output: Contribution to journal › Review article › peer-review
Open AccessFile7 Citations (Scopus)250 Downloads (Pure) -
2020
Breaking down the cell wall: strategies for antibiotic discovery targeting bacterial transpeptidases
Cochrane, S. & Lohans, C. T., 01 May 2020, In: European Journal of Medicinal Chemistry. 194, 15 p., 112262.Research output: Contribution to journal › Review article › peer-review
Open AccessFile39 Citations (Scopus)994 Downloads (Pure) -
From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets
Cochrane, R., Alexander, F., Boland, C., Fetics, S., Caffrey, M. & Cochrane, S., 29 Jun 2020, (Early online date) In: Chemical Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)64 Downloads (Pure) -
Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars
Calabrese, C., Uriarte, I., Vallejo-Lopez, M., Basterretxea, F., Cochrane, S., Davis, B., Corzana, F. & Cocinero, E. J., 2020, In: ACS Central Science. 6, 2, p. 293-303 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)72 Downloads (Pure) -
2019
A Chemical-Intervention Strategy to Circumvent Peptide Hydrolysis by D-Stereoselective Peptidases
Bann, S., Ballantine, R., Li, Y.-X., Qian, P.-Y. & Cochrane, S., 27 Nov 2019, In: Journal of Medicinal Chemistry. 62, 22, p. 10466-10472Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)176 Downloads (Pure) -
Dissecting the binding interactions of teixobactin with the bacterial cell wall precursor lipid II
Chiorean, S., Antwi, I., Carney, D., Kotsogianni, I., Giltrap, A., Alexander, F. M., Cochrane, S. A., Payne, R., Martin, N., Henninot, A. & Vederas, J., 24 Sept 2019, (Early online date) In: ChemBioChem. 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)253 Downloads (Pure) -
Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria
Ballantine, R., McCallion, C. E., Nassour, E., Tokajian , S. & Cochrane, S., 12 Mar 2019, In: Med Chem Commun. 10, 3, p. 484-487 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)260 Downloads (Pure) -
2018
Rational Design of New Cyclic Analogues of the Antimicrobial Lipopeptide Tridecaptin A1
Ballantine, R., Li, Y.-X., Qian, P.-Y. & Cochrane, S., 04 Sept 2018, (Early online date) In: Chemical Communications. p. 1-4Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)236 Downloads (Pure) -
Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design
Dong, Y. Y., Wang, H., Pike, A. C. W., Cochrane, S. A., Hamedzadeh, S., Wyszynski, F., Bushell, S., Royer, S. F., Widdick, D. A., Sajid, A., Boshoff, H. I., Park, Y., Lucas, R., Liu, W.-M., Lee, S. S., Machida, T., Minall, L., Mehmood, S., Belaya, K. & Liu, W.-W. & 12 others, , 01 Nov 2018, In: Cell. 175, p. 1045-1058 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)306 Downloads (Pure) -
2017
Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147
Bakhtiary, A., Cochrane, S. A., Mercier, P., McKay, R. T., Miskolzie, M., Sit, C. S. & Vederas, J. C., 13 Dec 2017, In: Journal of the American Chemical Society. 139, 49, p. 17803–17810Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)535 Downloads (Pure) -
2016
Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II
Cochrane, S. A., Findlay, B., Bakhtiary, A., Acedo, J. Z., Rodriguez-Lopez, E. M., Mercier, P. & Vederas, J. C., 11 Oct 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. 11561-11566 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile101 Citations (Scopus)368 Downloads (Pure) -
Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates
Cochrane, S. A. & Vederas, J. C., Jan 2016, In: Medicinal Research Reviews. 36, 1, p. 4-31 28 p.Research output: Contribution to journal › Article › peer-review
342 Citations (Scopus) -
2015
Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria
Cochrane, S. A., Lohans, C. T., van Belkum, M. J., Bels, M. A. & Vederas, J. C., 07 Jun 2015, In: Organic & biomolecular chemistry. 13, 21, p. 6073-6081Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria
Cochrane, S. A., Li, X., He, S., Yu, M., Wu, M. & Vederas, J. C., 24 Dec 2015, In: Journal of Medicinal Chemistry. 58, 24, p. 9779-85 7 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1
Cochrane, S. A., Surgenor, R. R., Khey, K. M. W. & Vederas, J. C., 06 Nov 2015, In: Organic Letters. 17, 21, p. 5428-31 4 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2014
Biochemical, structural, and genetic characterization of tridecaptin A₁, an antagonist of Campylobacter jejuni
Lohans, C. T., van Belkum, D. M. J., Cochrane, S. A., Huang, D. Z., Sit, D. C. S., McMullen, P. L. M. & Vederas, P. J. C., 24 Jan 2014, In: ChemBioChem. 15, 2, p. 243-249Research output: Contribution to journal › Article › peer-review
57 Citations (Scopus) -
Key residues in octyl-tridecaptin A1 analogues linked to stable secondary structures in the membrane
Cochrane, S. A., Findlay, D. B., Vederas, D. J. C. & Ratemi, D. E. S., 16 Jun 2014, In: ChemBioChem. 15, 9, p. 1295-9Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis)
Kwon, M., Cochrane, S. A., Vederas, J. C. & Ro, D.-K., 20 Dec 2014, In: FEBS Letters. 588, 24, p. 4597-4603Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1)
Cochrane, S. A., Lohans, C. T., Brandelli, J. R., Mulvey, G., Armstrong, G. D. & Vederas, J. C., 13 Feb 2014, In: Journal of Medicinal Chemistry. 57, 3, p. 1127-31Research output: Contribution to journal › Article › peer-review
53 Citations (Scopus) -
Unacylated tridecaptin A1 acts as an effective sensitiser of Gram-negative bacteria to other antibiotics
Cochrane, S. A. & Vederas, J. C., Dec 2014, In: International Journal of Antimicrobial Agents. 44, 6, p. 493-499Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
2013
Investigation of the ring-closing metathesis of peptides in water
Cochrane, S. A., Huang, Z. & Vederas, J. C., 28 Jan 2013, In: Organic & biomolecular chemistry. 11, 4, p. 630-9 10 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2011
Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147
Liu, W., Chan, A. S. H., Liu, H., Cochrane, S. A. & Vederas, J. C., 14 Sept 2011, In: Journal of the American Chemical Society. 133, 36, p. 14216-9 4 p.Research output: Contribution to journal › Article › peer-review
85 Citations (Scopus)