Projects per year
Personal profile
Research Interests
My research focuses on the application of mathematical models to enhance our understanding of biological responses to radiation, spanning a range of scales from individual cells to whole organisms.
In my PhD I developed models of how heavy-element nanoparticles impacted energy deposition in radiation therapy, with a focus on the use of gold nanoparticle to improve treatment outcomes. Comparison with experimental data led to the development of new models of biological response to these advanced exposures to better explain the nanoscale impact of these agents.
Following this, I have worked in a number of posts in both QUB and Massachusetts General Hospital, Boston, applying these techniques in a range of systems, including models of intercellular signalling, normal tissue complication, and intrinsic radiosensitivity.
I am continuing this work in my current post as a Queen's University Research Fellow within the CCRCB, building a portfolio of computational tools to better understand radiation responses, in systems such as proton therapy, nanoparticle-enhanced therapy, and radionuclide therapy. This work is being carried out with a range of national and international collaborators, including at the University of Manchester, Massachusetts General Hospital, and Oncoray Dresden.
Achievements
2018 recipient of the Radiation Research Society Jack Fowler Award for ourstanding junior investigators in radiobiology.
Recipient of a Marie Curie International Outgoing Fellowship from 2014-2017 in partnership with MGH.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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Development of a portable hypoxia chamber for ultra‑high dose rate laser‑driven proton radiobiology applications
Chaudhary, P., Gwynne, D., Odlozilik, B., McMurray, A., Milluzzo, G., Maiorino, C., Doria, D., Ahmed, H., Romagnani, L., Alejo, A., H, P., Green, J. S., Carroll, D., Booth, N., McKenna, P., Kar, S., Petringa, G., Catalano, R., Cammarata, F., Cirrone, G. A. P. & 3 others, , 15 Apr 2022, In: Radiation Oncology. 17, 77.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Differential responses to 223Ra and Alpha-particles exposure in prostate cancer driven by mitotic catastrophe
Guerra Liberal, F. D. C., Moreira, H., Redmond, K. M., O'Sullivan, J. M., Alshehri, A. H. D., Wright, T. C., Dunne, V. L., Campfield, C., Biggart, S., McMahon, S. J. & Prise, K. M., 28 Jul 2022, In: Frontiers in oncology. 12, 877302.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
DNA repair inhibitors potentiate fractionated radiotherapy more than single-dose radiotherapy in breast cancer cells
Wong, W-K., Guerra Liberal, F. D. C. & McMahon, S. J., 04 Aug 2022, (Early online date) In: Cancers. 14, 15, e3794.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Dose estimation after a mixed field exposure: Radium-223 and intensity modulated radiotherapy
Bastiani, I., McMahon, S. J., Turner, P., Redmond, K. M., McGarry, C. K., Cole, A., O'Sullivan, J. M., Prise, K. M., Ainsbury, L. & Anderson, R., 01 Mar 2022, In: Nuclear Medicine and Biology. 106-107, p. 10-20 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Downloads (Pure) -
Evaluating Iodine-125 DNA damage benchmarks of Monte Carlo DNA damage models
Thompson, S. J., Rooney, A., Prise, K. & McMahon, S., 18 Jan 2022, (Early online date) In: Cancers.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Downloads (Pure)
Prizes
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Jack Fowler Award
McMahon, Stephen (Recipient), 25 Sep 2018
Prize: Prize (including medals and awards)
Activities
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Agreements and disagreements in phenomenological proton RBE models
Stephen McMahon (Advisor)
Oct 2020Activity: Talk or presentation types › Oral presentation
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Mechanistic Modelling of Intrinsic Radiation Sensitivity
Stephen McMahon (Advisor)
16 Sep 2020Activity: Talk or presentation types › Invited talk
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Revisiting oxygen depletion models for FLASH radiotherapy
Stephen McMahon (Advisor)
04 Nov 2019Activity: Talk or presentation types › Oral presentation
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Is averaged LET a sufficient surrogate for proton radiobiology?
Stephen McMahon (Advisor)
08 Feb 2019Activity: Talk or presentation types › Oral presentation
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Analysis and Development of Phenomenological Models for the Relative Biological Effectiveness in Proton Therapy
Stephen McMahon (Examiner)
23 Aug 2019Activity: Examination types › PhD external examination
Press / Media
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Proton therapy for prostate cancer: does the evidence support the hype?
26/07/2019
1 Media contribution
Press/Media: Other
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Tumour growth models shed light on radionuclide therapy
Kevin Prise, Francisco Liberal, Joseph O'Sullivan, Stephen McMahon & Hugo Moreira
06/03/2019
1 Media contribution
Press/Media: Research
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Tumour growth models shed light on radionuclide therapy
06/03/2019
1 item of Media coverage
Press/Media: Research
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Radiosensitivity model addresses personalized therapy
Stephen McMahon, Aimee L. McNamara, Jan Schuemann, Harald Paganetti & Kevin Prise
06/10/2017
1 item of Media coverage
Press/Media: Research
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Radiosensitization: which element is optimal?
Stephen McMahon, Harald Paganetti & Kevin Prise
10/02/2016
1 item of Media coverage
Press/Media: Research