• Room 02.011 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr McMahon is open to PhD applications in areas of modelling responses to radiotherapy, including; - Proton Relative Biological Effectiveness - Intrinsic radio sensitivity - The impacts of intercellular communication on radiation responses

20082019
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Personal profile

Research Interests

My research focuses on the application of mathematical models to enhance our understanding of biological responses to radiation, spanning a range of scales from individual cells to whole organisms.

In my PhD I developed models of how heavy-element nanoparticles impacted energy deposition in radiation therapy, with a focus on the use of gold nanoparticle to improve treatment outcomes. Comparison with experimental data led to the development of new models of biological response to these advanced exposures to better explain the nanoscale impact of these agents.

Following this, I have worked in a number of posts in both QUB and Massachusetts General Hospital, Boston, applying these techniques in a range of systems, including models of intercellular signalling, normal tissue complication, and intrinsic radiosensitivity.

I am continuing this work in my current post as a Queen's University Research Fellow within the CCRCB, building a portfolio of computational tools to better understand radiation responses, in systems such as proton therapy, nanoparticle-enhanced therapy, and radionuclide therapy. This work is being carried out with a range of national and international collaborators, including at the University of Manchester, Massachusetts General Hospital, and Oncoray Dresden.

Achievements

2018 recipient of the Radiation Research Society Jack Fowler Award for ourstanding junior investigators in radiobiology.

Recipient of a Marie Curie International Outgoing Fellowship from 2014-2017 in partnership with MGH.

Fingerprint Dive into the research topics where Stephen McMahon is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 11 Similar Profiles
Radiotherapy Medicine & Life Sciences
Nanoparticles Medicine & Life Sciences
Radiation Medicine & Life Sciences
Gold Medicine & Life Sciences
Relative Biological Effectiveness Medicine & Life Sciences
Protons Medicine & Life Sciences
DNA Damage Medicine & Life Sciences
Cell Survival Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2008 2019

10 Citations (Scopus)
176 Downloads (Pure)

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
Clinical Medicine
Gadolinium
Nanoparticles
Radiation-Sensitizing Agents
Siloxanes
1 Citation (Scopus)
67 Downloads (Pure)

Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

Matsuya, Y., McMahon, S. J., Ghita, M., Yoshii, Y., Sato, T., Date, H. & Prise, K. M., 01 Jul 2019, In : Scientific Reports. 9, 1, p. 9483

Research output: Contribution to journalArticle

Open Access
File
Radiation
Cell Survival
Intensity-Modulated Radiotherapy
Survival
DNA
2 Citations (Scopus)
100 Downloads (Pure)

Mechanistic Modelling of Radiation Responses

McMahon, S. J. & Prise, K. M., 10 Feb 2019, In : Cancers. 11, 2, 23 p., 205.

Research output: Contribution to journalReview article

Open Access
File
Radiobiology
Radiation
Cell- and Tissue-Based Therapy
Linear Models
Radiotherapy

Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics

Oesten, H., von Neubeck, C., Jakob, A., Enghardt, W., Krause, M., McMahon, S., Grassberger, C., Paganetti, H. & Luhr, A., 22 Apr 2019, In : Radiation Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness

Newpower, M., Patel, D., Bronk, L., Guan, F., Chaudhary, P., McMahon, S. J., Prise, K. M., Schettino, G., Grosshans, D. R. & Mohan, R., 05 Feb 2019, In : International journal of radiation oncology, biology, physics.

Research output: Contribution to journalArticle

Relative Biological Effectiveness
proton energy
Protons
energy spectra
protons

Prizes

Jack Fowler Award

Stephen McMahon (Recipient), 25 Sep 2018

Prize: Prize (including medals and awards)

jacks
radiobiology
physics
radiation

Activities 2016 2017

  • 5 Invited or keynote talk at national or international conference
  • 3 Oral presentation

Mechanistic Predictions of Intrinsic Radiosensitivity

Stephen McMahon (Presenter)
11 Jan 2017

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Temporal modelling of DNA damage repair and implications for non-targeted effects

Stephen McMahon (Presenter)
17 Oct 2017

Activity: Talk or presentation typesOral presentation

Modelling and predicting the relative biological effectiveness of proton beam therapy

Stephen McMahon (Presenter)
15 Oct 2017

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Gold Nanoparticles: Macro- and Micro-Dosimetric Considerations and Implications for Radiosensitisation

Stephen McMahon (Presenter)
27 Jan 2016

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Gold Nanoparticle Radiosensitisation: More than just dose enhancement?

Stephen McMahon (Presenter)
15 Oct 2016

Activity: Talk or presentation typesInvited or keynote talk at national or international conference

Press / Media

Tumour growth models shed light on radionuclide therapy

Stephen McMahon

06/03/2019

1 item of Media coverage

Press/Media: Research

Tumour growth models shed light on radionuclide therapy

Kevin Prise, Francisco Liberal, Joseph O'Sullivan, Stephen McMahon & Hugo Moreira

06/03/2019

1 Media contribution

Press/Media: Research