Stephen McMahon

Queen's University Research Fellowship, School of Medicine, Dentistry and Biomedical Sciences
Centre for Cancer Research and Cell Biology

Phone+44 (0)28 9097 2620
Emailstephen.mcmahon@qub.ac.uk

Room 02.011 - CCRCB
United Kingdom

Accepting PhD Students

PhD projects

Dr McMahon is open to PhD applications in areas of modelling responses to radiotherapy, including; - Proton Relative Biological Effectiveness - Intrinsic radio sensitivity - The impacts of intercellular communication on radiation responses

Research output per year

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Personal profile

Research Interests

My research focuses on the application of mathematical models to enhance our understanding of biological responses to radiation, spanning a range of scales from individual cells to whole organisms.

In my PhD I developed models of how heavy-element nanoparticles impacted energy deposition in radiation therapy, with a focus on the use of gold nanoparticle to improve treatment outcomes. Comparison with experimental data led to the development of new models of biological response to these advanced exposures to better explain the nanoscale impact of these agents.

Following this, I have worked in a number of posts in both QUB and Massachusetts General Hospital, Boston, applying these techniques in a range of systems, including models of intercellular signalling, normal tissue complication, and intrinsic radiosensitivity.

I am continuing this work in my current post as a Queen's University Research Fellow within the CCRCB, building a portfolio of computational tools to better understand radiation responses, in systems such as proton therapy, nanoparticle-enhanced therapy, and radionuclide therapy. This work is being carried out with a range of national and international collaborators, including at the University of Manchester, Massachusetts General Hospital, and Oncoray Dresden.

Achievements

2018 recipient of the Radiation Research Society Jack Fowler Award for ourstanding junior investigators in radiobiology.

Recipient of a Marie Curie International Outgoing Fellowship from 2014-2017 in partnership with MGH.

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Research Output

67 Article
2 Chapter
2 Conference contribution
2 Meeting abstract
5 More

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journal › Article

Open Access

File

12 Citations (Scopus)

214 Downloads (Pure)

Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

Matsuya, Y., McMahon, S. J., Ghita, M., Yoshii, Y., Sato, T., Date, H. & Prise, K. M., 01 Jul 2019, In : Scientific Reports. 9, 1, p. 9483

Research output: Contribution to journal › Article

Open Access

File

1 Citation (Scopus)

91 Downloads (Pure)

Mechanistic Modelling of Radiation Responses

McMahon, S. J. & Prise, K. M., 10 Feb 2019, In : Cancers. 11, 2, 23 p., 205.

Research output: Contribution to journal › Review article

Open Access

File

3 Citations (Scopus)

121 Downloads (Pure)

Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics

Oesten, H., von Neubeck, C., Jakob, A., Enghardt, W., Krause, M., McMahon, S., Grassberger, C., Paganetti, H. & Luhr, A., 22 Apr 2019, In : Radiation Research.

Research output: Contribution to journal › Article