Projects per year
Personal profile
Research Interests
My research focuses on the application of mathematical models to enhance our understanding of biological responses to radiation, spanning a range of scales from individual cells to whole organisms.
In my PhD I developed models of how heavy-element nanoparticles impacted energy deposition in radiation therapy, with a focus on the use of gold nanoparticle to improve treatment outcomes. Comparison with experimental data led to the development of new models of biological response to these advanced exposures to better explain the nanoscale impact of these agents.
Following this, I have worked in a number of posts in both QUB and Massachusetts General Hospital, Boston, applying these techniques in a range of systems, including models of intercellular signalling, normal tissue complication, and intrinsic radiosensitivity.
I am continuing this work in my current post as a Queen's University Research Fellow within the CCRCB, building a portfolio of computational tools to better understand radiation responses, in systems such as proton therapy, nanoparticle-enhanced therapy, and radionuclide therapy. This work is being carried out with a range of national and international collaborators, including at the University of Manchester, Massachusetts General Hospital, and Oncoray Dresden.
Achievements
2018 recipient of the Radiation Research Society Jack Fowler Award for ourstanding junior investigators in radiobiology.
Recipient of a Marie Curie International Outgoing Fellowship from 2014-2017 in partnership with MGH.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Projects
- 1 Active
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A randomised feasibility trial of stereotactic prostate radiotherapy with or without elective nodal irradiation in high-risk localised prostate cancer (SPORT Trial)
Houlihan, O. A., Redmond, K., Fairmichael, C., Lyons, C. A., McGarry, C. K., Mitchell, D., Cole, A., O'Connor, J., McMahon, S., Irvine, D., Hyland, W., Hanna, M., Prise, K. M., Hounsell, A. R., O'Sullivan, J. M. & Jain, S., 08 Mar 2023, (Early online date) In: International Journal of Radiation Oncology Biology Physics.Research output: Contribution to journal › Article › peer-review
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Cellular irradiations with laser-driven carbon ions at ultra-high dose rates
Chaudhary, P., Milluzzo, G., McIlvenny, A., Ahmed, H., McMurray, A., Maiorino, C., Polin, K., Romagnani, L., Doria, D., McMahon, S. J., Botchway, S. W., Rajeev, P. P., Prise, K. M. & Borghesi, M., 09 Jan 2023, In: Physics in Medicine and Biology. 68, 025015.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
Investigating the potential contribution of inter-track interactions within ultra-high dose-rate proton therapy
Thompson, S. J., Prise, K. M. & McMahon, S. J., 02 Feb 2023, (Early online date) In: Physics in Medicine and Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields
Matsuya, Y., McMahon, S. J., Butterworth, K. T., Yachi, Y., Saga, R., Sato, T. & Prise, K. M., 23 Mar 2023, (Early online date) In: Physics in Medicine and Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Proposing a clinical model for RBE based on proton track-end counts
Henthorn, N. T., Gardner, L. L., Aitkenhead, A. H., Rowland, B. C., Shin, J., Smith, E. A. K., Merchant, M. J., Mackay, R. I., Kirkby, K. J., Chaudhary, P., Prise, K. M., McMahon, S. J. & Underwood, T. S. A., 12 Jan 2023, (Early online date) In: International journal of radiation oncology, biology, physics.Research output: Contribution to journal › Article › peer-review
Prizes
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Jack Fowler Award
McMahon, Stephen (Recipient), 25 Sep 2018
Prize: Prize (including medals and awards)
Activities
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Agreements and disagreements in phenomenological proton RBE models
Stephen McMahon (Advisor)
Oct 2020Activity: Talk or presentation types › Oral presentation
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Mechanistic Modelling of Intrinsic Radiation Sensitivity
Stephen McMahon (Advisor)
16 Sep 2020Activity: Talk or presentation types › Invited talk
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Mechanistic modelling of biological responses to radiation-induced damage
Stephen McMahon (Advisor)
06 Dec 2019Activity: Talk or presentation types › Invited talk
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Bridging the gap between physical interactions and biological responses
Stephen McMahon (Advisor)
05 Dec 2019Activity: Talk or presentation types › Oral presentation
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Revisiting oxygen depletion models for FLASH radiotherapy
Stephen McMahon (Advisor)
04 Nov 2019Activity: Talk or presentation types › Oral presentation
Press/Media
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Proton therapy for prostate cancer: does the evidence support the hype?
26/07/2019
1 Media contribution
Press/Media: Other
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Tumour growth models shed light on radionuclide therapy
Kevin Prise, Francisco Liberal, Joseph O'Sullivan, Stephen McMahon & Hugo Moreira
06/03/2019
1 Media contribution
Press/Media: Research
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Tumour growth models shed light on radionuclide therapy
06/03/2019
1 item of Media coverage
Press/Media: Research
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Radiosensitivity model addresses personalized therapy
Stephen McMahon, Aimee L. McNamara, Jan Schuemann, Harald Paganetti & Kevin Prise
06/10/2017
1 item of Media coverage
Press/Media: Research
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Radiosensitization: which element is optimal?
Stephen McMahon, Harald Paganetti & Kevin Prise
10/02/2016
1 item of Media coverage
Press/Media: Research