• Room 02.011 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr McMahon is open to PhD applications in areas of modelling responses to radiotherapy, including; - Proton Relative Biological Effectiveness - Intrinsic radio sensitivity - The impacts of intercellular communication on radiation responses

20082019

Research output per year

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Personal profile

Research Interests

My research focuses on the application of mathematical models to enhance our understanding of biological responses to radiation, spanning a range of scales from individual cells to whole organisms.

In my PhD I developed models of how heavy-element nanoparticles impacted energy deposition in radiation therapy, with a focus on the use of gold nanoparticle to improve treatment outcomes. Comparison with experimental data led to the development of new models of biological response to these advanced exposures to better explain the nanoscale impact of these agents.

Following this, I have worked in a number of posts in both QUB and Massachusetts General Hospital, Boston, applying these techniques in a range of systems, including models of intercellular signalling, normal tissue complication, and intrinsic radiosensitivity.

I am continuing this work in my current post as a Queen's University Research Fellow within the CCRCB, building a portfolio of computational tools to better understand radiation responses, in systems such as proton therapy, nanoparticle-enhanced therapy, and radionuclide therapy. This work is being carried out with a range of national and international collaborators, including at the University of Manchester, Massachusetts General Hospital, and Oncoray Dresden.

Achievements

2018 recipient of the Radiation Research Society Jack Fowler Award for ourstanding junior investigators in radiobiology.

Recipient of a Marie Curie International Outgoing Fellowship from 2014-2017 in partnership with MGH.

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Research Output

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
  • 12 Citations (Scopus)
    214 Downloads (Pure)

    Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

    Matsuya, Y., McMahon, S. J., Ghita, M., Yoshii, Y., Sato, T., Date, H. & Prise, K. M., 01 Jul 2019, In : Scientific Reports. 9, 1, p. 9483

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    91 Downloads (Pure)

    Mechanistic Modelling of Radiation Responses

    McMahon, S. J. & Prise, K. M., 10 Feb 2019, In : Cancers. 11, 2, 23 p., 205.

    Research output: Contribution to journalReview article

    Open Access
    File
  • 3 Citations (Scopus)
    121 Downloads (Pure)

    Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics

    Oesten, H., von Neubeck, C., Jakob, A., Enghardt, W., Krause, M., McMahon, S., Grassberger, C., Paganetti, H. & Luhr, A., 22 Apr 2019, In : Radiation Research.

    Research output: Contribution to journalArticle

    Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness

    Newpower, M., Patel, D., Bronk, L., Guan, F., Chaudhary, P., McMahon, S. J., Prise, K. M., Schettino, G., Grosshans, D. R. & Mohan, R., 05 Feb 2019, In : International journal of radiation oncology, biology, physics.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 2 Citations (Scopus)
    23 Downloads (Pure)

    Prizes

    Jack Fowler Award

    Stephen McMahon (Recipient), 25 Sep 2018

    Prize: Prize (including medals and awards)

  • Activities

    • 10 Oral presentation
    • 5 Invited or keynote talk at national or international conference
    • 1 Participation in workshop, seminar, course

    Early Career Researchers Forum Inaugural

    Aidan Cole (Organiser), Cristina Branco (Chair), Seyed Mehdi Jafarnejad (Organiser), Emma Allott (Organiser), Stephen McMahon (Participant), Karl Butterworth (Participant), Emma Kerr (Participant), Philip Dunne (Participant), Adone Tielenius Kruythoff-Mohd Sarip (Participant), Melissa LaBonte Wilson (Participant)
    25 Nov 2019

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    Mechanistic modelling to predict individual radiosensitivity to X-rays and heavy charged particles

    Stephen McMahon (Advisor)
    29 Aug 2019

    Activity: Talk or presentation typesOral presentation

    Is averaged LET a sufficient surrogate for proton radiobiology?

    Stephen McMahon (Advisor)
    08 Feb 2019

    Activity: Talk or presentation typesOral presentation

    Impact of Misrepair on DNA Double Strand Break Repair Kinetics

    Stephen McMahon (Advisor)
    26 Jun 2018

    Activity: Talk or presentation typesOral presentation

    Press / Media

    Tumour growth models shed light on radionuclide therapy

    Stephen McMahon

    06/03/2019

    1 item of Media coverage

    Press/Media: Research

    Tumour growth models shed light on radionuclide therapy

    Kevin Prise, Francisco Liberal, Joseph O'Sullivan, Stephen McMahon & Hugo Moreira

    06/03/2019

    1 Media contribution

    Press/Media: Research