• Room 02.011 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr McMahon is open to PhD applications in areas of modelling responses to radiotherapy, including; - Proton Relative Biological Effectiveness - Intrinsic radio sensitivity - The impacts of intercellular communication on radiation responses

20082019
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Research Output 2008 2019

2019
12 Citations (Scopus)
192 Downloads (Pure)

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
Clinical Medicine
Gadolinium
Nanoparticles
Radiation-Sensitizing Agents
Siloxanes
1 Citation (Scopus)
74 Downloads (Pure)

Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

Matsuya, Y., McMahon, S. J., Ghita, M., Yoshii, Y., Sato, T., Date, H. & Prise, K. M., 01 Jul 2019, In : Scientific Reports. 9, 1, p. 9483

Research output: Contribution to journalArticle

Open Access
File
Radiation
Cell Survival
Intensity-Modulated Radiotherapy
Survival
DNA
3 Citations (Scopus)
105 Downloads (Pure)

Mechanistic Modelling of Radiation Responses

McMahon, S. J. & Prise, K. M., 10 Feb 2019, In : Cancers. 11, 2, 23 p., 205.

Research output: Contribution to journalReview article

Open Access
File
Radiobiology
Radiation
Cell- and Tissue-Based Therapy
Linear Models
Radiotherapy

Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics

Oesten, H., von Neubeck, C., Jakob, A., Enghardt, W., Krause, M., McMahon, S., Grassberger, C., Paganetti, H. & Luhr, A., 22 Apr 2019, In : Radiation Research.

Research output: Contribution to journalArticle

2 Citations (Scopus)
6 Downloads (Pure)

Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness

Newpower, M., Patel, D., Bronk, L., Guan, F., Chaudhary, P., McMahon, S. J., Prise, K. M., Schettino, G., Grosshans, D. R. & Mohan, R., 05 Feb 2019, In : International journal of radiation oncology, biology, physics.

Research output: Contribution to journalArticle

Open Access
File
Relative Biological Effectiveness
proton energy
Protons
energy spectra
protons
2018
14 Citations (Scopus)
169 Downloads (Pure)

A New Standard DNA Damage (SDD) Data Format

Schuemann, J., McNamara, A. L., Warmenhoven, J. W., Henthorn, N. T., Kirkby, K. J., Merchant, M. J., Ingram, S., Paganetti, H., Held, K. D., Ramos-Mendez, J., Faddegon, B., Perl, J., Goodhead, D. T., Plante, I., Rabus, H., Nettelbeck, H., Friedland, W., Kundrát, P., Ottolenghi, A., Baiocco, G. & 35 others, Barbieri, S., Dingfelder, M., Incerti, S., Villagrasa, C., Bueno, M., Bernal, M. A., Guatelli, S., Sakata, D., Brown, J. M. C., Francis, Z., Kyriakou, I., Lampe, N., Ballarini, F., Carante, M. P., Davídková, M., Štěpán, V., Jia, X., Cucinotta, F. A., Schulte, R., Stewart, R. D., Carlson, D. J., Galer, S., Kuncic, Z., Lacombe, S., Milligan, J., Cho, S. H., Sawakuchi, G., Inaniwa, T., Sato, T., Li, W., Solov'yov, A. V., Surdutovich, E., Durante, M., Prise, K. M. & McMahon, S. J., 08 Nov 2018, In : Radiation Research. 191, 1, p. 76-92 17 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Damage
format
deoxyribonucleic acid
damage
DNA Repair
8 Citations (Scopus)
128 Downloads (Pure)

Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

Matsuya, Y., McMahon, S. J., Tsutsumi, K., Sasaki, K., Okuyama, G., Yoshii, Y., Mori, R., Oikawa, J., Prise, K. M. & Date, H., 29 May 2018, In : Scientific Reports. 8, 1, 14 p., 8287.

Research output: Contribution to journalArticle

Open Access
File
Ionizing Radiation
S Phase
Cell Cycle
Cell Survival
CHO Cells
3 Citations (Scopus)
148 Downloads (Pure)
Open Access
File
Linear Energy Transfer
Relative Biological Effectiveness
Protons
Radiotherapy
Biological Models
1 Citation (Scopus)
20 Downloads (Pure)

Mechanistic modelling of Radium-223 treatment of bone metastases

Moreira, H. M. R., Guerra Liberal, F. D. C., O'Sullivan, J. M., McMahon, S. J. & Prise, K. M., 14 Dec 2018, In : International journal of radiation oncology, biology, physics.

Research output: Contribution to journalArticle

Open Access
File
Radium
radium
metastasis
bones
tumors
3 Citations (Scopus)
129 Downloads (Pure)

Microbeam evolution: From single cell irradiation to pre-clinical studies

Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In : International journal of radiation biology.

Research output: Contribution to journalArticle

Open Access
File
Radiotherapy
Radiation
Synchrotrons
Organelles
DNA Damage
4 Citations (Scopus)
24 Downloads (Pure)
Open Access
File
toxicity
lungs
dosage
Lung
evaluation
3 Citations (Scopus)
55 Downloads (Pure)

Proton relative biological effectiveness (RBE): a multiscale problem

Underwood, T. & McMahon, S., 26 Jul 2018, In : British Journal of Radiology.

Research output: Contribution to journalArticle

Open Access
File
Relative Biological Effectiveness
Protons
Radiotherapy
Linear Energy Transfer
Photons
13 Citations (Scopus)
125 Downloads (Pure)

The linear quadratic model: usage, interpretation and challenges

McMahon, S., 19 Dec 2018, In : Physics in Medicine and Biology. 64, 1, p. 1-24

Research output: Contribution to journalArticle

Open Access
File
Linear Models
Cell Survival
Radiobiology
Physics
Ionizing Radiation
22 Citations (Scopus)
123 Downloads (Pure)
Open Access
File
Relative Biological Effectiveness
Proton Therapy
Radiobiology
Protons
Linear Energy Transfer
13 Citations (Scopus)
140 Downloads (Pure)

Toward A variable RBE for proton beam therapy

Willers, H., Allen, A., Grosshans, D., McMahon, S. J., von Neubeck, C., Wiese, C. & Vikram, B., 14 Jun 2018, In : Radiotherapy and Oncology.

Research output: Contribution to journalArticle

Open Access
File
Relative Biological Effectiveness
Proton Therapy
Protons
Neoplasms
Organs at Risk
2017
18 Citations (Scopus)
148 Downloads (Pure)

A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation

McMahon, S. J., McNamara, A. L., Schuemann, J., Paganetti, H. & Prise, K. M., 07 Sep 2017, In : Scientific Reports. 7, 1, 10790.

Research output: Contribution to journalArticle

Open Access
File
radiation
predictions
radiation tolerance
charged particles
dosage
17 Citations (Scopus)
135 Downloads (Pure)

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In : Scientific Reports. 7, 44752 .

Research output: Contribution to journalArticle

Open Access
File
Gold
Nanoparticles
X-Rays
DNA Damage
Radiation-Sensitizing Agents
2 Citations (Scopus)
155 Downloads (Pure)
Open Access
File
Prostate
Radiotherapy
Lymph Nodes
Seminal Vesicles
Prostatic Neoplasms
3 Citations (Scopus)
211 Downloads (Pure)
Open Access
File
Radiation Oncology
Nanotechnology
Oncology
nanotechnology
Radiotherapy
5 Citations (Scopus)

Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors

Underwood, T. S. A., Sung, W., McFadden, C. H., McMahon, S. J., Hall, D. C., McNamara, A. L., Paganetti, H., Sawakuchi, G. O. & Schuemann, J., 28 Mar 2017, In : Physics in Medicine and Biology. 62, 8, p. 3237-3249 13 p.

Research output: Contribution to journalArticle

Protons
Water
Linear Energy Transfer
Physics
Gold
26 Citations (Scopus)

Dependence of gold nanoparticle radiosensitization on cell geometry

Sung, W., Ye, S. J., McNamara, A. L., McMahon, S. J., Hainfeld, J., Shin, J., Smilowitz, H. M., Paganetti, H. & Schuemann, J., 14 May 2017, In : Nanoscale. 9, 18, p. 5843-5853 11 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Geometry
Cell membranes
Photons
125 Downloads (Pure)
Open Access
File
Bystander Effect
Radiation Effects
Apoptosis
Survival
Neoplasms
11 Citations (Scopus)
161 Downloads (Pure)

Mitochondria as a target for radiosensitisation by gold nanoparticles

McMahon, S. J., McNamara, A. L., Schuemann, J., Prise, K. M. & Paganetti, H., 03 Feb 2017, In : Journal of Physics: Conference Series. 777, 1, 012008.

Research output: Contribution to journalArticle

Open Access
File
mitochondria
gold
nanoparticles
deoxyribonucleic acid
cytoplasm
4 Citations (Scopus)
129 Downloads (Pure)
Open Access
File
Image-Guided Radiotherapy
Radiation
Radiotherapy
Therapeutics
Tumor Burden
2 Citations (Scopus)
759 Downloads (Pure)

Prostate cancer treated with brachytherapy; an exploratory study of dose-dependent biomarkers and quality of life

Osman, S. O. S., Horn, S., Brady, D., McMahon, S. J., Yoosuf, A. B. M., Mitchell, D., Crowther, K., Lyons, C. A., Hounsell, A. R., Prise, K. M., McGarry, C. K., Jain, S. & O'Sullivan, J. M., 14 Mar 2017, In : Radiation oncology (London, England). 12, 1, p. 53

Research output: Contribution to journalArticle

Open Access
File
Brachytherapy
Prostate
Prostatic Neoplasms
Biomarkers
Quality of Life
6 Citations (Scopus)
205 Downloads (Pure)
Open Access
File
Cone-Beam Computed Tomography
Radiotherapy
Radiobiology
Particle Accelerators
Calibration
1 Citation (Scopus)
hypoxia
radiation distribution
Cell Survival
Radiation
radiation therapy
2016
26 Citations (Scopus)

Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol

McNamara, A. L., Kam, W. W. Y., Scales, N., McMahon, S. J., Bennett, J. W., Byrne, H. L., Schuemann, J., Paganetti, H., Banati, R. & Kuncic, Z., 20 Jul 2016, In : Physics in Medicine and Biology. 61, 16, p. 5993-6010 18 p.

Research output: Contribution to journalArticle

Gold
Cytosol
Nanoparticles
Mitochondria
Organelles
58 Citations (Scopus)
222 Downloads (Pure)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
File
Radiation Effects
Gold
Nanoparticles
DNA Damage
Neoplasms
5 Citations (Scopus)
145 Downloads (Pure)
Open Access
File
DNA Damage
Appointments and Schedules
Radiation
Cell Line
Survival
26 Citations (Scopus)
160 Downloads (Pure)

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage

McMahon, S. J., Schuemann, J., Paganetti, H. & Prise, K. M., 2016, In : Scientific Reports. 6, 14 p., 33290.

Research output: Contribution to journalArticle

Open Access
File
DNA Repair
DNA Damage
Radiation
Radiation Tolerance
Ionizing Radiation
35 Citations (Scopus)
255 Downloads (Pure)

Optimising element choice for nanoparticle radiosensitisers

McMahon, S. J., Paganetti, H. & Prise, K. M., 2016, In : Nanoscale. 8, 1, p. 581-589 9 p.

Research output: Contribution to journalArticle

Open Access
File
Nanoparticles
Germanium
Radiation
Gadolinium
Silicon
17 Citations (Scopus)
126 Downloads (Pure)

Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

Taggart, L. E., McMahon, S. J., Butterworth, K. T., Currell, F. J., Schettino, G. & Prise, K. M., 15 Apr 2016, In : Nanotechnology. 27, 21, 11 p., 215101.

Research output: Contribution to journalArticle

Open Access
File
Protein Disulfide-Isomerases
Gold
Cells
Nanoparticles
Proteins
78 Citations (Scopus)

Roadmap to clinical use of gold nanoparticles for radiation sensitization

Schuemann, J., Berbeco, R., Chithrani, D. B., Cho, S. H., Kumar, R., McMahon, S. J., Sridhar, S. & Krishnan, S., 01 Jan 2016, In : International journal of radiation oncology, biology, physics. 94, 1, p. 189-205 17 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Radiation
gold
nanoparticles
131 Downloads (Pure)

WE-H-BRA-07: Mechanistic Modelling of the Relative Biological Effectiveness of Heavy Charged Particles

McMahon, S., McNamara, A., Schuemann, J., Prise, K. & Paganetti, H., Jun 2016, In : Medical Physics. 43, 6, p. 3844

Research output: Contribution to journalMeeting abstract

Open Access
File
Relative Biological Effectiveness
2015
58 Citations (Scopus)

Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy

Lin, Y., McMahon, S., Paganetti, H. & Schuemann, J., 07 May 2015, In : Physics in Medicine and Biology. 60, 10, p. 4149

Research output: Contribution to journalArticle

8 Citations (Scopus)
215 Downloads (Pure)
Open Access
File
Radiotherapy
Uncertainty
Neoplasms
Cell Survival
Radiation
4 Citations (Scopus)
171 Downloads (Pure)
Open Access
File
Radiation
Neoplasms
Tumor Burden
Survival
Prostate
19 Citations (Scopus)

Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons

Lin, Y., Paganetti, H., McMahon, S. J. & Schuemann, J., 17 Sep 2015, In : Medical Physics. 42, 10, p. 5890-5902 13 p.

Research output: Contribution to journalArticle

Photons
Gold
Nanoparticles
Protons
Radiotherapy
133 Downloads (Pure)

MO-FG-BRA-06: Material Optimisation for Nanoparticle-Sensitized Radiotherapy

McMahon, S., Paganetti, H. & Prise, K., Jun 2015, In : Medical Physics. 42, 6, 3565.

Research output: Contribution to journalArticle

Open Access
File
Nanoparticles
Radiotherapy
4 Citations (Scopus)
154 Downloads (Pure)
Open Access
File
Cultured Tumor Cells
fibroblasts
radiation distribution
tumors
Fibroblasts
2014
81 Citations (Scopus)

Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation

Lin, Y., McMahon, S., Scarpelli, M., Paganetti, H. & Schuemann, J., 21 Nov 2014, In : Physics in Medicine and Biology. 59, 24, p. 7675-7689 15 p.

Research output: Contribution to journalArticle

Photons
Gold
Nanoparticles
Protons
Radiotherapy
46 Citations (Scopus)

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
Four-Dimensional Computed Tomography
Lung Neoplasms
Radiotherapy
Organs at Risk
Dyspnea
2 Citations (Scopus)
177 Downloads (Pure)
Open Access
File
Radiotherapy
X-Rays
Cell Survival
Therapeutics
Non-Small Cell Lung Carcinoma
85 Citations (Scopus)
277 Downloads (Pure)

Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

Chaudhary, P., I Marshall, T., Perozziello, F. M., Manti, L., Currell, F. J., Hanton, F., McMahon, S. J., Kavanagh, J. N., Cirrone, G. A. P., Romano, F., Prise, K. M. & Schettino, G., 01 Sep 2014, In : International Journal of Radiation: Oncology - Biology - Physics. 90, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Open Access
File
Relative Biological Effectiveness
proton beams
Linear Energy Transfer
linear energy transfer (LET)
Protons
52 Citations (Scopus)
234 Downloads (Pure)

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Taggart, L. E., McMahon, S. J., Currell, F. J., Prise, K. M. & Butterworth, K. T., 16 Sep 2014, In : Cancer Nanotechnology. 5, 5, 12 p., PMC4164854.

Research output: Contribution to journalArticle

Open Access
File
Gold
Nanoparticles
gold
nanoparticles
Radiation-Sensitizing Agents
85 Citations (Scopus)
204 Downloads (Pure)

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy

Sancey, L., Lux, F., Kotb, S., Roux, S., Dufort, S., Bianchi, A., Cremillieux, Y., Fries, P., Coll, J-L., Rodriguez-Lafrasse, C., Janier, M., Dutreix, M., Barberi-Heyob, M., Boschetti, F., Denat, F., Louis, C., Porcel, E., Lacombe, S., Le Duc, G., Deutsch, E. & 9 others, Perfettini, J-L., Detappe, A., Verry, C., Berbeco, R., Butterworth, K. T., Mcmahon, S. J., Prise, K. M., Perriat, P. & Tillement, O., Sep 2014, In : British Journal of Radiology. 87, 1041, 15 p., 20140134.

Research output: Contribution to journalLiterature review

Open Access
File
2 Citations (Scopus)

Using Process Algebra to Model Radiation Induced Bystander Effects

Lintott, R., McMahon, S., Prise, K., Addie-Lagorio, C. & Shankland, C., 2014, Computational Methods in Systems Biology: 12th International Conference, CMSB 2014, Manchester, UK, November 17-19, 2014, Proceedings. Springer-Verlag, Vol. 8859. p. 196-210 15 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 8859).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Process Algebra
Algebra
Radiation
Dose
Cell