• Room 02.011 - CCRCB

    United Kingdom

Accepting PhD Students

PhD projects

Dr McMahon is open to PhD applications in areas of modelling responses to radiotherapy, including; - Proton Relative Biological Effectiveness - Intrinsic radio sensitivity - The impacts of intercellular communication on radiation responses

20082019

Research output per year

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Research Output

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Article
2019

AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

Lux, F., Tran, V. L., Thomas, E., Dufort, S., Rossetti, F., Martini, M., Truillet, C., Doussineau, T., Bort, G., Denat, F., Boschetti, F., Angelovski, G., Detappe, A., Crémillieux, Y., Mignet, N., Doan, B-T., Larrat, B., Meriaux, S., Barbier, E., Roux, S. & 28 others, Fries, P., Müller, A., Abadjian, M-C., Anderson, C., Canet-Soulas, E., Bouziotis, P., Barberi-Heyob, M., Frochot, C., Verry, C., Balosso, J., Evans, M., Sidi-Boumedine, J., Janier, M., Butterworth, K., McMahon, S., Prise, K., Aloy, M-T., Ardail, D., Rodriguez-Lafrasse, C., Porcel, E., Lacombe, S., Berbeco, R., Allouch, A., Perfettini, J-L., Chargari, C., Deutsch, E., Le Duc, G. & Tillement, O., 01 Jan 2019, In : British Journal of Radiology. 92, 1093, 19 p., 20180365.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
214 Downloads (Pure)

Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

Matsuya, Y., McMahon, S. J., Ghita, M., Yoshii, Y., Sato, T., Date, H. & Prise, K. M., 01 Jul 2019, In : Scientific Reports. 9, 1, p. 9483

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
91 Downloads (Pure)

Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics

Oesten, H., von Neubeck, C., Jakob, A., Enghardt, W., Krause, M., McMahon, S., Grassberger, C., Paganetti, H. & Luhr, A., 22 Apr 2019, In : Radiation Research.

Research output: Contribution to journalArticle

Using the Proton Energy Spectrum and Microdosimetry To Model Proton Relative Biological Effectiveness

Newpower, M., Patel, D., Bronk, L., Guan, F., Chaudhary, P., McMahon, S. J., Prise, K. M., Schettino, G., Grosshans, D. R. & Mohan, R., 05 Feb 2019, In : International journal of radiation oncology, biology, physics.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
24 Downloads (Pure)
2018

A New Standard DNA Damage (SDD) Data Format

Schuemann, J., McNamara, A. L., Warmenhoven, J. W., Henthorn, N. T., Kirkby, K. J., Merchant, M. J., Ingram, S., Paganetti, H., Held, K. D., Ramos-Mendez, J., Faddegon, B., Perl, J., Goodhead, D. T., Plante, I., Rabus, H., Nettelbeck, H., Friedland, W., Kundrát, P., Ottolenghi, A., Baiocco, G. & 35 others, Barbieri, S., Dingfelder, M., Incerti, S., Villagrasa, C., Bueno, M., Bernal, M. A., Guatelli, S., Sakata, D., Brown, J. M. C., Francis, Z., Kyriakou, I., Lampe, N., Ballarini, F., Carante, M. P., Davídková, M., Štěpán, V., Jia, X., Cucinotta, F. A., Schulte, R., Stewart, R. D., Carlson, D. J., Galer, S., Kuncic, Z., Lacombe, S., Milligan, J., Cho, S. H., Sawakuchi, G., Inaniwa, T., Sato, T., Li, W., Solov'yov, A. V., Surdutovich, E., Durante, M., Prise, K. M. & McMahon, S. J., 08 Nov 2018, In : Radiation Research. 191, 1, p. 76-92 17 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
187 Downloads (Pure)

Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

Matsuya, Y., McMahon, S. J., Tsutsumi, K., Sasaki, K., Okuyama, G., Yoshii, Y., Mori, R., Oikawa, J., Prise, K. M. & Date, H., 29 May 2018, In : Scientific Reports. 8, 1, 14 p., 8287.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
146 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
166 Downloads (Pure)

Mechanistic modelling of Radium-223 treatment of bone metastases

Moreira, H. M. R., Guerra Liberal, F. D. C., O'Sullivan, J. M., McMahon, S. J. & Prise, K. M., 14 Dec 2018, In : International journal of radiation oncology, biology, physics.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
41 Downloads (Pure)

Microbeam evolution: From single cell irradiation to pre-clinical studies

Ghita, M., Fernandez-Palomo, C., Fukunaga, H., Fredericia, P. M., Schettino, G., Bräuer-Krisch, E., Butterworth, K. T., McMahon, S. J. & Prise, K. M., 22 Jan 2018, In : International journal of radiation biology.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
149 Downloads (Pure)
4 Citations (Scopus)
41 Downloads (Pure)

Proton relative biological effectiveness (RBE): a multiscale problem

Underwood, T. & McMahon, S., 26 Jul 2018, In : British Journal of Radiology.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
72 Downloads (Pure)

The linear quadratic model: usage, interpretation and challenges

McMahon, S., 19 Dec 2018, In : Physics in Medicine and Biology. 64, 1, p. 1-24

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
147 Downloads (Pure)
Open Access
File
22 Citations (Scopus)
143 Downloads (Pure)

Toward A variable RBE for proton beam therapy

Willers, H., Allen, A., Grosshans, D., McMahon, S. J., von Neubeck, C., Wiese, C. & Vikram, B., 14 Jun 2018, In : Radiotherapy and Oncology.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
157 Downloads (Pure)
2017

A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation

McMahon, S. J., McNamara, A. L., Schuemann, J., Paganetti, H. & Prise, K. M., 07 Sep 2017, In : Scientific Reports. 7, 1, 10790.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
165 Downloads (Pure)

A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation

Ghita, M., McMahon, S. J., Taggart, L. E., Butterworth, K. T., Schettino, G. & Prise, K. M., 16 Mar 2017, In : Scientific Reports. 7, 44752 .

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
151 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
172 Downloads (Pure)

Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors

Underwood, T. S. A., Sung, W., McFadden, C. H., McMahon, S. J., Hall, D. C., McNamara, A. L., Paganetti, H., Sawakuchi, G. O. & Schuemann, J., 28 Mar 2017, In : Physics in Medicine and Biology. 62, 8, p. 3237-3249 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Dependence of gold nanoparticle radiosensitization on cell geometry

Sung, W., Ye, S. J., McNamara, A. L., McMahon, S. J., Hainfeld, J., Shin, J., Smilowitz, H. M., Paganetti, H. & Schuemann, J., 14 May 2017, In : Nanoscale. 9, 18, p. 5843-5853 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
Open Access
File
139 Downloads (Pure)

Mitochondria as a target for radiosensitisation by gold nanoparticles

McMahon, S. J., McNamara, A. L., Schuemann, J., Prise, K. M. & Paganetti, H., 03 Feb 2017, In : Journal of Physics: Conference Series. 777, 1, 012008.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
177 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
147 Downloads (Pure)

Prostate cancer treated with brachytherapy; an exploratory study of dose-dependent biomarkers and quality of life

Osman, S. O. S., Horn, S., Brady, D., McMahon, S. J., Yoosuf, A. B. M., Mitchell, D., Crowther, K., Lyons, C. A., Hounsell, A. R., Prise, K. M., McGarry, C. K., Jain, S. & O'Sullivan, J. M., 14 Mar 2017, In : Radiation oncology (London, England). 12, 1, p. 53

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
782 Downloads (Pure)
Open Access
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6 Citations (Scopus)
222 Downloads (Pure)
1 Citation (Scopus)
2016

Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol

McNamara, A. L., Kam, W. W. Y., Scales, N., McMahon, S. J., Bennett, J. W., Byrne, H. L., Schuemann, J., Paganetti, H., Banati, R. & Kuncic, Z., 20 Jul 2016, In : Physics in Medicine and Biology. 61, 16, p. 5993-6010 18 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Imaging and radiation effects of gold nanoparticles in tumour cells

McQuaid, H. N., Muir, M. F., Taggart, L. E., McMahon, S. J., Coulter, J. A., Hyland, W. B., Jain, S., Butterworth, K. T., Schettino, G., Prise, K. M., Hirst, D., Botchway, S. W. & Currell, F., 20 Jan 2016, In : Scientific Reports. 6, 10 p., 19442.

Research output: Contribution to journalArticle

Open Access
File
58 Citations (Scopus)
239 Downloads (Pure)
Open Access
File
5 Citations (Scopus)
167 Downloads (Pure)

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage

McMahon, S. J., Schuemann, J., Paganetti, H. & Prise, K. M., 2016, In : Scientific Reports. 6, 14 p., 33290.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
180 Downloads (Pure)

Optimising element choice for nanoparticle radiosensitisers

McMahon, S. J., Paganetti, H. & Prise, K. M., 2016, In : Nanoscale. 8, 1, p. 581-589 9 p.

Research output: Contribution to journalArticle

Open Access
File
35 Citations (Scopus)
284 Downloads (Pure)

Protein disulphide isomerase as a target for nanoparticle-mediated sensitisation of cancer cells to radiation

Taggart, L. E., McMahon, S. J., Butterworth, K. T., Currell, F. J., Schettino, G. & Prise, K. M., 15 Apr 2016, In : Nanotechnology. 27, 21, 11 p., 215101.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
144 Downloads (Pure)

Roadmap to clinical use of gold nanoparticles for radiation sensitization

Schuemann, J., Berbeco, R., Chithrani, D. B., Cho, S. H., Kumar, R., McMahon, S. J., Sridhar, S. & Krishnan, S., 01 Jan 2016, In : International journal of radiation oncology, biology, physics. 94, 1, p. 189-205 17 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)
2015

Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy

Lin, Y., McMahon, S., Paganetti, H. & Schuemann, J., 07 May 2015, In : Physics in Medicine and Biology. 60, 10, p. 4149

Research output: Contribution to journalArticle

58 Citations (Scopus)
Open Access
File
8 Citations (Scopus)
233 Downloads (Pure)
4 Citations (Scopus)
187 Downloads (Pure)

Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons

Lin, Y., Paganetti, H., McMahon, S. J. & Schuemann, J., 17 Sep 2015, In : Medical Physics. 42, 10, p. 5890-5902 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

MO-FG-BRA-06: Material Optimisation for Nanoparticle-Sensitized Radiotherapy

McMahon, S., Paganetti, H. & Prise, K., Jun 2015, In : Medical Physics. 42, 6, 3565.

Research output: Contribution to journalArticle

Open Access
File
150 Downloads (Pure)
Open Access
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4 Citations (Scopus)
170 Downloads (Pure)
2014

Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation

Lin, Y., McMahon, S., Scarpelli, M., Paganetti, H. & Schuemann, J., 21 Nov 2014, In : Physics in Medicine and Biology. 59, 24, p. 7675-7689 15 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Gold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditions

Jain, S., Coulter, J. A., Butterworth, K. T., Hounsell, A. R., McMahon, S. J., Hyland, W. B., Muir, M. F., Dickson, G. R., Prise, K. M., Currell, F. J., Hirst, D. G. & O'Sullivan, J. M., Feb 2014, In : Radiotherapy and Oncology. 110, 2, p. 342-347 6 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
9 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
195 Downloads (Pure)

Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment

Chaudhary, P., I Marshall, T., Perozziello, F. M., Manti, L., Currell, F. J., Hanton, F., McMahon, S. J., Kavanagh, J. N., Cirrone, G. A. P., Romano, F., Prise, K. M. & Schettino, G., 01 Sep 2014, In : International Journal of Radiation: Oncology - Biology - Physics. 90, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Open Access
File
85 Citations (Scopus)
295 Downloads (Pure)

The role of mitochondrial function in gold nanoparticle mediated radiosensitisation

Taggart, L. E., McMahon, S. J., Currell, F. J., Prise, K. M. & Butterworth, K. T., 16 Sep 2014, In : Cancer Nanotechnology. 5, 5, 12 p., PMC4164854.

Research output: Contribution to journalArticle

Open Access
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52 Citations (Scopus)
253 Downloads (Pure)
2013

A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

McMahon, S. J., Butterworth, K. T., Trainor, C., McGarry, C. K., O'Sullivan, J. M., Schettino, G., Hounsell, A. R. & Prise, K. M., 22 Jan 2013, In : PloS one. 8, 1, 12 p., e54526.

Research output: Contribution to journalArticle

Open Access
File
37 Citations (Scopus)
131 Downloads (Pure)
21 Citations (Scopus)

Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest

Kavanagh, J. N., Currell, F. J., Timson, D. J., Savage, K. I., Richard, D. J., McMahon, S. J., Hartley, O., Cirrone, G. A. P., Romano, F., Prise, K. M., Bassler, N., Holzscheiter, M. H. & Schettino, G., 03 May 2013, In : Scientific Reports. 3, 10 p., 1770.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
184 Downloads (Pure)
Open Access
File
33 Citations (Scopus)
177 Downloads (Pure)
16 Citations (Scopus)
39 Downloads (Pure)