Projects per year
Personal profile
Research Statement
My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
In addition to my teaching commitments at undergraduate and postgraduate level, I also act as one of the Deputy Directors for the Wellcome-Wolfson Institute for Experimental Medicine and Academic Lead for the Faculty of Medicine, Health and Life Sciences Advanced Imaging Core Technology Unit (CTU).
Further information on the work in my laboratory can be found at:
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Projects
R2513CEM: Molecular dissection of the retina to elucidate early changes in diabetes
18/07/2018 → …
Project: Research
R2374CEM: Evaluation of CAMKII as a therapeutic target for diabetic macular oedema
30/03/2017 → …
Project: Research
R4745CEM: COMP-Ang1: Vascular Normalization and Neuroprotection for Diabetic Retinopathy
Curtis, T., Medina, R. & Stitt, A.
28/01/2016 → …
Project: Research
Research Output
Ion channels and myogenic activity in retinal arterioles
Barabas, P., Augustine, J., Fernandez Gonzalez, J., McGeown, G., McGahon, M. & Curtis, T., 26 Feb 2020, In : Current Topics in Membranes. 85, 44 p.Research output: Contribution to journal › Article
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In : JCI insight. 4, 6, 18 p., e122442.Research output: Contribution to journal › Article
Open Access
File
2
Citations
(Scopus)
181
Downloads
(Pure)
COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells
Rochfort, K. D., Carroll, L. S., Barabas, P., Curtis, T. M., Ambati, B. K., Barron, N. & Cummins, P. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3547-3555 9 p.Research output: Contribution to journal › Article
Open Access
File
Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina
Carroll, L. S., Uehara, H., Fang, D., Choi, S., Zhang, X., Singh, M., Sandhu, Z., Cummins, P. M., Curtis, T. M., Stitt, A. W., Archer, B. J. & Ambati, B. K., 03 Jun 2019, In : Investigative ophthalmology & visual science. 60, 7, p. 2494-2502 9 p.Research output: Contribution to journal › Article
Open Access
File
Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis
O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3297-3309Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
154
Downloads
(Pure)