Projects per year
Personal profile
Research Statement
My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
In addition to my teaching commitments at undergraduate and postgraduate level, I also act as one of the Deputy Directors for the Wellcome-Wolfson Institute for Experimental Medicine and Academic Lead for the Faculty of Medicine, Health and Life Sciences Advanced Imaging Core Technology Unit (CTU).
Further information on the work in my laboratory can be found at:
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R1688CEM: mRNA localisation: a subcellular mechanistic target to treat pathological angiogenesis
12/09/2022 → …
Project: Research
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R6789CVS: The role of TRPV4 channels in diabetes-induced retinal endothelial dysfunction
01/08/2010 → …
Project: Research
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R2467CVS: Celluar mechanisms responsible for disruption of retinal neurovascular coupling in diabetes
01/08/2009 → …
Project: Research
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R2570RED: Molecular mechanisms in detine sensitivity and pain <MEDICI/BIOMED>
El Karim, I., Curtis, T. & Lundy, F.
01/08/2007 → …
Project: Research
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A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Sá-Pessoa, J., López-Montesino, S., Przybyszewska, K., Rodríguez-Escudero, I., Marshall, H., Ova, A., Schroeder, G. N., Barabas, P., Molina, M., Curtis, T., Cid, V. J. & Bengoechea, J. A., 16 Feb 2023, In: Nature Communications. 14, 20 p., 871.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Geometrically reconstructing confocal microscopy images for modelling the retinal microvasculature as a 3D cylindrical network
Troendle, E. P., Barabas, P. & Curtis, T. M., 31 Aug 2022, Proceedings of the 24th Irish Machine Vision and Image Processing Conference. Irish Pattern Recognition and Classification Society, p. 169-176Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open AccessFile7 Downloads (Pure) -
Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy
Albargothy, M. J., Azizah, N. N., Stewart, S. L., Troendle, E. P., Steel, D. H. W., Curtis, T. M. & Taggart, M. J., 16 Jul 2022, (Early online date) In: Journal of Anatomy.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Downloads (Pure) -
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
O'Hare, M., Esquiva, G., McGahon, M. K., Hombrebueno, J. M. R., Augustine, J., Canning, P., Edgar, K. S., Barabas, P., Friedel, T., Cincolà, P., Henry, J., Mayne, K., Ferrin, H., Stitt, A. W., Lyons, T. J., Brazil, D. P., Grieve, D. J., McGeown, J. G. & Curtis, T. M., 22 Sep 2022, In: JCI insight. 7, 18, 18 p., e155128.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
COMP-Ang1: Therapeutic potential of an engineered Angiopoietin-1 variant
Wallace, R. G., Rochfort, K. D., Barabas, P., Curtis, T. M., Uehara, H., Ambati, B. K. & Cummins, P. M., 25 Sep 2021, (Early online date) In: Vascular Pharmacology. 106919.Research output: Contribution to journal › Review article › peer-review
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Cell Calcium (Journal)
Tim Curtis (Peer reviewer)
12 Nov 2022 → …Activity: Publication peer-review and editorial work types › Publication peer-review
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British Society for Paediatric Endocrinology and Diabetes (BSPED) Annual Conference
Tim Curtis (Invited speaker)
04 Nov 2022Activity: Talk or presentation types › Invited talk
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Launch Event for All-Island Congenital Heart Disease Network
Tim Curtis (Contributor)
20 Oct 2022Activity: Other activity types › Other
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The Irish Times - Researchers uncover process of blindness in people with diabetes
Tim Curtis (Contributor)
24 Sep 2022Activity: Other activity types › Other
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EURETINA Conference 2022, Hamburg
Tim Curtis (Invited speaker)
02 Sep 2022Activity: Talk or presentation types › Invited talk