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Tim Curtis

Professor

  • Room 01.061 - CEM

    United Kingdom

Accepting PhD Students

PhD projects

Professor Curtis is open to PhD applications from candidates with a basic science or clinical background. His areas of interest include: - Vascular Physiology - Diabetic Retinopathy - Therapeutics for Eye Disease Previous research experience is desirable although not essential.

19962020

Research output per year

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Personal profile

Research Statement

My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
 
In addition to my teaching commitments at undergraduate and postgraduate level, I also act as one of the Deputy Directors for the Wellcome-Wolfson Institute for Experimental Medicine and Academic Lead for the Faculty of Medicine, Health and Life Sciences Advanced Imaging Core Technology Unit (CTU).
 
Further information on the work in my laboratory can be found at:
 

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Projects

R2520CEM: 2-HDP: a novel therapeutic for diabetic retinopathy

Curtis, T. & Stitt, A.

01/08/2018 → …

Project: Research

R2515CEM: Investigation of aberrant QKI splicing in diabetes and the specific role of QKI7 as a novel target to reverse EC dysfunction

Margariti, A., Curtis, T., Grieve, D., Simpson, D. & Stitt, A.

30/07/2018 → …

Project: Research

R2513CEM: Molecular dissection of the retina to elucidate early changes in diabetes

Simpson, D. & Curtis, T.

18/07/2018 → …

Project: Research

R2374CEM: Evaluation of CAMKII as a therapeutic target for diabetic macular oedema

Curtis, T. & Stitt, A.

30/03/2017 → …

Project: Research

R4745CEM: COMP-Ang1: Vascular Normalization and Neuroprotection for Diabetic Retinopathy

Curtis, T., Medina, R. & Stitt, A.

28/01/2016 → …

Project: Research

Research Output

Ion channels and myogenic activity in retinal arterioles

Barabas, P., Augustine, J., Fernandez Gonzalez, J., McGeown, G., McGahon, M. & Curtis, T., 26 Feb 2020, In : Current Topics in Membranes. 85, 44 p.

Research output: Contribution to journal › Article

    • CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation

    Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In : JCI insight. 4, 6, 18 p., e122442.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 3 Citations (Scopus)
    221 Downloads (Pure)

    COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells

    Rochfort, K. D., Carroll, L. S., Barabas, P., Curtis, T. M., Ambati, B. K., Barron, N. & Cummins, P. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3547-3555 9 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 90 Downloads (Pure)

    Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

    Carroll, L. S., Uehara, H., Fang, D., Choi, S., Zhang, X., Singh, M., Sandhu, Z., Cummins, P. M., Curtis, T. M., Stitt, A. W., Archer, B. J. & Ambati, B. K., 03 Jun 2019, In : Investigative ophthalmology & visual science. 60, 7, p. 2494-2502 9 p.

    Research output: Contribution to journal › Article

    Open Access
    File
    • 111 Downloads (Pure)

    Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

    O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3297-3309

    Research output: Contribution to journal › Article

    Open Access
    File
    • 2 Citations (Scopus)
    182 Downloads (Pure)

    Thesis

    Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling

    Author: Gill, E., Jul 2020

    Supervisor: Grieve, D. (Supervisor) & Curtis, T. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy

    MRGX1-TRPAI in lnflammatory Pain Signalling

    Author: McMillan, H., Jul 2020

    Supervisor: El Karim, I. (Supervisor), Lundy, F. (Supervisor) & Curtis, T. (Supervisor)

    Student thesis: Doctoral Thesis › Doctor of Philosophy