Projects per year
Personal profile
Research Statement
My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
In addition to my teaching commitments at undergraduate and postgraduate level, I also act as one of the Deputy Directors for the Wellcome-Wolfson Institute for Experimental Medicine and Academic Lead for the Faculty of Medicine, Health and Life Sciences Advanced Imaging Core Technology Unit (CTU).
Further information on the work in my laboratory can be found at:
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- 33 Similar Profiles
Diabetic Retinopathy
Medicine & Life Sciences
Arterioles
Medicine & Life Sciences
Smooth Muscle
Medicine & Life Sciences
Retina
Medicine & Life Sciences
Endothelin-1
Medicine & Life Sciences
Smooth Muscle Myocytes
Medicine & Life Sciences
Muscle Cells
Medicine & Life Sciences
Endothelial Cells
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2011 2017
- 1 Finished
R1757CVS: The role of mechanosensitive TRP channels in arteriolar myogenic signalling and blood flow autoregulation
Curtis, T., McGeown, G. & Zholos, A.
01/08/2011 → 24/11/2017
Project: Research
Research Output 1996 2019
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In : JCI insight. 4, 6, 18 p., e122442.Research output: Contribution to journal › Article
Open Access
File
Retinal Neovascularization
Choroidal Neovascularization
Calcium-Calmodulin-Dependent Protein Kinases
Pathologic Neovascularization
Intercellular Signaling Peptides and Proteins
COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells
Rochfort, K. D., Carroll, L. S., Barabas, P., Curtis, T. M., Ambati, B. K., Barron, N. & Cummins, P. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3547-3555 9 p.Research output: Contribution to journal › Article
Open Access
File
Blood-Retinal Barrier
Endothelial Cells
Phenotype
Glucose
Hyperglycemia
Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina
Carroll, L. S., Uehara, H., Fang, D., Choi, S., Zhang, X., Singh, M., Sandhu, Z., Cummins, P. M., Curtis, T. M., Stitt, A. W., Archer, B. J. & Ambati, B. K., 03 Jun 2019, In : Investigative ophthalmology & visual science. 60, 7, p. 2494-2502 9 p.Research output: Contribution to journal › Article
Open Access
File
Blood Vessels
Retina
Visual Acuity
Cartilage Oligomeric Matrix Protein
Angiopoietin-1
Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis
O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3297-3309Research output: Contribution to journal › Article
Open Access
File
Endothelial Cells
Ligation
Retina
Retinal Neovascularization
Staining and Labeling
P347 A survey of cardiovascular disease in UK cystic fibrosis centres
Downey, D. G., Bengoechea, J., Curtis, T., Grieve, D. & Harbinson, M., Jun 2019, In : Journal of Cystic Fibrosis. 18, p. S155-S156Research output: Contribution to journal › Meeting abstract