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Personal profile
Research Statement
My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
In addition to my teaching commitments at undergraduate and postgraduate level, I also act as one of the Deputy Directors for the Wellcome-Wolfson Institute for Experimental Medicine and Academic Lead for the Faculty of Medicine, Health and Life Sciences Advanced Imaging Core Technology Unit (CTU).
Further information on the work in my laboratory can be found at:
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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R2513CEM: Molecular dissection of the retina to elucidate early changes in diabetes
18/07/2018 → …
Project: Research
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R4745CEM: COMP-Ang1: Vascular Normalization and Neuroprotection for Diabetic Retinopathy
Curtis, T., Medina, R. & Stitt, A.
28/01/2016 → …
Project: Research
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R2258CII: Mas related gene receptors as novel modules for pain relief
El Karim, I., Curtis, T. & Lundy, F.
16/12/2015 → …
Project: Research
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Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy
Albargothy, M. J., Azizah, N. N., Stewart, S. L., Troendle, E. P., Steel, D. H. W., Curtis, T. M. & Taggart, M. J., 16 Jul 2022, (Early online date) In: Journal of Anatomy.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
O'Hare, M., Esquiva, G., McGahon, M. K., Hombrebueno, J. M. R., Augustine, J., Canning, P., Edgar, K. S., Barabas, P., Friedel, T., Cincolà, P., Henry, J., Mayne, K., Ferrin, H., Stitt, A. W., Lyons, T. J., Brazil, D. P., Grieve, D. J., McGeown, J. G. & Curtis, T. M., 22 Sep 2022, In: JCI insight. 7, 18, e155128.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Poster abstract: Targeting TRP channels for the restoration of microvascular barrier function in diabetic macular oedema
Rollo, A., Barabas, P., Augustine, J., Tarban, S., Friedel, T., Simpson, D. A. & Curtis, T., 28 Mar 2022, In: Diabetic Medicine. 39, S1, P71.Research output: Contribution to journal › Meeting abstract › peer-review
Open Access -
COMP-Ang1: Therapeutic potential of an engineered Angiopoietin-1 variant
Wallace, R. G., Rochfort, K. D., Barabas, P., Curtis, T. M., Uehara, H., Ambati, B. K. & Cummins, P. M., 25 Sep 2021, (Early online date) In: Vascular Pharmacology. 106919.Research output: Contribution to journal › Review article › peer-review
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Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves
McMillan, H., Lundy, F. T., Dunne, O. M., Al-Natour, B., Jeanneau, C., About, I., Curtis, T. M. & El Karim, I., 01 May 2021, In: The FASEB Journal. 35, 5, p. e21492 e21492.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Downloads (Pure)