Projects per year
Personal profile
Research Statement
My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
Besides my teaching commitments at undergraduate and postgraduate level, I presently hold the role of Academic Lead for the Advanced Imaging Core Technology Unit (CTU) in the Faculty of Medicine, Health, and Life Sciences. Previously, I served as Deputy Director for the Wellcome-Wolfson Institute for Experimental Medicine from 2016 to 2023.
Further information on the work in my laboratory can be found at:
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R1688CEM: mRNA localisation: a subcellular mechanistic target to treat pathological angiogenesis
Costa, G. (PI) & Curtis, T. (CoI)
12/09/2022 → …
Project: Research
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R6789CVS: The role of TRPV4 channels in diabetes-induced retinal endothelial dysfunction
Curtis, T. (PI) & McGeown, G. (CoI)
01/08/2010 → …
Project: Research
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R2520CEM: 2-HDP: a novel therapeutic for diabetic retinopathy
Curtis, T. (PI) & Stitt, A. (CoI)
01/08/2018 → 30/11/2022
Project: Research
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R2515CEM: Investigation of aberrant QKI splicing in diabetes and the specific role of QKI7 as a novel target to reverse EC dysfunction
Margariti, A. (PI), Curtis, T. (CoI), Grieve, D. (CoI), Simpson, D. (CoI) & Stitt, A. (CoI)
30/07/2018 → 20/05/2022
Project: Research
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R2513CEM: Molecular dissection of the retina to elucidate early changes in diabetes
Simpson, D. (PI) & Curtis, T. (CoI)
18/07/2018 → 30/04/2022
Project: Research
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Contextual evaluation of segmentation models using spatial reasoning
Porter, V., Styles, I., Curtis, T. M., Taggart, M. J., Albargothy, M. J. & Gault, R., 01 Oct 2024, 26th Irish Machine Vision and Image Processing Conference (IMVIP 2024): Proceedings. 10 ed. Institution of Engineering and Technology (IET), Vol. 2024. p. 266-274 9 p. (IET Conference Proceedings).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open AccessFile32 Downloads (Pure) -
Immunological isolation and characterization of neuronal progenitors from human dental pulp: a laboratory‐based investigation
McMillan, H. P., Lundy, F. T., Dunne, O. M., McLoughlin, K. J., About, I., Curtis, T. M. & El Karim, I., Aug 2024, In: International Endodontic Journal. 57, 8, p. 1136-1146 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)34 Downloads (Pure) -
Investigating the validity of structure learning algorithms in identifying risk factors for intervention in patients with diabetes
Zahoor, S., Constantinou, A. C., Curtis, T. M. & Hasanuzzaman, M., 21 Mar 2024, 20 p. (arXiv).Research output: Working paper
File23 Downloads (Pure) -
Modified lipoprotein-induced sFlt1 production in human placental trophoblasts is mediated by protein kinase C
Chow, R. P., Zhao, J., Li, Y., Curtis, T. M., Lyons, T. J. & Yu, J. Y., 17 Nov 2024, (Early online date) In: European Journal of Pharmacology. 177138.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Downloads (Pure) -
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status
Anderson, A., Alfahad, N., Wimalachandra, D., Bouzinab, K., Rudzinska, P., Wood, H., Fazey, I., Xu, H., Barnes, N. M., Narendran, P., Lord, J. M., Rauz, S., Ganley, I. G., Curtis, T. M., Wallace, G. R. & Hombrebueno, J. R., 06 Feb 2024, In: Nature Communications. 15, 16 p., 1124.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)32 Downloads (Pure)
Activities
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Dundalk Institute of Technology
Curtis, T. (Invited speaker)
08 Apr 2025Activity: Talk or presentation types › Invited talk
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Northern Ireland Science Festival 2025 - Imaging Core Facility Tour
Curtis, T. (Contributor)
15 Feb 2025Activity: Other activity types › Other
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Ministry of Innovation, Science and Technology (Israeli-Hungarian Scientific Research Program) (External organisation)
Curtis, T. (Reviewer)
04 Feb 2025Activity: Membership types › Membership of external research organisation
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Journal of Neuroinflammation (Journal)
Curtis, T. (Peer reviewer)
22 Oct 2024 → …Activity: Publication peer-review and editorial work types › Publication peer-review
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Pan-Ireland Ophthalmology Day (POD) 2024
Curtis, T. (Invited speaker)
11 Oct 2024Activity: Talk or presentation types › Invited talk