• Room 01.061 - WWIEM Block 6 MBC Site

    United Kingdom

Accepting PhD Students

19962019
If you made any changes in Pure these will be visible here soon.

Personal profile

Research Statement

My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
 
In addition to my teaching commitments at undergraduate and postgraduate level, I also act as one of the Deputy Directors for the Wellcome-Wolfson Institute for Experimental Medicine and Academic Lead for the Faculty of Medicine, Health and Life Sciences Advanced Imaging Core Technology Unit (CTU).
 
Further information on the work in my laboratory can be found at:
 

Fingerprint Dive into the research topics where Tim Curtis is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 33 Similar Profiles
Diabetic Retinopathy Medicine & Life Sciences
Arterioles Medicine & Life Sciences
Smooth Muscle Medicine & Life Sciences
Retina Medicine & Life Sciences
Endothelin-1 Medicine & Life Sciences
Smooth Muscle Myocytes Medicine & Life Sciences
Muscle Cells Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2017

Research Output 1996 2019

2 Citations (Scopus)

CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation

Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In : JCI insight. 4, 6, 18 p., e122442.

Research output: Contribution to journalArticle

Open Access
File
Retinal Neovascularization
Choroidal Neovascularization
Calcium-Calmodulin-Dependent Protein Kinases
Pathologic Neovascularization
Intercellular Signaling Peptides and Proteins

COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells

Rochfort, K. D., Carroll, L. S., Barabas, P., Curtis, T. M., Ambati, B. K., Barron, N. & Cummins, P. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3547-3555 9 p.

Research output: Contribution to journalArticle

Open Access
File
Blood-Retinal Barrier
Endothelial Cells
Phenotype
Glucose
Hyperglycemia

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina

Carroll, L. S., Uehara, H., Fang, D., Choi, S., Zhang, X., Singh, M., Sandhu, Z., Cummins, P. M., Curtis, T. M., Stitt, A. W., Archer, B. J. & Ambati, B. K., 03 Jun 2019, In : Investigative ophthalmology & visual science. 60, 7, p. 2494-2502 9 p.

Research output: Contribution to journalArticle

Open Access
File
Blood Vessels
Retina
Visual Acuity
Cartilage Oligomeric Matrix Protein
Angiopoietin-1

Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis

O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In : Investigative ophthalmology & visual science. 60, 10, p. 3297-3309

Research output: Contribution to journalArticle

Open Access
File
Endothelial Cells
Ligation
Retina
Retinal Neovascularization
Staining and Labeling

P347 A survey of cardiovascular disease in UK cystic fibrosis centres

Downey, D. G., Bengoechea, J., Curtis, T., Grieve, D. & Harbinson, M., Jun 2019, In : Journal of Cystic Fibrosis. 18, p. S155-S156

Research output: Contribution to journalMeeting abstract