Projects per year
Personal profile
Research Statement
My research interests are mainly focused on the mechanisms underlying the development of diabetic retinopathy and identification of novel therapeutic strategies for the early stage treatment of this disease. My group is also undertaking research into the basic mechanisms controlling blood flow, vascular permeability and angiogenesis in the eye which provides an important foundation for our diabetic retinopathy-related studies. Much of the work in my laboratory is interdisciplinary, spanning through molecular biology, protein biochemistry, electrophysiology, pharmacology, live-cell and in vivo imaging, software development and clinical-based research. My research has been supported by various funding agencies including the BBSRC, MRC, HSC R&D Division, Fight for Sight, Diabetes UK, British Heart Foundation and Wellcome Trust.
Besides my teaching commitments at undergraduate and postgraduate level, I presently hold the role of Academic Lead for the Advanced Imaging Core Technology Unit (CTU) in the Faculty of Medicine, Health, and Life Sciences. Previously, I served as Deputy Director for the Wellcome-Wolfson Institute for Experimental Medicine from 2016 to 2023.
Further information on the work in my laboratory can be found at:
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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R1688CEM: mRNA localisation: a subcellular mechanistic target to treat pathological angiogenesis
Costa, G. (PI) & Curtis, T. (CoI)
12/09/2022 → …
Project: Research
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R6789CVS: The role of TRPV4 channels in diabetes-induced retinal endothelial dysfunction
Curtis, T. (PI) & McGeown, G. (CoI)
01/08/2010 → …
Project: Research
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R2520CEM: 2-HDP: a novel therapeutic for diabetic retinopathy
Curtis, T. (PI) & Stitt, A. (CoI)
01/08/2018 → 30/11/2022
Project: Research
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R2515CEM: Investigation of aberrant QKI splicing in diabetes and the specific role of QKI7 as a novel target to reverse EC dysfunction
Margariti, A. (PI), Curtis, T. (CoI), Grieve, D. (CoI), Simpson, D. (CoI) & Stitt, A. (CoI)
30/07/2018 → 20/05/2022
Project: Research
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R2513CEM: Molecular dissection of the retina to elucidate early changes in diabetes
Simpson, D. (PI) & Curtis, T. (CoI)
18/07/2018 → 30/04/2022
Project: Research
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3D electron microscopy reveals novel ultrastructural changes in the diabetic retinal neurovascular unit
Albargothy, M. J., Troendle, E. P., Laws, R., Barabas, P., Steel, D. H. W., Taggart, M. J. & Curtis, T. M., 02 Oct 2025, (Early online date) In: Diabetologia. 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Inhibition of glycolysis modulates retinal endothelial cell function and pathological neovascularization
Hughes, D., Bertelli, P. M., Pedrini, E., Allen, L.-D., Branco, C., Curtis, T. M., Medina, R. J., Stitt, A. W. & Lechner, J., Oct 2025, In: Experimental Eye Research. 259, 12 p., 110535.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Intelligent point prompt generation for interactive segmentation
Porter, V., Styles, I., Curtis, T. & Gault, R., 01 Sept 2025, Proceedings of the Irish Machine Vision and Image Processing Conference 2025. Irish Pattern Recognition & Classification Society, p. 144-148 (Proceedings of the Irish Machine Vision and Image Processing Conference).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open AccessFile4 Downloads (Pure) -
Investigating the validity of structure learning algorithms in identifying risk factors for intervention in patients with diabetes
Zahoor, S., Constantinou, A. C., Curtis, T. M. & Hasanuzzaman, M., 04 Nov 2025, In: Knowledge-Based Systems. 329, Part B, 20 p., 114382.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Scavenging acrolein with 2-HDP preserves neurovascular integrity in a rat model of diabetic retinal disease
Augustine, J., Troendle, E. P., Friedel, T., Baldwin, C., Byrne, E. M., Ashraf, S., Canning, P., McAleese, C. A., Rollo, A. G., Barabas, P., Lyons, T. J., Ulmschneider, M. B., Stitt, A. W. & Curtis, T. M., Nov 2025, In: Diabetologia. 68, 11, p. 2609-2629 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure)
Activities
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Belfast Eye Conference 2025
Curtis, T. (Invited speaker)
16 Nov 2025Activity: Talk or presentation types › Invited talk
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Inflammation (Journal)
Curtis, T. (Peer reviewer)
14 Nov 2025 → …Activity: Publication peer-review and editorial work types › Publication peer-review
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European Vision Institute Clinical Research Network Annual Meeting
Curtis, T. (Keynote speaker)
13 Nov 2025Activity: Talk or presentation types › Invited talk
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New drug to prevent diabetic sight loss - featured in The Independent, Daily Mirror, Daily Express, Daily Mail, Irish times, London Evening Standard, and more than 200 news outlets globally.
Curtis, T. (Contributor)
27 Oct 2025Activity: Other activity types › Other
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External Academic Appeal Reviewer — Dundalk Institute of Technology (DkIT)
Curtis, T. (Examiner)
22 Oct 2025Activity: Other activity types › Other