Research output per year
Research output per year
- 1 - 50 out of 98 results
Search results
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2024
Contextual evaluation of segmentation models using spatial reasoning
Porter, V., Styles, I., Curtis, T. M., Taggart, M. J., Albargothy, M. J. & Gault, R., 25 Sept 2024, Proceedings of the 26th Irish Machine Vision and Image Processing Conference 2024. 10 ed. IET Conference Proceedings: Irish Pattern Recognition & Classification Society, Vol. 2024. p. 266-274 (IET Conference Proceedings).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open AccessFile15 Downloads (Pure) -
Immunological isolation and characterization of neuronal progenitors from human dental pulp: a laboratory‐based investigation
McMillan, H. P., Lundy, F. T., Dunne, O. M., McLoughlin, K. J., About, I., Curtis, T. M. & El Karim, I., Aug 2024, In: International Endodontic Journal. 57, 8, p. 1136-1146 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)33 Downloads (Pure) -
Investigating the validity of structure learning algorithms in identifying risk factors for intervention in patients with diabetes
Zahoor, S., Constantinou, A. C., Curtis, T. M. & Hasanuzzaman, M., 21 Mar 2024, 20 p. (arXiv).Research output: Working paper
File7 Downloads (Pure) -
Modified lipoprotein-induced sFlt1 production in human placental trophoblasts is mediated by protein kinase C
Chow, R. P., Zhao, J., Li, Y., Curtis, T. M., Lyons, T. J. & Yu, J. Y., 17 Nov 2024, (Early online date) In: European Journal of Pharmacology. 177138.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Downloads (Pure) -
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status
Anderson, A., Alfahad, N., Wimalachandra, D., Bouzinab, K., Rudzinska, P., Wood, H., Fazey, I., Xu, H., Barnes, N. M., Narendran, P., Lord, J. M., Rauz, S., Ganley, I. G., Curtis, T. M., Wallace, G. R. & Hombrebueno, J. R., 06 Feb 2024, In: Nature Communications. 15, 16 p., 1124.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)26 Downloads (Pure) -
Sitagliptin eye drops prevent the impairment of retinal neurovascular unit in the new Trpv2 +/− rat model
Ramos, H., Augustine, J., Karan, B. M., Hernández, C., Stitt, A. W., Curtis, T. M. & Simó, R., 30 Nov 2024, In: Journal of Neuroinflammation. 21, 312.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Downloads (Pure) -
2023
Aldehyde dehydrogenase and aldo-keto reductase enzymes: basic concepts and emerging roles in diabetic retinopathy
Karan, B. M., Little, K., Augustine, J., Stitt, A. W. & Curtis, T. M., 21 Jul 2023, In: Antioxidants. 12, 7, 21 p., 1466.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)55 Downloads (Pure) -
A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Sá-Pessoa, J., López-Montesino, S., Przybyszewska, K., Rodríguez-Escudero, I., Marshall, H., Ova, A., Schroeder, G. N., Barabas, P., Molina, M., Curtis, T., Cid, V. J. & Bengoechea, J. A., 16 Feb 2023, In: Nature Communications. 14, 20 p., 871.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)114 Downloads (Pure) -
Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy
Albargothy, M. J., Azizah, N. N., Stewart, S. L., Troendle, E. P., Steel, D. H. W., Curtis, T. M. & Taggart, M. J., 01 Aug 2023, In: Journal of Anatomy. 243, 2, p. 245-257 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)107 Downloads (Pure) -
2022
Geometrically reconstructing confocal microscopy images for modelling the retinal microvasculature as a 3D cylindrical network
Troendle, E. P., Barabas, P. & Curtis, T. M., 31 Aug 2022, Proceedings of the 24th Irish Machine Vision and Image Processing Conference. Irish Pattern Recognition & Classification Society, p. 169-176Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open AccessFile46 Downloads (Pure) -
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
O'Hare, M., Esquiva, G., McGahon, M. K., Hombrebueno, J. M. R., Augustine, J., Canning, P., Edgar, K. S., Barabas, P., Friedel, T., Cincolà, P., Henry, J., Mayne, K., Ferrin, H., Stitt, A. W., Lyons, T. J., Brazil, D. P., Grieve, D. J., McGeown, J. G. & Curtis, T. M., 22 Sept 2022, In: JCI insight. 7, 18, 18 p., e155128.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)60 Downloads (Pure) -
2021
COMP-Ang1: Therapeutic potential of an engineered Angiopoietin-1 variant
Wallace, R. G., Rochfort, K. D., Barabas, P., Curtis, T. M., Uehara, H., Ambati, B. K. & Cummins, P. M., 25 Sept 2021, (Early online date) In: Vascular Pharmacology. 106919.Research output: Contribution to journal › Review article › peer-review
8 Citations (Scopus) -
Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves
McMillan, H., Lundy, F. T., Dunne, O. M., Al-Natour, B., Jeanneau, C., About, I., Curtis, T. M. & El Karim, I., 01 May 2021, In: The FASEB Journal. 35, 5, 14 p., e21492.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)76 Downloads (Pure) -
The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy
Augustine, J., Troendle, E. P., Barabas, P., McAleese, C. A., Friedel, T., Stitt, A. W. & Curtis, T. M., 18 Feb 2021, In: Frontiers in Endocrinology. 11, 24 p., 621938.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Citations (Scopus)214 Downloads (Pure) -
2020
Ion channels and myogenic activity in retinal arterioles
Barabas, P., Augustine, J., Fernandez Gonzalez, J., McGeown, G., McGahon, M. & Curtis, T., 26 Feb 2020, (Early online date) In: Current Topics in Membranes. 85, 44 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Single-cell transcriptomic profiling provides insights into retinal endothelial barrier properties
Watson, M. I., Barabas, P., McGahon, M., McMahon, M., Fuchs, M. A., Curtis, T. M. & Simpson, D. A., 27 Nov 2020, In: Molecular Vision. 26, p. 766-779 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)124 Downloads (Pure) -
VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions
Llorián-Salvador, M., Barabas, P., Byrne, E. M., Lechner, J., Augustine, J., Curtis, T. M., Chen, M. & Xu, H., 18 Sept 2020, In: Investigative ophthalmology & visual science. 61, 11, 1 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)96 Downloads (Pure) -
2019
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In: JCI insight. 4, 6, 18 p., e122442.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)390 Downloads (Pure) -
COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells
Rochfort, K. D., Carroll, L. S., Barabas, P., Curtis, T. M., Ambati, B. K., Barron, N. & Cummins, P. M., 01 Aug 2019, In: Investigative ophthalmology & visual science. 60, 10, p. 3547-3555 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)150 Downloads (Pure) -
Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina
Carroll, L. S., Uehara, H., Fang, D., Choi, S., Zhang, X., Singh, M., Sandhu, Z., Cummins, P. M., Curtis, T. M., Stitt, A. W., Archer, B. J. & Ambati, B. K., 03 Jun 2019, In: Investigative ophthalmology & visual science. 60, 7, p. 2494-2502 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)209 Downloads (Pure) -
Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis
O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In: Investigative ophthalmology & visual science. 60, 10, p. 3297-3309Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)357 Downloads (Pure) -
Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy
Hombrebueno, J. R., Cairns, L., Dutton, L. R., Lyons, T. J., Brazil, D. P., Moynagh, P., Curtis, T. M. & Xu, H., 29 Oct 2019, (Early online date) In: JCI insight. 4, 23, e129760.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)106 Downloads (Pure) -
2018
Characterization of a spontaneously immortalized murine Müller glial cell line QMMuC-1
Augustine, J., Pavlou, S., O'Hare, M., Harkin, K., Stitt, A., Curtis, T., Xu, H. & Chen, M., 01 Mar 2018, In: Investigative Opthalmology and Visual Science. 59, 3, p. 1666-1674Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)447 Downloads (Pure) -
Expanding inter-institutional opportunities for Masters research students
Taggart, M. & Curtis, T., Sept 2018, Physiology News, 112, p. 48-49 2 p.Research output: Contribution to specialist publication › Article
Open Access -
Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
Curtis, T. M., McLaughlin, D., O'Hare, M., Kur, J., Barabas, P., Revolta, G., Scholfield, C. N., McGeown, G. & McGahon, M. K., 14 Jul 2018, In: Journal of visualized experiments : JoVE. 137, 19 p., e57944.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)194 Downloads (Pure) -
Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
McDowell, R. E., Barabas, P., Augustine, J., Chevallier, O., McCarron, P., Chen, M., McGeown, J. G. & Curtis, T. M., Dec 2018, In: Diabetologia. 61, 12, p. 2654-2667 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Citations (Scopus)348 Downloads (Pure) -
2017
Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents
Owolabi, B. O., Musale, V., Ojo, O. O., Moffett, R. C., McGahon, M. K., Curtis, T. M., Conlon, J. M., Flatt, P. R. & Abdel-Wahab, Y. H. A., Jul 2017, In: Biochimie. 138, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)480 Downloads (Pure) -
Esculentin-2CHa(1–30) and its analogues: stability and mechanisms of insulinotropic action
Vasu, S., McGahon, M. K., Moffett, R. C., Curtis, T. M., Conlon, J. M., Abdel-Wahab, Y. H. A. & Flatt, P. R., Mar 2017, In: The Journal of endocrinology. 232, p. 423-435 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)398 Downloads (Pure) -
PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation
Rajapakse, D., Chen, M., Curtis, T. & Xu, H., 09 Oct 2017, In: Aging. 9, 10, p. 2052-2068Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)287 Downloads (Pure) -
TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity?
Clarke, R., Monaghan, K., About, I., Griffin, C. S., Sergeant, G. P., El Karim, I., McGeown, J. G., Cosby, S. L., Curtis, T. M., McGarvey, L. P. & Lundy, F. T., 20 Sept 2017, In: European Respiratory Journal. 50, 3, 10 p., 1700995.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)188 Downloads (Pure) -
Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture
Rajapakse, D., Curtis, T., Chen, M. & Xu, H., 14 Nov 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-12 6926485.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Citations (Scopus)217 Downloads (Pure) -
2016
Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells
El Karim, I. A., McCrudden, M. T. C., McGahon, M. K., Curtis, T. M., Jeanneau, C., Giraud, T., Irwin, C. R., Linden, G. J., Lundy, F. T. & About, I., Apr 2016, In: Journal of Endodontics. 42, 4, p. 589-595 7 p.Research output: Contribution to journal › Article › peer-review
File31 Citations (Scopus)673 Downloads (Pure) -
Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina
McDowell, R. E., McGahon, M. K., Augustine, J., Chen, M., McGeown, G. & Curtis, T. M., 01 Sept 2016, In: Investigative ophthalmology & visual science. 57, 11, p. 4762-4771 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)373 Downloads (Pure) -
Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance
Ojo, O. O., Srinivasan, D. K., Owolabi, B. O., McGahon, M. K., Moffett, R. C., Curtis, T. M., Conlon, J. M., Flatt, P. R. & Abdel-Wahab, Y. H. A., Aug 2016, In: Biological Chemistry. 397, 8, p. 753-764 12 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
The progress in understanding and treatment of diabetic retinopathy
Stitt, A. W., Curtis, T. M., Chen, M., Medina, R. J., McKay, G. J., Jenkins, A., Gardiner, T. A., Lyons, T. J., Hammes, H.-P., Simó, R. & Lois, N., Mar 2016, In: Progress in Retinal and Eye Research. 51, p. 156-186Research output: Contribution to journal › Article › peer-review
844 Citations (Scopus) -
TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles
McGahon, M. K., Fernández, J. A., Dash, D. P., McKee, J., Simpson, D. A., Zholos, A. V., McGeown, J. G. & Curtis, T. M., 01 Oct 2016, In: Investigative ophthalmology & visual science. 57, 13, p. 5637-5647 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Citations (Scopus)438 Downloads (Pure) -
2015
CaV3.1 T-Type Ca2+ Channels Contribute to Myogenic Signalling in Rat Retinal Arterioles
Fernandez, J. A., McGahon, M. K., McGeown, J. G. & Curtis, T. M., Aug 2015, In: Investigative Ophthalmology and Visual Science. 56, 9, p. 5125-5132 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)422 Downloads (Pure) -
Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium
Monaghan, K., McNaughten, J., McGahon, M. K., Kelly, C., Kyle, D., Yong, P. H., McGeown, G. & Curtis, T. M., 05 Jun 2015, In: PloS one. 10, 6, 16 p., e0128359.Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)393 Downloads (Pure) -
TNF alpha-Induced p38MAPK Activation Regulates TRPA1 and TRPV4 Activity in Odontoblast-Like Cells
El Karim, I., McCrudden, M. T. C., Linden, G. J., Abdullah, H., Curtis, T. M., McGahon, M., About, I., Irwin, C. & Lundy, F. T., Nov 2015, In: American Journal of Pathology. 185, 11, p. 2994-3002 9 p.Research output: Contribution to journal › Article › peer-review
59 Citations (Scopus) -
2014
Acridine orange leukocyte fluorography in mice
Cahoon, J. M., Olson, P. R., Nielson, S., Miya, T. R., Bankhead, P., McGeown, J. G., Curtis, T. M. & Ambati, B. K., Mar 2014, In: Experimental Eye Research. 120, p. 15-19 5 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Automated detection and measurement of isolated retinal arterioles by a combination of edge enhancement and cost analysis
Fernández, J. A., Bankhead, P., Zhou, H., McGeown, J. G. & Curtis, T. M., Mar 2014, In: PloS one. 9, 3, 11 p., e91791.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)370 Downloads (Pure) -
Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in severe asthma
McGarvey, L. P., Butler, C. A., Stokesberry, S., Polley, L., McQuaid, S., Abdullah, H., Ashraf, S., McGahon, M. K., Curtis, T. M., Arron, J., Choy, D., Warke, T. J., Bradding, P., Ennis, M., Zholos, A., Costello, R. W. & Heaney, L. G., Mar 2014, In: Journal of Allergy and Clinical Immunology. 133, 3, p. 704-712 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile140 Citations (Scopus)792 Downloads (Pure) -
Pathophysiology and Pathogenesis of Diabetic Retinopathy
Xu, H., Curtis, T. & Stitt, A., Aug 2014, Diapedia, The Living Textbook of Diabetes [internet].Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Role of ion channels and subcellular Ca2+ signalling in arachidonic acid induced dilation of pressurised retinal arterioles
Kur, J., McGahon, M., Fernández, J. A., Scholfield, N., McGeown, G. & Curtis, T., 02 May 2014, In: Investigative ophthalmology & visual science. 55, 5, p. 2893-2902Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)359 Downloads (Pure) -
The Role of K+ and Cl- Channels in the Regulation of Retinal Arteriolar Tone and Blood Flow
Needham, M., McGahon, M. K., Bankhead, P., Gardiner, T. A., Scholfield, C. N., Curtis, T. M. & McGeown, J. G., 07 Apr 2014, In: Investigative ophthalmology & visual science. 55, 4, p. 2157-2165 9 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
2013
Advanced glycation end products and diabetic retinopathy
Chen, M., Curtis, T. M. & Stitt, A. W., 31 Jul 2013, In: Current medicinal chemistry. 20, 26, p. 3234-3240Research output: Contribution to journal › Article › peer-review
99 Citations (Scopus) -
Advances in our understanding of diabetic retinopathy
Stitt, A. W., Lois, N., Medina, R. J., Adamson, P. & Curtis, T. M., 01 Jul 2013, In: Clinical science (London, England : 1979). 125, 1, p. 1-17Research output: Contribution to journal › Article › peer-review
139 Citations (Scopus) -
Ca(2+) sparks promote myogenic tone in retinal arterioles
Kur, J., Bankhead, P., Scholfield, C. N., Curtis, T. M. & McGeown, J., Apr 2013, In: British Journal of Pharmacology. 168, 7, p. 1675–1686 12 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
GABAergic control of arteriolar diameter in the rat retina
Hinds, K., Monaghan, K. P., Frølund, B., McGeown, G. & Curtis, T. M., Oct 2013, In: Investigative ophthalmology & visual science. 54, 10, p. 6798-805 8 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease
McDowell, R. E., McGeown, G., Stitt, A. W. & Curtis, T., Feb 2013, In: FUTURE MEDICINAL CHEMISTRY. 5, 2, p. 189-211Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus)