Research output per year
Research output per year
- 1 - 50 out of 88 results
Search results
-
2023
Aldehyde dehydrogenase and aldo-keto reductase enzymes: basic concepts and emerging roles in diabetic retinopathy
Karan, B. M., Little, K., Augustine, J., Stitt, A. W. & Curtis, T. M., 21 Jul 2023, In: Antioxidants. 12, 7, 1466.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Downloads (Pure) -
A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection
Sá-Pessoa, J., López-Montesino, S., Przybyszewska, K., Rodríguez-Escudero, I., Marshall, H., Ova, A., Schroeder, G. N., Barabas, P., Molina, M., Curtis, T., Cid, V. J. & Bengoechea, J. A., 16 Feb 2023, In: Nature Communications. 14, 20 p., 871.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
2022
Investigation of heterocellular features of the mouse retinal neurovascular unit by 3D electron microscopy
Albargothy, M. J., Azizah, N. N., Stewart, S. L., Troendle, E. P., Steel, D. H. W., Curtis, T. M. & Taggart, M. J., 16 Jul 2022, (Early online date) In: Journal of Anatomy.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure) -
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
O'Hare, M., Esquiva, G., McGahon, M. K., Hombrebueno, J. M. R., Augustine, J., Canning, P., Edgar, K. S., Barabas, P., Friedel, T., Cincolà, P., Henry, J., Mayne, K., Ferrin, H., Stitt, A. W., Lyons, T. J., Brazil, D. P., Grieve, D. J., McGeown, J. G. & Curtis, T. M., 22 Sep 2022, In: JCI insight. 7, 18, 18 p., e155128.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Downloads (Pure) -
2021
Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves
McMillan, H., Lundy, F. T., Dunne, O. M., Al-Natour, B., Jeanneau, C., About, I., Curtis, T. M. & El Karim, I., 01 May 2021, In: The FASEB Journal. 35, 5, 14 p., e21492.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Downloads (Pure) -
The Role of Lipoxidation in the Pathogenesis of Diabetic Retinopathy
Augustine, J., Troendle, E. P., Barabas, P., McAleese, C. A., Friedel, T., Stitt, A. W. & Curtis, T. M., 18 Feb 2021, In: Frontiers in Endocrinology. 11, 24 p., 621938.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)145 Downloads (Pure) -
2020
Ion channels and myogenic activity in retinal arterioles
Barabas, P., Augustine, J., Fernandez Gonzalez, J., McGeown, G., McGahon, M. & Curtis, T., 26 Feb 2020, (Early online date) In: Current Topics in Membranes. 85, 44 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Single-cell transcriptomic profiling provides insights into retinal endothelial barrier properties
Watson, M. I., Barabas, P., McGahon, M., McMahon, M., Fuchs, M. A., Curtis, T. M. & Simpson, D. A., 27 Nov 2020, In: Molecular Vision. 26, p. 766-779 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Downloads (Pure) -
VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions
Llorián-Salvador, M., Barabas, P., Byrne, E. M., Lechner, J., Augustine, J., Curtis, T. M., Chen, M. & Xu, H., 18 Sep 2020, In: Investigative ophthalmology & visual science. 61, 11, 1 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)61 Downloads (Pure) -
2019
CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In: JCI insight. 4, 6, 18 p., e122442.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)348 Downloads (Pure) -
COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells
Rochfort, K. D., Carroll, L. S., Barabas, P., Curtis, T. M., Ambati, B. K., Barron, N. & Cummins, P. M., 01 Aug 2019, In: Investigative ophthalmology & visual science. 60, 10, p. 3547-3555 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)126 Downloads (Pure) -
Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina
Carroll, L. S., Uehara, H., Fang, D., Choi, S., Zhang, X., Singh, M., Sandhu, Z., Cummins, P. M., Curtis, T. M., Stitt, A. W., Archer, B. J. & Ambati, B. K., 03 Jun 2019, In: Investigative ophthalmology & visual science. 60, 7, p. 2494-2502 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)168 Downloads (Pure) -
Involvement of TRPV1 and TRPV4 Channels in Retinal Angiogenesis
O'Leary, C., McGahon, M. K., Ashraf, S., McNaughten, J., Friedel, T., Cincolà, P., Barabas, P., Fernandez, J. A., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 01 Aug 2019, In: Investigative ophthalmology & visual science. 60, 10, p. 3297-3309Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)298 Downloads (Pure) -
Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy
Hombrebueno, J. R., Cairns, L., Dutton, L. R., Lyons, T. J., Brazil, D. P., Moynagh, P., Curtis, T. M. & Xu, H., 29 Oct 2019, (Early online date) In: JCI insight. 4, 23, e129760.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)63 Downloads (Pure) -
2018
Characterization of a spontaneously immortalized murine Müller glial cell line QMMuC-1
Augustine, J., Pavlou, S., O'Hare, M., Harkin, K., Stitt, A., Curtis, T., Xu, H. & Chen, M., 01 Mar 2018, In: Investigative Opthalmology and Visual Science. 59, 3, p. 1666-1674Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)386 Downloads (Pure) -
Expanding inter-institutional opportunities for Masters research students
Taggart, M. & Curtis, T., Sep 2018, Physiology News, 112, p. 48-49.Research output: Contribution to specialist publication › Article
Open Access -
Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies
Curtis, T. M., McLaughlin, D., O'Hare, M., Kur, J., Barabas, P., Revolta, G., Scholfield, C. N., McGeown, G. & McGahon, M. K., 14 Jul 2018, In: Journal of visualized experiments : JoVE. 137, 19 p., e57944.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)152 Downloads (Pure) -
Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine
McDowell, R. E., Barabas, P., Augustine, J., Chevallier, O., McCarron, P., Chen, M., McGeown, J. G. & Curtis, T. M., Dec 2018, In: Diabetologia. 61, 12, p. 2654-2667 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)309 Downloads (Pure) -
2017
Actions of PGLa-AM1 and its [A14K] and [A20K] analogues and their therapeutic potential as anti-diabetic agents
Owolabi, B. O., Musale, V., Ojo, O. O., Moffett, R. C., McGahon, M. K., Curtis, T. M., Conlon, J. M., Flatt, P. R. & Abdel-Wahab, Y. H. A., Jul 2017, In: Biochimie. 138, p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)394 Downloads (Pure) -
Esculentin-2CHa(1–30) and its analogues: stability and mechanisms of insulinotropic action
Vasu, S., McGahon, M. K., Moffett, R. C., Curtis, T. M., Conlon, J. M., Abdel-Wahab, Y. H. A. & Flatt, P. R., Mar 2017, In: The Journal of endocrinology. 232, p. 423-435 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)358 Downloads (Pure) -
PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation
Rajapakse, D., Chen, M., Curtis, T. & Xu, H., 09 Oct 2017, In: Aging. 9, 10, p. 2052-2068Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)257 Downloads (Pure) -
TRPA1 activation in a human sensory neuronal model: relevance to cough hypersensitivity?
Clarke, R., Monaghan, K., About, I., Griffin, C. S., Sergeant, G. P., El Karim, I., McGeown, J. G., Cosby, S. L., Curtis, T. M., McGarvey, L. P. & Lundy, F. T., 20 Sep 2017, In: European Respiratory Journal. 50, 3, 10 p., 1700995.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)167 Downloads (Pure) -
Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture
Rajapakse, D., Curtis, T., Chen, M. & Xu, H., 14 Nov 2017, In: Oxidative Medicine and Cellular Longevity. 2017, p. 1-12 6926485.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)204 Downloads (Pure) -
2016
Biodentine Reduces Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells
El Karim, I. A., McCrudden, M. T. C., McGahon, M. K., Curtis, T. M., Jeanneau, C., Giraud, T., Irwin, C. R., Linden, G. J., Lundy, F. T. & About, I., Apr 2016, In: Journal of Endodontics. 42, 4, p. 589-595 7 p.Research output: Contribution to journal › Article › peer-review
File19 Citations (Scopus)604 Downloads (Pure) -
Diabetes Impairs the Aldehyde Detoxifying Capacity of the Retina
McDowell, R. E., McGahon, M. K., Augustine, J., Chen, M., McGeown, G. & Curtis, T. M., 01 Sep 2016, In: Investigative ophthalmology & visual science. 57, 11, p. 4762-4771 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)362 Downloads (Pure) -
Molecular mechanisms mediating the beneficial metabolic effects of [Arg4]tigerinin-1R in mice with diet-induced obesity and insulin resistance
Ojo, O. O., Srinivasan, D. K., Owolabi, B. O., McGahon, M. K., Moffett, R. C., Curtis, T. M., Conlon, J. M., Flatt, P. R. & Abdel-Wahab, Y. H. A., Aug 2016, In: Biological Chemistry. 397, 8, p. 753-764 12 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
The progress in understanding and treatment of diabetic retinopathy
Stitt, A. W., Curtis, T. M., Chen, M., Medina, R. J., McKay, G. J., Jenkins, A., Gardiner, T. A., Lyons, T. J., Hammes, H-P., Simó, R. & Lois, N., Mar 2016, In: Progress in Retinal and Eye Research. 51, p. 156-186Research output: Contribution to journal › Article › peer-review
381 Citations (Scopus) -
TRPV2 Channels Contribute to Stretch-Activated Cation Currents and Myogenic Constriction in Retinal Arterioles
McGahon, M. K., Fernández, J. A., Dash, D. P., McKee, J., Simpson, D. A., Zholos, A. V., McGeown, J. G. & Curtis, T. M., 01 Oct 2016, In: Investigative ophthalmology & visual science. 57, 13, p. 5637-5647 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)408 Downloads (Pure) -
2015
CaV3.1 T-Type Ca2+ Channels Contribute to Myogenic Signalling in Rat Retinal Arterioles
Fernandez, J. A., McGahon, M. K., McGeown, J. G. & Curtis, T. M., Aug 2015, In: Investigative Ophthalmology and Visual Science. 56, 9, p. 5125-5132 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)373 Downloads (Pure) -
Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium
Monaghan, K., McNaughten, J., McGahon, M. K., Kelly, C., Kyle, D., Yong, P. H., McGeown, G. & Curtis, T. M., 05 Jun 2015, In: PloS one. 10, 6, 16 p., e0128359.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Citations (Scopus)364 Downloads (Pure) -
TNF alpha-Induced p38MAPK Activation Regulates TRPA1 and TRPV4 Activity in Odontoblast-Like Cells
El Karim, I., McCrudden, M. T. C., Linden, G. J., Abdullah, H., Curtis, T. M., McGahon, M., About, I., Irwin, C. & Lundy, F. T., Nov 2015, In: American Journal of Pathology. 185, 11, p. 2994-3002 9 p.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus) -
2014
Acridine orange leukocyte fluorography in mice
Cahoon, J. M., Olson, P. R., Nielson, S., Miya, T. R., Bankhead, P., McGeown, J. G., Curtis, T. M. & Ambati, B. K., Mar 2014, In: Experimental Eye Research. 120, p. 15-19 5 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Automated detection and measurement of isolated retinal arterioles by a combination of edge enhancement and cost analysis
Fernández, J. A., Bankhead, P., Zhou, H., McGeown, J. G. & Curtis, T. M., Mar 2014, In: PloS one. 9, 3, 11 p., e91791.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)354 Downloads (Pure) -
Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in severe asthma
McGarvey, L. P., Butler, C. A., Stokesberry, S., Polley, L., McQuaid, S., Abdullah, H., Ashraf, S., McGahon, M. K., Curtis, T. M., Arron, J., Choy, D., Warke, T. J., Bradding, P., Ennis, M., Zholos, A., Costello, R. W. & Heaney, L. G., Mar 2014, In: Journal of Allergy and Clinical Immunology. 133, 3, p. 704-712 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Citations (Scopus)686 Downloads (Pure) -
Role of ion channels and subcellular Ca2+ signalling in arachidonic acid induced dilation of pressurised retinal arterioles
Kur, J., McGahon, M., Fernández, J. A., Scholfield, N., McGeown, G. & Curtis, T., 02 May 2014, In: Investigative ophthalmology & visual science. 55, 5, p. 2893-2902Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)317 Downloads (Pure) -
The Role of K+ and Cl- Channels in the Regulation of Retinal Arteriolar Tone and Blood Flow
Needham, M., McGahon, M. K., Bankhead, P., Gardiner, T. A., Scholfield, C. N., Curtis, T. M. & McGeown, J. G., 07 Apr 2014, In: Investigative ophthalmology & visual science. 55, 4, p. 2157-2165 9 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
2013
Advanced glycation end products and diabetic retinopathy
Chen, M., Curtis, T. M. & Stitt, A. W., 31 Jul 2013, In: Current medicinal chemistry. 20, 26, p. 3234-3240Research output: Contribution to journal › Article › peer-review
84 Citations (Scopus) -
Advances in our understanding of diabetic retinopathy
Stitt, A. W., Lois, N., Medina, R. J., Adamson, P. & Curtis, T. M., 01 Jul 2013, In: Clinical science (London, England : 1979). 125, 1, p. 1-17Research output: Contribution to journal › Article › peer-review
115 Citations (Scopus) -
Ca(2+) sparks promote myogenic tone in retinal arterioles
Kur, J., Bankhead, P., Scholfield, C. N., Curtis, T. M. & McGeown, JG., Apr 2013, In: British Journal of Pharmacology. 168, 7, p. 1675–1686 12 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
GABAergic control of arteriolar diameter in the rat retina
Hinds, K., Monaghan, K. P., Frølund, B., McGeown, G. & Curtis, T. M., Oct 2013, In: Investigative ophthalmology & visual science. 54, 10, p. 6798-805 8 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Therapeutic potential of targeting lipid aldehydes and lipoxidation end-products in the treatment of ocular disease
McDowell, R. E., McGeown, G., Stitt, A. W. & Curtis, T., Feb 2013, In: FUTURE MEDICINAL CHEMISTRY. 5, 2, p. 189-211Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
TRP channels in vascular disorders
Zholos, A. V. & Curtis, T. M., 2013, In: Current Topics In Medicinal Chemistry. 13, 3, p. 295-309Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
2012
Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells
Guduric-Fuchs, J., O'Connor, A., Cullen, A., Harwood, L., Medina, R. J., O'Neill, C., Stitt, A. W., Curtis, T. & Simpson, D., Jun 2012, In: Journal of Cellular Biochemistry. 113, 6, p. 2098-2111 14 p.Research output: Contribution to journal › Article › peer-review
56 Citations (Scopus) -
Fast Retinal Vessel Detection and Measurement Using Wavelets and Edge Location Refinement
Bankhead, P., Scholfield, C. N., McGeown, J. G. & Curtis, T. M., 12 Mar 2012, In: PLoS ONE. 7, 3, 12 p., e32435.Research output: Contribution to journal › Article › peer-review
Open AccessFile234 Citations (Scopus)535 Downloads (Pure) -
Feedback via Ca²⁺-activated ion channels modulates endothelin 1 signaling in retinal arteriolar smooth muscle
Stewart, M., Needham, M., Bankhead, P., Gardiner, T., Scholfield, N., Curtis, T. & McGeown, G., Mar 2012, In: Investigative Ophthalmology and Visual Science. 53, 6, p. 3059-3066 8 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Pharmacological profiling of store-operated Ca(2+) entry in retinal arteriolar smooth muscle
McGahon, M. K., McKee, J., Dash, D. P., Brown, E., Simpson, D. A., Curtis, T. M., McGeown, J. G. & Scholfield, C. N., Oct 2012, In: Microcirculation (New York, N.Y. : 1994). 19, 7, p. 586-597 12 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
2011
Detecting Ca2+ sparks on stationary and varying baselines.
Bankhead, P., Scholfield, N., Curtis, T. & McGeown, G., Mar 2011, In: American Journal of Physiology - Cell Physiology. 301, 3, p. C717-C728 12 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Diabetes-related adduct formation and retinopathy
Stitt, A. W. & Curtis, T. M., Jun 2011, In: Journal of Ocular Biology , Diseases, and Informatics. 4, 1-2, p. 10-18 9 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Human dental pulp fibroblasts express the “cold-sensing” transient receptor potential channels TRPA1 and TRPM8
El Karim, I. A., Linden, G. J., Curtis, T. M., About, I., McGahon, M. K., Irwin, C. R., Killough, S. A. & Lundy, F. T., 01 Apr 2011, In: Journal of Endodontics. 37, 4, p. 473-478Research output: Contribution to journal › Article › peer-review
41 Citations (Scopus) -
Human odontoblasts express functional thermo-sensitive TRP channels: implications for dentin sensitivity
El Karim, I. A., Linden, G. J., Curtis, T. M., About, I., McGahon, M. K., Irwin, C. R. & Lundy, F. T., 01 Oct 2011, In: Pain. 152, 10, p. 2211-2223Research output: Contribution to journal › Article › peer-review
73 Citations (Scopus)