Research output per year
Research output per year
- 22 results
Search results
-
2024
Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
Stevenson, L., Cairns, L., Li, X., Jammula, S., Taylor, H., Douglas, R., McCabe, N., Gavory, G., Jacq, X., Fitzgerald, R. C., Kennedy, R. D., Harrison, T. & Turkington, R. C., 30 Dec 2024, In: Scientific Reports. 14, 14 p., 32121 .Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Jurisic, A., Sung, P.-J., Wappett, M., Daubriac, J., Lobb, I. T., Kung, W.-W., Crawford, N., Page, N., Cassidy, E., Feutren-Burton, S., Rountree, J. S. S., Helm, M. D., O'Dowd, C. R., Kennedy, R. D., Gavory, G., Cranston, A. N., Longley, D. B., Jacq, X. & Harrison, T., 11 Apr 2024, In: Clinical and Translational Medicine. 14, 4, 22 p., e1648.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Downloads (Pure) -
2022
Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development
Page, N., Wappett, M., O'Dowd, C. R., O'Rourke, M., Gavory, G., Zhang, L., Rountree, J. S. S., Jordan, L., Barker, O., Gibson, H., Boyd, C., Feutren-Burton, S., McLean, E., Trevitt, G. & Harrison, T., 20 Sept 2022, (Early online date) In: Scientific Reports. 12, 14 p., 15715.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)109 Downloads (Pure) -
2020
A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis
Humphreys, L. M., Fox, J. P., Higgins, C. A., Majkut, J., Sessler, T., McLaughlin, K., McCann, C., Roberts, J. Z., Crawford, N. T., McDade, S. S., Scott, C. J., Harrison, T. & Longley, D. B., 31 Jan 2020, (Early online date) In: EMBO Reports. 21, e49254.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Citations (Scopus)206 Downloads (Pure) -
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer
Khawaja, H., Campbell, A., Roberts, J. Z., Javadi, A., O’Reilly, P., McArt, D., Allen, W. L., Majkut, J., Rehm, M., Bardelli, A., Di Nicolantonio, F., Scott, C. J., Kennedy, R., Vitale, N., Harrison, T., Sansom, O. J., Longley, D. B., Evergren, E. & Van Schaeybroeck, S., 29 Oct 2020, (Early online date) In: Cell death and disease. 11, 10, 18 p., 930.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)109 Downloads (Pure) -
Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial
Inhaled Interferon Beta COVID-19 Study Group, 12 Nov 2020, In: The Lancet Respiratory Medicine. 9, 2, p. 196-206 11 p.Research output: Contribution to journal › Article › peer-review
335 Citations (Scopus) -
2019
Identification and SAR exploration of a novel series of Legumain inhibitors
Eddie, S. L., Gregson, A., Graham, E., Burton, S., Harrison, T., Burden, R., Scott, C. J., Mullan, P. B. & Williams, R., 15 Jun 2019, In: Bioorganic & Medicinal Chemistry Letters. 29, 12, p. 1546-1548 3 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
2018
Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial
MESOS study investigators, Jul 2018, In: The Lancet Respiratory Medicine. 6, 7, p. 499-510 12 p.Research output: Contribution to journal › Article › peer-review
110 Citations (Scopus) -
Identification and structure-guided development of pyrimidinone based USP7 inhibitors
O'Dowd, C. R., Helm, M. D., Rountree, J. S. S., Flasz, J. T., Arkoudis, E., Miel, H., Hewitt, P. R., Jordan, L., Barker, O., Hughes, C., Rozycka, E., Cassidy, E., McClelland, K., Odrzywol, E., Page, N., Fuetren-Burton, S., Dvorkin, S., Gavory, G. & Harrison, T., 08 Mar 2018, In: ACS Medicinal Chemistry Letters. 9, 3, p. 238-243Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Citations (Scopus)440 Downloads (Pure) -
2017
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Gavory, G., O'Dowd, C., Helm, M. D., Flasz, J., Arkoudis, E., Dossang, A., Hughes, C., Cassidy, E., McClelland, K., Odrzywol, E., Page, N., Barker, O., Miel, H. & Harrison, T., 04 Dec 2017, In: Nature Chemical Biology. 14, p. 118-125Research output: Contribution to journal › Article › peer-review
Open AccessFile159 Citations (Scopus)2220 Downloads (Pure) -
Identification and Characterization of Dual Inhibitors of the USP25/ 28 Deubiquitinating Enzyme Subfamily
Wrigley, J. D., Gavory, G., Simpson, I., Preston, M., Plant, H., Bradley, J., Goeppert, A. U., Rozycka, E., Davies, G., Walsh, J., Valentine, A., McClelland, K., Odrzywol, K. E., Renshaw, J., Boros, J., Tart, J., Leach, L., Nowak, T., Ward, R. A. & Harrison, T. & 1 others, , 13 Nov 2017, In: ACS Chemical Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile68 Citations (Scopus)1117 Downloads (Pure) -
RalB GTPase: A potential novel target for RAS mutant colorectal cancer.
Khawaja, H., O'Reilly, P., McArt, D., Harrison, T., Johnston, P. & Van Schaeybroeck, S., 18 Sept 2017, In: Annals of Oncology. 28, supply_5, p. v573Research output: Contribution to journal › Meeting abstract › peer-review
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2016
Delivering a Research-Enabled Multistakeholder Partnership for Enhanced Patient Care at a Population Level: The Northern Ireland Comprehensive Cancer Program
Lawler, M., Gavin, A., Salto-Tellez, M., Kennedy, R. D., Van Schaeybroeck, S., Wilson, R. H., Harkin, D. P., Grayson, M., Boyd, R. E., Hamilton, P. W., McArt, D. G., James, J., Robson, T., Ladner, R. D., Prise, K. M., O'Sullivan, J. M., Harrison, T., Murray, L., Johnston, P. G. & Waugh, D. J., 01 Mar 2016, In: Cancer. 122, 5, p. 664-673 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)376 Downloads (Pure) -
FLIP: a targetable mediator of resistance to radiation in non-small cell lung cancer
McLaughlin, K. A., Nemeth, Z., Bradley, C. A., Humphreys, L., Stasik, I., Fenning, C., Majkut, J., Higgins, C., Crawford, N., Holohan, C., Johnston, P. G., Harrison, T., Hanna, G. G., Butterworth, K. T., Prise, K. M. & Longley, D. B., 01 Oct 2016, In: Molecular Cancer Therapeutics. p. 2432-2441 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)311 Downloads (Pure) -
Mebendazole: A candidate FDA approved drug for repurposing in leukaemia
Matchett, K. B., Grishagin, I. V., Kettyle, L. M., Gavory, G., Harrison, T., Mills, K. & Thompson, A., 01 Apr 2016, p. 121-122. 1 p.Research output: Contribution to conference › Abstract › peer-review
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2015
Research in Progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)
Heaney, L. G., Djukanovic, R., Woodcock, A., Walker, S., Matthews, J. G., Pavord, I. D., Bradding, P., Niven, R., Brightling, C. E., Chaudhuri, R., Arron, J. R., Choy, D. F., Cowan, D., Mansur, A., Menzies-Gow, A., Adcock, I., Chung, K. F., Corrigan, C., Coyle, P. & Harrison, T. & 16 others, , 23 Jul 2015, In: Thorax. 71, 2, p. 1587-189 3 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile80 Citations (Scopus)887 Downloads (Pure) -
2014
P3 SAR exploration of biphenyl carbamate based Legumain inhibitors
Higgins, C., Bouazzaoui, S., Gaddale Devanna, K., D'Costa, Z., Templeman, A., O'Rourke, M., Young, A., Scott, C., Harrison, T., Mullan, P. & Williams, R., 01 Jun 2014, In: Bioorganic and Medicinal Chemistry Letters. 24, 11, p. 2521-2524Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. a randomized trial
Djukanović, R., Harrison, T., Johnston, S. L., Gabbay, F., Wark, P., Thomson, N. C., Niven, R., Singh, D., Reddel, H. K., Davies, D. E., Marsden, R., Boxall, C., Dudley, S., Plagnol, V., Holgate, S. T., Monk, P., INTERCIA Study Group & McGarvey, L., 15 Jul 2014, In: American Journal of Respiratory and Critical Care Medicine. 190, 2, p. 145-154 10 p.Research output: Contribution to journal › Article › peer-review
229 Citations (Scopus) -
2012
Activation of and dependence on ataxia telangiectasia mutated kinase in PTEN-deficient tumor cells
McCabe, N., Walker, S. M., Goffard, N., Wikstrom, K., Greenan, C., McLean, E., McDyer, F. A., Keating, K. E., James, I., Harrison, T., Mullan, P. B., Harkin, D. P., Chen, C. & Kennedy, R. D., 20 May 2012, In: Journal of Clinical Oncology. 30, 15, S, 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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A PROGNOSTIC SIGNATURE FOR PTEN-DEFICIENT GLIOBLASTOMAS
Gonda, D. D., Li, J., McCabe, N., Walker, S., Goffard, N., Wikstrom, K., McLean, E., Greenan, C., Delaney, T., McCarthy, M., McDyer, F., Keating, K. E., James, I. F., Harrison, T., Mullan, P., Harkin, D. P., Carter, B. S., Kennedy, R. & Chen, C. C., Oct 2012, In: Journal of Neuro-Oncology. 14, 6, p. 98 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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2011
An evaluation of siRNA screening in identification of targets in PTEN deficient tumor cells
McCabe, N., Walker, S. M., Wikstrom, K., Greenan, C., McLean, E., Delaney, T., McCarthy, M., Cochrane, D., Wilson, C., Davison, T. S., McDyer, F. A., Jellema, G. L., Goffard, N., James, I., Harrison, T., Mullan, P. B., Harkin, D. P. & Kennedy, R. D., 20 May 2011, In: Journal of Clinical Oncology. 29, 15, 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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2000
Rationalised prescribing for community acquired pneumonia: a closed loop audit
Clements, H., Stephenson, T., Gabriel, V., Harrison, T., Millar, M., Smyth, A., Tong, W. & Linton, C. J., 01 Oct 2000, In: Archives of Disease in Childhood. 83, 4, p. 320-324 5 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Citations (Scopus)