Projects per year
I am an MRC Clinical Research Fellow and specialty registrar in Medical Microbiology, interested in new treatment strategies for complex respiratory infections. The focus of my PhD is investigating a potential cell therapy for mycobacterial pulmonary infections, under the supervision of Prof Cecilia O'Kane, Dr Anna Krasnodembskaya and Dr Gunnar Schroeder.
Mesenchymal stromal cells (MSCs) are multipotent adult cells that regenerate injured tissues in normal health. Recent discoveries about their ability to modulate immune cells and release antimicrobial factors have highlighted a potential role in treating difficult infections. I am studying MSC ability to enhance macrophages in the killing of non-tuberculous mycobacteria (NTM).These bacteria are multi-drug resistant and are a growing cause of respiratory infection in patients with impaired immunity and structural lung disease. The typical antibiotic course for NTM pulmonary infection lasts around 18 months and has poor outcomes for many patients.
My aim is to help bring better treatments to the bedside by testing MSCs and other new approaches to improve immune clearance of difficult respiratory pathogens like NTM.
Shaw, T. D., McAuley, D. F. & O'Kane, C. M., 18 Mar 2019, In: Expert opinion on emerging drugs. 24, 1, p. 29-41 13 p.
Research output: Contribution to journal › Review article › peer-review
The use of high-throughput sequencing to investigate an outbreak of glycopeptide-resistant Enterococcus faecium with a novel quinupristin-dalfopristin resistance mechanism.Shaw, T., Fairley, D. J., Schneiders, T., Pathiraja, M., Hill, R. L. R., Werner, G., Elborn, J. & McMullan, R., 24 Feb 2018, (Early online date) In: European Journal of Clinical Microbiology and Infectious Diseases. p. 1-9
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)86 Downloads (Pure)
A putative novel mechanism of resistance to quinupristin-dalfopristin in clinical isolates of Enterococcus faecium in Northern IrelandShaw, T. D., Schneiders, T., Pathiraja, M., Hill, R. L. R., Elborn, J. S. & McMullan, R., 12 May 2014.
Research output: Contribution to conference › Paper › peer-review
Shaw, T. D., Downey, D. G., Moore, J. E., Rendall, J. C. & Elborn, J. S., Aug 2014, In: BMJ Open Respiratory Research. 1, p. 1-7 e000021.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile17 Citations (Scopus)156 Downloads (Pure)