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I'm a specialty registrar in Infectious Diseases and Medical Microbiology, interested in new strategies to enhance the immune response against difficult-to-treat pathogens, with a focus on non-tuberculous mycobacteria (NTM)
NTM pulmonary disease is an emerging infectious disease with poor clinical outcomes and few effective therapies. Mesenchymal stromal cells (MSCs) are mature, multipotent cells that regenerate injured tissues in normal health. Recent discoveries about their ability to modulate immune cells and release antimicrobial factors have highlighted a potential role in treating difficult infections.
Currently, I'm working with Prof Cecilia O'Kane, Dr Anna Krasnodembskaya, Dr Gunnar Schroeder and Dr Beckie Ingram to develop clinically-relevant models of NTM infection for testing the potential of MSCs and other immunomodulatory therapies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious DiseasesShaw, T. D., Krasnodembskaya, A. D., Schroeder, G. N., Zumla, A., Maeurer, M. & O'Kane, C. M., 06 Oct 2021, (Early online date) In: Clinical microbiology reviews. 34, 4, e00064-21.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile95 Downloads (Pure)
Shaw, T. D., Smyth, M., Turner, G. & Hunter, M., Aug 2021, In: Journal of clinical tuberculosis and other mycobacterial diseases. 24, 100261.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile24 Downloads (Pure)
The utility of 16S rRNA gene sequencing on intraoperative specimens from intracranial infections: an 8-year study in a regional UK neurosurgical unitShaw, T. D., Curran, T., Cooke, S., McMullan, R. & Hunter, M., 20 Dec 2021, (Early online date) In: British journal of neurosurgery. p. 1-6
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile23 Downloads (Pure)
Shaw, T. D., McAuley, D. F. & O'Kane, C. M., 18 Mar 2019, In: Expert opinion on emerging drugs. 24, 1, p. 29-41 13 p.
Research output: Contribution to journal › Review article › peer-review
The use of high-throughput sequencing to investigate an outbreak of glycopeptide-resistant Enterococcus faecium with a novel quinupristin-dalfopristin resistance mechanism.Shaw, T., Fairley, D. J., Schneiders, T., Pathiraja, M., Hill, R. L. R., Werner, G., Elborn, J. & McMullan, R., 24 Feb 2018, (Early online date) In: European Journal of Clinical Microbiology and Infectious Diseases. p. 1-9
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Shaw, Timothy (Recipient), 08 Jul 2022
Prize: Prize (including medals and awards)
Investigating the antimicrobial efficacy of mesenchymal stromal cells as a novel potential therapy for Mycobacterium avium pulmonary infectionAuthor: Shaw, T., Dec 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy