• Room 03.007 - CCRCB

    United Kingdom

20042018

Research output per year

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Research Output

2018

A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424

Woodcock, V. K., Clive, S., Wilson, R. H., Coyle, V. M., Stratford, M. R. L., Folkes, L. K., Eastell, R., Barton, C., Jones, P., Kazmi-Stokes, S., Turner, H., Halford, S., Harris, A. L. & Middleton, M. R., 20 Mar 2018, In : British Journal of Cancer. 118, p. 770-776 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
136 Downloads (Pure)

CHALLENGE-UK: A UK cohort of the colon health and lifelong exercise change study: A phase III randomised control trial.

Brown, M., Yates, T., Forde, C., Adams, R., Booth, C., Courneya, K., Donnelly, M., O'Callaghan, C., Russell, A., Storey, D., Thomas, A., Wilson, R. & Coyle, V., Nov 2018, In : Journal of sports sciences. 36, S1, p. 22

Research output: Contribution to journalMeeting abstract

Transcriptional Subtyping and CD8 Immunohistochemistry Identifies Patients With Stage II and III Colorectal Cancer With Poor Prognosis Who Benefit From Adjuvant Chemotherapy

Allen, W., Dunne, P., McDade, S., Scanlon, E., Loughrey, M., Coleman, H., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N. A., Jithesh, P. V., Arthur, K., Wilson, R., Coyle, V., McArt, D., Johnston, P., Murray, G. I., Samuel, L. M., Nuciforo, P., Jimenez, J. & 12 others, Argiles, G., Dienstmann, R., Picariello, L., Nobili, S., Mini, E., Sheahan, K., Ryan, E., Tabernero, J., Messerini, L., Van Schaeybroeck, S., Lawler, M. & Longley, D., 13 Jun 2018, In : JCO Precision Oncology. 2018, p. 1-15

Research output: Contribution to journalArticle

Open Access
File
256 Downloads (Pure)

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival

Alderdice, M., Dunne, P. D., Cole, A. J., O'Reilly, P. G., McArt, D. G., Bingham, V., Fuchs, M-A., McQuaid, S., Loughrey, M. B., Graeme, M. I., Samuel, L. M., Lawler, M., Wilson, R. H., Salto-Tellez, M. & Coyle, V. M., 16 Jun 2017, In : Modern Pathology .

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2016

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours

Jamieson, D., Griffin, M., Sludden, J., Drew, Y., Cresti, N., Swales, K., Merriman, M., Allen, R., Bevan, P., Buerkle, M., Mala, C., Coyle, V., Rodgers, L., Dean, E., Greystoke, A., Banerji, U., Wilson, R., Evans, J., Anthoney, A., Ranson, M. & 2 others, Boddy, A. & Plummer, R., Nov 2016, In : European Journal of Cancer. 68, 11 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
276 Downloads (Pure)

Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer

Graham, D. M., Coyle, V. M., Kennedy, R. D. & Wilson, R. H., Jun 2016, In : Current Colorectal Cancer Reports. 12, 3, p. 141-150 10 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
496 Downloads (Pure)

The EASI-SWITCH trial: Early switch to oral antbiotics in patients with low risk neutropenic sepsis.

Forde, C., McMullan, R., Clarke, M., Wilson, R., Plummer, E. R., Thomas, A. L., barnes, R., Adams, R., Chau, I., Grayson, M., McDowell, C., Agus, A., brown, E., Storey, D. G., McAuley, D. & Coyle, V., 2016.

Research output: Contribution to conferencePoster

2015

Immune modulation in advanced radiotherapies: Targeting out-of-field effects

Hanna, G. G., Coyle, V. M. & Prise, K. M., 28 Nov 2015, In : Cancer Letters. 368, 2, p. 246-251 6 p.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
171 Downloads (Pure)
2014

Diagnostic value of increased sensitivity by massively parallel sequencing

Alderdice, M., Maxwell, P., Coyle, V., Wilson, R. & Salto-Tellez, M., 03 Nov 2014.

Research output: Contribution to conferencePoster

2013

A randomised double-blind placebo-controlled phase II study of AGI004 for control of chemotherapy-induced diarrhoea

Coyle, V. M., Lungulescu, D., Toganel, C., Niculescu, A., Pop, S., Ciuleanu, T., Cebotaru, C., Devane, J., Martin, M. & Wilson, R. H., 19 Mar 2013, In : British Journal of Cancer. 108, 5, p. 1027-1033 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2012
8 Citations (Scopus)

A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer

Allen, W., Stevenson, L., Coyle, V., Jithesh, P., Proutski, I., Carson, G., Gordon, M. A., Lenz, H. J. D., Van Schaeybroeck, S., Longley, D. & Johnston, P., Jan 2012, In : Molecular Cancer Therapeutics. 11, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Metastatic melanoma: A regional review and future directions

Khan, K. H., Goody, R. B., Hameed, H., Jalil, A., Coyle, V. & McAleer, J. J. A., Sep 2012, In : Tumori. 98, 5, p. 575-580 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
6 Citations (Scopus)
2010

Genomic markers for decision making: What is preventing us from using markers?

Coyle, V. & Johnston, P. G., Feb 2010, In : Nature Reviews Clinical Oncology. 7, 2, p. 90-97 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer

McLornan, D. P., Barrett, H. L., Cummins, R., McDermott, U., McDowell, C., Conlon, S. J., Coyle, V. M., Van Schaeybroeck, S., Wilson, R., Kay, E. W., Longley, D. B. & Johnston, P. G., 01 Jul 2010, In : Clinical Cancer Research. 16, 13, p. 3442-3451 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2009

Basic Genomics for Practising Oncologists

Coyle, V., Allen, W., Jithesh, P. & Johnston, P., Sep 2009, Bethesda Handbook of Clinical Oncology. Springer, p. 584 553 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genomic profiling of colorectal cancer

Coyle, V. & Johnston, P. G., Sep 2009, In : European Journal of Cancer. 45, SUPPL. 1, p. 371-374 4 p.

Research output: Contribution to journalArticle

Predicting response to irinotecan/5-fluorouracil (5-FU) chemotherapy for advanced colorectal cancer based on gene expression in primary tumour

Coyle, V., Allen, W., Jithesh, P., McManus, D., Stevenson, M., Harte, R., Eatock, M., Wilson, R. & Johnston, P., May 2009, In : American Journal of Clinical Oncology. 27

Research output: Contribution to journalArticle

2008

Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Allen, W., Coyle, V., Jithesh, P., Proutski, I., Stevenson, L., Fenning, C., Longley, D., Wilson, R., Gordon, M., Lenz, H. J. & Johnston, P., 15 Oct 2008, In : Clinical Cancer Research. 14, 20, p. 6647-6655 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2007

Prognostic and predictive markers in colorectal cancer - The role of new genomic technologies

Coyle, V., Allen, W. L., Longley, D. B. & Johnston, P. G., Dec 2007, In : Current Pharmacogenomics. 5, 4, p. 255-261 7 p.

Research output: Contribution to journalArticle

The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells.

Allen, W., McLean, E., Coyle, V., Boyer, J., Longley, D. & Johnston, P., 2007, In : Molecular Cancer Therapeutics. 6, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2006

Gastrointestinal infections

Coyle, V., McMullan, R. & Johnston, P., 2006, Infection in the Cancer Patient A Practical Guide. 1st ed. Oxford University Press, p. 61-78

Research output: Chapter in Book/Report/Conference proceedingChapter

2004

Catheter-related bloodstream infection in adult haematology patients: Catheter removal practice and outcome

Coyle, V. M., Morris, T. C. M., McMullan, R., Rooney, P. J. & Hedderwick, S., 01 Aug 2004, In : Journal of Hospital Infection. 57, 4, p. 325-331 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)