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20042018
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Research Output 2004 2018

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Article
2018
2 Citations (Scopus)
115 Downloads (Pure)

A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424

Woodcock, V. K., Clive, S., Wilson, R. H., Coyle, V. M., Stratford, M. R. L., Folkes, L. K., Eastell, R., Barton, C., Jones, P., Kazmi-Stokes, S., Turner, H., Halford, S., Harris, A. L. & Middleton, M. R., 20 Mar 2018, In : British Journal of Cancer. 118, p. 770-776 7 p.

Research output: Contribution to journalArticle

Open Access
File
Maximum Tolerated Dose
Neoplasms
Bone Remodeling
Alopecia
Anorexia
238 Downloads (Pure)

Transcriptional Subtyping and CD8 Immunohistochemistry Identifies Patients With Stage II and III Colorectal Cancer With Poor Prognosis Who Benefit From Adjuvant Chemotherapy

Allen, W., Dunne, P., McDade, S., Scanlon, E., Loughrey, M., Coleman, H., McCann, C., McLaughlin, K., Nemeth, Z., Syed, N. A., Jithesh, P. V., Arthur, K., Wilson, R., Coyle, V., McArt, D., Johnston, P., Murray, G. I., Samuel, L. M., Nuciforo, P., Jimenez, J. & 12 others, Argiles, G., Dienstmann, R., Picariello, L., Nobili, S., Mini, E., Sheahan, K., Ryan, E., Tabernero, J., Messerini, L., Van Schaeybroeck, S., Lawler, M. & Longley, D., 13 Jun 2018, In : JCO Precision Oncology. 2018, p. 1-15

Research output: Contribution to journalArticle

Open Access
File
Adjuvant Chemotherapy
Colorectal Neoplasms
Immunohistochemistry
Standard of Care
Neoplasms
2017
6 Citations (Scopus)

Natural killer-like signature observed post therapy in locally advanced rectal cancer is a determinant of pathological response and improved survival

Alderdice, M., Dunne, P. D., Cole, A. J., O'Reilly, P. G., McArt, D. G., Bingham, V., Fuchs, M-A., McQuaid, S., Loughrey, M. B., Graeme, M. I., Samuel, L. M., Lawler, M., Wilson, R. H., Salto-Tellez, M. & Coyle, V. M., 16 Jun 2017, In : Modern Pathology .

Research output: Contribution to journalArticle

Open Access
Rectal Neoplasms
Chemoradiotherapy
Survival
Neoplasms
Natural Killer Cells
2016
3 Citations (Scopus)
250 Downloads (Pure)

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours

Jamieson, D., Griffin, M., Sludden, J., Drew, Y., Cresti, N., Swales, K., Merriman, M., Allen, R., Bevan, P., Buerkle, M., Mala, C., Coyle, V., Rodgers, L., Dean, E., Greystoke, A., Banerji, U., Wilson, R., Evans, J., Anthoney, A., Ranson, M. & 2 others, Boddy, A. & Plummer, R., Nov 2016, In : European Journal of Cancer. 68, 11 p.

Research output: Contribution to journalArticle

Open Access
File
Mitogen-Activated Protein Kinase Kinases
Pharmacokinetics
Extracellular Signal-Regulated MAP Kinases
Neoplasms
MAP Kinase Kinase 1
23 Citations (Scopus)
479 Downloads (Pure)

Molecular Subtypes and Personalized Therapy in Metastatic Colorectal Cancer

Graham, D. M., Coyle, V. M., Kennedy, R. D. & Wilson, R. H., Jun 2016, In : Current Colorectal Cancer Reports. 12, 3, p. 141-150 10 p.

Research output: Contribution to journalArticle

Open Access
File
Colorectal Neoplasms
Therapeutics
Precision Medicine
Gene Regulatory Networks
Immunotherapy
2015
29 Citations (Scopus)
155 Downloads (Pure)

Immune modulation in advanced radiotherapies: Targeting out-of-field effects

Hanna, G. G., Coyle, V. M. & Prise, K. M., 28 Nov 2015, In : Cancer Letters. 368, 2, p. 246-251 6 p.

Research output: Contribution to journalArticle

Open Access
File
Radiotherapy
Therapeutics
Radiation
Bystander Effect
Neoplasms
2013
2 Citations (Scopus)

A randomised double-blind placebo-controlled phase II study of AGI004 for control of chemotherapy-induced diarrhoea

Coyle, V. M., Lungulescu, D., Toganel, C., Niculescu, A., Pop, S., Ciuleanu, T., Cebotaru, C., Devane, J., Martin, M. & Wilson, R. H., 19 Mar 2013, In : British Journal of Cancer. 108, 5, p. 1027-1033 7 p.

Research output: Contribution to journalArticle

Diarrhea
Placebos
Drug Therapy
Transdermal Patch
Mecamylamine
2012
8 Citations (Scopus)
antineoplaston A10
Adjuvant Chemotherapy
Retrospective Studies
Breast Neoplasms
Cyclophosphamide
20 Citations (Scopus)

A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer

Allen, W., Stevenson, L., Coyle, V., Jithesh, P., Proutski, I., Carson, G., Gordon, M. A., Lenz, H. J. D., Van Schaeybroeck, S., Longley, D. & Johnston, P., Jan 2012, In : Molecular Cancer Therapeutics. 11, 1, p. 119-131 13 p.

Research output: Contribution to journalArticle

Systems Biology
Drug Resistance
Fluorouracil
Colorectal Neoplasms
Caspase 8
12 Citations (Scopus)

Metastatic melanoma: A regional review and future directions

Khan, K. H., Goody, R. B., Hameed, H., Jalil, A., Coyle, V. & McAleer, J. J. A., Sep 2012, In : Tumori. 98, 5, p. 575-580 6 p.

Research output: Contribution to journalArticle

Melanoma
temozolomide
Dacarbazine
Neoplasm Metastasis
Therapeutics
6 Citations (Scopus)
irinotecan
Pharmacogenetics
Mitogen-Activated Protein Kinases
Colorectal Neoplasms
Null Lymphocytes
2010
14 Citations (Scopus)

Genomic markers for decision making: What is preventing us from using markers?

Coyle, V. & Johnston, P. G., Feb 2010, In : Nature Reviews Clinical Oncology. 7, 2, p. 90-97 8 p.

Research output: Contribution to journalArticle

Decision Making
Clinical Trials
Gene Expression Profiling
Neoplasms
Research Personnel
52 Citations (Scopus)

Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer

McLornan, D. P., Barrett, H. L., Cummins, R., McDermott, U., McDowell, C., Conlon, S. J., Coyle, V. M., Van Schaeybroeck, S., Wilson, R., Kay, E. W., Longley, D. B. & Johnston, P. G., 01 Jul 2010, In : Clinical Cancer Research. 16, 13, p. 3442-3451 10 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Colorectal Neoplasms
Caspase 8
Neoplasms
Survival
2009

Genomic profiling of colorectal cancer

Coyle, V. & Johnston, P. G., Sep 2009, In : European Journal of Cancer. 45, SUPPL. 1, p. 371-374 4 p.

Research output: Contribution to journalArticle

Predicting response to irinotecan/5-fluorouracil (5-FU) chemotherapy for advanced colorectal cancer based on gene expression in primary tumour

Coyle, V., Allen, W., Jithesh, P., McManus, D., Stevenson, M., Harte, R., Eatock, M., Wilson, R. & Johnston, P., May 2009, In : American Journal of Clinical Oncology. 27

Research output: Contribution to journalArticle

2008
18 Citations (Scopus)

Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Allen, W., Coyle, V., Jithesh, P., Proutski, I., Stevenson, L., Fenning, C., Longley, D., Wilson, R., Gordon, M., Lenz, H. J. & Johnston, P., 15 Oct 2008, In : Clinical Cancer Research. 14, 20, p. 6647-6655 9 p.

Research output: Contribution to journalArticle

irinotecan
Cell Line
DNA Fingerprinting
Oligonucleotide Array Sequence Analysis
Colonic Neoplasms
2007

Prognostic and predictive markers in colorectal cancer - The role of new genomic technologies

Coyle, V., Allen, W. L., Longley, D. B. & Johnston, P. G., Dec 2007, In : Current Pharmacogenomics. 5, 4, p. 255-261 7 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Technology
oxaliplatin
irinotecan
Fluorouracil
39 Citations (Scopus)

The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells.

Allen, W., McLean, E., Coyle, V., Boyer, J., Longley, D. & Johnston, P., 2007, In : Molecular Cancer Therapeutics. 6, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

2004
26 Citations (Scopus)

Catheter-related bloodstream infection in adult haematology patients: Catheter removal practice and outcome

Coyle, V. M., Morris, T. C. M., McMullan, R., Rooney, P. J. & Hedderwick, S., 01 Aug 2004, In : Journal of Hospital Infection. 57, 4, p. 325-331 7 p.

Research output: Contribution to journalArticle

Catheter-Related Infections
Central Venous Catheters
Hematology
Catheters
Sepsis