Projects per year
Personal profile
Interests
Dr. Kett's research interests lie in the development and characterisation of
- freeze-dried and spray-dried formats for mucosal (nasal, inhaled, sublingual and vaginal) administration of material including vaccine, antibiotic and HIV microbicides.
- mucosal delivery of nanoparticles encapsulating payloads such as antibiotics and vaccine
More fundamental research includes investigation into the mechanisms of protein protection during freeze-drying using thermal analysis techniques (DSC, MTDSC and isothermal microcalorimetry) as well as neutron scattering in collaboration with colleagues at the Rutherford Appleton Laboratory.
She has also worked extensively in the use of thermal techniques to characterise amorphous systems and the detection of polymorphic transitions.
Dr. Kett was involved in the foundation of the Clinical Raman microscopy unit together with colleagues from the schools of chemistry and Medicine, Dentistry & Biomedical Science and has published on the use of this technique for the identification of polymorphic changes in pharmaceutical systems.
In 2002 she was awarded the Royal Society of Chemistry Thermal Methods Group Cyril Keattch award for “The Application of Thermoanalytical Techniques to the Study of the Freeze Drying Process”.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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R3022PMY: Inhaled Azithromycin for Treatment of Chronic Respiratory Infection
Kett, V. (PI), Ingram, B. (CoI) & Tunney, M. (CoI)
09/02/2018 → 31/01/2021
Project: Research
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R2003PMY: Chemokine-based microbicides: a pathway from a first-in-human study towards Phase2/3 and licensure
Malcolm, K. (PI), Boyd, P. (CoI) & Kett, V. (CoI)
13/02/2015 → 31/12/2017
Project: Research
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R6286PMY: European Consortium on Neutralising Antibodies Using gp41 - EURONEUT-41
Malcolm, K. (PI), Andrews, G. (CoI), Kett, V. (CoI) & Woolfson, D. (CoI)
01/08/2007 → 31/12/2012
Project: Research
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Pulmonary delivery of antibiotics to the lungs: current state and future prospects
Dallal Bashi, Y. H., Mairs, R., Murtadha, R. & Kett, V., 15 Jan 2025, In: Pharmaceutics. 17, 1, 23 p., 111.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Inhaled dry powder liposomal azithromycin for treatment of chronic lower respiratory tract infection
Dallal Bashi, Y. H., Ali, A., Al Ayoub, Y., Assi, K. H., Mairs, R., McCarthy, H. O., Tunney, M. M. & Kett, V. L., 25 Mar 2024, In: International Journal of Pharmaceutics. 653, 11 p., 123841.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)65 Downloads (Pure) -
Aerosolised micro and nanoparticle: formulation and delivery method for lung imaging
Munir, M., Setiawan, H., Awaludin, R. & Kett, V. L., Feb 2023, In: Clinical and Translational Imaging. 11, p. 33-50Research output: Contribution to journal › Review article › peer-review
4 Citations (Scopus) -
Development of a Spray-Dried Formulation of Peptide-Dna Nanoparticles into a Dry Powder for Pulmonary Delivery Using Factorial Design
Munir, M., Kett, V. L., Dunne, N. J. & McCarthy, H. O., 19 Apr 2022, (Early online date) In: Pharmaceutical Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)230 Downloads (Pure) -
Poster abstract: Formulation and in vitro tests of silicone elastomer vaginal rings containing lyoprotectant and metronidazole
Wang, C., Malcolm, R. K., Kett, V. & Gilpin, D., 10 Jun 2022.Research output: Contribution to conference › Abstract
Open AccessFile28 Downloads (Pure)
Prizes
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Invent 2014 Life and Health Category
Kett, V. (Recipient), Oct 2014
Prize: Prize (including medals and awards)
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QUB Green Fund Award
Hall, M. (Recipient), Hanna, L.-A. (Recipient), Kett, V. (Recipient), Brown, T. (Recipient) & Lyttle, C. (Recipient), 12 Dec 2019
Prize: Prize (including medals and awards)
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Royal Society of Chemistry Thermal Methods Group Cyril Keattch Award for "The Application of Thermoanalytical Techniques to the Study of the Freeze-Drying Process"
Kett, V. (Recipient), 2002
Prize: Prize (including medals and awards)
Activities
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QUB Annual Learning and Teaching Conference
Parsons, C. (Presenter), Carson, L. (Contributor), Kett, V. (Contributor), Laverty, G. (Contributor), McCague, P. (Contributor), Gilpin, D. (Contributor), Al-Jamal, W. (Contributor) & Hanna, L.-A. (Contributor)
23 Mar 2022 → 13 Apr 2022Activity: Participating in or organising an event types › Participation in conference
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PhD external examiner University of Greenwich
Kett, V. (Examiner)
2022Activity: Examination types › PhD external examination
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PhD External Examiner, University of Strathclyde
Kett, V. (Examiner)
2019Activity: Examination types › PhD external examination
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PhD External Examiner, University of East Anglia
Kett, V. (Examiner)
2019Activity: Examination types › PhD external examination
Press/Media
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Can The Mucosal Immunity Protect Against COVID-19?
13/07/2021
1 item of Media coverage
Press/Media: Research
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Intranasal vaccines aim to stop COVID-19 where it starts
06/06/2021
1 Media contribution
Press/Media: Expert Comment
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To Beat COVID, We May Need a Good Shot in the Nose- Scientific American
01/03/2021
1 item of Media coverage
Press/Media: Research
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Researchers at Queen’s University Belfast have Developed a Vaginal Ring Capable of Providing Sustained Delivery of OB-002 (5P12-RANTES) for HIV Prevention
Malcolm, K., Boyd, P., Kett, V. & McBride, J.
12/02/2019
1 item of Media coverage
Press/Media: Research