Victoria Bingham

Research output

Research output per year 2009 2020

• 33 Article
• 1 Conference contribution
• 1 Poster

Research output per year

Research output per year

Search results

• 2020

  Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

  McCain, R. S., McManus, D. T., McQuaid, S., James, J. A., Salto-Tellez, M., Reid, N. B., Craig, S., Chisambo, C., Bingham, V., McCarron, E., Parkes, E., Turkington, R. C. & Coleman, H. G., 01 Jan 2020, In: Cancer Causes and Control. 31, 1, p. 1-11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tobacco Smoking
  • Molecular Epidemiology
  • Molecular Pathology
  • Adenocarcinoma
  • Alcohols
  1 Citation (Scopus)

  65 Downloads (Pure)

• A robust multiplex immunofluorescence and digital pathology workflow for the characterisation of the tumour immune microenvironment

  Viratham Pulsawatdi, A., Craig, S. G., Bingham, V., McCombe, K., Humphries, M. P., Senevirathne, S., Richman, S. D., Quirke, P., Campo, L., Domingo, E., Maughan, T. S., James, J. A. & Salto-Tellez, M., 16 Jul 2020, In: Molecular oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Workflow
  • Tumor Microenvironment
  • Fluorescent Antibody Technique
  • Pathology
  • Biomarkers
  2 Citations (Scopus)

  96 Downloads (Pure)

• Comparison of different anti‐Ki67 antibody clones and hot‐spot sizes for assessing proliferative index and grading in pancreatic neuroendocrine tumours using manual and image analysis

  Owens, R., Gilmore, E., Bingham, V., Cardwell, C., McBride, H., McQuaid, S., Humphries, M. P. & Kelly, P., 02 Jul 2020, In: Histopathology. p. 646–658

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuroendocrine Tumors
  • Antibodies
  • Patient Care
  • Guidelines
  • Neoplasms
  1 Citation (Scopus)

  5 Downloads (Pure)

• Comparison of molecular assays for HPV testing in oropharyngeal squamous cell carcinomas: a population-based study in Northern Ireland

  Craig, S., Anderson, L., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Bingham, V., Cuschieri, K., McQuaid, S., Schache, A., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., Jan 2020, In: Cancer Epidemiology, Biomarkers, & Prevention. 29, 1, p. 31-38

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Northern Ireland
  • Squamous Cell Carcinoma
  • Population
  • DNA
  • RNA
  4 Citations (Scopus)

  48 Downloads (Pure)

• Glucocorticoid Receptor Expression Predicts Good Outcome in response to Taxane-Free, Anthracycline-Based Therapy in Triple Negative Breast Cancer

  Elkashif, A., Bingham, V., Haddock, P., Humphries, M., McQuaid, S., Mullan, P., McCarthy, H. & Buckley, N. E., 20 May 2020, In: Journal of Oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • taxane
  • Triple Negative Breast Neoplasms
  • Anthracyclines
  • Glucocorticoid Receptors
  • Drug Therapy
  35 Downloads (Pure)

• Identifying mismatch repair deficient colon cancer near perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population-based series

  Loughrey, M. B., McGrath, J., Coleman, H. G., Bankhead, P., Maxwell, P., McGready, C., Bingham, V., Humphries, M. P., Craig, S. G., McQuaid, S., Salto-Tellez, M. & James, J. A., 13 Aug 2020, (Accepted) In: Histopathology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Microsatellite Instability
  • DNA Mismatch Repair
  • Colonic Neoplasms
  • Microsatellite Repeats
  • Immunohistochemistry
  1 Citation (Scopus)

• Immune status is prognostic for poor survival in colorectal cancer patients and is associated with tumour hypoxia

  Craig, S. G., Humphries, M. P., Alderdice, M., Bingham, V., Richman, S. D., Loughrey, M. B., Coleman, H. G., Viratham-Pulsawatdi, A., McCombe, K., Murray, G. I., Blake, A., Domingo, E., Robineau, J., Brown, L., Fisher, D., Seymour, M. T., Quirke, P., Bankhead, P., McQuaid, S., Lawler, M. & 4 others, McArt, D. G., Maughan, T. S., James, J. A. & Salto-Tellez, M., 20 Jul 2020, In: British Journal of Cancer.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Hypoxia
  • Colorectal Neoplasms
  • Survival
  • Hypoxia
  • Immunohistochemistry
  3 Citations (Scopus)

• Improving the Diagnostic Accuracy of the PD-L1 Test with Image Analysis and Multiplex Hybridization

  Humphries, M. P., Bingham, V., Abdullahi Sidi, F., Craig, S. G., McQuaid, S., James, J. & Salto-Tellez, M., 29 Apr 2020, In: Cancers. 12, 5, 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ligands
  • Fluorescent Antibody Technique
  • Sensitivity and Specificity
  • Immunohistochemistry
  • Keratins
  4 Citations (Scopus)

  49 Downloads (Pure)

• PD-L1 Multiplex and Quantitative Image Analysis for Molecular Diagnostics

  Abdullahi Sidi, F., Bingham, V., Craig, S. G., McQuaid, S., James, J., Humphries, M. P. & Salto-Tellez, M., 23 Dec 2020, In: Cancers. 13, 1, 12 p., 29.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Molecular Pathology
  • Fluorescent Antibody Technique
  • Immunohistochemistry
  • liquid crystal polymer
  • Non-Small Cell Lung Carcinoma
  34 Downloads (Pure)

• Pin1 plays a key role in the response to treatment and clinical outcome in Triple Negative Breast Cancer

  Knowlson, C., Coulter, P., Bingham, V., McQuaid, S., Mullan, P. & Buckley, N. E., 09 Mar 2020, In: Therapeutic Advances in Medical Oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Triple Negative Breast Neoplasms
  • Standard of Care
  • Drug Therapy
  • Peptidylprolyl Isomerase
  • Taxoids
  2 Citations (Scopus)

• The adaptive immune and immune checkpoint landscape of neoadjuvant treated esophageal adenocarcinoma using digital pathology quantitation

  Humphries, M., Craig, S., Kacprzyk, R., Fisher, N., Bingham, V., McQuaid, S., Murray, G. I., McManus, D., Turkington, R., James, J. & Salto-Tellez, M., 01 Jun 2020, In: BMC Cancer. 20, 1, 11 p., 500.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adenocarcinoma
  • Pathology
  • Survival
  • Biomarkers
  • Immunotherapy
  3 Citations (Scopus)

  29 Downloads (Pure)
• 2019

  A Novel Role for Cathepsin S as a Potential Biomarker in Triple Negative Breast Cancer

  Wilkinson, R., Burden, R., McDowell, S., McArt, D., McQuaid, S., Bingham, V., Williams, R., Cox, O., O'Connor, R., McCabe, N., Kennedy, R., Buckley, N. E. & Scott, C., 28 Jun 2019, In: Journal of Oncology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • cathepsin S
  • Triple Negative Breast Neoplasms
  • Biomarkers
  • DNA Repair
  • DNA Damage
  4 Citations (Scopus)

  133 Downloads (Pure)

• Critical Appraisal of Programmed Death Ligand 1 Reflex Diagnostic Testing: Current Standards and Future Opportunities

  Humphries, M. P., McQuaid, S., Craig, S. G., Bingham, V., Maxwell, P., Maurya, M., McLean, F., Sampson, J., Higgins, P., Greene, C., James, J. & Salto-Tellez, M., 01 Jan 2019, In: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Reflex
  • Ligands
  • Immunohistochemistry
  • RNA
  • Pathology
  14 Citations (Scopus)

  153 Downloads (Pure)

• Fibroblast-derived Gremlin1 localises to epithelial cells at the base of the intestinal crypt

  Dutton, L. R., Hoare, O. P., McCorry, A. M. B., Redmond, K. L., Adam, N. E., Canamara, S., Bingham, V., Mullan, P. B., Lawler, M., Dunne, P. D. & Brazil, D. P., 23 Jul 2019, In: Oncotarget. 10, 45, p. 4630-4639 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Colorectal Neoplasms
  • Tumor Microenvironment
  • Fibroblasts
  • Epithelial Cells
  • Bone Morphogenetic Proteins
  4 Citations (Scopus)

  164 Downloads (Pure)

• NUP98 – a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

  Mullan, P. B., Bingham, V., Haddock, P., Irwin, G. W., Kay, E., McQuaid, S. & Buckley, N. E., 02 Apr 2019, In: BMC Cancer. 19, 13 p., 236.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • nuclear pore complex protein 98
  • Triple Negative Breast Neoplasms
  • Anthracyclines
  • Drug Therapy
  • Standard of Care
  6 Citations (Scopus)

  167 Downloads (Pure)

• Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

  Craig, S., Anderson, L., Schache, A., Moran, M., Graham, L., Currie, K., Rooney, K., Robinson, M., Upile, N., Brooker, R., Mesri, M., Bingham, V., McQuaid, S., Jones, T., McCance, D., Salto-Tellez, M., McDade, S. & James, J., 20 Mar 2019, In: British Journal of Cancer. 120, p. 827

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oropharyngeal Neoplasms
  • Guidelines
  • Squamous Cell Carcinoma
  • Survival
  • Immunohistochemistry
  14 Citations (Scopus)

  179 Downloads (Pure)
• 2018

  Assessment of PD-L1 Expression by Digital Pathology demonstrates prognostic significance for overall survival in Triple Negative Breast Cancer and a novel association with overall survival in ER-/HER+ breast cancer.

  Humphries, M., Craig, S., Bingham, V., McQuaid, S., James, J., Buckley, N. E. & Salto-Tellez, M., 2018, (Unpublished).

  Research output: Contribution to conference › Poster › peer-review

  • Triple Negative Breast Neoplasms
  • Biomarkers
  • Breast Neoplasms
  • Pathology
  • avelumab

• Automated Tumour Recognition and Digital Pathology Scoring Unravels New Role for PD-L1 in Predicting Good Outcome in ER-/HER2+ Breast Cancer

  Humphries, M., Hynes, S., Bingham, V., Cougot, D., James, J., Patel-Socha, F., Parkes, E., Blayney, J., O'Rorke, M., Irwin, G., McArt, D., Kennedy, R., Mullan, P., McQuaid, S., Salto-Tellez, M. & Buckley, N. E., 17 Dec 2018, In: Journal of Oncology. 2018, 14 p., 2937012.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biomarkers
  • Breast Neoplasms
  • Pathology
  • Triple Negative Breast Neoplasms
  • Drug Therapy
  13 Citations (Scopus)

  296 Downloads (Pure)

• Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

  Dunne, P. D., Coleman, H. G., Bankhead, P., Alderdice, M., Gray, R. T., McQuaid, S., Bingham, V., Loughrey, M. B., James, J. A., McCorry, A. M. B., Gilmore, A., Holohan, C., Klingbiel, D., Tejpar, S., Johnston, P. G., McArt, D. G., Nicolantonio, F. D., Longley, D. B. & Lawler, M., 13 Feb 2018, In: Oncotarget. 9, 17, p. 13834-13847 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adjuvant Chemotherapy
  • Colonic Neoplasms
  • Biomarkers
  • Recurrence
  • Neoplasms
  1 Citation (Scopus)

  309 Downloads (Pure)

• High PTGS2 expression in post neoadjuvant chemotherapy treated oesophageal adenocarcinoma is associated with improved survival: a population-based cohort study

  Spence, A., Trainor, J., McMenamin, U., Turkington, R., McQuaid, S., Bingham, V., James, J., Salto-Tellez, M., McManus, D., Johnston, B., Cardwell, C. & Coleman, H., 08 Nov 2018, In: Histopathology. p. 1-24

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Prostaglandin Endoperoxides
  • Adenocarcinoma
  • Cohort Studies
  • Drug Therapy
  • Survival
  99 Downloads (Pure)

• Sex hormone receptor expression and survival in esophageal adenocarcinoma: a prospective cohort study

  McMenamin, U. C., Trainor, J., Coleman, H. G., McManus, D. T., McQuaid, S., Bingham, V., James, J., Salto-Tellez, M., Johnston, B. T. & Turkington, R. C., 19 Oct 2018, In: Oncotarget. 9, 82, p. 35300-35312 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gonadal Steroid Hormones
  • Adenocarcinoma
  • Cohort Studies
  • Prospective Studies
  • Survival
  3 Citations (Scopus)

  202 Downloads (Pure)

• Vitamin D receptor as a marker of prognosis in oesophageal adenocarcinoma: a prospective cohort study

  McCain, S., Trainor, J., McManus, D. T., McMenamin, U. C., McQuaid, S., Bingham, V., James, J. A., Salto-Tellez, M., Turkington, R. C. & Coleman, H. G., 28 Sep 2018, In: Oncotarget. 9, 76, p. 34347-34356 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Calcitriol Receptors
  • Adenocarcinoma
  • Cohort Studies
  • Prospective Studies
  • Survival
  2 Citations (Scopus)

  206 Downloads (Pure)
• 2017

  Evaluation of PTGS2 expression, PIK3CA mutation, aspirin use and colon cancer survival in a population-based cohort study.

  Gray, R. T., Cantwell, M. M., Coleman, H. G., Loughrey, M. B., Bankhead, P., McQuaid, S., O'Neill, R. F., Arthur, K., Bingham, V., McGready, C., Gavin, A. T., Cardwell, C. R., Johnston, B. T., James, J. A., Hamilton, P. W., Salto-Tellez, M. & Murray, L. J., 27 Apr 2017, In: Clinical and translational gastroenterology. 8, e91.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclooxygenase 2
  • Aspirin
  • Colonic Neoplasms
  • Cohort Studies
  • Mutation
  29 Citations (Scopus)

  310 Downloads (Pure)

• Gremlin1 plays a key role in kidney development and renal fibrosis

  Church, R. H., Ali, I., Tate, M., Lavin, D., Krishnakumar, A., Kok, H. M., Romero, J., Dunne, P., Bingham, V., Goldschmeding, R., Martin, F. & Brazil, D., 18 Jan 2017, In: American journal of physiology. Renal physiology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fibrosis
  • Kidney
  • Folic Acid
  • Bone Morphogenetic Proteins
  • Genetic Background
  29 Citations (Scopus)

  275 Downloads (Pure)

• Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies

  Alvi, M., Loughrey, M. B., Dunne, P., McQuaid, S., Turkington, R., Fuchs, M-A., McGready, C., Bingham, V., Moore, W., Lawler, M., James, J. A., Murray, G. I., Wilson, R. H., Maxwell, P. & Salto-Tellez, M., 11 Jul 2017, In: British Journal of Cancer. 117, 2, p. 203-209

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microsatellite Instability
  • CpG Islands
  • Colorectal Neoplasms
  • Phenotype
  • Genotype
  259 Downloads (Pure)

• RNAscope in situ hybridization confirms mRNA integrity in formalin-fixed, paraffin-embedded cancer tissue samples

  Bingham, V., McIlreavey, L., Greene, C., O'Doherty, E., Clarke, R., Craig, S., Salto-Tellez, M., McQuaid, S., Lewis, C. & James, J., 16 Oct 2017, In: Oncotarget. 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Formaldehyde
  • Paraffin
  • In Situ Hybridization
  • Messenger RNA
  • Neoplasms
  22 Citations (Scopus)

  464 Downloads (Pure)

• Statin use, Candidate Mevalonate Pathway Biomarkers, and Colon Cancer Survival in a Population-Based Cohort Study

  Gray, R. T., Loughrey, M. B., Bankhead, P., Cardwell, C. R., McQuaid, S., O'Neill, R. F., Arthur, K., Bingham, V., McGready, C., Gavin, A. T., James, J. A., Hamilton, P. W., Salto-Tellez, M., Murray, L. J. & Coleman, H. G., 06 Jun 2017, In: British Journal of Cancer. 152, 5, p. S1023-S1024

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  21 Citations (Scopus)

  323 Downloads (Pure)
• 2016

  PTEN mRNA detection by chromogenic, RNA in situ technologies: a reliable alternative to PTEN immunohistochemistry

  Bingham, V., Ong, C. W., James, J., Maxwell, P., Waugh, D., Salto-Tellez, M. & McQuaid, S., Jan 2016, In: Human Pathology. 47, 1, p. 95-103 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Tensins
  • Phosphoric Monoester Hydrolases
  • Immunohistochemistry
  • RNA
  • Technology
  10 Citations (Scopus)

• Transcriptional upregulation of c-MET is associated with invasion and tumor budding in colorectal cancer

  Bradley, C. A., Dunne, P. D., Bingham, V., McQuaid, S., Khawaja, H., Craig, S., James, J., Moore, W. L., McArt, D. G., Lawler, M., Dasgupta, S., Johnston, P. G. & Van Schaeybroeck, S., 26 Oct 2016, In: Oncotarget. 7, 48, p. 78932-78945 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Colorectal Neoplasms
  • Up-Regulation
  • Neoplasms
  • In Situ Hybridization
  • RNA
  18 Citations (Scopus)

  276 Downloads (Pure)

• Upregulation of the MET transcript is consistently associated with invasion and tumor budding in colorectal cancer

  Bradley, C., Dunne, P., McQuaid, S., Bingham, V., Lawler, M., Salto-Tellez, M., Johnston, P. & Van Schaeybroeck, S., 2016, Upregulation of the MET transcript is consistently associated with invasion and tumor budding in colorectal cancer. abstract 924 ed. Proceedings: AACR Annual Meeting 2016; April 16-20 New Orleans

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Colorectal Neoplasms
  • Up-Regulation
  • Hepatocyte Growth Factor
  • Neoplasms
  • Myofibroblasts
• 2015

  Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility

  Alvi, M. A., McArt, D. G., Kelly, P., Fuchs, M-A., Alderdice, M., McCabe, C. M., Bingham, V., McGready, C., Tripathi, S., Emmert-Streib, F., Loughrey, M. B., McQuaid, S., Maxwell, P., Hamilton, P. W., Turkington, R., James, J. A., Wilson, R. H. & Salto-Tellez, M., 30 Jul 2015, In: Oncotarget. 6, 25, p. 20863-74 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Molecular Pathology
  • DNA Methylation
  • Gene Expression
  • Adenocarcinoma
  • Mutation
  24 Citations (Scopus)

  290 Downloads (Pure)
• 2012

  Rescue of glandular dysmorphogenesis in PTEN-deficient colorectal cancer epithelium by PPARγ-targeted therapy

  Jagan, I., Fatehullah, A., Deevi, R., Bingham, V. & Campbell, F., 30 Apr 2012, In: Oncogene. 32, null, p. 1305–1315

  Research output: Contribution to journal › Article › peer-review

  • Peroxisome Proliferator-Activated Receptors
  • Colorectal Neoplasms
  • Cell Cycle
  • Epithelium
  • Rosiglitazone
  15 Citations (Scopus)
• 2011

  Enhanced lymphocyte interferon (IFN)-γ responses in a PTEN mutation-negative Cowden disease kindred.

  Stevenson, R., Fatehullah, A., Bingham, V., Deevi, R., Jagan, I., Irvine, A., Armstrong, M., Morrison, P., Dimmick, I., Stewart, R. & Campbell, F., May 2011, In: Clinical and experimental immunology. 164(2), 2, p. 202-210 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Multiple Hamartoma Syndrome
  • Interferons
  • KIR Receptors
  • Lymphocytes
  • Interferon-gamma
  1 Citation (Scopus)
• 2010

  The Yin and Yang of vitamin D receptor (VDR) signaling in neoplastic progression: Operational networks and tissue-specific growth control

  Campbell, F. C., Xu, H., El-Tanani, M., Crowe, P. & Bingham, V., 01 Jan 2010, In: Biochemical Pharmacology. 79, 1, p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Yin-Yang
  • Calcitriol Receptors
  • Tissue
  • Organ Specificity
  • Growth
  73 Citations (Scopus)
• 2009

  Vitamin D Receptor Modulates the Neoplastic Phenotype Through Antagonistic Growth Regulatory Signals

  Xu, H., McCann, M., Zhang, Z., Posner, G. H., Bingham, V., El-Tanani, M. E-T. & Campbell, F., Aug 2009, In: Molecular Carcinogenesis. 48, 8, p. 758-772 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcitriol Receptors
  • Osteopontin
  • Cadherins
  • Phenotype
  • beta Catenin
  26 Citations (Scopus)