Epigenetic Regulation of Differentiation and Disease

We are particularly interested in studying how cell-fates are specified during development and miss-specified in diseases.

The research in my lab is aimed at achieving an integrated molecular and systems-level understanding of the mechanisms by which epigenetic machinery and transcription factors contribute to transcriptional reprogramming that defines cell-type identity during development and how this communication is altered in diseases such as cancer. To investigate these questions, we employ a multidisciplinary approach combining cutting-edge epigenetics and genomics together with computational biology tools in sophisticated and defined models of cellular differentiation and carcinogenesis.

The key topics of research is my lab are:

• Transcription Factors and Cell-Fate Specification
• Epigenomics of Cell-type Identity
• Signaling to Chromatin Crosstalk
• Epigenetic Regulation of Neurogenesis
• Chromatin and Cancer
• Systems Biology of Gene Regulatory Networks

 Please visit the lab web page for details.