Research Output per year
Personal profile
Research Interests
Epigenetic Regulation of Differentiation and Disease
We are particularly interested in studying how cell-fates are specified during development and miss-specified in diseases.
The research in my lab is aimed at achieving an integrated molecular and systems-level understanding of the mechanisms by which epigenetic machinery and transcription factors contribute to transcriptional reprogramming that defines cell-type identity during development and how this communication is altered in diseases such as cancer. To investigate these questions, we employ a multidisciplinary approach combining cutting-edge epigenetics and genomics together with computational biology tools in sophisticated and defined models of cellular differentiation and carcinogenesis.
The key topics of research is my lab are:
- Transcription Factors and Cell-Fate Specification
- Epigenomics of Cell-type Identity
- Signaling to Chromatin Crosstalk
- Epigenetic Regulation of Neurogenesis
- Chromatin and Cancer
- Systems Biology of Gene Regulatory Networks
Please visit the lab web page for details.
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Research Output
Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis
Noack, F., Pataskar, A., Schneider, M., Buchholz, F., Tiwari, V. K. & Calegari, F., Apr 2019, In : Life science alliance. 2, 2, 15 p., e201900331.Research output: Contribution to journal › Article
Open Access
File
1
Citation
(Scopus)
91
Downloads
(Pure)
Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features
Pataskar, A., Vanderlinden, W., Emmerig, J., Singh, A., Lipfert, J. & Tiwari, V. K., 22 Nov 2019, In : iScience. 21, p. 638-649 12 p.Research output: Contribution to journal › Article
Open Access
File
The centrosome protein AKNA regulates neurogenesis via microtubule organization
Camargo Ortega, G., Falk, S., Johansson, P. A., Peyre, E., Broix, L., Sahu, S. K., Hirst, W., Schlichthaerle, T., De Juan Romero, C., Draganova, K., Vinopal, S., Chinnappa, K., Gavranovic, A., Karakaya, T., Steininger, T., Merl-Pham, J., Feederle, R., Shao, W., Shi, S-H., Hauck, S. M. & 10 others, , 07 Mar 2019, In : Nature. 567, 7746, p. 113-117 5 p.Research output: Contribution to journal › Article
5
Citations
(Scopus)
Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program
Karow, M., Camp, J. G., Falk, S., Gerber, T., Pataskar, A., Gac-Santel, M., Kageyama, J., Brazovskaja, A., Garding, A., Fan, W., Riedemann, T., Casamassa, A., Smiyakin, A., Schichor, C., Götz, M., Tiwari, V. K., Treutlein, B. & Berninger, B., 18 Jun 2018, Nature Neuroscience. Nature Publishing Group, p. 1-9 9 p. (Nature Neuroscience).Research output: Chapter in Book/Report/Conference proceeding › Chapter
12
Citations
(Scopus)
Exploring the complexity of cortical development using single-cell transcriptomics
Jeong, H. & Tiwari, V. K., 02 Feb 2018, In : Frontiers in Neuroscience. 12, 9 p., 31.Research output: Contribution to journal › Article
Open Access
File
5
Citations
(Scopus)
106
Downloads
(Pure)
Prizes
Bruno Speck Award for outstanding work in the field of stem cell research
Vijay Tiwari (Recipient), 2013
Prize: Prize (including medals and awards)
European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship
Vijay Tiwari (Recipient), 2008
Prize: Prize (including medals and awards)
F1000 Faculty Member of the Year Award for the Developmental Biology Faculty
Vijay Tiwari (Recipient), 2016
Prize: Prize (including medals and awards)
JLM award at European Biotechnology Conference
Vijay Tiwari (Recipient), 2018
Prize: Prize (including medals and awards)
Junior Research Fellowship from Council of Scientific & Industrial Research
Vijay Tiwari (Recipient), 2002
Prize: Prize (including medals and awards)