• Room 01.019 - CEM

    United Kingdom

Accepting PhD Students

20042019

Research output per year

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Personal profile

Research Interests

Epigenetic Regulation of Differentiation and Disease

We are particularly interested in studying how cell-fates are specified during development and miss-specified in diseases.

The research in my lab is aimed at achieving an integrated molecular and systems-level understanding of the mechanisms by which epigenetic machinery and transcription factors contribute to transcriptional reprogramming that defines cell-type identity during development and how this communication is altered in diseases such as cancer. To investigate these questions, we employ a multidisciplinary approach combining cutting-edge epigenetics and genomics together with computational biology tools in sophisticated and defined models of cellular differentiation and carcinogenesis.

The key topics of research is my lab are:

  • Transcription Factors and Cell-Fate Specification
  • Epigenomics of Cell-type Identity
  • Signaling to Chromatin Crosstalk
  • Epigenetic Regulation of Neurogenesis
  • Chromatin and Cancer
  • Systems Biology of Gene Regulatory Networks

 Please visit the lab web page for details.

 

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Research Output

Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis

Noack, F., Pataskar, A., Schneider, M., Buchholz, F., Tiwari, V. K. & Calegari, F., Apr 2019, In : Life science alliance. 2, 2, 15 p., e201900331.

Research output: Contribution to journalArticle

Open Access
File
  • 1 Citation (Scopus)
    91 Downloads (Pure)

    Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features

    Pataskar, A., Vanderlinden, W., Emmerig, J., Singh, A., Lipfert, J. & Tiwari, V. K., 22 Nov 2019, In : iScience. 21, p. 638-649 12 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 53 Downloads (Pure)

    The centrosome protein AKNA regulates neurogenesis via microtubule organization

    Camargo Ortega, G., Falk, S., Johansson, P. A., Peyre, E., Broix, L., Sahu, S. K., Hirst, W., Schlichthaerle, T., De Juan Romero, C., Draganova, K., Vinopal, S., Chinnappa, K., Gavranovic, A., Karakaya, T., Steininger, T., Merl-Pham, J., Feederle, R., Shao, W., Shi, S-H., Hauck, S. M. & 10 others, Jungmann, R., Bradke, F., Borrell, V., Geerlof, A., Reber, S., Tiwari, V. K., Huttner, W. B., Wilsch-Bräuninger, M., Nguyen, L. & Götz, M., 07 Mar 2019, In : Nature. 567, 7746, p. 113-117 5 p.

    Research output: Contribution to journalArticle

  • 5 Citations (Scopus)

    Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

    Karow, M., Camp, J. G., Falk, S., Gerber, T., Pataskar, A., Gac-Santel, M., Kageyama, J., Brazovskaja, A., Garding, A., Fan, W., Riedemann, T., Casamassa, A., Smiyakin, A., Schichor, C., Götz, M., Tiwari, V. K., Treutlein, B. & Berninger, B., 18 Jun 2018, Nature Neuroscience. Nature Publishing Group, p. 1-9 9 p. (Nature Neuroscience).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  • 12 Citations (Scopus)

    Exploring the complexity of cortical development using single-cell transcriptomics

    Jeong, H. & Tiwari, V. K., 02 Feb 2018, In : Frontiers in Neuroscience. 12, 9 p., 31.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    106 Downloads (Pure)

    Prizes

    Bruno Speck Award for outstanding work in the field of stem cell research

    Vijay Tiwari (Recipient), 2013

    Prize: Prize (including medals and awards)

    F1000 Faculty Member of the Year Award for the Developmental Biology Faculty

    Vijay Tiwari (Recipient), 2016

    Prize: Prize (including medals and awards)

    JLM award at European Biotechnology Conference

    Vijay Tiwari (Recipient), 2018

    Prize: Prize (including medals and awards)

    Junior Research Fellowship from Council of Scientific & Industrial Research

    Vijay Tiwari (Recipient), 2002

    Prize: Prize (including medals and awards)