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    United Kingdom

Accepting PhD Students

20042019
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Personal profile

Research Interests

Epigenetic Regulation of Differentiation and Disease

We are particularly interested in studying how cell-fates are specified during development and miss-specified in diseases.

The research in my lab is aimed at achieving an integrated molecular and systems-level understanding of the mechanisms by which epigenetic machinery and transcription factors contribute to transcriptional reprogramming that defines cell-type identity during development and how this communication is altered in diseases such as cancer. To investigate these questions, we employ a multidisciplinary approach combining cutting-edge epigenetics and genomics together with computational biology tools in sophisticated and defined models of cellular differentiation and carcinogenesis.

The key topics of research is my lab are:

  • Transcription Factors and Cell-Fate Specification
  • Epigenomics of Cell-type Identity
  • Signaling to Chromatin Crosstalk
  • Epigenetic Regulation of Neurogenesis
  • Chromatin and Cancer
  • Systems Biology of Gene Regulatory Networks

 Please visit the lab web page for details.

 

Fingerprint Dive into the research topics where Vijay Tiwari is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
Epigenomics Medicine & Life Sciences
Chromatin Medicine & Life Sciences
Genes Medicine & Life Sciences
Transcription Factors Medicine & Life Sciences
Regulator Genes Medicine & Life Sciences
Epithelial-Mesenchymal Transition Medicine & Life Sciences
Neurogenesis Medicine & Life Sciences
Neurons Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2004 2019

1 Citation (Scopus)

Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis

Noack, F., Pataskar, A., Schneider, M., Buchholz, F., Tiwari, V. K. & Calegari, F., Apr 2019, In : Life science alliance. 2, 2, 15 p., e201900331.

Research output: Contribution to journalArticle

Open Access
File
DNA Methylation
Methylation
Cytosine
Transcription Factors
Neural Stem Cells

Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features

Pataskar, A., Vanderlinden, W., Emmerig, J., Singh, A., Lipfert, J. & Tiwari, V. K., 22 Nov 2019, In : iScience. 21, p. 638-649 12 p.

Research output: Contribution to journalArticle

Open Access
File
Regulator Genes
Nucleic Acid Regulatory Sequences
Epigenomics
DNA
Transcription Factors
3 Citations (Scopus)

The centrosome protein AKNA regulates neurogenesis via microtubule organization

Camargo Ortega, G., Falk, S., Johansson, P. A., Peyre, E., Broix, L., Sahu, S. K., Hirst, W., Schlichthaerle, T., De Juan Romero, C., Draganova, K., Vinopal, S., Chinnappa, K., Gavranovic, A., Karakaya, T., Steininger, T., Merl-Pham, J., Feederle, R., Shao, W., Shi, S-H., Hauck, S. M. & 10 othersJungmann, R., Bradke, F., Borrell, V., Geerlof, A., Reber, S., Tiwari, V. K., Huttner, W. B., Wilsch-Bräuninger, M., Nguyen, L. & Götz, M., 07 Mar 2019, In : Nature. 567, 7746, p. 113-117 5 p.

Research output: Contribution to journalArticle

Centrosome
Lateral Ventricles
Neurogenesis
Microtubules
Proteins
10 Citations (Scopus)

Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program

Karow, M., Camp, J. G., Falk, S., Gerber, T., Pataskar, A., Gac-Santel, M., Kageyama, J., Brazovskaja, A., Garding, A., Fan, W., Riedemann, T., Casamassa, A., Smiyakin, A., Schichor, C., Götz, M., Tiwari, V. K., Treutlein, B. & Berninger, B., 18 Jun 2018, Nature Neuroscience. Nature Publishing Group, p. 1-9 9 p. (Nature Neuroscience).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pericytes
Neural Stem Cells
Neurons
Transcription Factors
Cell Division
5 Citations (Scopus)

Exploring the complexity of cortical development using single-cell transcriptomics

Jeong, H. & Tiwari, V. K., 02 Feb 2018, In : Frontiers in Neuroscience. 12, 9 p., 31.

Research output: Contribution to journalArticle

Open Access
File
Neocortex
Lateral Ventricles
Brain
Population Characteristics
Regulator Genes

Prizes

Bruno Speck Award for outstanding work in the field of stem cell research

Vijay Tiwari (Recipient), 2013

Prize: Prize (including medals and awards)

F1000 Faculty Member of the Year Award for the Developmental Biology Faculty

Vijay Tiwari (Recipient), 2016

Prize: Prize (including medals and awards)

JLM award at European Biotechnology Conference

Vijay Tiwari (Recipient), 2018

Prize: Prize (including medals and awards)

Junior Research Fellowship from Council of Scientific & Industrial Research

Vijay Tiwari (Recipient), 2002

Prize: Prize (including medals and awards)