• Room 03.028 - Whitla Medical Building

    United Kingdom

Accepting PhD Students

PhD projects

I am always open to PhD applications in the field of nanopharmaceutical, targeted delivery, smart and novel nanomaterials, exosomes, immunotherapy, tumour microenvironment, and nanotoxicology.

20072020

Research output per year

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Research Output

Anti-angiogenic poly-L-lysine dendrimer binds heparin and neutralizes its activity

Al-Jamal, K. T., Al-Jamal, W. T., Kostarelos, K., Turton, J. A. & Florence, A. T., 2012, In : Results in pharma sciences. 2, p. 9-15 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery

Roberts, R., Al-Jamal, W. T., Whelband, M., Thomas, P., Jefferson, M., van den Bossche, J., Powell, P. P., Kostarelos, K. & Wileman, T., May 2013, In : Autophagy. 9, 5, p. 667-82 16 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Blood circulation and tissue biodistribution of lipid--quantum dot (L-QD) hybrid vesicles intravenously administered in mice

Al-Jamal, W. T., Al-Jamal, K. T., Cakebread, A., Halket, J. M. & Kostarelos, K., Sep 2009, In : Bioconjugate Chemistry. 20, 9, p. 1696-702 7 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Cationic Liposome- Multi-Walled Carbon Nanotubes Hybrids for Dual siPLK1 and Doxorubicin Delivery In Vitro

Pereira, S., Lee, J., Rubio, N., Hassan, H. A. F. M., Suffian, I. B. M., Wang, J. T-W., Klippstein, R., Ballesteros, B., Al-Jamal, W. T. & Al-Jamal, K. T., Oct 2015, In : Pharmaceutical Research. 32, 10, p. 3293-308

Research output: Contribution to journalArticle

16 Citations (Scopus)

Cationic poly-L-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo

Al-Jamal, K. T., Al-Jamal, W. T., Wang, J. T-W., Rubio, N., Buddle, J., Gathercole, D., Zloh, M. & Kostarelos, K., 26 Mar 2013, In : ACS Nano. 7, 3, p. 1905-17 13 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Construction of nanoscale multicompartment liposomes for combinatory drug delivery

Al-Jamal, W. T. & Kostarelos, K., 01 Mar 2007, In : International Journal of Pharmaceutics. 331, 2, p. 182-5 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
3 Citations (Scopus)

Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Al-Jamal, K. T., Nunes, A., Methven, L., Ali-Boucetta, H., Li, S., Toma, F. M., Herrero, M. A., Al-Jamal, W. T., ten Eikelder, H. M. M., Foster, J., Mather, S., Prato, M., Bianco, A. & Kostarelos, K., 25 Jun 2012, In : Angewandte Chemie (International ed. in English). 51, 26, p. 6389-93 5 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

Design and Engineering of Multifunctional Quantum-Dot based Nanoparticles for Simultaneous Therapeutic-Diagnostic Applications: Multifunctional Nanoparticles for Drug Delivery Applications - Imaging, Targeting, and Delivery

Tian, B., Al-Jamal, WT., Bossche, JVD. & Kostarelos, K., 2012, Springer US. S. S. & K. P. (eds.). Springer US, p. 345 365 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Design of Cationic Multiwalled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication

Guo, Y. C., Al-Jamal, W. T., Toma, F. M., Bianco, A., Prato, M., Al-Jamal, K. T. & Kostarelos, K., 15 Jul 2015, In : Bioconjugate Chemistry. 26, 7, p. 1370-1379

Research output: Contribution to journalArticle

33 Citations (Scopus)

Docetaxel-loaded liposomes The effect of lipid composition and purification on drug encapsulation and in vitro toxicity

Pereira, S., Egbu, R., Jannati, G. & Al-Jamal, W. T., 30 Nov 2016, In : International Journal of Pharmaceutics. 514, 1, p. 150-159

Research output: Contribution to journalArticle

26 Citations (Scopus)

Doxorubicin-loaded lipid-quantum dot hybrids: surface topography and release properties

Tian, B., Al-Jamal, W. T., Al-Jamal, K. T. & Kostarelos, K., 20 Sep 2011, In : International Journal of Pharmaceutics. 416, 2, p. 443-7 5 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

van den Bossche, J., Al-Jamal, W. T., Tian, B., Nunes, A., Fabbro, C., Bianco, A., Prato, M. & Kostarelos, K., 21 Oct 2010, In : Chemical Communications. 46, 39, p. 7379-81 3 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

EGFR-targeted immunoliposomes efficiently deliver docetaxel to prostate cancer cells

Eloy, J. O., Ruiz, A., de Lima, F. T., Petrilli, R., Raspantini, G., Nogueira, K. A. B., Santos, E., de Oliveira, C. S., Borges, J. C., Marchetti, J. M., Al-Jamal, W. T. & Chorilli, M., 06 Jun 2020, In : Colloids and Surfaces B: Biointerfaces. 194, 111185.

Research output: Contribution to journalArticle

Engineering thermosensitive liposome-nanoparticle hybrids loaded with doxorubicin for heat-triggered drug release

Al-Ahmady, Z., Lozano, N., Mei, K-C., Al-Jamal, W. T. & Kostarelos, K., 30 Nov 2016, In : International Journal of Pharmaceutics. 514, 1, p. 133-141

Research output: Contribution to journalArticle

14 Citations (Scopus)

Enhanced cellular internalization and gene silencing with a series of cationic dendron-multiwalled carbon nanotube:siRNA complexes

Al-Jamal, K. T., Toma, F. M., Yilmazer, A., Ali-Boucetta, H., Nunes, A., Herrero, M-A., Tian, B., Eddaoudi, A., Eddaoui, A., Al-Jamal, W. T., Bianco, A., Prato, M. & Kostarelo, K., Nov 2010, In : The FASEB Journal. 24, 11, p. 4354-65 12 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper-tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer

Silva, V. L., Kaassis, A., Dehsorkhi, A., Koffi, C-R., Severic, M., Abdelhamid, M., Nyimanu, D., Morris, C. J. & Al-Jamal, W. T., 11 Mar 2020, In : Biomaterials science.

Research output: Contribution to journalArticle

Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development

Feng, J., Byrne, N. M., Al Jamal, W. & Coulter, J. A., 11 Dec 2019, In : Cancers. 11, 12, 25 p., 1989.

Research output: Contribution to journalReview article

Open Access
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2 Citations (Scopus)
36 Downloads (Pure)
Open Access
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26 Citations (Scopus)
223 Downloads (Pure)

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A)

Borrello, M. T., Schinor, B., Bartels, K., Benelkebir, H., Pereira, S., Al-Jamal, W. T., Douglas, L., Duriez, P. J., Packham, G., Haufe, G. & Ganesan, A., 15 May 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 10, p. 2099-2101

Research output: Contribution to journalArticle

4 Citations (Scopus)

Functionalized-quantum-dot-liposome hybrids as multimodal nanoparticles for cancer

Al-Jamal, W. T., Al-Jamal, K. T., Bomans, P. H., Frederik, P. M. & Kostarelos, K., Sep 2008, In : Small. 4, 9, p. 1406-15 10 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Intracellular Activation of a Prostate Specific Antigen-Cleavable Doxorubicin Prodrug: A Key Feature Toward Prodrug-Nanomedicine Design

Pereira, S. G. T., Hudoklin, S., Kreft, M. E., Kostevsek, N., Stuart, M. C. A. & Al-Jamal, W. T., 25 Feb 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
38 Downloads (Pure)

Intracellular trafficking and gene expression of pH-sensitive, artificially enveloped adenoviruses in vitro and in vivo

van den Bossche, J., Al-Jamal, W. T., Yilmazer, A., Bizzarri, E., Tian, B. & Kostarelos, K., Apr 2011, In : Biomaterials. 32, 11, p. 3085-93 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy

Hodgins, N. O., Al-Jamal, W. T., Wang, J. T-W., Klippstein, R., Costa, P. M., Sosabowski, J. K., Marshall, J. F., Maher, J. & Al-Jamal, K. T., 28 Jun 2017, In : Journal of controlled release : official journal of the Controlled Release Society. 256, p. 141-152

Research output: Contribution to journalArticle

14 Citations (Scopus)

In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in mice

Hodgins, N. O., Al-Jamal, W. T., Wang, J. T-W., Parente-Pereira, A. C., Liu, M., Maher, J. & Al-Jamal, K. T., 10 Nov 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 241, p. 229-241

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
187 Downloads (Pure)

Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo

Al-Ahmady, Z. S., Al-Jamal, W. T., van den Bossche, J., Bui, T. T., Drake, A. F., Mason, A. J. & Kostarelos, K., 23 Oct 2012, In : ACS Nano. 6, 10, p. 9335-46 12 p.

Research output: Contribution to journalArticle

163 Citations (Scopus)

Lipid-quantum dot bilayer vesicles enhance tumor cell uptake and retention in vitro and in vivo

Al-Jamal, W. T., Al-Jamal, K. T., Tian, B., Lacerda, L., Bomans, P. H., Frederik, P. M. & Kostarelos, K., Mar 2008, In : ACS Nano. 2, 3, p. 408-18 11 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Liposome-gold nanorod hybrids for high-resolution visualization deep in tissues

Lozano, N., Al-Jamal, W. T., Taruttis, A., Beziere, N., Burton, N. C., van den Bossche, J., Mazza, M., Herzog, E., Ntziachristos, V. & Kostarelos, K., 15 Aug 2012, In : Journal of the American Chemical Society. 134, 32, p. 13256-8 3 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Liposome-nanoparticle hybrids for multimodal diagnostic and therapeutic applications

Al-Jamal, W. T. & Kostarelos, K., Feb 2007, In : Nanomedicine. 2, 1, p. 85-98 14 p.

Research output: Contribution to journalReview article

130 Citations (Scopus)

Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine

Al-Jamal, W. T. & Kostarelos, K., 18 Oct 2011, In : Accounts of Chemical Research. 44, 10, p. 1094-104 11 p.

Research output: Contribution to journalReview article

426 Citations (Scopus)

Liposomes-Based Nanoparticles for Cancer Therapy and Bioimaging: Nanooncology - Engineering Nanomaterials for Cancer Therapy

Cheung, C. & Al-Jamal, WT., 2018, (Accepted) Springer US. Gonçalves, G. & Tobias, G. (eds.). Springer US

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Liposome-Templated Indocyanine Green J- Aggregates for In Vivo Near Infrared Imaging and Stable Photothermal Heating

Cheung, C. C. L., Ma, G., Karatasos, K., Seitsonen, J., Ruokolainen, J., Koffi, C-R., Hassan, H. & Al-Jamal, W. T., 28 Feb 2020, In : Nanotheranostics. 4, 2, p. 91-106 16 p.

Research output: Contribution to journalArticle

Open Access
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19 Downloads (Pure)

Magnetic Drug Targeting Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humans

Al-Jamal, K. T., Bai, J., Wang, J. T-W., Protti, A., Southern, P., Bogart, L., Heidari, H., Li, X., Cakebread, A., Asker, D., Al-Jamal, W. T., Shah, A., Bals, S., Sosabowski, J. K. & Pankhurst, Q. A., 14 Sep 2016, In : Nano Letters. 16, 9, p. 5652-60

Research output: Contribution to journalArticle

59 Citations (Scopus)

Magneto-Liposomes as MRI Contrast Agents: A Systematic Study of Different Liposomal Formulations

Kostevšek, N., Cheung, C. C. L., Serša, I., Kreft, M. E., Monaco, I., Comes Franchini, M., Vidmar, J. & Al-Jamal, W. T., 06 May 2020, In : Nanomaterials. 10, 5, 18 p., 889.

Research output: Contribution to journalArticle

Open Access
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Multiphoton luminescence imaging of chemically functionalized multi-walled carbon nanotubes in cells and solid tumors

Rubio, N., Hirvonen, L. M., Chong, E. Z., Wang, J. T. W., Bourgognon, M., Kafa, H., Hassan, H. A. F. M., Al-Jamal, W. T., McCarthy, D., Hogstrand, C., Festy, F. & Al-Jamal, K. T., 07 Jun 2015, In : Chemical Communications. 51, 45, p. 9366-9369

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
162 Downloads (Pure)

Organ Biodistribution of Radiolabelled γδ T Cells Following Liposomal Alendronate Administration in Different Mouse Tumour Models

Wang, J. T-W., Hodgins, N. O., Al-Jamal, W., Maher, J., Sosabowski, J. K. & Al-Jamal, K. T., 06 Feb 2020, In : Nanotheranostics. 4, 2, p. 71-82 12 p.

Research output: Contribution to journalArticle

Open Access
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20 Downloads (Pure)

Passively Targeted Curcumin-Loaded PEGylated PLGA Nanocapsules for Colon Cancer Therapy In Vivo

Klippstein, R., Wang, J. T-W., El-Gogary, R. I., Bai, J., Mustafa, F., Rubio, N., Bansal, S., Al-Jamal, W. T. & Al-Jamal, K. T., 23 Sep 2015, In : Small. 11, 36, p. 4704-22

Research output: Contribution to journalArticle

Open Access
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42 Citations (Scopus)
212 Downloads (Pure)

Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia

Al-Jamal, W. T., Al-Ahmady, Z. S. & Kostarelos, K., Jun 2012, In : Biomaterials. 33, 18, p. 4608-17 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Polyethylene glycol conjugated polymeric nanocapsules for targeted delivery of quercetin to folate-expressing cancer cells in vitro and in vivo

El-Gogary, R. I., Rubio, N., Wang, J. T-W., Al-Jamal, W. T., Bourgognon, M., Kafa, H., Naeem, M., Klippstein, R., Abbate, V., Leroux, F., Bals, S., Van Tendeloo, G., Kamel, A. O., Awad, G. A. S., Mortada, N. D. & Al-Jamal, K. T., 07 Jan 2014, In : ACS Nano. 8, 2, p. 1384-401

Research output: Contribution to journalArticle

98 Citations (Scopus)

Quantum-Dot Toxicity

Al-Jamal, WT. & Kostarelos, K., 2012, Encyclopaedia of Nanotechnology. Bhushan, P. B. (ed.). Springer Netherlands, p. 2197 2200 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Real-time monitoring of magnetic drug targeting using fibered confocal fluorescence microscopy

Bai, J., Wang, J. T-W., Mei, K-C., Al-Jamal, W. T. & Al-Jamal, K. T., 28 Dec 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 244, Pt B, p. 240-246

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
23 Downloads (Pure)
Open Access
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3 Citations (Scopus)
8 Downloads (Pure)

Synthesis of Diagnostic Silicon Nanoparticles for Targeted Delivery of Thiourea to Epidermal Growth Factor Receptor-Expressing Cancer Cells

Behray, M., Webster, C. A., Pereira, S., Ghosh, P., Krishnamurthy, S., Al-Jamal, W. T. & Chao, Y., 23 Mar 2016, In : ACS Applied Materials and Interfaces. 8, 14, p. 8908-8917

Research output: Contribution to journalArticle

13 Citations (Scopus)

Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth

Al-Jamal, K. T., Al-Jamal, W. T., Akerman, S., Podesta, J. E., Yilmazer, A., Turton, J. A., Bianco, A., Vargesson, N., Kanthou, C., Florence, A. T., Tozer, G. M. & Kostarelos, K., 02 Mar 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 9, p. 3966-71 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

The effect of artificial lipid envelopment of Adenovirus 5 (Ad5) on liver de-targeting and hepatotoxicity

Yilmazer, A., Al-Jamal, W. T., van den Bossche, J. & Kostarelos, K., Jan 2013, In : Biomaterials. 34, 4, p. 1354-63 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo

Bai, J., Wang, J. T-W., Rubio, N., Protti, A., Heidari, H., Elgogary, R., Southern, P., Al-Jamal, W. T., Sosabowski, J. K., Shah, A. M., Bals, S., Pankhurst, Q. A. & Al-Jamal, K. T., 01 Jan 2016, In : Theranostics. 6, 3, p. 342-56

Research output: Contribution to journalArticle

Open Access
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36 Citations (Scopus)
172 Downloads (Pure)

Tumor targeting of functionalized quantum dot-liposome hybrids by intravenous administration

Al-Jamal, W. T., Al-Jamal, K. T., Tian, B., Cakebread, A., Halket, J. M. & Kostarelos, K., 01 Sep 2009, In : Molecular Pharmaceutics. 6, 2, p. 520-30 11 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)