Research Output per year
Research Output per year
Dr
Room 03.061 - CEM
United Kingdom
Accepting PhD Students
PhD projects
I am happy to discuss PhD opportunities in my lab with enthusiastic candidates. The focus of the project should be on MS, neuroinflammation, regenerative inflammation, inflammasomes in tissue damage and repair.
Research output per year
Dr Dombrowski’s research focuses on immune mechanisms in tissue damage and repair. Tissue damage can occur in infectious (e.g. bacteria, virus, fungi) or sterile settings (e.g. trauma, autoimmune attack). The Dombrowski group is primarily interested in the underlying immunological mechanisms that direct tissue repair and regeneration with the goal to identify novel therapeutic targets for immune-mediated diseases such as Multiple Sclerosis (MS).
Despite driving pathology in many diseases, the immune system is required for tissue regeneration. Innate immune receptors sense disruption of tissue homeostasis initiating a regenerative immune response that leads to the repair of the damaged tissue. Our central goal is to elucidate the mechanisms of regenerative inflammation in particular the role of the innate immune system in myelin regeneration in MS.
In MS the myelin sheath that covers nerve fibres is damaged due to an autoimmune attack against proteins in the myelin sheath. As a result the nerve fibres die leading to a loss of function, which can result in paralysis and other neurodegenerative symptoms. There is no cure for MS to date and there are no therapies that can restore damaged myelin in order to prevent nerve loss.
Current projects of the group investigate the function of inflammasomes during myelin damage and regeneration in the central nervous system (CNS) and the effects of IL-1 cytokines on oligodendrocytes in the CNS - the cells that produce myelin. Other projects in the group investigate the role of inflammasomes in regenerative inflammation after infectious tissue damage and the role of e-cigarette vapour as an inflammasome activator.
Dr Dombrowski has published her work in high-impact journals (e.g. Nature Neuroscience) and her research has been recognized in prestigious awards including an Early Career Fellowship from The Leverhulme Trust, the MS Society Reserach of the Year award and the invitation to the 64th Lindau Nobel Laureate Meeting for Physiology and Medicine as one of ten UK representatives.
Join the team!
The Dombrowski group is welcoming applications from enthusiastic and ambitious students and postdoctoral researchers who wish to work at the cutting-edge of regenerative immunology. Please contact Dr Yvonne Dombrowski for further information (y.dombrowski@qub.ac.uk).
Facebook: @TheDombrowskiLab https://www.facebook.com/thedombrowskilab/
Twitter: @DombrowskiLab https://twitter.com/dombrowskilab?lang=en ; @DombrowskiQUB https://twitter.com/dombrowskiqub?lang=en
Dr Laura Gritti, Research Fellow
Dr Katherine Feeney, Research Assistant
PhD students
Richard Creswell, 2020-present
Victor Asuzu, 2020-present
Sarah Kuhn, 2018-present
Daniel Crooks, 2017-present
Jenny Moi Fong Lau, 2017-2020
MSc students
Emma McKay (MSci Biol Sciences)
Caitlyn Harvey (MSc Exp Medicine)
Lauren Doherty (MSc in Molecular Biology & Biotechnology)
Research Volunteers/Assistants
Dr Stephen McGovern (2020-present)
BSc students
Tara Bertholon (Biol Sciences)
Anna Magennis (Hum Biol)
Former group members
Dr Rachael Bell
Dr Louise Johnston
Dr Pol O'Catnaigh
Research grants from the Royal Society, the Fritz-Thyssen-Foundation, the Freemasons of Ireland Medical Research Fund
The Leverhulme Trust career development fellowship
64th Lindau Nobel Laureate Meeting for Physiology and Medicine (1 of 10 Royal Society selected UK representatives)
MS Society Awards 2018 Best Research
Best flash talk, International Society for Neuroimmunology Meeting, Sydney (2018)
Best poster at the Irish Society of Immunology Meeting (2015)
Best Postdoctoral Researcher of the School of Medicine, Dentistry and Biomedical Sciences Annual Celebration of Excellence (2014)
British Neuropathological Society Pilot Grant (2013)
Best talk at the German Society of Dermatology Research (ADF) Meeting (2012)
2019
14th World Congress on Inflammation, Sydney, Australia, 15th-19th Sept 2019
MS Frontiers, Bath, 4th-5th July 2019
British Society for Immunology-Ulster Immunology Group Symposium, Belfast, 13th-14th June
Molecular Mechanisms of Inflammation, Trondheim, Norway, 3rd-6th June 2019
MS Symposium Antwerp, Antwerp, Belgium, 23rd May 2019 (keynote speaker)
University of Victoria, guest seminar, British Columbia, Canada, 19th March 2019
La Jolla Institute for Immunology, guest seminar, La Jolla, California, 15th March 2019
2018
University of Manchester, guest seminar, Manchester, 13th Dec 2018
RCSI Dublin, guest seminar, 8th October 2018,
NIMS Network Research Symposium, Belfast, 6th March 2019
2017
University of Milan-Bicocca, guest seminar, Milan, Italy, 15th Nov 2017
National University of Ireland Galway, CURAM, guest seminar, Galway, 14th Aug 2017
MS Frontiers, Edinburgh, 29th-30th June 2017
5th REMERGE Symposium, 26th June 2017, Belfast
Inaugural MS Research Symposium, Belfast, 9th May 2017
2016
Gordon Research Seminar Myelin, Tuscany, Italy14th-15th May 2016
Kenneth B Fraser Symposium, Belfast, 19th Apr 2016
2015
University of Manchester, guest seminar, Manchester, 1st Dec 2015
3rd Translational Immunology Conference, Würzburg, Germany, 29th-30th Oct 2015
MS Society UK Biomedical Research Grant Panel, 2019-present
British Society for Immunology - Ulster Immunology Group President, 2020-present
British Society for Immunology - Ulster Immunology Group Treasurer, 2017-2020
Modules
BMS2106 The Science of Disease (Module Coordinator)
SCM8097 MSc Experimental Medicine
SCM8067 MSc Experimental Medicine
MED1012 ePortfolio tutor for medical students
C25 CBL
WWIEM Presentation Skills for PhD students (facilitator)
MED2016 Student Selective Component Multiple Sclerosis: Much done much to do
BMS3012 Advanced Neuroscience (2017-2019)
SCM8097 MRes Translational Medicine (2016-2018)
BMS2016 Immunobiology (2012-2017)
PODT Pathology of Disease (2014-2016)
Supervision UG & PGT
MSc Students
Emma McKay 2020-2021 (Biol Sciences)
Caitlyn Harvey 2020-2021
Laura Suitor 2019-2020
Lauren Doherty 2019-2020
Gemma McIlwaine 2018-2019
Sarah Kuhn 2018 (in collaboration with LMU Munich), Erasmus student
MRes Students
Gerry Mullan 2017-2018 (intercalated)
Daniel Crooks 2016-2017
Samantha Gallaher 2016-2017
Natasha Boylan 2015-2016 (intercalated)
Samara Fleville 2014-2015 (intercalated)
BSc Students
Anna Magennis 2020-2021 (Hum Biol)
Tara Bertholon 2020-2021 (Biol Sciences)
Joseph Curran 2019-2020
Rachel Browne Murray 2018-2019
Lauren Kelly 2017-2018
Arianne Moore 2017-2018
Ian Devine 2017-2018
Lydia Roets 2016-2017
Georgiana Parau 2016-2017
Amy Evans 2016-2017 (Literature review module)
Daniel Crooks 2015-2016
Calum Macdonald 2015-2016
Andre O. Borba 2014-2015 (Literature review module)
Workplacement students/Professional studies
Tara Bertholon 2019-2020
Emma McKay 2018-2019
Summer Students/Erasmus students/Internships
Alice Adams (QUB Medicine) 2019
Joseph Curran (QUB, Biomedical Sciences) 2019
Sarunas Dzinkevicius 2018-2019
Lise Pradat (University of Auvergne, France) 2018, Erasmus student
Mattias Mehmed (QUB) 2018, BSI summer studentship
Samuel Moore (University of Cambridge) 2017
Anne-Laure Boinet (Ecole Nationale Superieure de Technologie des Biomolecules de Bordeaux) 2017
Andre B. Olivera (QUB) 2014
Samara Fleville (QUB) 2013 & 2014
Maeve Moore (QUB) 2014
Research output: Contribution to conference › Poster › peer-review
Research output: Contribution to conference › Poster › peer-review
Research output: Contribution to conference › Poster › peer-review
Research output: Contribution to conference › Poster › peer-review
Research output: Contribution to conference › Poster › peer-review
Dombrowski, Yvonne (Recipient), 2014
Prize: Prize (including medals and awards)
Dombrowski, Yvonne (Recipient), 2018
Prize: Prize (including medals and awards)
Dombrowski, Yvonne (Recipient), 01 Oct 2014
Prize: Fellowship awarded competitively
Dombrowski, Yvonne (Recipient), 2018
Prize: Prize (including medals and awards)
Yvonne Dombrowski (Invited speaker)
Activity: Talk or presentation types › Invited talk
Yvonne Dombrowski (Host)
Activity: Hosting a visitor types › Hosting an academic visitor
Yvonne Dombrowski (Participant)
Activity: Participating in or organising an event types › Participation in Festival/Exhibition
Yvonne Dombrowski (Host)
Activity: Hosting a visitor types › Hosting an academic visitor
Yvonne Dombrowski (Host)
Activity: Hosting a visitor types › Hosting an academic visitor
13/03/2017
1 item of Media coverage
Press/Media: Research
13/03/2017
1 item of Media coverage
Press/Media: Research