Yvonne Dombrowski

Research output

Research output per year 2006 2014 2015 2017 2018 2019 2024

• 40 Article
• 39 Poster
• 3 Conference contribution
• 3 Review article
• 3 More
  • 2 Meeting abstract
  • 1 Abstract

Research output per year

Research output per year

Search results

• 2024

  Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination

  de la Fuente, A. G., Dittmer, M., Heesbeen, E. J., de la Vega Gallardo, N., White, J. A., Young, A., McColgan, T., Dashwood, A., Mayne, K., Cabeza-Fernández, S., Falconer, J., Rodriguez-Baena, F. J., McMurran, C. E., Inayatullah, M., Rawji, K. S., Franklin, R. J. M., Dooley, J., Liston, A., Ingram, R. J. & Tiwari, V. K. & 3 others, Penalva, R., Dombrowski, Y. & Fitzgerald, D. C., 11 Mar 2024, In: Nature Communications. 15, 19 p., 1870.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • T Cell 100%
  • Remyelinization 100%
  • Regulatory T Cell 100%
  • Oligodendrocyte 40%
  • Alpha2 Integrin 20%
  1 Citation (Scopus)

  44 Downloads (Pure)

• Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

  Llorián-Salvador, M., de Fuente, A. G., McMurran, C. E., Dashwood, A., Dooley, J., Liston, A., Penalva, R., Dombrowski, Y., Stitt, A. W. & Fitzgerald, D. C., 05 Apr 2024, In: Molecular Neurodegeneration. 19, 17 p., 32.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phagocyte 100%
  • Gliosis 90%
  • Neuroprotective Agent 50%
  • Photoreceptor 50%
  • Nervous System 50%
  42 Downloads (Pure)
• 2023

  Regulation of caries‐induced pulp inflammation by NLRP3 inflammasome: a laboratory‐based investigation

  Al Natour, B., Lundy, F. T., About, I., Jeanneau, C., Dombrowski, Y. & El Karim, I. A., Feb 2023, In: International Endodontic Journal. 56, 2, p. 193-202 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Regulatory Mechanism 100%
  • Receptor 100%
  • Inflammasome 100%
  • Inflammation 100%
  • Pyrin Domain 100%
  4 Citations (Scopus)

  131 Downloads (Pure)
• 2022

  Innate and adaptive immune mechanisms regulating central nervous system remyelination

  Creswell, R. & Dombrowski, Y., Apr 2022, In: Current Opinion in Pharmacology. 63, 7 p., 102175.

  Research output: Contribution to journal › Review article › peer-review

  • Immunity 100%
  • Central Nervous System 100%
  • Remyelinization 100%
  • Remyelination 100%
  • Neuroinflammation 37%
  4 Citations (Scopus)
• 2021

  DNA Released by Dying Cells Induces CGAS-STING Mediated Pulp Inflammation

  Al-Natour, B., Lundy, F., Dombrowski, Y., About, I. & El Karim, I., 05 Feb 2021, In: Journal of Dental Research. 100, Spec IssB

  Research output: Contribution to journal › Meeting abstract › peer-review

• Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation

  Kodji, X., Kee, Z., McKenna, R., de Sousa Valente, J., Ravenscroft, H., McMillan, H., Gamble, J., Dombrowski, Y., Moynagh, P., Brough, D., Lundy, F. T., Brain, S. D. & El Karim, I. A., 23 Oct 2021, In: Pharmaceuticals (Basel, Switzerland). 14, 11, 1073.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ankyrin 100%
  • Receptor Potential 100%
  • NLRP3 Inflammasome 100%
  • Temporomandibular Joint 50%
  • NLR Family Pyrin Domain containing 3 50%
  2 Citations (Scopus)

  79 Downloads (Pure)

• Odontoblast cell death induces NLRP3 inflammasome-dependent sterile inflammation and regulates dental pulp cell migration, proliferation and differentiation

  Al Natour, B., Lundy, F. T., Moynah, P. N., About, I., Jeanneau, C., Irwin, C., Dombrowski, Y. & El Karim, I. A., 27 Jan 2021, In: International Endodontic Journal. 54, 6, p. 941-950 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cells 100%
  • Serositis 100%
  • Cell Proliferation 100%
  • Programmed Cell Death 100%
  • Cell Differentiation 100%
  8 Citations (Scopus)

  49 Downloads (Pure)
• 2020

  Odontoblast Cell Death Induces Inflammasome Dependent Reparative Inflammation

  Al-Natour, B., Lundy, F., Dombrowski, Y., About, I. & El Karim, I., Jul 2020, In: Journal of Dental Research. 99, Spec Iss A

  Research output: Contribution to journal › Meeting abstract › peer-review

  • Programmed Cell Death 100%
  • Inflammasome 100%
  • Odontoblast 100%
  • Inflammation 100%
  • Cells 76%
• 2019

  Inflammasome component expression in myelin damage and regeneration in vivo

  McKay, E., Gritti, L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasome Product IL-1beta Enhances Myelination and Remyelination of Organotypic Brain Slices

  Crooks, D., Fitzgerald, D., Bankhead, P. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasome Product IL-1beta Enhances Myelination and Remyelination of Organotypic Brain Slices 

  Crooks, D., Bankhead, P., Fitzgerald, D. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasomes: novel players in OPC proliferation and myelin regeneration

  Gritti, L., McKay, E., Crooks, D., Boinet, A.-L., Fleville, S., Fitzgerald, D. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasomes are expressed in murine CNS lesions and inflammasome products IL-1beta and IL-18 promote remyelination. 

  Crooks, D., Fleville, S., Boylan, N., Roets, L., Lavelle, E., Fitzgerald, D. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• Investigating the role of inflammasomes in tissue repair​

  Lau, M. F., Kelly, L., Krasnodembskaya, A., Fitzgerald, D., Ingram, R., O'Kane, C. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• Oligodendrocytes in Development, Myelin Generation and Beyond

  Kuhn, S., Gritti, L., Crooks, D. & Dombrowski, Y., 12 Nov 2019, In: Cells. 8, 11, 23 p., 1424.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Development 100%
  • Myelin 100%
  • Oligodendrocyte 100%
  • Stem Cell 26%
  • Oligodendrocyte Progenitor 25%
  351 Citations (Scopus)

  456 Downloads (Pure)

• Poster abstract: AIM2-mediated inflammasome activation contributes to N-methyl-N-nitrosourea induced photoreceptor death

  Chen, M., Harkin, K., Dombrowski, Y. & Xu, H., 2019.

  Research output: Contribution to conference › Abstract › peer-review

• Pro-inflammatory IL-1β enhances oligodendrocyte progenitor cell proliferation and

  Kuhn, S., Mullan, G., McIlwaine, G., Fleville, S., Dittmer, M., Guzman de la Fuente, A., Fitzgerald, D. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• Pro-inflammatory IL-1β enhances oligodendrocyte progenitor cell proliferation and differentiation and promotes myelin protein production

  Kuhn, S., Mullan, G., McIlwaine, G., Fleville, S., Dittmer, M., Guzman de la Fuente, A., Fitzgerald, D. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• The intrinsic mechanisms of inflammasomes in murine mixed glia cultures

  McIlwaine, G., Kuhn, S., Mullan, G., Gritti, L., Fitzgerald, D. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review

• The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination

  McMurran, C. E., Guzman de la Fuente, A., Penalva, R., Ben Menachem-Zidon, O., Dombrowski, Y., Falconer, J., Gonzalez, G. A., Zhao, C., Krause, F. N., Young, A. M. H., Griffin, J. L., Jones, C. A., Hollins, C., Heimesaat, M. M., Fitzgerald, D. C. & Franklin, R. J. M., 18 Nov 2019, (Early online date) In: Proceedings of the National Academy of Sciences of the United States of America. 116, 50, p. 25311

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microflora 100%
  • Central Nervous System 100%
  • Remyelinization 100%
  • Regeneration 40%
  • Oligodendrocyte Progenitor 40%
  32 Citations (Scopus)

  105 Downloads (Pure)

• The role of inflammasomes and IL-1beta in sterile CNS damage and regeneration

  Gritti, L., Crooks, D., Kuhn, S., Mullan, G., McKay, E., Fitzgerald, D., Bankhead, P. & Dombrowski, Y., 2019.

  Research output: Contribution to conference › Poster › peer-review
• 2018

  Characterization of a murine mixed neuron-glia model and cellular responses to regulatory T cell-derived factors

  Dittmer, M., Young, A., O'Hagan, T., Eleftheriadis, G., Bankhead, P., Dombrowski, Y., Medina, R. J. & Fitzgerald, D. C., 02 May 2018, In: Molecular Brain. 11, 1, p. 1-25

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuron 100%
  • Oligodendrocyte 100%
  • Glia 100%
  • Regulatory T Cell 100%
  • Oligodendrocyte Progenitor 50%
  16 Citations (Scopus)

  445 Downloads (Pure)

• Identifying molecular targets in brain repair for multiple sclerosis

  Crooks, D., Boylan, N., De La Vega Gallardo, N., Evans, F., Bankhead, P., Fitzgerald, D. & Dombrowski, Y., 06 Mar 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasome-derived IL-1beta and IL-18 promote oligodendrocyte differentiation and CNS myelination in vitro

  Dombrowski, Y., Mar 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasome expression in the healthy and diseased CNS.  

  Mullan, G., Fleville, S., Crooks, D., Fitzgerald, D. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasome Product IL-1beta Enhances Axonal Ensheathment of Organotypic Brain Slices Ex Vivo  

  Crooks, D., Fitzgerald, D., Bankhead, P. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasomes activation occurs in lipopolysaccharide induced Acute Respiratory Distress Syndrome (ARDS) in murine model 

  Lau, J.M.-S., Kelly, L., Fitzgerald, D., O'Kane, C. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasomes are expressed in murine CNS lesions and inflammasome products IL-1beta and IL-18 promote CNS myelination

  Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasomes are expressed in murine CNS lesions and inflammasome products IL-1beta and IL-18 promote myelin production

  Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Inflammasomes are expressed in murine CNS lesions and inflammasome products IL-1beta and IL-18 promote remyelination.  

  Crooks, D., Fleville, S., Boylan, N., Roets, L., Lavelle, E., Fitzgerald, D. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Pro-inflammatory IL-1β enhances oligodendrocyte progenitor cell proliferation and

  Kuhn, S., Mullan, G., Fleville, S., Crooks, D., Fitzgerald, D. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• Regenerating CNS myelin: Emerging roles of regulatory T cells and CCN proteins

  Gallardo, N. D. L. V., Dittmer, M., Dombrowski, Y. & Fitzgerald, D. C., 01 Dec 2018, (Early online date) In: Neurochemistry International.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Cell Protein 100%
  • Myelin 100%
  • Central Nervous System 100%
  • Oligodendrocyte 50%
  • Myelinogenesis 50%
  28 Citations (Scopus)

  719 Downloads (Pure)

• The effects of E-cigarettes on pulmonary inflammation and inflammasome activation  

  Bell, R., O'Kane, C., Shyamsundar, M. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• The effects of E-cigarettes on pulmonary inflammation and inflammasome activation  

  Bell, R., O'Kane, C., Shyamsundar, M. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review

• The effects of E-cigarettes on pulmonary inflammation and inflammasome activation  

  Bell, R., O'Kane, C., Shyamsundar, M. & Dombrowski, Y., 2018.

  Research output: Contribution to conference › Poster › peer-review
• 2017

  Inflammasome expression in CNS lesions and the effect of inflammasome-derived IL-1beta and IL-18 on glial cells in vitro: XIII European Meeting on GLial Cells in Health and Disease, Edinburgh

  Dombrowski, Y., 09 Jul 2017.

  Research output: Contribution to conference › Poster › peer-review

• INFLAMMASOMES ARE EXPRESSED IN CNS LESIONS AND INFLAMMASOME PRODUCTS IL-1BETA AND IL-18 PROMOTE MYELIN PRODUCTION IN VITRO: Nature Regeneration, Milan

  Dombrowski, Y., 16 Nov 2017.

  Research output: Contribution to conference › Poster › peer-review

• Investigation of the role of inflammasomes in CNS (re)myelination

  Crooks, D., Boylan, N., De La Vega Gallardo, N., Evans, F., Bankhead, P., Fitzgerald, D. & Dombrowski, Y., 26 Jun 2017.

  Research output: Contribution to conference › Poster › peer-review

• Regulatory T cells are required for remyelination in the brain in vivo

  Penalva, R., Falconer, J., Naughton, M., Dombrowski, Y. & Fitzgerald, D., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Regulatory T cells are required for remyelination in the brain in vivo

  Penalva, R., Falconer, J., Naughton, M., Dombrowski, Y. & Fitzgerald, D., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Regulatory T cells enhance oligodendrocyte differentiation

  Dittmer, M., O'Hagan, T., Eleftheriadis, G., Fleville, S., Falconer, J., Bankhead, P., Medina, R., Dombrowski, Y. & Fitzgerald, D., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Regulatory T cells enhance oligodendrocyte differentiation in vitro

  Dittmer, M., O'Hagan, T., Eleftheriadis, G., Fleville, S., Bankhead, P., Dombrowski, Y., Medina, R. & Fitzgerald, D., 2017.

  Research output: Contribution to conference › Poster › peer-review

• Regulatory T cells promote myelin regeneration in the central nervous system: MS Frontiers, Edinburgh

  Dombrowski, Y., 30 Jun 2017.

  Research output: Contribution to conference › Poster › peer-review

• Regulatory T cells promote myelin regeneration in the central nervous system

  Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., Hassan, R., Moffat, J., Falconer, J., Boyd, A., Hamilton, P., Allen, I. V., Kissenpfennig, A., Moynagh, P. N., Evergren, E. & Perbal, B. & 5 others, Williams, A. C., Ingram, R. J., Chan, J. R., Franklin, R. J. M. & Fitzgerald, D. C., May 2017, In: Nature Neuroscience. 20, 5, p. 674–680 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Central Nervous System 100%
  • Regulatory T Cell 100%
  • Regeneration 100%
  • Myelin 100%
  • Oligodendrocyte 100%
  333 Citations (Scopus)

  1360 Downloads (Pure)

• The innate immune receptor NLRP12 maintains intestinal homeostasis by regulating microbiome diversity

  Lau, J. M. F. & Dombrowski, Y., 24 Jul 2017, In: Cellular and Molecular Immunology.

  Research output: Contribution to journal › Article

  • Microbiome 100%
  • Homeostasis 100%
  • Inflammatory Bowel Disease 100%
  • Immune Receptor 100%
  • NLRP12 100%
  10 Citations (Scopus)
• 2016

  Regulatory T cells are required for oligodendrocyte differentiation in vivo: Gordon Myelin Conference, Tuscany/Italy

  Dombrowski, Y., 2016.

  Research output: Contribution to conference › Poster › peer-review
• 2015

  Inflammasome expression in CNS demyelination

  Dombrowski, Y., Sept 2015.

  Research output: Contribution to conference › Poster

• Inflammasome expression in demyelinated CNS lesions

  Dombrowski, Y., 22 Jun 2015.

  Research output: Contribution to conference › Poster

• Inflammasome expression in demyelinated CNS lesions

  Fleville, S., Dittmer, M., Fitzgerald, D. & Dombrowski, Y., Jul 2015.

  Research output: Contribution to conference › Poster

• Inflammasome expression in demyelinated CNS lesions

  Fleville, S., Dittmer, M., Fitzgerald, D. & Dombrowski, Y., 2015.

  Research output: Contribution to conference › Poster › peer-review