Research output per year
Research output per year
Project Details
Layman's description
A two-year study by Dr Martin of Queen's University Belfast will look at increasing the amount of airway surface liquid, which is vital for keeping the airways moist and allows people with CF to clear mucus more easily. People with CF often suffer with infection due the build up of mucus.
The research will look for ways of identifying Channel Activating Proteases (CAPs) to help stop too much sodium being reabsorbed and therefore enabling the lungs to clear thick mucus. This could revolutionise CF treatment and prevent lung damage and infection occurring.
The research will look for ways of identifying Channel Activating Proteases (CAPs) to help stop too much sodium being reabsorbed and therefore enabling the lungs to clear thick mucus. This could revolutionise CF treatment and prevent lung damage and infection occurring.
| Acronym | R2634PMY |
|---|---|
| Status | Active |
| Effective start/end date | 01/08/2009 → … |
Research output
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Inhibition of protease-ENaC signaling improves mucociliary function in cystic fibrosis airways
Reihill, J. A., Walker, B., Hamilton, R. A., Ferguson, T. E. G., Elborn, J. S., Stutts, M. J., Harvey, B. J., Saint-Criq, V., Hendrick, S. M. & Martin, S. L., Sep 2016, In: American Journal of Respiratory and Critical Care Medicine. 194, 6, p. 701-710 10 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
CHANNEL ACTIVATING PROTEASES (CAPS): Identification of novel targets for correcting sodium channel dysfunction in cystic fibrosis
Reihill, J., Walker, B., Elborn, S. & Martin, L., Oct 2012.Research output: Contribution to conference › Paper › peer-review