β-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics

E.J. Amigues; E. Armstrong; M. Dvorakova; M.E. Migaud; M. Huang

doi:10.1080/15257770902865415

β-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics

E.J. Amigues, E. Armstrong, M. Dvorakova, M.E. Migaud^*, M. Huang^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.

Original language	English
Pages (from-to)	238-259
Journal	Nucleosides Nucleotides & Nucleic Acids
Volume	28
Issue number	3
DOIs	https://doi.org/10.1080/15257770902865415
Publication status	Published - 30 Mar 2009

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abstract = "The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.",

author = "E.J. Amigues and E. Armstrong and M. Dvorakova and M.E. Migaud and M. Huang",

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T1 - β-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics

AU - Amigues, E.J.

AU - Armstrong, E.

AU - Dvorakova, M.

AU - Migaud, M.E.

AU - Huang, M.

PY - 2009/3/30

Y1 - 2009/3/30

N2 - The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.

AB - The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.

U2 - 10.1080/15257770902865415

DO - 10.1080/15257770902865415

M3 - Article

VL - 28

SP - 238

EP - 259

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

SN - 1525-7770

IS - 3

ER -

β-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics

Abstract

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