β-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics

E.J. Amigues, E. Armstrong, M. Dvorakova, M.E. Migaud*, M. Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild hydrogenation conditions. These analogues were modelled as to define their similarity to nicotinamide riboside and quantify their ability to bind NAD-dependent protein deacetylases.

Original languageEnglish
Pages (from-to)238-259
JournalNucleosides Nucleotides & Nucleic Acids
Volume28
Issue number3
DOIs
Publication statusPublished - 30 Mar 2009

Fingerprint

Dive into the research topics of 'β-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics'. Together they form a unique fingerprint.

Cite this