1020 - NEW INSIGHTS INTO INFLAMMASOME SIGNALLING AND FUNCTION DURING INFLAMMATION

Rebecca Coll, Kate Schroder, Dave Boucher

Research output: Contribution to conferenceAbstract

Abstract

Inflammasomes are signalling hubs that assemble in response to cell stress or microbial infection, and provide an activation platform for the zymogen protease, caspase-1. Upon activation, caspase-1 triggers the maturation and secretion of potent pro-inflammatory mediators (interleukin-1beta and -18) and induces cell lysis, culminating in the activation of the immune system and antimicrobial defence. Inflammasome signalling can, however, also drive pathology in a range of human auto-inflammatory, inflammatory, metabolic and neurodegenerative diseases. Here we reveal the mechanisms by which inflammasomes signal, and how a small molecule inflammasome inhibitor can silence pathological inflammasome signalling for therapeutic management of disease.
Original languageEnglish
PagesS32
Number of pages1
DOIs
Publication statusPublished - 21 Aug 2019
Event48th Annual Scientific Meeting International Society for Experimental Hematology - Brisbane Convention & Exhibition Centre, Brisbane, Australia
Duration: 22 Aug 201925 Aug 2019
https://www.iseh.org/page/2019Meeting

Conference

Conference48th Annual Scientific Meeting International Society for Experimental Hematology
Abbreviated titleISEH
CountryAustralia
CityBrisbane
Period22/08/201925/08/2019
Internet address

Fingerprint Dive into the research topics of '1020 - NEW INSIGHTS INTO INFLAMMASOME SIGNALLING AND FUNCTION DURING INFLAMMATION'. Together they form a unique fingerprint.

  • Cite this

    Coll, R., Schroder, K., & Boucher, D. (2019). 1020 - NEW INSIGHTS INTO INFLAMMASOME SIGNALLING AND FUNCTION DURING INFLAMMATION. S32. Abstract from 48th Annual Scientific Meeting International Society for Experimental Hematology, Brisbane, Australia. https://doi.org/10.1016/j.exphem.2019.06.258