1020 - NEW INSIGHTS INTO INFLAMMASOME SIGNALLING AND FUNCTION DURING INFLAMMATION

Rebecca Coll; Kate Schroder; Dave Boucher

doi:10.1016/j.exphem.2019.06.258

Abstract

Inflammasomes are signalling hubs that assemble in response to cell stress or microbial infection, and provide an activation platform for the zymogen protease, caspase-1. Upon activation, caspase-1 triggers the maturation and secretion of potent pro-inflammatory mediators (interleukin-1beta and -18) and induces cell lysis, culminating in the activation of the immune system and antimicrobial defence. Inflammasome signalling can, however, also drive pathology in a range of human auto-inflammatory, inflammatory, metabolic and neurodegenerative diseases. Here we reveal the mechanisms by which inflammasomes signal, and how a small molecule inflammasome inhibitor can silence pathological inflammasome signalling for therapeutic management of disease.

Original language	English
Pages	S32
Number of pages	1
DOIs	https://doi.org/10.1016/j.exphem.2019.06.258
Publication status	Published - 21 Aug 2019
Event	48th Annual Scientific Meeting International Society for Experimental Hematology - Brisbane Convention & Exhibition Centre, Brisbane, Australia Duration: 22 Aug 2019 → 25 Aug 2019 https://www.iseh.org/page/2019Meeting

Conference

Conference	48th Annual Scientific Meeting International Society for Experimental Hematology
Abbreviated title	ISEH
Country/Territory	Australia
City	Brisbane
Period	22/08/2019 → 25/08/2019
Internet address	https://www.iseh.org/page/2019Meeting

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "1020 - NEW INSIGHTS INTO INFLAMMASOME SIGNALLING AND FUNCTION DURING INFLAMMATION",

abstract = "Inflammasomes are signalling hubs that assemble in response to cell stress or microbial infection, and provide an activation platform for the zymogen protease, caspase-1. Upon activation, caspase-1 triggers the maturation and secretion of potent pro-inflammatory mediators (interleukin-1beta and -18) and induces cell lysis, culminating in the activation of the immune system and antimicrobial defence. Inflammasome signalling can, however, also drive pathology in a range of human auto-inflammatory, inflammatory, metabolic and neurodegenerative diseases. Here we reveal the mechanisms by which inflammasomes signal, and how a small molecule inflammasome inhibitor can silence pathological inflammasome signalling for therapeutic management of disease.",

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doi = "10.1016/j.exphem.2019.06.258",

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T1 - 1020 - NEW INSIGHTS INTO INFLAMMASOME SIGNALLING AND FUNCTION DURING INFLAMMATION

AU - Coll, Rebecca

AU - Schroder, Kate

AU - Boucher, Dave

PY - 2019/8/21

Y1 - 2019/8/21

N2 - Inflammasomes are signalling hubs that assemble in response to cell stress or microbial infection, and provide an activation platform for the zymogen protease, caspase-1. Upon activation, caspase-1 triggers the maturation and secretion of potent pro-inflammatory mediators (interleukin-1beta and -18) and induces cell lysis, culminating in the activation of the immune system and antimicrobial defence. Inflammasome signalling can, however, also drive pathology in a range of human auto-inflammatory, inflammatory, metabolic and neurodegenerative diseases. Here we reveal the mechanisms by which inflammasomes signal, and how a small molecule inflammasome inhibitor can silence pathological inflammasome signalling for therapeutic management of disease.

AB - Inflammasomes are signalling hubs that assemble in response to cell stress or microbial infection, and provide an activation platform for the zymogen protease, caspase-1. Upon activation, caspase-1 triggers the maturation and secretion of potent pro-inflammatory mediators (interleukin-1beta and -18) and induces cell lysis, culminating in the activation of the immune system and antimicrobial defence. Inflammasome signalling can, however, also drive pathology in a range of human auto-inflammatory, inflammatory, metabolic and neurodegenerative diseases. Here we reveal the mechanisms by which inflammasomes signal, and how a small molecule inflammasome inhibitor can silence pathological inflammasome signalling for therapeutic management of disease.

U2 - 10.1016/j.exphem.2019.06.258

DO - 10.1016/j.exphem.2019.06.258

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T2 - 48th Annual Scientific Meeting International Society for Experimental Hematology

Y2 - 22 August 2019 through 25 August 2019