(18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT.

Gerard Hanna; K. Carson; T. Lynch; J. McAleese; V. Cosgrove; R. Eakin; D.P. Stewart; Joe O'Sullivan; A Hounsell

doi:10.1016/j.ijrobp.2009.04.045

(18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT.

Gerard Hanna, K. Carson, T. Lynch, J. McAleese, V. Cosgrove, R. Eakin, D.P. Stewart, Joe O'Sullivan, A Hounsell

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Purpose: Positron emission tomography (PET), in addition to computed tomography (CT), has an effect in target volume definition for radical radiotherapy (RT) for non–small-cell lung cancer (NSCLC). In previously PET-CT staged patients with NSCLC, we assessed the effect of using an additional planning PET-CT scan for gross tumor volume (GTV) definition. Methods and Materials: A total of 28 patients with Stage IA-IIIB NSCLC were enrolled. All patients had undergone staging PET-CT to ensure suitability for radical RT. Of the 28 patients, 14 received induction chemotherapy. In place of a RT planning CT scan, patients underwent scanning on a PET-CT scanner. In a virtual planning study, four oncologists independently delineated the GTVon the CT scan alone and then on the PET-CTscan. Intraobserver and interobserver variability were assessed using the concordance index (CI), and the results were compared using the Wilcoxon signed ranks test. Results: PET-CT improved the CI between observers when defining the GTVusing the PET-CT images compared with using CTalone for matched cases (median CI, 0.57 for CTand 0.64 for PET-CT, p = .032). The median of the mean percentage of volume change from GTVCT to GTVFUSED was 5.21% for the induction chemotherapy group and 18.88% for the RT-alone group. Using the Mann-Whitney U test, this was significantly different (p = .001). Conclusion: PET-CT RT planning scan, in addition to a staging PET-CT scan, reduces interobserver variability in GTV definition for NSCLC. The GTV size with PET-CT compared with CT in the RT-alone group increased and was reduced in the induction chemotherapy group.

Original language	English
Pages (from-to)	24-30
Number of pages	7
Journal	International journal of radiation oncology, biology, physics
Volume	77
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2009.04.045
Publication status	Published - 01 May 2010

Bibliographical note

This publication in one of the top two leading radiotherapy journals was the 1st published clinical publication to test the pure performance of PET/CT for radiotherapy planning, beyond the impact that PET/CT had on staging alone.

Keywords

Lung Cancer
NSCLC
PET/CT
RADIOTHERAPY

ASJC Scopus subject areas

Cancer Research
Oncology
Radiology Nuclear Medicine and imaging
Radiation

Access to Document

10.1016/j.ijrobp.2009.04.045

Link to publication in Scopus

Fingerprint Dive into the research topics of '(18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT.'. Together they form a unique fingerprint.

Cite this

@article{e2046b6b97f94c1db0d73df02a34b168,

title = "(18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT.",

abstract = "Purpose: Positron emission tomography (PET), in addition to computed tomography (CT), has an effect in target volume definition for radical radiotherapy (RT) for non–small-cell lung cancer (NSCLC). In previously PET-CT staged patients with NSCLC, we assessed the effect of using an additional planning PET-CT scan for gross tumor volume (GTV) definition. Methods and Materials: A total of 28 patients with Stage IA-IIIB NSCLC were enrolled. All patients had undergone staging PET-CT to ensure suitability for radical RT. Of the 28 patients, 14 received induction chemotherapy. In place of a RT planning CT scan, patients underwent scanning on a PET-CT scanner. In a virtual planning study, four oncologists independently delineated the GTVon the CT scan alone and then on the PET-CTscan. Intraobserver and interobserver variability were assessed using the concordance index (CI), and the results were compared using the Wilcoxon signed ranks test. Results: PET-CT improved the CI between observers when defining the GTVusing the PET-CT images compared with using CTalone for matched cases (median CI, 0.57 for CTand 0.64 for PET-CT, p = .032). The median of the mean percentage of volume change from GTVCT to GTVFUSED was 5.21% for the induction chemotherapy group and 18.88% for the RT-alone group. Using the Mann-Whitney U test, this was significantly different (p = .001). Conclusion: PET-CT RT planning scan, in addition to a staging PET-CT scan, reduces interobserver variability in GTV definition for NSCLC. The GTV size with PET-CT compared with CT in the RT-alone group increased and was reduced in the induction chemotherapy group.",

keywords = "Lung Cancer, NSCLC, PET/CT, RADIOTHERAPY",

author = "Gerard Hanna and K. Carson and T. Lynch and J. McAleese and V. Cosgrove and R. Eakin and D.P. Stewart and Joe O'Sullivan and A Hounsell",

note = "This publication in one of the top two leading radiotherapy journals was the 1st published clinical publication to test the pure performance of PET/CT for radiotherapy planning, beyond the impact that PET/CT had on staging alone. ",

year = "2010",

month = may,

day = "1",

doi = "10.1016/j.ijrobp.2009.04.045",

language = "English",

volume = "77",

pages = "24--30",

journal = "International Journal of Radiation: Oncology - Biology - Physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

number = "1",

}

(18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT. / Hanna, Gerard; Carson, K.; Lynch, T.; McAleese, J.; Cosgrove, V.; Eakin, R.; Stewart, D.P.; O'Sullivan, Joe ; Hounsell, A.

In: International journal of radiation oncology, biology, physics, Vol. 77, No. 1, 01.05.2010, p. 24-30.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - (18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT.

AU - Hanna, Gerard

AU - Carson, K.

AU - Lynch, T.

AU - McAleese, J.

AU - Cosgrove, V.

AU - Eakin, R.

AU - Stewart, D.P.

AU - O'Sullivan, Joe

AU - Hounsell, A

N1 - This publication in one of the top two leading radiotherapy journals was the 1st published clinical publication to test the pure performance of PET/CT for radiotherapy planning, beyond the impact that PET/CT had on staging alone.

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Purpose: Positron emission tomography (PET), in addition to computed tomography (CT), has an effect in target volume definition for radical radiotherapy (RT) for non–small-cell lung cancer (NSCLC). In previously PET-CT staged patients with NSCLC, we assessed the effect of using an additional planning PET-CT scan for gross tumor volume (GTV) definition. Methods and Materials: A total of 28 patients with Stage IA-IIIB NSCLC were enrolled. All patients had undergone staging PET-CT to ensure suitability for radical RT. Of the 28 patients, 14 received induction chemotherapy. In place of a RT planning CT scan, patients underwent scanning on a PET-CT scanner. In a virtual planning study, four oncologists independently delineated the GTVon the CT scan alone and then on the PET-CTscan. Intraobserver and interobserver variability were assessed using the concordance index (CI), and the results were compared using the Wilcoxon signed ranks test. Results: PET-CT improved the CI between observers when defining the GTVusing the PET-CT images compared with using CTalone for matched cases (median CI, 0.57 for CTand 0.64 for PET-CT, p = .032). The median of the mean percentage of volume change from GTVCT to GTVFUSED was 5.21% for the induction chemotherapy group and 18.88% for the RT-alone group. Using the Mann-Whitney U test, this was significantly different (p = .001). Conclusion: PET-CT RT planning scan, in addition to a staging PET-CT scan, reduces interobserver variability in GTV definition for NSCLC. The GTV size with PET-CT compared with CT in the RT-alone group increased and was reduced in the induction chemotherapy group.

AB - Purpose: Positron emission tomography (PET), in addition to computed tomography (CT), has an effect in target volume definition for radical radiotherapy (RT) for non–small-cell lung cancer (NSCLC). In previously PET-CT staged patients with NSCLC, we assessed the effect of using an additional planning PET-CT scan for gross tumor volume (GTV) definition. Methods and Materials: A total of 28 patients with Stage IA-IIIB NSCLC were enrolled. All patients had undergone staging PET-CT to ensure suitability for radical RT. Of the 28 patients, 14 received induction chemotherapy. In place of a RT planning CT scan, patients underwent scanning on a PET-CT scanner. In a virtual planning study, four oncologists independently delineated the GTVon the CT scan alone and then on the PET-CTscan. Intraobserver and interobserver variability were assessed using the concordance index (CI), and the results were compared using the Wilcoxon signed ranks test. Results: PET-CT improved the CI between observers when defining the GTVusing the PET-CT images compared with using CTalone for matched cases (median CI, 0.57 for CTand 0.64 for PET-CT, p = .032). The median of the mean percentage of volume change from GTVCT to GTVFUSED was 5.21% for the induction chemotherapy group and 18.88% for the RT-alone group. Using the Mann-Whitney U test, this was significantly different (p = .001). Conclusion: PET-CT RT planning scan, in addition to a staging PET-CT scan, reduces interobserver variability in GTV definition for NSCLC. The GTV size with PET-CT compared with CT in the RT-alone group increased and was reduced in the induction chemotherapy group.

KW - Lung Cancer

KW - NSCLC

KW - PET/CT

KW - RADIOTHERAPY

UR - http://www.scopus.com/inward/record.url?scp=77950592144&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2009.04.045

DO - 10.1016/j.ijrobp.2009.04.045

M3 - Article

C2 - 19665324

VL - 77

SP - 24

EP - 30

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 1

ER -