3-anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

D.G. Smith, M. Buffet, A.E. Fenwick, David Haigh, R.J. Ife, M. Saunders, B.P. Slingsby, R. Stacey, R.W. Ward

Research output: Contribution to journalArticlepeer-review

154 Citations (Scopus)

Abstract

Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases. (C) 2001 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)635-639
Number of pages5
JournalBioorganic & Medicinal Chemistry Letters
Volume11
Issue number5
Publication statusPublished - 12 Mar 2001

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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