Abstract
The treatment strategy required for the effective healing of diabetic foot ulcer (DFU) is a complex process that is requiring several combined therapeutic approaches. As a result, there is significant clinical and economic burden associated in treating DFU. Furthermore, these treatments are often unsuccessful, commonly resulting in lower-limb amputation. The use of drug-loaded scaffolds to treat DFU has previously been investigated using electrospinning and Fused Deposition Modeling (FDM) 3D printing techniques; however, the rapidly evolving field of bioprinting is creating new opportunities for innovation within this research area. In this study, 3D bioprinted scaffolds with different designs have been fabricated for the delivery of an antibiotic (levoflocixin) to DFU. The scaffolds were fully characterised by a variety of techniques (e.g., SEM, DSC/TGA, FTIR, and mechanical characterisation), demonstrating excellent mechanical properties and providing sustained drug release for 4 weeks. This proof of concept study demonstrates the innovative potential of bioprinting technologies in fabrication of antibiotic scaffolds for the treatment of DFU.
Original language | English |
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Journal | Drug Delivery and Translational Research |
Early online date | 11 Jan 2022 |
DOIs | |
Publication status | Early online date - 11 Jan 2022 |
Keywords
- Diabetic foot ulcer
- diabetes mellitus
- bioprinting
- wound healing
- drug delivery
- additive manufacturing
- scaffolds
- implants
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Dive into the research topics of '3D bioprinted scaffolds for diabetic wound healing applications'. Together they form a unique fingerprint.Press / Media
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3D treatment that could revolutionise diabetes treatment
Katie Glover, Essyrose Mathew, Giulia Pitzanti, Erin Magee & Dimitrios Lamprou
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3 items of Media coverage, 1 Media contribution
Press/Media: Research
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Novel carbon dioxide wound sensors for pathogen detection and therapeutic monitoring
Author: Magee, E., Jul 2022Supervisor: Gilmore, B. (Supervisor) & Mills, A. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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