TY - CHAP
T1 - 3D printed implants for long-acting drug delivery
AU - Dedeloudi, Aikaterini
AU - Andersen, Sune
AU - Hopson, Peyton
AU - Lamprou, Dimitrios A.
PY - 2024/5/13
Y1 - 2024/5/13
N2 - 3D-printed implantable drug delivery systems (DDSs) are a class of novel therapeutic approaches with promising characteristics for developing personalised therapies. The pharmacokinetic and pharmacodynamic profile of long-acting implantable drug release scaffolds provide significant potential in reducing treatment limitations, like patient compliance, therapeutic threshold, drug bioavailability, and side effects. The manufacturing process of 3D-printed implants involves an initial selection of materials, techniques, and a rational formulation process design. Physico-chemical characteristics of materials, material compatibility, and manufacturing techniques are critical in developing diverse and multifunctional scaffolds defined by a long-acting drug release rate. In this chapter, an overview in manufacturing techniques, DDSs classification, critical design parameters, and prospects of 3D-printed implantable DDSs is given.
AB - 3D-printed implantable drug delivery systems (DDSs) are a class of novel therapeutic approaches with promising characteristics for developing personalised therapies. The pharmacokinetic and pharmacodynamic profile of long-acting implantable drug release scaffolds provide significant potential in reducing treatment limitations, like patient compliance, therapeutic threshold, drug bioavailability, and side effects. The manufacturing process of 3D-printed implants involves an initial selection of materials, techniques, and a rational formulation process design. Physico-chemical characteristics of materials, material compatibility, and manufacturing techniques are critical in developing diverse and multifunctional scaffolds defined by a long-acting drug release rate. In this chapter, an overview in manufacturing techniques, DDSs classification, critical design parameters, and prospects of 3D-printed implantable DDSs is given.
KW - 3D Printing
KW - Implantable Scaffolds
KW - Implant
KW - Drug Delivery Systems
KW - Additive Manufacturing
KW - Biomaterials
U2 - 10.1002/9781119836001.ch5
DO - 10.1002/9781119836001.ch5
M3 - Chapter (peer-reviewed)
SN - 9781119835974
T3 - Advances in Pharmaceutical Technology
SP - 89
EP - 114
BT - 3D printing of pharmaceutical and drug delivery devices: progress from bench to bedside
A2 - Lamprou, Dimitrios A.
A2 - Douroumis, Dennis
A2 - Qi, Sheng
PB - John Wiley & Sons Ltd
ER -