3D Printed Multifunctional PEEK Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis

Ce Zhu, Miaomiao He, Dan Sun, Yong Huang, Leizhen Huang, Meixuan Du, Jingcheng Wang, Juehan Wang, Zhongyang Li, Bowen Hu, Yueming Song, Yubao Li, guanjun Feng, Li Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, we developed the first 3D-printed polyetheretherketone (PEEK)-based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis. A 3D-printed PEEK/graphene nanocomposite scaffold was deposited with a drug-laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating. The graphene nanosheets within the scaffold served as effective photothermal agents that endowed the scaffold with on-demand photothermal conversion function under near-infrared laser irradiation. The bioactive hydroxyapatite coating significantly boosted the stem cell proliferation in vitro and promoted new bone growth in vivo. The presence of antibiotics and anti-cancer drugs enabled eradication of drug-resistant bacteria and ablation of osteosarcoma cancer cells, the treatment efficacy of which can be further enhanced by on-demand laser-induced heating. The promising results demonstrate the strong potential of our multi-functional scaffold in applications such as bone defect repair and multimodal treatment of osteosarcoma and osteomyelitis.
Original languageEnglish
JournalACS Applied Materials and Interfaces
Early online date29 Sep 2021
DOIs
Publication statusEarly online date - 29 Sep 2021

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