Abstract
Osteosarcoma is a challenging bone disease which is commonly associated with critically sized bone defects and cancer recurrence. Here, we designed and developed a multifunctional, hierarchical structured bone scaffold which can meet the demanding requirements for osteosarcoma management. The 3D printed Ti6Al4V scaffold with hydrothermally induced TiO2/TiP coating can offer a unique photothermal conversion property for in vitro bone cancer ablation. The scaffold is also infused with drug-laden gelatin/hydroxyapatite nanocomposite, which provides the ideal porous structure for cell adhesion/bone ingrowth and promotes bone regeneration. The scaffold has been thoroughly characterized by SEM/EDX, TEM, XPS, XRD, TGA, and UV–vis, and its in vitro bone cancer ablation efficiency has been validated using MG-63 cells. The hybrid scaffold showed excellent biocompatibility, and its osteointegration function has been demonstrated using an animal model.
| Original language | English |
|---|---|
| Journal | Bioconjugate Chemistry |
| Early online date | 07 Sep 2021 |
| DOIs | |
| Publication status | Early online date - 07 Sep 2021 |
Keywords
- Organic Chemistry
- Pharmaceutical Science
- Pharmacology
- Biomedical Engineering
- Bioengineering
- Biotechnology
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- 3D printed multi-functional Ti6Al4V based hybrid scaffold for the management of osteosarcoma
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