3D printing: an appealing technology for the manufacturing of solid oral dosage forms

Giulia Pitzanti, Essyrose Mathew, Gavin Andrews, David Jones, Dimitrios Lamprou*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)
159 Downloads (Pure)

Abstract

Objectives
The traditional manufacturing methods of solid oral dosage forms (SODFs) are reported to be time-consuming, highly expensive and not tailored to the patient’s needs. Three-dimensional printing (3DP) is an innovative emerging technology that can help to overcome these issues. The aim of this review is to describe the most employed 3DP technologies, materials and the state of the art on 3DP SODFs. Characterization techniques of 3DP SODFs, challenges and regulatory issues are also discussed.

Key findings
The interest in the investigation of the suitability of 3DP as an alternative strategy for the fabrication of SODFs is growing. Different 3DP technologies and starting materials have been investigated for the development of SODFs. Numerous SODFs with complex geometries and composition, and with different release patterns, have been successfully manufactured via 3DP. Despite that, just one 3DP SODF has reached the market.

Summary
3DP can be a promising alternative to the classical SODFs manufacturing methods. However, numerous technically and regulatory challenges still need to be addressed in order 3DP to be extensively used in the pharmaceutical sector.

Original languageEnglish
Pages (from-to)1427–1449
Number of pages23
JournalJournal of Pharmacy and Pharmacology
Volume74
Issue number10
Early online date16 Sept 2021
DOIs
Publication statusPublished - 01 Oct 2022

Keywords

  • 3D Printing
  • DOSAGE FORMS
  • Oral Drug Delivery
  • Pharmaceutics
  • Polymers
  • Three-dimensional printing (3DP)

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