5-Fluorouracil: Molecular mechanisms of cell death

Daniel B. Longley, Patrick G. Johnston

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

5-Fluorouracil (5-FU) has been the mainstay of colorectal cancer treatment for over 40 years. However, response rates for 5-FU in advanced colorectal cancer are modest. Although combining 5-FU with the newer chemotherapeutic agents oxaliplatin and irinotecan has improved response rates, new therapeutic strategies are necessary. Understanding the molecular mechanism by which tumors become resistant to 5-FU is needed if drug resistance is to be overcome. Tumor drug resistance is often due to insufficient chemotherapy-induced cell death. In this chapter, we describe the mechanisms of action of 5-FU, focusing on 5-FU-induced cell death. In the future, strategies aimed at increasing the effectiveness of 5-FU may target the cell death and cell survival pathways that are activated by this drug.

Original languageEnglish
Title of host publicationApoptosis, Cell Signaling, and Human Diseases
PublisherHumana Press
Pages263-278
Number of pages16
Volume1
ISBN (Print)1588296776, 9781588296771
DOIs
Publication statusPublished - 01 Dec 2007

Keywords

  • 5-Fluorouracil
  • apoptosis
  • Bcl-2
  • death receptors
  • growth factor receptors

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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