A Brief Overview of Radiation-Induced Effects on Spermatogenesis and Oncofertility

Hisanori Fukunaga*, Akinari Yokoya, Kevin M. Prise

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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The genotoxicity of radiation on germ cells may be passed on to the next generation, thus its elucidation is not only a scientific issue but also an ethical, legal, and social issue in modern society. In this article, we briefly overview the effects of radiation on spermatogenesis and its associated genotoxicity, including the latest findings in the field of radiobiology. The potential role of transgenerational effects is still poorly understood, and further research in this area is desirable. Furthermore, from the perspective of oncofertility, we discuss the historical background and clinical importance of preserving male fertility during radiation treatment and the potential of microbeam radiotherapy. We hope that this review will contribute to stimulating further discussions and investigations for therapies for pediatric and adolescent/young adult patients.
Original languageEnglish
Article numbere805
Number of pages13
Issue number3
Early online date04 Feb 2022
Publication statusEarly online date - 04 Feb 2022


  • adolescent/young adult patient
  • ethical
  • legal
  • social issue
  • microbeam radiotherapy
  • oncofertility
  • radiation
  • spermatogenesis
  • transgenerational effect


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