A charged-particle microbeam .1. Development of an experimental system for targeting cells individually with counted particles

M. Folkard, B. Vojnovic, Kevin Prise, A.G. Bowey, R.J. Locke, Giuseppe Schettino, B.D. Michael

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Charged-particle microbeams provide a unique opportunity to control precisely, the dose to individual cells and the localization of dose within the cell. The Gray Laboratory is now routinely operating a charged-particle microbeam capable of delivering targeted and counted particles to individual cells, at a dose-rate sufficient to permit a number of single-cell assays of radiation damage to be implemented. By this means, it is possible to study a number of important radiobiological processes in ways that cannot be achieved using conventional methods. This report describes the rationale, development and current capabilities of the Gray Laboratory microbeam.
Original languageEnglish
Pages (from-to)375-385
Number of pages11
JournalInternational journal of radiation biology
Volume72
Publication statusPublished - 1997

Fingerprint Dive into the research topics of 'A charged-particle microbeam .1. Development of an experimental system for targeting cells individually with counted particles'. Together they form a unique fingerprint.

Cite this